Published in J Am Chem Soc on April 29, 2008
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Coibamide A, a natural lariat depsipeptide, inhibits VEGFA/VEGFR2 expression and suppresses tumor growth in glioblastoma xenografts. Invest New Drugs (2015) 0.78
Exploring bioactive properties of marine cyanobacteria isolated from the Portuguese coast: high potential as a source of anticancer compounds. Mar Drugs (2013) 0.78
Defining the structural parameters that confer anticonvulsant activity by the site-by-site modification of (R)-N'-benzyl 2-amino-3-methylbutanamide. J Med Chem (2011) 0.77
Blue-Print Autophagy: Potential for Cancer Treatment. Mar Drugs (2016) 0.77
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Depsipeptide companeramides from a Panamanian marine cyanobacterium associated with the coibamide producer. J Nat Prod (2015) 0.76
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A pseudopterane diterpene isolated from the octocoral Pseudopterogorgia acerosa inhibits the inflammatory response mediated by TLR-ligands and TNF-alpha in macrophages. PLoS One (2013) 0.75
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Is the oral route possible for peptide and protein drug delivery? Drug Discov Today (2006) 1.38
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Safety and efficacy of an attenuated vaccine against severe rotavirus gastroenteritis. N Engl J Med (2006) 9.93
Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula. Chem Biol (2004) 4.58
Marine natural products as anticancer drugs. Mol Cancer Ther (2005) 2.93
A novel DNA-based microfluorimetric method to evaluate antimalarial drug activity. Am J Trop Med Hyg (2004) 2.87
Single cell genome amplification accelerates identification of the apratoxin biosynthetic pathway from a complex microbial assemblage. PLoS One (2011) 2.73
Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula. J Nat Prod (2004) 2.71
Metamorphic enzyme assembly in polyketide diversification. Nature (2009) 2.64
The genomisotopic approach: a systematic method to isolate products of orphan biosynthetic gene clusters. Chem Biol (2007) 2.32
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The taccalonolides: microtubule stabilizers that circumvent clinically relevant taxane resistance mechanisms. Cancer Res (2008) 2.19
Taccalonolides E and A: Plant-derived steroids with microtubule-stabilizing activity. Cancer Res (2003) 2.01
Lyngbyatoxin biosynthesis: sequence of biosynthetic gene cluster and identification of a novel aromatic prenyltransferase. J Am Chem Soc (2004) 1.73
Moorea producens gen. nov., sp. nov. and Moorea bouillonii comb. nov., tropical marine cyanobacteria rich in bioactive secondary metabolites. Int J Syst Evol Microbiol (2011) 1.71
In vitro and in vivo experimental models for drug screening and development for Chagas disease. Mem Inst Oswaldo Cruz (2010) 1.71
Marine natural products as novel antioxidant prototypes. J Nat Prod (2003) 1.70
The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore. J Pharmacol Exp Ther (2002) 1.59
Molecular networking as a dereplication strategy. J Nat Prod (2013) 1.57
Metabolic coupling of dehydration and decarboxylation in the curacin A pathway: functional identification of a mechanistically diverse enzyme pair. J Am Chem Soc (2006) 1.55
Metabolic engineering of lipid catabolism increases microalgal lipid accumulation without compromising growth. Proc Natl Acad Sci U S A (2013) 1.51
Microtubule dynamics as a target in oncology. Cancer Treat Rev (2008) 1.50
Visualizing the spatial distribution of secondary metabolites produced by marine cyanobacteria and sponges via MALDI-TOF imaging. Mol Biosyst (2008) 1.47
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Dereplication and de novo sequencing of nonribosomal peptides. Nat Methods (2009) 1.41
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula. Proc Natl Acad Sci U S A (2011) 1.40
Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway. Structure (2010) 1.39
Isolation of swinholide A and related glycosylated derivatives from two field collections of marine cyanobacteria. Org Lett (2005) 1.39
Identification and biological activities of new taccalonolide microtubule stabilizers. J Med Chem (2011) 1.38
Interpretation of tandem mass spectra obtained from cyclic nonribosomal peptides. Anal Chem (2009) 1.37
GNAT-like strategy for polyketide chain initiation. Science (2007) 1.36
Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis. J Am Chem Soc (2009) 1.35
Synergistic allelochemicals from a freshwater cyanobacterium. Proc Natl Acad Sci U S A (2010) 1.33
Apratoxin D, a potent cytotoxic cyclodepsipeptide from papua new guinea collections of the marine cyanobacteria Lyngbya majuscula and Lyngbya sordida. J Nat Prod (2008) 1.29
Cloning and biochemical characterization of the hectochlorin biosynthetic gene cluster from the marine cyanobacterium Lyngbya majuscula. J Nat Prod (2007) 1.28
Organization, evolution, and expression analysis of the biosynthetic gene cluster for scytonemin, a cyanobacterial UV-absorbing pigment. Appl Environ Microbiol (2009) 1.28
Oxo-phytodienoic acid-containing galactolipids in Arabidopsis: jasmonate signaling dependence. Plant Physiol (2007) 1.27
Venturamides A and B: antimalarial constituents of the panamanian marine Cyanobacterium Oscillatoria sp. J Nat Prod (2007) 1.26
Sponge-derived fijianolide polyketide class: further evaluation of their structural and cytotoxicity properties. J Med Chem (2007) 1.26
Deep-sea hydrothermal vents: potential hot spots for natural products discovery? J Nat Prod (2010) 1.25
Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A. J Nat Prod (2009) 1.25
Characterization of the initial enzymatic steps of barbamide biosynthesis. J Nat Prod (2006) 1.25
Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry. Biochemistry (2006) 1.24
Relative stereochemistry determination and synthesis of the major chlorosulfolipid from Ochromonas danica. J Am Chem Soc (2009) 1.23
Evolved diversification of a modular natural product pathway: apratoxins F and G, two cytotoxic cyclic depsipeptides from a Palmyra collection of Lyngbya bouillonii. Chembiochem (2010) 1.22
New tricks from ancient algae: natural products biosynthesis in marine cyanobacteria. Curr Opin Chem Biol (2009) 1.22
Imaging mass spectrometry of natural products. Nat Prod Rep (2009) 1.20
Potent taccalonolides, AF and AJ, inform significant structure-activity relationships and tubulin as the binding site of these microtubule stabilizers. J Am Chem Soc (2011) 1.20
The guineamides, novel cyclic depsipeptides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula. J Nat Prod (2003) 1.20
The unique mechanistic transformations involved in the biosynthesis of modular natural products from marine cyanobacteria. Nat Prod Rep (2010) 1.19
Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly. J Nat Prod (2002) 1.19
Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching. J Biol Chem (2007) 1.18
Underestimated biodiversity as a major explanation for the perceived rich secondary metabolite capacity of the cyanobacterial genus Lyngbya. Environ Microbiol (2011) 1.18
Docking and hydropathic scoring of polysubstituted pyrrole compounds with antitubulin activity. Bioorg Med Chem (2007) 1.18
Antimalarial linear lipopeptides from a Panamanian strain of the marine cyanobacterium Lyngbya majuscula. J Nat Prod (2007) 1.17
Lyngbouilloside, a novel glycosidic macrolide from the marine cyanobacterium Lyngbya bouillonii. J Nat Prod (2002) 1.17
Hydrosoluble formazan XTT: its application to natural products drug discovery for Leishmania. J Microbiol Methods (2003) 1.16
Oxylipin profiling of the hypersensitive response in Arabidopsis thaliana. Formation of a novel oxo-phytodienoic acid-containing galactolipid, arabidopside E. J Biol Chem (2006) 1.16
Antileishmanial constituents of the Panamanian endophytic fungus Edenia sp. J Nat Prod (2008) 1.16
Cellular studies reveal mechanistic differences between taccalonolide A and paclitaxel. Cell Cycle (2011) 1.16
Palmyramide A, a cyclic depsipeptide from a Palmyra Atoll collection of the marine cyanobacterium Lyngbya majuscula. J Nat Prod (2010) 1.16
Hoiamide a, a sodium channel activator of unusual architecture from a consortium of two papua new Guinea cyanobacteria. Chem Biol (2009) 1.15
Acetyl analogs of combretastatin A-4: synthesis and biological studies. Bioorg Med Chem (2011) 1.14
The genome of tolypocladium inflatum: evolution, organization, and expression of the cyclosporin biosynthetic gene cluster. PLoS Genet (2013) 1.13
Interrogating the bioactive pharmacophore of the latrunculin chemotype by investigating the metabolites of two taxonomically unrelated sponges. J Med Chem (2008) 1.13
Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities. Nat Prod Rep (2014) 1.13
Crowdsourcing natural products discovery to access uncharted dimensions of fungal metabolite diversity. Angew Chem Int Ed Engl (2013) 1.11
Significant natural product biosynthetic potential of actinorhizal symbionts of the genus frankia, as revealed by comparative genomic and proteomic analyses. Appl Environ Microbiol (2011) 1.10
Influence of lipid-soluble gating modifier toxins on sodium influx in neocortical neurons. J Pharmacol Exp Ther (2008) 1.10
A concise enantioselective synthesis of the chlorosulfolipid malhamensilipin A. J Am Chem Soc (2010) 1.10
Structure and absolute stereochemistry of phormidolide, a new toxic metabolite from the marine cyanobacterium Phormidium sp. J Org Chem (2002) 1.09
Novel 2-methoxyestradiol analogues with antitumor activity. Cancer Res (2003) 1.09
Conformational switch triggered by alpha-ketoglutarate in a halogenase of curacin A biosynthesis. Proc Natl Acad Sci U S A (2010) 1.08
Design, synthesis, and biological evaluations of 2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoline analogs of combretastatin-A4. J Med Chem (2010) 1.07
Hurghadolide A and swinholide I, potent actin-microfilament disrupters from the Red Sea sponge Theonella swinhoei. J Nat Prod (2006) 1.07
Structure-based discovery of a boronic acid bioisostere of combretastatin A-4. Chem Biol (2005) 1.07
Porphyria cutanea tarda: multiplicity of risk factors including HFE mutations, hepatitis C, and inherited uroporphyrinogen decarboxylase deficiency. Dig Dis Sci (2002) 1.06
DNA methyl transferase inhibiting halogenated monoterpenes from the Madagascar red marine alga Portieria hornemannii. J Nat Prod (2006) 1.06
Symplocamide A, a potent cytotoxin and chymotrypsin inhibitor from the marine Cyanobacterium Symploca sp. J Nat Prod (2007) 1.06
Palmyrolide A, an unusually stabilized neuroactive macrolide from Palmyra Atoll cyanobacteria. Org Lett (2010) 1.06
The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8. Proc Natl Acad Sci U S A (2008) 1.05
Cytotoxic veraguamides, alkynyl bromide-containing cyclic depsipeptides from the marine cyanobacterium cf. Oscillatoria margaritifera. J Nat Prod (2011) 1.05
Terminal alkene formation by the thioesterase of curacin A biosynthesis: structure of a decarboxylating thioesterase. J Biol Chem (2011) 1.03
Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance. J Med Chem (2010) 1.02
Natural products chemistry and taxonomy of the marine cyanobacterium Blennothrix cantharidosmum. J Nat Prod (2008) 1.02
Practical total syntheses of epiquinamide enantiomers. Org Lett (2006) 1.02
Viridamides A and B, lipodepsipeptides with antiprotozoal activity from the marine cyanobacterium Oscillatoria nigro-viridis. J Nat Prod (2008) 1.01
Coibamide A induces mTOR-independent autophagy and cell death in human glioblastoma cells. PLoS One (2013) 1.01
Somocystinamide A, a novel cytotoxic disulfide dimer from a Fijian marine cyanobacterial mixed assemblage. Org Lett (2002) 1.01