Viridamides A and B, lipodepsipeptides with antiprotozoal activity from the marine cyanobacterium Oscillatoria nigro-viridis.

PubWeight™: 1.01‹?› | Rank: Top 15%

🔗 View Article (PMC 2656441)

Published in J Nat Prod on August 21, 2008

Authors

T Luke Simmons1, Niclas Engene, Luis David Ureña, Luz I Romero, Eduardo Ortega-Barría, Lena Gerwick, William H Gerwick

Author Affiliations

1: Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California 92093-0212, USA.

Articles cited by this

MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment. Brief Bioinform (2004) 72.40

Drug development for neglected diseases: a deficient market and a public-health policy failure. Lancet (2002) 11.72

Visceral leishmaniasis: current status of control, diagnosis, and treatment, and a proposed research and development agenda. Lancet Infect Dis (2002) 7.17

PCR primers to amplify 16S rRNA genes from cyanobacteria. Appl Environ Microbiol (1997) 6.70

Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula. Chem Biol (2004) 4.58

Control of Chagas disease. World Health Organ Tech Rep Ser (2002) 4.00

Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing beta-galactosidase. Antimicrob Agents Chemother (1996) 3.62

Nifurtimox-eflornithine combination therapy for second-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Congo. Clin Infect Dis (2007) 2.31

Nitrogen-containing metabolites from marine cyanobacteria. Alkaloids Chem Biol (2001) 2.21

The world's most neglected diseases. BMJ (2002) 2.15

Structure of trichamide, a cyclic peptide from the bloom-forming cyanobacterium Trichodesmium erythraeum, predicted from the genome sequence. Appl Environ Microbiol (2006) 2.07

Biogenetic diversity of cyanobacterial metabolites. Adv Appl Microbiol (2007) 1.61

Treatment perspectives for human African trypanosomiasis. Fundam Clin Pharmacol (2003) 1.46

Phylogenetic and morphological evaluation of the genera Anabaena, Aphanizomenon, Trichormus and Nostoc (Nostocales, Cyanobacteria). Int J Syst Evol Microbiol (2005) 1.42

Evolution and pathology in chagas disease--a review. Mem Inst Oswaldo Cruz (2006) 1.33

Venturamides A and B: antimalarial constituents of the panamanian marine Cyanobacterium Oscillatoria sp. J Nat Prod (2007) 1.26

Antimalarial linear lipopeptides from a Panamanian strain of the marine cyanobacterium Lyngbya majuscula. J Nat Prod (2007) 1.17

Antileukemia activity in the Osillatoriaceae: isolation of Debromoaplysiatoxin from Lyngbya. Science (1977) 1.10

Carmabins A and B, new lipopeptides from the Caribbean cyanobacterium Lyngbya majuscula. J Nat Prod (1998) 1.08

Phylogenetic diversity and the structural basis of substrate specificity in the beta/alpha-barrel fold basic amino acid decarboxylases. J Biol Chem (2007) 1.05

Apramides A-G, novel lipopeptides from the marine cyanobacterium Lyngbya majuscula. J Nat Prod (2000) 1.04

Genotypic and phenotypic diversity of cyanobacteria assigned to the genus Phormidium (Oscillatoriales) from different habitats and geographical sites. Arch Microbiol (2006) 1.03

Synthesis and gas chromatography/mass spectrometry analysis of stereoisomers of 2-hydroxy-3-methylpentanoic acid. Methods Enzymol (2000) 1.02

Natural products chemistry and taxonomy of the marine cyanobacterium Blennothrix cantharidosmum. J Nat Prod (2008) 1.02

Common evolutionary origin of planktonic and benthic nitrogen-fixing oscillatoriacean cyanobacteria from tropical oceans. FEMS Microbiol Lett (2006) 0.99

Distribution of suramin, an antitrypanosomal drug, across the blood-brain and blood-cerebrospinal fluid interfaces in wild-type and P-glycoprotein transporter-deficient mice. Antimicrob Agents Chemother (2007) 0.98

Antiplasmodial metabolites isolated from the marine octocoral Muricea austera. J Nat Prod (2006) 0.94

Antileishmanial structure-activity relationships of synthetic phospholipids: in vitro and in vivo activities of selected derivatives. Antimicrob Agents Chemother (2007) 0.81

Trypanosoma cruzi as a model system to study the expression of exogenous genes coding for polyamine biosynthetic enzymes. Induction of DFMO resistance in transgenic parasites. Biochim Biophys Acta (2007) 0.79

Articles by these authors

Safety and efficacy of an attenuated vaccine against severe rotavirus gastroenteritis. N Engl J Med (2006) 9.93

Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula. Chem Biol (2004) 4.58

Efficacy and safety of an oral live attenuated human rotavirus vaccine against rotavirus gastroenteritis during the first 2 years of life in Latin American infants: a randomised, double-blind, placebo-controlled phase III study. Lancet (2008) 4.50

Marine natural products as anticancer drugs. Mol Cancer Ther (2005) 2.93

A novel DNA-based microfluorimetric method to evaluate antimalarial drug activity. Am J Trop Med Hyg (2004) 2.87

Single cell genome amplification accelerates identification of the apratoxin biosynthetic pathway from a complex microbial assemblage. PLoS One (2011) 2.73

Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula. J Nat Prod (2004) 2.71

Metamorphic enzyme assembly in polyketide diversification. Nature (2009) 2.64

The genomisotopic approach: a systematic method to isolate products of orphan biosynthetic gene clusters. Chem Biol (2007) 2.32

Biosynthetic origin of natural products isolated from marine microorganism-invertebrate assemblages. Proc Natl Acad Sci U S A (2008) 2.23

The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit. Gene (2002) 2.09

Lyngbyatoxin biosynthesis: sequence of biosynthetic gene cluster and identification of a novel aromatic prenyltransferase. J Am Chem Soc (2004) 1.73

Moorea producens gen. nov., sp. nov. and Moorea bouillonii comb. nov., tropical marine cyanobacteria rich in bioactive secondary metabolites. Int J Syst Evol Microbiol (2011) 1.71

In vitro and in vivo experimental models for drug screening and development for Chagas disease. Mem Inst Oswaldo Cruz (2010) 1.71

Marine natural products as novel antioxidant prototypes. J Nat Prod (2003) 1.70

The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore. J Pharmacol Exp Ther (2002) 1.59

Molecular networking as a dereplication strategy. J Nat Prod (2013) 1.57

Metabolic coupling of dehydration and decarboxylation in the curacin A pathway: functional identification of a mechanistically diverse enzyme pair. J Am Chem Soc (2006) 1.55

Metabolic engineering of lipid catabolism increases microalgal lipid accumulation without compromising growth. Proc Natl Acad Sci U S A (2013) 1.51

Visualizing the spatial distribution of secondary metabolites produced by marine cyanobacteria and sponges via MALDI-TOF imaging. Mol Biosyst (2008) 1.47

Biologically active secondary metabolites from marine cyanobacteria. Curr Opin Biotechnol (2010) 1.42

Dereplication and de novo sequencing of nonribosomal peptides. Nat Methods (2009) 1.41

Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula. Proc Natl Acad Sci U S A (2011) 1.40

Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway. Structure (2010) 1.39

Isolation of swinholide A and related glycosylated derivatives from two field collections of marine cyanobacteria. Org Lett (2005) 1.39

Interpretation of tandem mass spectra obtained from cyclic nonribosomal peptides. Anal Chem (2009) 1.37

GNAT-like strategy for polyketide chain initiation. Science (2007) 1.36

Coibamide A, a potent antiproliferative cyclic depsipeptide from the Panamanian marine cyanobacterium Leptolyngbya sp. J Am Chem Soc (2008) 1.36

Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis. J Am Chem Soc (2009) 1.35

Synergistic allelochemicals from a freshwater cyanobacterium. Proc Natl Acad Sci U S A (2010) 1.33

Apratoxin D, a potent cytotoxic cyclodepsipeptide from papua new guinea collections of the marine cyanobacteria Lyngbya majuscula and Lyngbya sordida. J Nat Prod (2008) 1.29

Cloning and biochemical characterization of the hectochlorin biosynthetic gene cluster from the marine cyanobacterium Lyngbya majuscula. J Nat Prod (2007) 1.28

Organization, evolution, and expression analysis of the biosynthetic gene cluster for scytonemin, a cyanobacterial UV-absorbing pigment. Appl Environ Microbiol (2009) 1.28

Oxo-phytodienoic acid-containing galactolipids in Arabidopsis: jasmonate signaling dependence. Plant Physiol (2007) 1.27

Venturamides A and B: antimalarial constituents of the panamanian marine Cyanobacterium Oscillatoria sp. J Nat Prod (2007) 1.26

Characterization of the initial enzymatic steps of barbamide biosynthesis. J Nat Prod (2006) 1.25

Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A. J Nat Prod (2009) 1.25

Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry. Biochemistry (2006) 1.24

Relative stereochemistry determination and synthesis of the major chlorosulfolipid from Ochromonas danica. J Am Chem Soc (2009) 1.23

Evolved diversification of a modular natural product pathway: apratoxins F and G, two cytotoxic cyclic depsipeptides from a Palmyra collection of Lyngbya bouillonii. Chembiochem (2010) 1.22

New tricks from ancient algae: natural products biosynthesis in marine cyanobacteria. Curr Opin Chem Biol (2009) 1.22

Imaging mass spectrometry of natural products. Nat Prod Rep (2009) 1.20

The guineamides, novel cyclic depsipeptides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula. J Nat Prod (2003) 1.20

The unique mechanistic transformations involved in the biosynthesis of modular natural products from marine cyanobacteria. Nat Prod Rep (2010) 1.19

Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly. J Nat Prod (2002) 1.19

Underestimated biodiversity as a major explanation for the perceived rich secondary metabolite capacity of the cyanobacterial genus Lyngbya. Environ Microbiol (2011) 1.18

Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching. J Biol Chem (2007) 1.18

Lyngbouilloside, a novel glycosidic macrolide from the marine cyanobacterium Lyngbya bouillonii. J Nat Prod (2002) 1.17

Antimalarial linear lipopeptides from a Panamanian strain of the marine cyanobacterium Lyngbya majuscula. J Nat Prod (2007) 1.17

Hydrosoluble formazan XTT: its application to natural products drug discovery for Leishmania. J Microbiol Methods (2003) 1.16

Oxylipin profiling of the hypersensitive response in Arabidopsis thaliana. Formation of a novel oxo-phytodienoic acid-containing galactolipid, arabidopside E. J Biol Chem (2006) 1.16

Antileishmanial constituents of the Panamanian endophytic fungus Edenia sp. J Nat Prod (2008) 1.16

Palmyramide A, a cyclic depsipeptide from a Palmyra Atoll collection of the marine cyanobacterium Lyngbya majuscula. J Nat Prod (2010) 1.16

Hoiamide a, a sodium channel activator of unusual architecture from a consortium of two papua new Guinea cyanobacteria. Chem Biol (2009) 1.15

Significant natural product biosynthetic potential of actinorhizal symbionts of the genus frankia, as revealed by comparative genomic and proteomic analyses. Appl Environ Microbiol (2011) 1.10

Influence of lipid-soluble gating modifier toxins on sodium influx in neocortical neurons. J Pharmacol Exp Ther (2008) 1.10

A concise enantioselective synthesis of the chlorosulfolipid malhamensilipin A. J Am Chem Soc (2010) 1.10

Structure and absolute stereochemistry of phormidolide, a new toxic metabolite from the marine cyanobacterium Phormidium sp. J Org Chem (2002) 1.09

Marine natural product drug discovery: Leads for treatment of inflammation, cancer, infections, and neurological disorders. Immunopharmacol Immunotoxicol (2010) 1.09

Conformational switch triggered by alpha-ketoglutarate in a halogenase of curacin A biosynthesis. Proc Natl Acad Sci U S A (2010) 1.08

DNA methyl transferase inhibiting halogenated monoterpenes from the Madagascar red marine alga Portieria hornemannii. J Nat Prod (2006) 1.06

Symplocamide A, a potent cytotoxin and chymotrypsin inhibitor from the marine Cyanobacterium Symploca sp. J Nat Prod (2007) 1.06

Palmyrolide A, an unusually stabilized neuroactive macrolide from Palmyra Atoll cyanobacteria. Org Lett (2010) 1.06

The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8. Proc Natl Acad Sci U S A (2008) 1.05

Cytotoxic veraguamides, alkynyl bromide-containing cyclic depsipeptides from the marine cyanobacterium cf. Oscillatoria margaritifera. J Nat Prod (2011) 1.05

Terminal alkene formation by the thioesterase of curacin A biosynthesis: structure of a decarboxylating thioesterase. J Biol Chem (2011) 1.03

Natural products chemistry and taxonomy of the marine cyanobacterium Blennothrix cantharidosmum. J Nat Prod (2008) 1.02

Practical total syntheses of epiquinamide enantiomers. Org Lett (2006) 1.02

Somocystinamide A, a novel cytotoxic disulfide dimer from a Fijian marine cyanobacterial mixed assemblage. Org Lett (2002) 1.01

Almiramides A-C: discovery and development of a new class of leishmaniasis lead compounds. J Med Chem (2010) 1.01

The C1q domain containing proteins: Where do they come from and what do they do? Dev Comp Immunol (2010) 1.00

The hoiamides, structurally intriguing neurotoxic lipopeptides from Papua New Guinea marine cyanobacteria. J Nat Prod (2010) 0.99

Probing marine natural product defenses with DESI-imaging mass spectrometry. Proc Natl Acad Sci U S A (2009) 0.99

Temporal dynamics of natural product biosynthesis in marine cyanobacteria. Proc Natl Acad Sci U S A (2011) 0.98

Real-time metabolomics on living microorganisms using ambient electrospray ionization flow-probe. Anal Chem (2013) 0.98

The chemical ecology of cyanobacteria. Nat Prod Rep (2012) 0.98

Cyanolide A, a glycosidic macrolide with potent Molluscicidal activity from the Papua New Guinea cyanobacterium Lyngbya bouillonii. J Nat Prod (2010) 0.97

Isolation of four new cyclic depsipeptides, antanapeptins A-D, and dolastatin 16 from a Madagascan collection of Lyngbya majuscula. J Nat Prod (2002) 0.97

Hydroxyalkenylresorcinols from Stylogyne turbacensis. J Nat Prod (2007) 0.97