Published in Virology on August 08, 2008
Getting a grip on prions: oligomers, amyloids, and pathological membrane interactions. Annu Rev Biochem (2009) 2.80
Rabbits are not resistant to prion infection. Proc Natl Acad Sci U S A (2012) 1.63
The strain-encoded relationship between PrP replication, stability and processing in neurons is predictive of the incubation period of disease. PLoS Pathog (2011) 1.49
Cells expressing anchorless prion protein are resistant to scrapie infection. J Virol (2009) 1.07
Prion protein biosynthesis and its emerging role in neurodegeneration. Trends Biochem Sci (2009) 0.97
Prion-like propagation of cytosolic protein aggregates: insights from cell culture models. Prion (2009) 0.96
Cellular aspects of prion replication in vitro. Viruses (2013) 0.95
Neuronal low-density lipoprotein receptor-related protein 1 binds and endocytoses prion fibrils via receptor cluster 4. J Cell Sci (2010) 0.94
Recombinant prion protein refolded with lipid and RNA has the biochemical hallmarks of a prion but lacks in vivo infectivity. PLoS One (2013) 0.90
Human PrP90-231-induced cell death is associated with intracellular accumulation of insoluble and protease-resistant macroaggregates and lysosomal dysfunction. Cell Death Dis (2011) 0.86
The role of the prion protein membrane anchor in prion infection. Prion (2009) 0.84
The Prion Protein N1 and N2 Cleavage Fragments Bind to Phosphatidylserine and Phosphatidic Acid; Relevance to Stress-Protection Responses. PLoS One (2015) 0.81
Characterization of intracellular dynamics of inoculated PrP-res and newly generated PrP(Sc) during early stage prion infection in Neuro2a cells. Virology (2014) 0.80
A specific population of abnormal prion protein aggregates is preferentially taken up by cells and disaggregated in a strain-dependent manner. J Virol (2013) 0.79
Modulation of Glycosaminoglycans Affects PrPSc Metabolism but Does Not Block PrPSc Uptake. J Virol (2015) 0.78
Uptake and degradation of protease-sensitive and -resistant forms of abnormal human prion protein aggregates by human astrocytes. Am J Pathol (2014) 0.77
Human tonsil-derived follicular dendritic-like cells are refractory to human prion infection in vitro and traffic disease-associated prion protein to lysosomes. Am J Pathol (2013) 0.77
Disease-associated mutations in the prion protein impair laminin-induced process outgrowth and survival. J Biol Chem (2012) 0.76
Prions Ex Vivo: What Cell Culture Models Tell Us about Infectious Proteins. Int J Cell Biol (2013) 0.76
Prions on the run: How extracellular vesicles serve as delivery vehicles for self-templating protein aggregates. Prion (2017) 0.75
PrPSc formation and clearance as determinants of prion tropism. PLoS Pathog (2017) 0.75
Prion strains depend on different endocytic routes for productive infection. Sci Rep (2017) 0.75
Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. J Mol Appl Genet (1982) 54.79
Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus. Cell (1983) 25.46
Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production. Mol Cell Biol (1986) 16.65
The most infectious prion protein particles. Nature (2005) 5.37
The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive. J Biol Chem (1991) 4.23
129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal. Mol Neurobiol (1995) 3.60
N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): implications regarding the site of conversion of PrP to the protease-resistant state. J Virol (1991) 3.55
Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells. J Cell Biol (1990) 3.46
Scrapie-infected murine neuroblastoma cells produce protease-resistant prion proteins. J Virol (1988) 3.37
Antibodies to a scrapie prion protein. Nature (1984) 3.09
Evidence for synthesis of scrapie prion proteins in the endocytic pathway. J Biol Chem (1992) 2.67
The state of the prion. Nat Rev Microbiol (2004) 2.60
Characterization of scrapie infection in mouse neuroblastoma cells. J Gen Virol (1987) 2.54
Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody. Proc Natl Acad Sci U S A (2001) 2.53
Neurological illness in transgenic mice expressing a prion protein with an insertional mutation. Neuron (1998) 2.40
Cultured cell sublines highly susceptible to prion infection. J Virol (2000) 2.38
A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis. J Virol (1997) 2.32
Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrP(Sc)) into contiguous membranes. EMBO J (2002) 2.16
Ultrastructural localization of scrapie prion proteins in cytoplasmic vesicles of infected cultured cells. Lab Invest (1991) 2.13
Molecular location of a species-specific epitope on the hamster scrapie agent protein. J Virol (1991) 1.89
Uptake and neuritic transport of scrapie prion protein coincident with infection of neuronal cells. J Neurosci (2005) 1.85
In vitro replication of scrapie agent in a neuronal model: infection of PC12 cells. J Gen Virol (1984) 1.80
Mouse-adapted scrapie infection of SN56 cells: greater efficiency with microsome-associated versus purified PrP-res. J Virol (2006) 1.35
Heparan sulfate is a cellular receptor for purified infectious prions. J Biol Chem (2005) 1.32
Susceptibility of common fibroblast cell lines to transmissible spongiform encephalopathy agents. J Infect Dis (2004) 1.25
Stimulation of PrP(C) retrograde transport toward the endoplasmic reticulum increases accumulation of PrP(Sc) in prion-infected cells. J Biol Chem (2002) 1.25
Cell division modulates prion accumulation in cultured cells. Proc Natl Acad Sci U S A (2007) 1.25
Acute formation of protease-resistant prion protein does not always lead to persistent scrapie infection in vitro. J Biol Chem (2004) 1.21
PrPSc incorporation to cells requires endogenous glycosaminoglycan expression. J Biol Chem (2005) 1.17
Molecular basis of scrapie strain glycoform variation. J Biol Chem (2002) 1.16
Inhibition of protease-resistant prion protein formation in a transformed deer cell line infected with chronic wasting disease. J Virol (2006) 1.14
Membrane microdomains, caveolae, and caveolar endocytosis of sphingolipids. Mol Membr Biol (2006) 1.13
Characterization of scrapie agent isolated from sheep in Japan. Microbiol Immunol (1985) 1.11
A novel epitope for the specific detection of exogenous prion proteins in transgenic mice and transfected murine cell lines. Virology (1999) 1.09
The scrapie prion protein is present in flotillin-1-positive vesicles in central- but not peripheral-derived neuronal cell lines. Eur J Neurosci (2005) 1.07
PrPc does not mediate internalization of PrPSc but is required at an early stage for de novo prion infection of Rov cells. J Virol (2007) 1.01
Skin-derived dendritic cells acquire and degrade the scrapie agent following in vitro exposure. Immunology (2005) 0.91
Short-term study of the uptake of PrP(Sc) by the Peyer's patches in hamsters after oral exposure to scrapie. J Comp Pathol (2006) 0.88
Development and characterization of clonal cell lines derived from septal cholinergic neurons. Brain Res (1990) 0.86
Molecular aspects of disease pathogenesis in the transmissible spongiform encephalopathies. Mol Biotechnol (2006) 0.86
Biosynthesis of the prion proteins in scrapie-infected cells in culture. Braz J Med Biol Res (1994) 0.81
Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein. Nat Methods (2007) 3.74
Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays. PLoS Pathog (2010) 2.63
Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking. Nat Methods (2008) 2.56
Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105-125. EMBO J (2007) 2.12
The cellular prion protein (PrP(C)): its physiological function and role in disease. Biochim Biophys Acta (2007) 2.09
Mutant PrP is delayed in its exit from the endoplasmic reticulum, but neither wild-type nor mutant PrP undergoes retrotranslocation prior to proteasomal degradation. J Biol Chem (2003) 1.64
Rabbits are not resistant to prion infection. Proc Natl Acad Sci U S A (2012) 1.63
Nonpsychoactive cannabidiol prevents prion accumulation and protects neurons against prion toxicity. J Neurosci (2007) 1.61
Nitrogen balance and delta15N: why you're not what you eat during nutritional stress. Rapid Commun Mass Spectrom (2005) 1.55
Mutant prion protein expression is associated with an alteration of the Rab GDP dissociation inhibitor alpha (GDI)/Rab11 pathway. Mol Cell Proteomics (2009) 1.52
Transmission and adaptation of chronic wasting disease to hamsters and transgenic mice: evidence for strains. J Virol (2007) 1.46
Biochemical dysfunction in heart mitochondria exposed to ischaemia and reperfusion. Biochem J (2005) 1.40
Cytosolic prion protein (PrP) is not toxic in N2a cells and primary neurons expressing pathogenic PrP mutations. J Biol Chem (2005) 1.39
Molecular distinction between pathogenic and infectious properties of the prion protein. J Virol (2003) 1.38
Multiple amino acid residues within the rabbit prion protein inhibit formation of its abnormal isoform. J Virol (2003) 1.35
Susceptibilities of nonhuman primates to chronic wasting disease. Emerg Infect Dis (2009) 1.33
Prion protein repeat expansion results in increased aggregation and reveals phenotypic variability. Mol Cell Biol (2007) 1.31
Nitrogen balance and delta15N: why you're not what you eat during pregnancy. Rapid Commun Mass Spectrom (2004) 1.29
Stromal cell-derived factor-1alpha activation of tissue-engineered endothelial progenitor cell matrix enhances ventricular function after myocardial infarction by inducing neovasculogenesis. Circulation (2010) 1.28
Lower specific infectivity of protease-resistant prion protein generated in cell-free reactions. Proc Natl Acad Sci U S A (2011) 1.26
Prion protein at the crossroads of physiology and disease. Trends Neurosci (2011) 1.26
Susceptibility of common fibroblast cell lines to transmissible spongiform encephalopathy agents. J Infect Dis (2004) 1.25
Acute formation of protease-resistant prion protein does not always lead to persistent scrapie infection in vitro. J Biol Chem (2004) 1.21
An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo. J Biol Chem (2013) 1.18
Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease. Proc Natl Acad Sci U S A (2004) 1.18
Molecular basis of scrapie strain glycoform variation. J Biol Chem (2002) 1.16
Dimerization of F0F1ATP synthase from bovine heart is independent from the binding of the inhibitor protein IF1. Biochim Biophys Acta (2002) 1.14
Neurotoxic mutants of the prion protein induce spontaneous ionic currents in cultured cells. J Biol Chem (2010) 1.12
A novel, drug-based, cellular assay for the activity of neurotoxic mutants of the prion protein. J Biol Chem (2009) 1.11
Mutational analysis of topological determinants in prion protein (PrP) and measurement of transmembrane and cytosolic PrP during prion infection. J Biol Chem (2003) 1.10
Cells expressing anchorless prion protein are resistant to scrapie infection. J Virol (2009) 1.07
Neurodegenerative illness in transgenic mice expressing a transmembrane form of the prion protein. J Neurosci (2005) 1.07
Circulating fibrocytes correlate with bronchiolitis obliterans syndrome development after lung transplantation: a novel clinical biomarker. Ann Thorac Surg (2011) 1.07
Adenosine A₂A agonist improves lung function during ex vivo lung perfusion. Ann Thorac Surg (2011) 1.07
Octapeptide repeat insertions increase the rate of protease-resistant prion protein formation. Protein Sci (2006) 1.07
A naturally occurring C-terminal fragment of the prion protein (PrP) delays disease and acts as a dominant-negative inhibitor of PrPSc formation. J Biol Chem (2011) 1.07
Aggregated, wild-type prion protein causes neurological dysfunction and synaptic abnormalities. J Neurosci (2008) 1.07
Crucial role for prion protein membrane anchoring in the neuroinvasion and neural spread of prion infection. J Virol (2010) 1.06
Prion protein misfolding and disease. Curr Opin Struct Biol (2009) 1.06
Non-infectious aggregates of the prion protein react with several PrPSc-directed antibodies. J Neurochem (2008) 1.04
An N-terminal polybasic domain and cell surface localization are required for mutant prion protein toxicity. J Biol Chem (2011) 1.03
GFP-tagged prion protein is correctly localized and functionally active in the brains of transgenic mice. Neurobiol Dis (2004) 1.02
Prion neurotoxicity: insights from prion protein mutants. Curr Issues Mol Biol (2009) 1.02
Human prion proteins with pathogenic mutations share common conformational changes resulting in enhanced binding to glycosaminoglycans. Proc Natl Acad Sci U S A (2007) 1.02
Optimal promoter usage for lentiviral vector-mediated transduction of cultured central nervous system cells. J Neurosci Methods (2010) 1.01
Flexible N-terminal region of prion protein influences conformation of protease-resistant prion protein isoforms associated with cross-species scrapie infection in vivo and in vitro. J Biol Chem (2004) 1.01
Visualization of prion infection in transgenic mice expressing green fluorescent protein-tagged prion protein. J Neurosci (2005) 0.99
Comparative profiling of highly enriched 22L and Chandler mouse scrapie prion protein preparations. Proteomics (2010) 0.99
A nine amino acid domain is essential for mutant prion protein toxicity. J Neurosci (2011) 0.98
Prion protein with an octapeptide insertion has impaired neuroprotective activity in transgenic mice. EMBO J (2007) 0.98
N-terminally deleted forms of the prion protein activate both Bax-dependent and Bax-independent neurotoxic pathways. J Neurosci (2007) 0.98
DNA aptamers that bind to PrP(C) and not PrP(Sc) show sequence and structure specificity. Exp Biol Med (Maywood) (2006) 0.98
Fishing for prion protein function. PLoS Biol (2009) 0.97
Mammalian prion protein suppresses Bax-induced cell death in yeast. J Biol Chem (2005) 0.97
A deleted prion protein that is neurotoxic in vivo is localized normally in cultured cells. J Neurochem (2008) 0.97
Copper and zinc cause delivery of the prion protein from the plasma membrane to a subset of early endosomes and the Golgi. J Neurochem (2003) 0.96
Endocytosis of prion protein is required for ERK1/2 signaling induced by stress-inducible protein 1. J Neurosci (2008) 0.96
Multiple biochemical similarities between infectious and non-infectious aggregates of a prion protein carrying an octapeptide insertion. J Neurochem (2007) 0.95
A mutant prion protein sensitizes neurons to glutamate-induced excitotoxicity. J Neurosci (2013) 0.95
Cell-to-cell propagation of infectious cytosolic protein aggregates. Proc Natl Acad Sci U S A (2013) 0.95
The neurotoxicity of prion protein (PrP) peptide 106-126 is independent of the expression level of PrP and is not mediated by abnormal PrP species. Mol Cell Neurosci (2005) 0.94
A transmembrane form of the prion protein is localized in the Golgi apparatus of neurons. J Biol Chem (2005) 0.93
The N-terminal, polybasic region of PrP(C) dictates the efficiency of prion propagation by binding to PrP(Sc). J Neurosci (2012) 0.93
Levels of abnormal prion protein in deer and elk with chronic wasting disease. Emerg Infect Dis (2007) 0.93
Tissue-engineered pro-angiogenic fibroblast scaffold improves myocardial perfusion and function and limits ventricular remodeling after infarction. J Thorac Cardiovasc Surg (2010) 0.92
In vitro and in vivo studies of F(0)F(1)ATP synthase regulation by inhibitor protein IF(1) in goat heart. Biochim Biophys Acta (2004) 0.91
The N-terminal, polybasic region is critical for prion protein neuroprotective activity. PLoS One (2011) 0.91
Recombinant prion protein refolded with lipid and RNA has the biochemical hallmarks of a prion but lacks in vivo infectivity. PLoS One (2013) 0.90
GFP-tagged mutant prion protein forms intra-axonal aggregates in transgenic mice. Neurobiol Dis (2008) 0.89
Strain specific resistance to murine scrapie associated with a naturally occurring human prion protein polymorphism at residue 171. PLoS Pathog (2011) 0.88
Ion channels induced by the prion protein: mediators of neurotoxicity. Prion (2012) 0.87
Gender, race, and socioeconomic status affects outcomes after lung cancer resections in the United States. Ann Thorac Surg (2011) 0.87
Immunopurification of pathological prion protein aggregates. PLoS One (2009) 0.86
Rapamycin blocks fibrocyte migration and attenuates bronchiolitis obliterans in a murine model. Ann Thorac Surg (2013) 0.86
The ectopic F(O)F(1) ATP synthase of rat liver is modulated in acute cholestasis by the inhibitor protein IF1. J Bioenerg Biomembr (2010) 0.85
Scrapie infection of prion protein-deficient cell line upon ectopic expression of mutant prion proteins. J Biol Chem (2007) 0.85
Doppel induces degeneration of cerebellar Purkinje cells independently of Bax. Am J Pathol (2007) 0.85
Identification and removal of proteins that co-purify with infectious prion protein improves the analysis of its secondary structure. Proteomics (2011) 0.85
A highly toxic cellular prion protein induces a novel, nonapoptotic form of neuronal death. Am J Pathol (2010) 0.83
Cyclic tetrapyrrole sulfonation, metals, and oligomerization in antiprion activity. Antimicrob Agents Chemother (2007) 0.83
A Drug-Based Cellular Assay (DBCA) for studying cytotoxic and cytoprotective activities of the prion protein: A practical guide. Methods (2010) 0.83
Fluorescence and kinetic analysis of the SpoIIAB phosphorylation reaction, a key regulator of sporulation in Bacillus subtilis. Biochemistry (2004) 0.83
Prion protein with an insertional mutation accumulates on axonal and dendritic plasmalemma and is associated with distinctive ultrastructural changes. Am J Pathol (2009) 0.82
Post-transcriptional suppression of pathogenic prion protein expression in Drosophila neurons. J Neurochem (2003) 0.82
The toxicity of a mutant prion protein is cell-autonomous, and can be suppressed by wild-type prion protein on adjacent cells. PLoS One (2012) 0.82
Prion protein lacks robust cytoprotective activity in cultured cells. Mol Neurodegener (2008) 0.82
Targeting the cellular prion protein to treat neurodegeneration. Future Med Chem (2012) 0.81
Disinfection and sterilization of prion-contaminated medical instruments. Infect Control Hosp Epidemiol (2010) 0.81
Amyloid formation via supramolecular peptide assemblies. Biochemistry (2007) 0.81
Chronic wasting disease agents in nonhuman primates. Emerg Infect Dis (2014) 0.79
A specific population of abnormal prion protein aggregates is preferentially taken up by cells and disaggregated in a strain-dependent manner. J Virol (2013) 0.79
Lack of prion infectivity in fixed heart tissue from patients with Creutzfeldt-Jakob disease or amyloid heart disease. J Virol (2013) 0.78
The study of the pathogenic mechanism of mitochondrial diseases provides information on basic bioenergetics. Biochim Biophys Acta (2008) 0.78
Cell surface expression of the prion protein in yeast does not alter copper utilization phenotypes. J Biol Chem (2004) 0.78
Proteomics analysis of amyloid and nonamyloid prion disease phenotypes reveals both common and divergent mechanisms of neuropathogenesis. J Proteome Res (2014) 0.77
Proteomics applications in prion biology and structure. Expert Rev Proteomics (2015) 0.76
Co-infection with the friend retrovirus and mouse scrapie does not alter prion disease pathogenesis in susceptible mice. PLoS One (2012) 0.76
Characterization of novel synthesized small molecular compounds against non-small cell lung cancer. Ann Thorac Surg (2011) 0.75