Published in Cell Res on February 07, 2012
Autophagy in infection, inflammation and immunity. Nat Rev Immunol (2013) 4.16
Identification of a candidate therapeutic autophagy-inducing peptide. Nature (2013) 3.76
The machinery of macroautophagy. Cell Res (2013) 3.13
Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia. Proc Natl Acad Sci U S A (2013) 2.33
Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells. Nat Cell Biol (2013) 2.00
Polyglutamine tracts regulate beclin 1-dependent autophagy. Nature (2017) 1.48
Two-site recognition of phosphatidylinositol 3-phosphate by PROPPINs in autophagy. Mol Cell (2012) 1.37
Atomistic autophagy: the structures of cellular self-digestion. Cell (2014) 1.23
Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes. Science (2015) 1.21
Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy. Mol Cell Biol (2013) 1.16
Evolution of Bcl-2 homology motifs: homology versus homoplasy. Trends Cell Biol (2012) 1.08
Role of the Crosstalk between Autophagy and Apoptosis in Cancer. J Oncol (2013) 1.07
Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex. Elife (2014) 1.06
Multipolar functions of BCL-2 proteins link energetics to apoptosis. Trends Cell Biol (2012) 1.05
Beclin orthologs: integrative hubs of cell signaling, membrane trafficking, and physiology. Trends Cell Biol (2015) 1.00
Structure of the novel C-terminal domain of vacuolar protein sorting 30/autophagy-related protein 6 and its specific role in autophagy. J Biol Chem (2012) 1.00
Survival or death: disequilibrating the oncogenic and tumor suppressive autophagy in cancer. Cell Death Dis (2013) 0.99
Regulation of the autophagic bcl-2/beclin 1 interaction. Cells (2012) 0.98
Role of the inositol 1,4,5-trisphosphate receptor/Ca2+-release channel in autophagy. Cell Commun Signal (2012) 0.92
Autophagy Contributes to the Death/Survival Balance in Cancer PhotoDynamic Therapy. Cells (2012) 0.83
Comparative gene identification-58 (CGI-58) promotes autophagy as a putative lysophosphatidylglycerol acyltransferase. J Biol Chem (2014) 0.83
The Role of Cardiolipin in Cardiovascular Health. Biomed Res Int (2015) 0.82
Beclin 1, an Essential Component and Master Regulator of PI3K-III in Health and Disease. Curr Pathobiol Rep (2013) 0.82
Post-translationally-modified structures in the autophagy machinery: an integrative perspective. FEBS J (2015) 0.82
Beclin 1 biology and its role in heart disease. Curr Cardiol Rev (2015) 0.81
Conformational Flexibility Enables the Function of a BECN1 Region Essential for Starvation-Mediated Autophagy. Biochemistry (2016) 0.80
Cardiolipin and its different properties in mitophagy and apoptosis. J Histochem Cytochem (2015) 0.80
Conformational flexibility of BECN1: Essential to its key role in autophagy and beyond. Protein Sci (2016) 0.80
Identification of BECN1 and ATG14 Coiled-Coil Interface Residues That Are Important for Starvation-Induced Autophagy. Biochemistry (2016) 0.79
Rescuing apoptotic neurons in Alzheimer's disease using wheat germ agglutinin-conjugated and cardiolipin-conjugated liposomes with encapsulated nerve growth factor and curcumin. Int J Nanomedicine (2015) 0.79
The BECN1 N-terminal domain is intrinsically disordered. Autophagy (2016) 0.79
Cardiolipin remodeling by TAZ/tafazzin is selectively required for the initiation of mitophagy. Autophagy (2015) 0.79
ALCAT1 controls mitochondrial etiology of fatty liver diseases, linking defective mitophagy to steatosis. Hepatology (2015) 0.78
BECLIN 1-VPS34 COMPLEX ARCHITECTURE: UNDERSTANDING THE NUTS AND BOLTS OF THERAPEUTIC TARGETS. Front Biol (Beijing) (2015) 0.77
Mechanisms of Autophagy Initiation. Annu Rev Biochem (2017) 0.76
Targeting autophagy for disease therapy. Nat Biotechnol (2013) 0.76
Sensing Membrane Curvature in Macroautophagy. J Mol Biol (2017) 0.76
Sanofi-Cell Research outstanding paper award of 2012. Cell Res (2013) 0.75
Human Atg8-cardiolipin interactions in mitophagy: Specific properties of LC3B, GABARAPL2 and GABARAP. Autophagy (2016) 0.75
BECN2 interacts with ATG14 through a metastable coiled-coil to mediate autophagy. Protein Sci (2017) 0.75
Structural biology of the macroautophagy machinery. Front Biol (Beijing) (2014) 0.75
BECN1/Beclin 1 sorts cell-surface APP/amyloid β precursor protein for lysosomal degradation. Autophagy (2016) 0.75
PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity. EMBO J (2016) 0.75
Self-eating with your fingers. Cell Res (2012) 0.75
Mutation-Structure-Function Relationship Based Integrated Strategy Reveals the Potential Impact of Deleterious Missense Mutations in Autophagy Related Proteins on Hepatocellular Carcinoma (HCC): A Comprehensive Informatics Approach. Int J Mol Sci (2017) 0.75
Structural transitions in conserved, ordered Beclin 1 domains essential to regulating autophagy. J Biol Chem (2017) 0.75
Plant Bax Inhibitor-1 Interacts with ATG6 to Regulate Autophagy and Programmed Cell Death. Autophagy (2017) 0.75
Role of Cardiolipin in Mitochondrial Signaling Pathways. Front Cell Dev Biol (2017) 0.75
Beclin 1 expression is associated with the occurrence and development of esophageal squamous cell carcinoma. Oncol Lett (2017) 0.75
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88
Phaser crystallographic software. J Appl Crystallogr (2007) 108.34
PHENIX: building new software for automated crystallographic structure determination. Acta Crystallogr D Biol Crystallogr (2002) 53.61
Protein structure comparison by alignment of distance matrices. J Mol Biol (1993) 34.74
Substructure solution with SHELXD. Acta Crystallogr D Biol Crystallogr (2002) 27.16
Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature (1999) 23.62
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell (2005) 21.01
The Buccaneer software for automated model building. 1. Tracing protein chains. Acta Crystallogr D Biol Crystallogr (2006) 18.18
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest (2003) 16.67
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A (2003) 15.59
Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J (2007) 11.72
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J Cell Biol (2008) 9.37
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol (2006) 9.17
Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell (2002) 8.38
Mitochondria supply membranes for autophagosome biogenesis during starvation. Cell (2010) 8.29
Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol (2009) 7.96
Membrane recognition by phospholipid-binding domains. Nat Rev Mol Cell Biol (2008) 7.43
Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol (1998) 7.41
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell (2008) 7.32
Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep (2001) 7.13
How proteins produce cellular membrane curvature. Nat Rev Mol Cell Biol (2006) 6.90
Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. Genomics (1999) 6.23
Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. J Biol Chem (2007) 5.21
Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A (2008) 4.71
The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond. Trends Cell Biol (2010) 4.15
The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function. Autophagy (2005) 4.02
Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae. J Biol Chem (1998) 3.93
Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene products. J Cell Biol (1997) 3.61
Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L. J Cell Biol (2010) 2.98
The autophagy effector Beclin 1: a novel BH3-only protein. Oncogene (2008) 2.94
Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation. Autophagy (2010) 2.91
The regulation of autophagy - unanswered questions. J Cell Sci (2011) 2.73
Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria. Cell Death Dis (2010) 2.61
Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function. Cancer Res (2001) 2.51
Molecular basis of Bcl-xL's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of Beclin-1. J Mol Biol (2007) 2.08
Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme. Nat Struct Mol Biol (2006) 2.03
The crystal structure of microtubule-associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8. Genes Cells (2004) 1.98
Cardiolipin microdomains localize to negatively curved regions of Escherichia coli membranes. Proc Natl Acad Sci U S A (2011) 1.86
Current knowledge of the pre-autophagosomal structure (PAS). FEBS Lett (2010) 1.72
Interplay of proteins and lipids in generating membrane curvature. Curr Opin Cell Biol (2010) 1.64
Mitochondrial cardiolipin involved in outer-membrane protein biogenesis: implications for Barth syndrome. Curr Biol (2009) 1.62
Crystal structures of the membrane-binding C2 domain of human coagulation factor V. Nature (1999) 1.58
pH-dissociation characteristics of cardiolipin and its 2'-deoxy analogue. Lipids (1993) 1.53
Iodixanol: a nonionic iso-osmotic centrifugation medium for the formation of self-generated gradients. Anal Biochem (1994) 1.37
Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis. Protein Cell (2010) 1.32
Atg14 and UVRAG: mutually exclusive subunits of mammalian Beclin 1-PI3K complexes. Autophagy (2009) 1.29
Phospholipid composition of highly purified mitochondrial outer membranes of rat liver and Neurospora crassa. Is cardiolipin present in the mitochondrial outer membrane? Biochim Biophys Acta (1997) 1.28
Milk fat globule epidermal growth factor 8 (MFG-E8) binds to oxidized phosphatidylserine: implications for macrophage clearance of apoptotic cells. Cell Death Differ (2004) 1.05
Weaning-induced expression of a milk-fat globule protein, MFG-E8, in mouse mammary glands, as demonstrated by the analyses of its mRNA, protein and phosphatidylserine-binding activity. Biochem J (2006) 0.90
Purification of human respiratory syncytial virus by ultracentrifugation in iodixanol density gradient. J Virol Methods (2007) 0.85
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Transcriptomic analysis of autistic brain reveals convergent molecular pathology. Nature (2011) 10.16
In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature (2012) 7.80
Molecular mechanisms of caspase regulation during apoptosis. Nat Rev Mol Cell Biol (2004) 6.76
iPS cells produce viable mice through tetraploid complementation. Nature (2009) 6.51
Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature (2010) 6.26
The draft genome of the transgenic tropical fruit tree papaya (Carica papaya Linnaeus). Nature (2008) 5.54
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol Cell Biol (2002) 5.39
PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling. Cell (2006) 5.28
Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. J Biol Chem (2007) 5.21
China's research culture. Science (2010) 5.08
Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. Cell (2002) 4.33
Mechanism of XIAP-mediated inhibition of caspase-9. Mol Cell (2003) 4.07
Increasing solar absorption for photocatalysis with black hydrogenated titanium dioxide nanocrystals. Science (2011) 3.89
Structural basis for sequence-specific recognition of DNA by TAL effectors. Science (2012) 3.64
RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice. Neuron (2003) 3.58
Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J Biol Chem (2006) 3.40
Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations. J Clin Invest (2006) 3.27
MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors. Cell Stem Cell (2010) 3.18
Structure of the protein phosphatase 2A holoenzyme. Cell (2006) 3.07
Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry. Nat Struct Mol Biol (2006) 3.00
Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14. EMBO J (2005) 2.99
Percentage of subjects with no heavy drinking days: evaluation as an efficacy endpoint for alcohol clinical trials. Alcohol Clin Exp Res (2010) 2.89
Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. Nat Cell Biol (2010) 2.78
Annotated expressed sequence tags and cDNA microarrays for studies of brain and behavior in the honey bee. Genome Res (2002) 2.78
Structural insights into the regulatory particle of the proteasome from Methanocaldococcus jannaschii. Mol Cell (2009) 2.75
A study of machine-learning-based approaches to extract clinical entities and their assertions from discharge summaries. J Am Med Inform Assoc (2011) 2.70
Structure of the apoptotic protease-activating factor 1 bound to ADP. Nature (2005) 2.63
Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi. Nat Struct Biol (2002) 2.60
C. elegans screen identifies autophagy genes specific to multicellular organisms. Cell (2010) 2.50
Dicer recognizes the 5' end of RNA for efficient and accurate processing. Nature (2011) 2.49
The process of mRNA-tRNA translocation. Proc Natl Acad Sci U S A (2007) 2.45
Structure and mechanism of an amino acid antiporter. Science (2009) 2.40
Contribution of enteric infection, altered intestinal barrier function, and maternal malnutrition to infant malnutrition in Bangladesh. Clin Infect Dis (2011) 2.38
Cyclic di-GMP sensing via the innate immune signaling protein STING. Mol Cell (2012) 2.38
Electronic origin of high-temperature superconductivity in single-layer FeSe superconductor. Nat Commun (2012) 2.37
Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegans. Science (2002) 2.36
Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. PLoS Biol (2006) 2.35
Phase diagram and electronic indication of high-temperature superconductivity at 65 K in single-layer FeSe films. Nat Mater (2013) 2.34
Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling. Mol Cell (2004) 2.31
Prediction of protein-protein interactions using random decision forest framework. Bioinformatics (2005) 2.30
Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer. Cancer Res (2010) 2.27
Human papillomavirus type 16 and squamous cell carcinoma of the head and neck. Clin Cancer Res (2002) 2.20
Prognostic significance of tumor-associated macrophages in solid tumor: a meta-analysis of the literature. PLoS One (2012) 2.14
P38 MAP kinase is activated at early stages in Alzheimer's disease brain. Exp Neurol (2003) 2.14
tRNA binds to cytochrome c and inhibits caspase activation. Mol Cell (2010) 2.14
The tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury. PLoS One (2013) 2.14
pH sensing by intracellular Salmonella induces effector translocation. Science (2010) 2.13
Crystal structure of NLRC4 reveals its autoinhibition mechanism. Science (2013) 2.10
Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans. Nature (2005) 2.08
Structure of a site-2 protease family intramembrane metalloprotease. Science (2007) 2.08
Chaperone-mediated pathway of proteasome regulatory particle assembly. Nature (2009) 2.07
Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state. Stem Cell Reports (2013) 2.05
Quality of life in chronic kidney disease (CKD): a cross-sectional analysis in the Renal Research Institute-CKD study. Am J Kidney Dis (2005) 2.05
Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim. Nat Struct Mol Biol (2004) 2.03
SseL, a Salmonella deubiquitinase required for macrophage killing and virulence. Proc Natl Acad Sci U S A (2007) 1.99
Aurora B regulates formin mDia3 in achieving metaphase chromosome alignment. Dev Cell (2011) 1.98
Two rice phosphate transporters, OsPht1;2 and OsPht1;6, have different functions and kinetic properties in uptake and translocation. Plant J (2008) 1.97
The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell (2011) 1.95
Meta-analysis of the impact of human papillomavirus (HPV) on cancer risk and overall survival in head and neck squamous cell carcinomas (HNSCC). Head Neck Oncol (2010) 1.94
Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylation. Mol Cell (2008) 1.93
The Songbird Neurogenomics (SoNG) Initiative: community-based tools and strategies for study of brain gene function and evolution. BMC Genomics (2008) 1.93
A cattle-human comparative map built with cattle BAC-ends and human genome sequence. Genome Res (2003) 1.92
Mechanism of substrate recognition and transport by an amino acid antiporter. Nature (2010) 1.92
T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface. Immunity (2007) 1.92
Identification of a copper-binding metallothionein in pathogenic mycobacteria. Nat Chem Biol (2008) 1.90
BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage. Proc Natl Acad Sci U S A (2009) 1.90
Kinetics of avibactam inhibition against Class A, C, and D β-lactamases. J Biol Chem (2013) 1.89
Inhibitors selective for mycobacterial versus human proteasomes. Nature (2009) 1.89
Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins. Cell (2006) 1.88
Structural basis of ultraviolet-B perception by UVR8. Nature (2012) 1.86
Dynamics of intracellular bacterial replication at the single cell level. Proc Natl Acad Sci U S A (2010) 1.83
Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: implications for treatment and survival. Oncogene (2004) 1.82
Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1. Nat Genet (2005) 1.82
A paradigm for virus-host coevolution: sequential counter-adaptations between endogenous and exogenous retroviruses. PLoS Pathog (2007) 1.79
Broadband graphene terahertz modulators enabled by intraband transitions. Nat Commun (2012) 1.79
S-nitrosylating agents: a novel class of compounds that increase cystic fibrosis transmembrane conductance regulator expression and maturation in epithelial cells. Mol Pharmacol (2006) 1.79
Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element. Mol Cell Biol (2004) 1.77
Structure of a presenilin family intramembrane aspartate protease. Nature (2012) 1.76
Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4. Cell (2010) 1.73
The WD40 repeat PtdIns(3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes. Dev Cell (2011) 1.73
Hematocrit is associated with fibrosis in patients with nonalcoholic steatohepatitis. Eur J Gastroenterol Hepatol (2014) 1.71
Pharmacogenetic approach at the serotonin transporter gene as a method of reducing the severity of alcohol drinking. Am J Psychiatry (2011) 1.69
Restriction landmark genome scanning identifies culture-induced DNA methylation instability in the human embryonic stem cell epigenome. Hum Mol Genet (2007) 1.68
Information filtering via biased heat conduction. Phys Rev E Stat Nonlin Soft Matter Phys (2011) 1.68
Structural mechanism of demethylation and inactivation of protein phosphatase 2A. Cell (2008) 1.67
Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors. Cell Res (2011) 1.67
Structural basis for the modular recognition of single-stranded RNA by PPR proteins. Nature (2013) 1.66
Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes. Drug Metab Dispos (2003) 1.66
The Salmonella kinase SteC targets the MAP kinase MEK to regulate the host actin cytoskeleton. Cell Host Microbe (2012) 1.66
Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation. Cell (2013) 1.66
Caspases, IAPs and Smac/DIABLO: mechanisms from structural biology. Trends Biochem Sci (2004) 1.66
The ADH1C polymorphism modifies the risk of squamous cell carcinoma of the head and neck associated with alcohol and tobacco use. Cancer Epidemiol Biomarkers Prev (2005) 1.64
Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms. Nature (2008) 1.64