Published in J Clin Invest on September 01, 2008
The multiple signaling systems regulating virulence in Pseudomonas aeruginosa. Microbiol Mol Biol Rev (2012) 2.36
Racial differences in paraoxonase-1 (PON1): a factor in the health of southerners? Environ Health Perspect (2009) 1.53
Glucose depletion in the airway surface liquid is essential for sterility of the airways. PLoS One (2011) 1.26
Paraoxonase 1 (PON1) status and substrate hydrolysis. Toxicol Appl Pharmacol (2008) 1.21
Human PON1, a biomarker of risk of disease and exposure. Chem Biol Interact (2010) 1.09
Association of organophosphate pesticide exposure and paraoxonase with birth outcome in Mexican-American women. PLoS One (2011) 1.02
The roles of PON1 and PON2 in cardiovascular disease and innate immunity. Curr Opin Lipidol (2009) 1.00
A novel metagenomic short-chain dehydrogenase/reductase attenuates Pseudomonas aeruginosa biofilm formation and virulence on Caenorhabditis elegans. PLoS One (2011) 1.00
Paraoxonase 1 status as a risk factor for disease or exposure. Adv Exp Med Biol (2010) 0.99
A common mutation in paraoxonase-2 results in impaired lactonase activity. J Biol Chem (2009) 0.97
Glycosaminoglycan binding facilitates entry of a bacterial pathogen into central nervous systems. PLoS Pathog (2011) 0.96
Dietary cholesterol increases paraoxonase 1 enzyme activity. J Lipid Res (2012) 0.88
Additional Common Polymorphisms in the PON Gene Cluster Predict PON1 Activity but Not Vascular Disease. J Lipids (2012) 0.87
Inhaled lactonase reduces Pseudomonas aeruginosa quorum sensing and mortality in rat pneumonia. PLoS One (2014) 0.87
Inflammation, infection, cancer and all that…the role of paraoxonases. Adv Exp Med Biol (2014) 0.86
Quorum-sensing-regulated virulence factors in Pseudomonas aeruginosa are toxic to Lucilia sericata maggots. Microbiology (2009) 0.85
Role of PON2 in innate immune response in an acute infection model. Mol Genet Metab (2013) 0.84
Human pathogenic bacteria, fungi, and viruses in Drosophila: disease modeling, lessons, and shortcomings. Virulence (2014) 0.84
Human paraoxonase-1 (PON1): Gene structure and expression, promiscuous activities and multiple physiological roles. Gene (2015) 0.83
Novel common and rare genetic determinants of paraoxonase activity: FTO, SERPINA12, and ITGAL. J Lipid Res (2012) 0.83
The Drosophila melanogaster host model. J Oral Microbiol (2012) 0.82
Nosocomial infections after severe trauma are associated with lower apolipoproteins B and AII. J Trauma Acute Care Surg (2013) 0.80
Engineering human PON1 in an E. coli expression system. Adv Exp Med Biol (2010) 0.80
Role of PON in anoxia-reoxygenation injury: a Drosophila melanogaster transgenic model. PLoS One (2014) 0.77
Paraoxonases-1, -2 and -3: What are their functions? Chem Biol Interact (2016) 0.76
Expression of human paraoxonase 1 decreases superoxide levels and alters bacterial colonization in the gut of Drosophila melanogaster. PLoS One (2012) 0.76
Paraoxonases as protective agents against N-acyl homoserine lactone - producing pathogenic microorganisms. Maedica (Buchar) (2013) 0.75
Analysis of esterase enzyme activity in adults of the major malaria vector Anopheles funestus. Parasit Vectors (2016) 0.75
Host modification of a bacterial quorum-sensing signal induces a phenotypic switch in bacterial symbionts. Proc Natl Acad Sci U S A (2017) 0.75
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development (1993) 58.26
The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell (1996) 17.42
Structural identification of autoinducer of Photobacterium fischeri luciferase. Biochemistry (1981) 11.48
Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication. Science (1993) 10.85
The host defense of Drosophila melanogaster. Annu Rev Immunol (2007) 10.75
Cellular control of the synthesis and activity of the bacterial luminescent system. J Bacteriol (1970) 10.35
Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms. Nature (2000) 10.32
Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients. Proc Natl Acad Sci U S A (2006) 8.85
Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis. J Bacteriol (2003) 8.11
Regulation of las and rhl quorum sensing in Pseudomonas aeruginosa. J Bacteriol (1997) 6.74
Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment. J Bacteriol (2003) 6.36
A hierarchical quorum-sensing cascade in Pseudomonas aeruginosa links the transcriptional activators LasR and RhIR (VsmR) to expression of the stationary-phase sigma factor RpoS. Mol Microbiol (1996) 6.07
Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A (1999) 5.82
Detecting and characterizing N-acyl-homoserine lactone signal molecules by thin-layer chromatography. Proc Natl Acad Sci U S A (1997) 5.39
Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase. Nature (2001) 4.73
AiiA, an enzyme that inactivates the acylhomoserine lactone quorum-sensing signal and attenuates the virulence of Erwinia carotovora. Proc Natl Acad Sci U S A (2000) 4.18
Contribution of specific Pseudomonas aeruginosa virulence factors to pathogenesis of pneumonia in a neonatal mouse model of infection. Infect Immun (1996) 4.08
Acyl-homoserine lactone quorum sensing in gram-negative bacteria: a signaling mechanism involved in associations with higher organisms. Proc Natl Acad Sci U S A (2000) 4.00
QscR, a modulator of quorum-sensing signal synthesis and virulence in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A (2001) 3.96
Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis. Nature (1998) 3.84
Social cheating in Pseudomonas aeruginosa quorum sensing. Proc Natl Acad Sci U S A (2007) 3.42
Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. J Lipid Res (2005) 3.01
Contribution of quorum sensing to the virulence of Pseudomonas aeruginosa in burn wound infections. Infect Immun (1999) 2.67
Interspecies communication in bacteria. J Clin Invest (2003) 2.55
Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities. Drug Metab Dispos (1991) 2.51
The Drosophila melanogaster toll pathway participates in resistance to infection by the gram-negative human pathogen Pseudomonas aeruginosa. Infect Immun (2003) 2.41
Pseudomonas aeruginosa cell-to-cell signaling is required for virulence in a model of acute pulmonary infection. Infect Immun (2000) 2.40
Drosophila as a model host for Pseudomonas aeruginosa infection. J Bacteriol (2001) 2.36
Paraoxonase and atherosclerosis. Arterioscler Thromb Vasc Biol (2001) 2.34
The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)homoserine lactone contributes to virulence and induces inflammation in vivo. J Bacteriol (2002) 2.18
Inducible antibacterial defence system in Drosophila. Nature (1972) 2.08
Chlamydia pneumoniae as an emerging risk factor in cardiovascular disease. JAMA (2002) 1.95
Pseudomonas aeruginosa quorum-sensing systems may control virulence factor expression in the lungs of patients with cystic fibrosis. Infect Immun (2002) 1.85
Prevalence of local immune response against oral infection in a Drosophila/Pseudomonas infection model. PLoS Pathog (2006) 1.83
Human and murine paraoxonase 1 are host modulators of Pseudomonas aeruginosa quorum-sensing. FEMS Microbiol Lett (2005) 1.81
Structure-reactivity studies of serum paraoxonase PON1 suggest that its native activity is lactonase. Biochemistry (2005) 1.80
Identification of quorum-quenching N-acyl homoserine lactonases from Bacillus species. Appl Environ Microbiol (2002) 1.78
A cystic fibrosis epidemic strain of Pseudomonas aeruginosa displays enhanced virulence and antimicrobial resistance. J Bacteriol (2005) 1.74
Analysis of quorum sensing-deficient clinical isolates of Pseudomonas aeruginosa. J Med Microbiol (2004) 1.69
Direct detection of N-acylhomoserine lactones in cystic fibrosis sputum. FEMS Microbiol Lett (2002) 1.65
The paraoxonase gene family and atherosclerosis. Free Radic Biol Med (2005) 1.56
Quorum quenching enzyme activity is widely conserved in the sera of mammalian species. FEBS Lett (2005) 1.47
Paraoxonase-2 deficiency enhances Pseudomonas aeruginosa quorum sensing in murine tracheal epithelia. Am J Physiol Lung Cell Mol Physiol (2006) 1.45
Characterization of cell-to-cell signaling-deficient Pseudomonas aeruginosa strains colonizing intubated patients. J Clin Microbiol (2004) 1.40
Pseudomonas aeruginosa mutations in lasI and rhlI quorum sensing systems result in milder chronic lung infection. Microbiology (2001) 1.39
Pseudomonas aeruginosa relA contributes to virulence in Drosophila melanogaster. Infect Immun (2004) 1.32
Pseudomonas aeruginosa with lasI quorum-sensing deficiency during corneal infection. Invest Ophthalmol Vis Sci (2004) 1.22
High affinity, stability, and lactonase activity of serum paraoxonase PON1 anchored on HDL with ApoA-I. Biochemistry (2005) 1.21
Purification of rabbit and human serum paraoxonase. Biochemistry (1991) 1.21
Human and rabbit paraoxonases: purification, cloning, sequencing, mapping and role of polymorphism in organophosphate detoxification. Chem Biol Interact (1993) 1.14
Suppression of Drosophila cellular immunity by directed expression of the ExoS toxin GAP domain of Pseudomonas aeruginosa. Cell Microbiol (2005) 1.13
Identification of residues essential for human paraoxonase (PON1) arylesterase/organophosphatase activities. Biochemistry (1999) 1.06
Chromogenic and fluorogenic assays for the lactonase activity of serum paraoxonases. Chembiochem (2006) 1.04
Biochemical and physiological studies of soluble esterases from Drosophila melanogaster. Biochem Genet (1991) 0.94
How to kill a mocking bug? Cell Microbiol (2006) 0.91
Paraoxonase 2 gene C311S polymorphism is associated with a risk of large vessel disease stroke in a Polish population. Cerebrovasc Dis (2007) 0.88
Helicobacter pylori infection and ischaemic heart disease: an overview of the general literature. Dig Liver Dis (2005) 0.88
Role of Pseudomonas aeruginosa quorum-sensing systems in a mouse model of chronic respiratory infection. J Med Microbiol (2005) 0.86
Serum paraoxonase activity is decreased in the active stage of Behçet's disease. Br J Ophthalmol (2004) 0.83
Serum paraoxonase-1 activity in Helicobacter pylori infected subjects. Atherosclerosis (2006) 0.82
Paraoxonase 1, 2 and 3 DNA variants and susceptibility to childhood inflammatory bowel disease. Gut (2006) 0.81
Transfer and expression of an organophosphate insecticide-degrading gene from Pseudomonas in Drosophila melanogaster. Proc Natl Acad Sci U S A (1990) 0.77
In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature (2012) 7.80
iPS cells produce viable mice through tetraploid complementation. Nature (2009) 6.51
Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs. Science (2008) 6.28
Bacterial competition: surviving and thriving in the microbial jungle. Nat Rev Microbiol (2010) 5.63
The draft genome of the transgenic tropical fruit tree papaya (Carica papaya Linnaeus). Nature (2008) 5.54
Pseudomonas aeruginosa anaerobic respiration in biofilms: relationships to cystic fibrosis pathogenesis. Dev Cell (2002) 4.94
A component of innate immunity prevents bacterial biofilm development. Nature (2002) 4.73
Motile cilia of human airway epithelia are chemosensory. Science (2009) 4.40
Increasing solar absorption for photocatalysis with black hydrogenated titanium dioxide nanocrystals. Science (2011) 3.89
Segregation of receptor and ligand regulates activation of epithelial growth factor receptor. Nature (2003) 3.61
RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice. Neuron (2003) 3.58
Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escape. Cell (2002) 3.53
An in vitro model of differentiated human airway epithelia. Methods for establishing primary cultures. Methods Mol Biol (2002) 3.48
Identification of psl, a locus encoding a potential exopolysaccharide that is essential for Pseudomonas aeruginosa PAO1 biofilm formation. J Bacteriol (2004) 3.39
Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound. Microbiology (2002) 3.37
Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth. Sci Transl Med (2010) 3.36
MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors. Cell Stem Cell (2010) 3.18
Alginate is not a significant component of the extracellular polysaccharide matrix of PA14 and PAO1 Pseudomonas aeruginosa biofilms. Proc Natl Acad Sci U S A (2003) 3.02
Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung. Nature (2012) 2.94
The impact of quorum sensing and swarming motility on Pseudomonas aeruginosa biofilm formation is nutritionally conditional. Mol Microbiol (2006) 2.94
Percentage of subjects with no heavy drinking days: evaluation as an efficacy endpoint for alcohol clinical trials. Alcohol Clin Exp Res (2010) 2.89
Assembly and development of the Pseudomonas aeruginosa biofilm matrix. PLoS Pathog (2009) 2.85
Practical reconstruction method for bioluminescence tomography. Opt Express (2005) 2.83
Annotated expressed sequence tags and cDNA microarrays for studies of brain and behavior in the honey bee. Genome Res (2002) 2.78
A novel host defense system of airways is defective in cystic fibrosis. Am J Respir Crit Care Med (2006) 2.61
The porcine lung as a potential model for cystic fibrosis. Am J Physiol Lung Cell Mol Physiol (2008) 2.53
Analysis of Pseudomonas aeruginosa conditional psl variants reveals roles for the psl polysaccharide in adhesion and maintaining biofilm structure postattachment. J Bacteriol (2006) 2.53
Characterization of colony morphology variants isolated from Pseudomonas aeruginosa biofilms. Appl Environ Microbiol (2005) 2.41
Contribution of enteric infection, altered intestinal barrier function, and maternal malnutrition to infant malnutrition in Bangladesh. Clin Infect Dis (2011) 2.38
The exopolysaccharide alginate protects Pseudomonas aeruginosa biofilm bacteria from IFN-gamma-mediated macrophage killing. J Immunol (2005) 2.30
Loss of anion transport without increased sodium absorption characterizes newborn porcine cystic fibrosis airway epithelia. Cell (2010) 2.24
Pseudomonas aeruginosa uses a cyclic-di-GMP-regulated adhesin to reinforce the biofilm extracellular matrix. Mol Microbiol (2010) 2.24
Pseudomonas aeruginosa rugose small-colony variants have adaptations that likely promote persistence in the cystic fibrosis lung. J Bacteriol (2009) 2.22
Statistical analysis of Pseudomonas aeruginosa biofilm development: impact of mutations in genes involved in twitching motility, cell-to-cell signaling, and stationary-phase sigma factor expression. Appl Environ Microbiol (2002) 2.19
Prognostic significance of tumor-associated macrophages in solid tumor: a meta-analysis of the literature. PLoS One (2012) 2.14
The tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury. PLoS One (2013) 2.14
Heavy metal resistance of biofilm and planktonic Pseudomonas aeruginosa. Appl Environ Microbiol (2003) 2.06
Quality of life in chronic kidney disease (CKD): a cross-sectional analysis in the Renal Research Institute-CKD study. Am J Kidney Dis (2005) 2.05
Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state. Stem Cell Reports (2013) 2.05
The pel polysaccharide can serve a structural and protective role in the biofilm matrix of Pseudomonas aeruginosa. PLoS Pathog (2011) 2.04
The ΔF508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs. Sci Transl Med (2011) 2.01
Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children. Am J Respir Crit Care Med (2010) 1.94
The Songbird Neurogenomics (SoNG) Initiative: community-based tools and strategies for study of brain gene function and evolution. BMC Genomics (2008) 1.93
A cattle-human comparative map built with cattle BAC-ends and human genome sequence. Genome Res (2003) 1.92
Genetic and biochemical analyses of the Pseudomonas aeruginosa Psl exopolysaccharide reveal overlapping roles for polysaccharide synthesis enzymes in Psl and LPS production. Mol Microbiol (2009) 1.91
Interleukin-9 induces goblet cell hyperplasia during repair of human airway epithelia. Am J Respir Cell Mol Biol (2003) 1.85
Human and murine paraoxonase 1 are host modulators of Pseudomonas aeruginosa quorum-sensing. FEMS Microbiol Lett (2005) 1.81
Broadband graphene terahertz modulators enabled by intraband transitions. Nat Commun (2012) 1.79
S-nitrosylating agents: a novel class of compounds that increase cystic fibrosis transmembrane conductance regulator expression and maturation in epithelial cells. Mol Pharmacol (2006) 1.79
Role of f-box factor foxj1 in differentiation of ciliated airway epithelial cells. Am J Physiol Lung Cell Mol Physiol (2003) 1.76
Survival and growth in the presence of elevated copper: transcriptional profiling of copper-stressed Pseudomonas aeruginosa. J Bacteriol (2006) 1.75
Hematocrit is associated with fibrosis in patients with nonalcoholic steatohepatitis. Eur J Gastroenterol Hepatol (2014) 1.71
The Pel and Psl polysaccharides provide Pseudomonas aeruginosa structural redundancy within the biofilm matrix. Environ Microbiol (2011) 1.69
Pharmacogenetic approach at the serotonin transporter gene as a method of reducing the severity of alcohol drinking. Am J Psychiatry (2011) 1.69
Quorum sensing and motility mediate interactions between Pseudomonas aeruginosa and Agrobacterium tumefaciens in biofilm cocultures. Proc Natl Acad Sci U S A (2006) 1.68
Phosphorus limitation enhances biofilm formation of the plant pathogen Agrobacterium tumefaciens through the PhoR-PhoB regulatory system. J Bacteriol (2004) 1.67
Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors. Cell Res (2011) 1.67
Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation. Cell (2013) 1.66
Inactivation of a Pseudomonas aeruginosa quorum-sensing signal by human airway epithelia. Proc Natl Acad Sci U S A (2004) 1.66
Pseudomonas aeruginosa biofilm matrix polysaccharide Psl is regulated transcriptionally by RpoS and post-transcriptionally by RsmA. Mol Microbiol (2010) 1.66
Air trapping and airflow obstruction in newborn cystic fibrosis piglets. Am J Respir Crit Care Med (2013) 1.65
Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein. Cell Res (2012) 1.64
Prevalence of covert duplicate publications in Budd-Chiari syndrome articles in China: a systematic analysis. Am J Med (2013) 1.63
Effects of topiramate on methamphetamine-induced changes in attentional and perceptual-motor skills of cognition in recently abstinent methamphetamine-dependent individuals. Prog Neuropsychopharmacol Biol Psychiatry (2006) 1.62
UCA1, a long non-coding RNA up-regulated in colorectal cancer influences cell proliferation, apoptosis and cell cycle distribution. Pathology (2014) 1.61
The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia. Am J Physiol Lung Cell Mol Physiol (2010) 1.61
Curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells. Int J Cancer (2006) 1.57
Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease. Proc Natl Acad Sci U S A (2009) 1.56
Inflammatory response in airway epithelial cells isolated from patients with cystic fibrosis. Am J Respir Crit Care Med (2002) 1.56
The Bcl-2 homology domain 3 mimetic gossypol induces both Beclin 1-dependent and Beclin 1-independent cytoprotective autophagy in cancer cells. J Biol Chem (2010) 1.55
Construction of genetic linkage maps and comparative genome analysis of catfish using gene-associated markers. Genetics (2009) 1.55
The accessory genome of Pseudomonas aeruginosa. Microbiol Mol Biol Rev (2010) 1.53
Hydrogen peroxide inhibits mTOR signaling by activation of AMPKalpha leading to apoptosis of neuronal cells. Lab Invest (2010) 1.52
Aliskiren enhances protective effects of valsartan against type 2 diabetic nephropathy in mice. J Hypertens (2010) 1.52
Androgenetic haploid embryonic stem cells produce live transgenic mice. Nature (2012) 1.51
Resveratrol facilitates pain attenuation in a rat model of neuropathic pain through the activation of spinal Sirt1. Reg Anesth Pain Med (2013) 1.50
Adeno-associated virus types 5 and 6 use distinct receptors for cell entry. Hum Gene Ther (2006) 1.50
Structure of adeno-associated virus serotype 5. J Virol (2004) 1.50
The effect of the chemical, biological, and physical environment on quorum sensing in structured microbial communities. Anal Bioanal Chem (2006) 1.49
Lysozyme secretion by submucosal glands protects the airway from bacterial infection. Am J Respir Cell Mol Biol (2005) 1.49
Loss of Bardet-Biedl syndrome proteins alters the morphology and function of motile cilia in airway epithelia. Proc Natl Acad Sci U S A (2008) 1.49
ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy. EMBO Rep (2014) 1.49
A 1463 gene cattle-human comparative map with anchor points defined by human genome sequence coordinates. Genome Res (2004) 1.48
The extracellular matrix protects Pseudomonas aeruginosa biofilms by limiting the penetration of tobramycin. Environ Microbiol (2013) 1.47
Prognostic role of circulating tumor cells and disseminated tumor cells in patients with prostate cancer: a systematic review and meta-analysis. Tumour Biol (2014) 1.46
Paraoxonase-2 deficiency enhances Pseudomonas aeruginosa quorum sensing in murine tracheal epithelia. Am J Physiol Lung Cell Mol Physiol (2006) 1.45
Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5. Free Radic Biol Med (2008) 1.45