Published in J Biol Chem on September 04, 2008
SecA, a remarkable nanomachine. Cell Mol Life Sci (2011) 1.04
Maximal efficiency of coupling between ATP hydrolysis and translocation of polypeptides mediated by SecB requires two protomers of SecA. J Bacteriol (2008) 0.96
Energetics of SecA dimerization. J Mol Biol (2011) 0.92
Defining the solution state dimer structure of Escherichia coli SecA using Förster resonance energy transfer. Biochemistry (2013) 0.85
Dimeric SecA couples the preprotein translocation in an asymmetric manner. PLoS One (2011) 0.83
Defining the Escherichia coli SecA dimer interface residues through in vivo site-specific photo-cross-linking. J Bacteriol (2013) 0.82
SecA: a potential antimicrobial target. Future Med Chem (2015) 0.79
Analysis of SecA dimerization in solution. Biochemistry (2014) 0.78
VMD: visual molecular dynamics. J Mol Graph (1996) 117.02
EMAN: semiautomated software for high-resolution single-particle reconstructions. J Struct Biol (1999) 27.52
SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields. J Struct Biol (1996) 22.89
E. coli mutant pleiotropically defective in the export of secreted proteins. Cell (1981) 7.72
The binding cascade of SecB to SecA to SecY/E mediates preprotein targeting to the E. coli plasma membrane. Cell (1990) 3.58
Structural basis for signal-sequence recognition by the translocase motor SecA as determined by NMR. Cell (2007) 3.06
Nucleotide control of interdomain interactions in the conformational reaction cycle of SecA. Science (2002) 2.72
SecA protein is required for secretory protein translocation into E. coli membrane vesicles. Cell (1988) 2.41
SecA protein, a peripheral protein of the Escherichia coli plasma membrane, is essential for the functional binding and translocation of proOmpA. EMBO J (1989) 2.33
Escherichia coli translocase: the unravelling of a molecular machine. Mol Microbiol (2000) 2.19
Modeling tricks and fitting techniques for multiresolution structures. Structure (2001) 2.11
Dissociation of the dimeric SecA ATPase during protein translocation across the bacterial membrane. EMBO J (2002) 1.92
A large conformational change of the translocation ATPase SecA. Proc Natl Acad Sci U S A (2004) 1.86
Complex behavior in solution of homodimeric SecA. Protein Sci (2002) 1.83
Crystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPase. Proc Natl Acad Sci U S A (2003) 1.83
SecA, the peripheral subunit of the Escherichia coli precursor protein translocase, is functional as a dimer. Biochemistry (1993) 1.74
SecA protein needs both acidic phospholipids and SecY/E protein for functional high-affinity binding to the Escherichia coli plasma membrane. J Biol Chem (1991) 1.71
The catalytic cycle of the escherichia coli SecA ATPase comprises two distinct preprotein translocation events. EMBO J (1997) 1.64
The bacterial translocase: a dynamic protein channel complex. Cell Mol Life Sci (2003) 1.55
Structure of dimeric SecA, the Escherichia coli preprotein translocase motor. J Mol Biol (2006) 1.53
SecA, an essential component of the secretory machinery of Escherichia coli, exists as homodimer. Biochem Biophys Res Commun (1991) 1.53
Phospholipid-induced monomerization and signal-peptide-induced oligomerization of SecA. J Biol Chem (2002) 1.50
Escherichia coli preprotein translocase. J Biol Chem (1996) 1.40
A significant fraction of functional SecA is permanently embedded in the membrane. SecA cycling on and off the membrane is not essential during protein translocation. J Biol Chem (1996) 1.38
Crystal structure of the translocation ATPase SecA from Thermus thermophilus reveals a parallel, head-to-head dimer. J Mol Biol (2006) 1.30
A novel dimer interface and conformational changes revealed by an X-ray structure of B. subtilis SecA. J Mol Biol (2006) 1.27
Ring-like pore structures of SecA: implication for bacterial protein-conducting channels. Proc Natl Acad Sci U S A (2003) 1.18
SecA protein is required for translocation of a model precursor protein into inverted vesicles of Escherichia coli plasma membrane. Proc Natl Acad Sci U S A (1993) 1.14
Bacillus subtilis SecA ATPase exists as an antiparallel dimer in solution. Biochemistry (2003) 1.14
Complexes between protein export chaperone SecB and SecA. Evidence for separate sites on SecA providing binding energy and regulatory interactions. J Biol Chem (2000) 1.13
The active ring-like structure of SecA revealed by electron crystallography: conformational change upon interaction with SecB. J Struct Biol (2007) 0.82
A plaque-specific antibody clears existing β-amyloid plaques in Alzheimer's disease mice. Neuron (2012) 3.32
Transforming growth factor-beta1 induces the differentiation of myogenic cells into fibrotic cells in injured skeletal muscle: a key event in muscle fibrogenesis. Am J Pathol (2004) 2.78
Cellular internalization of exosomes occurs through phagocytosis. Traffic (2010) 2.21
Repression of the miR-17-92 cluster by p53 has an important function in hypoxia-induced apoptosis. EMBO J (2009) 2.21
Ultra-potent antibodies against respiratory syncytial virus: effects of binding kinetics and binding valence on viral neutralization. J Mol Biol (2005) 1.80
Octamer 4 small interfering RNA results in cancer stem cell-like cell apoptosis. Cancer Res (2008) 1.76
Activation of DegP chaperone-protease via formation of large cage-like oligomers upon binding to substrate proteins. Proc Natl Acad Sci U S A (2008) 1.68
Adeno-associated virus vector-mediated minidystrophin gene therapy improves dystrophic muscle contractile function in mdx mice. Hum Gene Ther (2002) 1.56
Monoclonal antibody clearance. Impact of modulating the interaction of IgG with the neonatal Fc receptor. J Biol Chem (2006) 1.42
Acute kidney injury in a Chinese hospitalized population. Blood Purif (2010) 1.41
Calcium/calmodulin-dependent protein kinase (CaMK) IV mediates nucleocytoplasmic shuttling and release of HMGB1 during lipopolysaccharide stimulation of macrophages. J Immunol (2008) 1.39
Cholesterol involvement in the pathogenesis of neurodegenerative diseases. Mol Cell Neurosci (2009) 1.35
miR-17-5p Promotes migration of human hepatocellular carcinoma cells through the p38 mitogen-activated protein kinase-heat shock protein 27 pathway. Hepatology (2010) 1.31
Visualization of synaptotagmin I oligomers assembled onto lipid monolayers. Proc Natl Acad Sci U S A (2003) 1.30
Humanized IgG1 variants with differential binding properties to the neonatal Fc receptor: relationship to pharmacokinetics in mice and primates. Drug Metab Dispos (2006) 1.28
Causes of spinal cord injury. Top Spinal Cord Inj Rehabil (2013) 1.21
Bowl-shaped oligomeric structures on membranes as DegP's new functional forms in protein quality control. Proc Natl Acad Sci U S A (2009) 1.19
Ring-like pore structures of SecA: implication for bacterial protein-conducting channels. Proc Natl Acad Sci U S A (2003) 1.18
TINY, a dehydration-responsive element (DRE)-binding protein-like transcription factor connecting the DRE- and ethylene-responsive element-mediated signaling pathways in Arabidopsis. J Biol Chem (2007) 1.18
Prevalence of psoriasis in China: a population-based study in six cities. Eur J Dermatol (2012) 1.17
NS-398, a cyclooxygenase-2-specific inhibitor, delays skeletal muscle healing by decreasing regeneration and promoting fibrosis. Am J Pathol (2005) 1.16
Bunyamwera virus possesses a distinct nucleocapsid protein to facilitate genome encapsidation. Proc Natl Acad Sci U S A (2013) 1.11
Cloning, characterization and expression of escapin, a broadly antimicrobial FAD-containing L-amino acid oxidase from ink of the sea hare Aplysia californica. J Exp Biol (2005) 1.09
The PH domain containing protein CKIP-1 binds to IFP35 and Nmi and is involved in cytokine signaling. Cell Signal (2006) 1.08
Structural characterization of full-length NSF and 20S particles. Nat Struct Mol Biol (2012) 1.08
Development of proteomic patterns for detecting lung cancer. Dis Markers (2004) 1.07
Blockade of store-operated Ca(2+) entry inhibits hepatocarcinoma cell migration and invasion by regulating focal adhesion turnover. Cancer Lett (2012) 1.06
Nonclassical protein secretion by Bacillus subtilis in the stationary phase is not due to cell lysis. J Bacteriol (2011) 1.06
New hepatitis E virus genotype in camels, the Middle East. Emerg Infect Dis (2014) 1.03
Additional in vitro and in vivo evidence for SecA functioning as dimers in the membrane: dissociation into monomers is not essential for protein translocation in Escherichia coli. J Bacteriol (2007) 1.02
Role for the pleckstrin homology domain-containing protein CKIP-1 in AP-1 regulation and apoptosis. EMBO J (2005) 1.02
Fall-induced spinal cord injury: External causes and implications for prevention. J Spinal Cord Med (2015) 1.02
Decorin gene transfer promotes muscle cell differentiation and muscle regeneration. Mol Ther (2007) 1.02
Cys32 and His105 are the critical residues for the calcium-dependent cysteine proteolytic activity of CvaB, an ATP-binding cassette transporter. J Biol Chem (2003) 1.01
STAT3, a Poor Survival Predicator, Is Associated with Lymph Node Metastasis from Breast Cancer. J Breast Cancer (2013) 1.00
Metastatic thyroid follicular carcinoma presenting as a primary renal tumor. Intern Med (2012) 0.99
Cellular toxicity of TiO2 nanoparticles in anatase and rutile crystal phase. Biol Trace Elem Res (2010) 0.99
Inhibition of glycogen synthase kinase-3β by Angelica sinensis extract decreases β-amyloid-induced neurotoxicity and tau phosphorylation in cultured cortical neurons. J Neurosci Res (2010) 0.99
The role of preferred beliefs in skepticism about psychology. Am Psychol (2012) 0.96
NF-κB negatively impacts the myogenic potential of muscle-derived stem cells. Mol Ther (2011) 0.95
Structure-based discovery and experimental verification of novel AI-2 quorum sensing inhibitors against Vibrio harveyi. ChemMedChem (2008) 0.95
Electroluminescence from ZnO-nanofilm/Si-micropillar heterostructure arrays. Opt Express (2012) 0.94
Matrix metalloproteinase-3 and vitamin d receptor genetic polymorphisms, and their interactions with occupational exposure in lumbar disc degeneration. J Occup Health (2009) 0.94
Kupffer cell-generated PGE2 triggers the febrile response of guinea pigs to intravenously injected LPS. Am J Physiol Regul Integr Comp Physiol (2006) 0.93
Development of a multi-criteria index ranking system for urban runoff best management practices (BMPs) selection. Environ Monit Assess (2013) 0.92
Improved K-means clustering algorithm for exploring local protein sequence motifs representing common structural property. IEEE Trans Nanobioscience (2005) 0.92
Packaging of chemicals in the defensive secretory glands of the sea hare Aplysia californica. J Exp Biol (2006) 0.91
Discovery of the first SecA inhibitors using structure-based virtual screening. Biochem Biophys Res Commun (2008) 0.91
Membrane localization of beta-amyloid 1-42 in lysosomes: a possible mechanism for lysosome labilization. J Biol Chem (2010) 0.91
Reconstitution of functionally efficient SecA-dependent protein-conducting channels: transformation of low-affinity SecA-liposome channels to high-affinity SecA-SecYEG-SecDF·YajC channels. Biochem Biophys Res Commun (2013) 0.91
Smurf1 ubiquitin ligase targets Kruppel-like factor KLF2 for ubiquitination and degradation in human lung cancer H1299 cells. Biochem Biophys Res Commun (2011) 0.91
Naked-eye sensitive detection of immunoglubulin G by enlargement of Au nanoparticles in vitro. Angew Chem Int Ed Engl (2002) 0.90
BMP2 is superior to BMP4 for promoting human muscle-derived stem cell-mediated bone regeneration in a critical-sized calvarial defect model. Cell Transplant (2012) 0.90
A polysaccharide from Strongylocentrotus nudus eggs protects against myelosuppression and immunosuppression in cyclophosphamide-treated mice. Int Immunopharmacol (2011) 0.89
Mesenchymal stem cell-mediated suppression of hypertrophic scarring is p53 dependent in a rabbit ear model. Stem Cell Res Ther (2014) 0.89
Promotion of spinosad biosynthesis by chromosomal integration of the Vitreoscilla hemoglobin gene in Saccharopolyspora spinosa. Sci China Life Sci (2012) 0.89
Differential ubiquitination of Smad1 mediated by CHIP: implications in the regulation of the bone morphogenetic protein signaling pathway. J Mol Biol (2007) 0.89
Relationship between Serum Lipoprotein Ratios and Insulin Resistance in Polycystic Ovary Syndrome. Int J Endocrinol (2012) 0.89
Electrophysiological studies in Xenopus oocytes for the opening of Escherichia coli SecA-dependent protein-conducting channels. J Membr Biol (2007) 0.89
A preliminary analysis of non-small cell lung cancer biomarkers in serum. Biomed Environ Sci (2003) 0.89
Characterization of the structure and function of Escherichia coli DegQ as a representative of the DegQ-like proteases of bacterial HtrA family proteins. Structure (2011) 0.89
Serum immunoglobulin A/C3 ratio predicts progression of immunoglobulin A nephropathy. Nephrology (Carlton) (2013) 0.89
Acetaminophen: antipyretic or hypothermic in mice? In either case, PGHS-1b (COX-3) is irrelevant. Prostaglandins Other Lipid Mediat (2007) 0.88
SecA alone can promote protein translocation and ion channel activity: SecYEG increases efficiency and signal peptide specificity. J Biol Chem (2011) 0.88
Establishment of an efficient genetic transformation system in Scenedesmus obliquus. J Biotechnol (2012) 0.88
Improved protein secondary structure prediction using support vector machine with a new encoding scheme and an advanced tertiary classifier. IEEE Trans Nanobioscience (2004) 0.88
Human umbilical cord blood-derived mononuclear cell transplantation: case series of 30 subjects with hereditary ataxia. J Transl Med (2011) 0.88
Effect of pomegranate peel polyphenol gel on cutaneous wound healing in alloxan-induced diabetic rats. Chin Med J (Engl) (2013) 0.87
Trichosanthin inhibits integration of human immunodeficiency virus type 1 through depurinating the long-terminal repeats. Mol Biol Rep (2009) 0.87
Structural and functional characterization of ryanodine receptor-natrin toxin interaction. Biophys J (2008) 0.87
E. coli chaperones DnaK, Hsp33 and Spy inhibit bacterial functional amyloid assembly. Prion (2011) 0.87
Templated xerogels as platforms for biomolecule-less biomolecule sensors. Anal Chim Acta (2006) 0.87
A novel functional assessment of the differentiation of micropatterned muscle cells. J Biomech (2008) 0.87
Extraction and determination of some psychotropic drugs in urine samples using dispersive liquid-liquid microextraction followed by high-performance liquid chromatography. J Pharm Biomed Anal (2008) 0.87
Whole-organ CT perfusion of the pancreas: impact of iterative reconstruction on image quality, perfusion parameters and radiation dose in 256-slice CT-preliminary findings. PLoS One (2013) 0.86
The first low microM SecA inhibitors. Bioorg Med Chem (2010) 0.86
Beneficial effect of mechanical stimulation on the regenerative potential of muscle-derived stem cells is lost by inhibiting vascular endothelial growth factor. Arterioscler Thromb Vasc Biol (2013) 0.86
Design, synthesis and biological evaluation of rose bengal analogues as SecA inhibitors. ChemMedChem (2013) 0.86
Fluorescein analogues inhibit SecA ATPase: the first sub-micromolar inhibitor of bacterial protein translocation. ChemMedChem (2012) 0.86
Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension. J Clin Invest (2016) 0.86
Proteomic analysis of the transition from quiescent to proliferating stages in rat liver hepatectomy model. Proteomics (2006) 0.85
Optimization of protein therapeutics by directed evolution. Drug Discov Today (2003) 0.85
Insights into the biosynthesis of 12-membered resorcylic acid lactones from heterologous production in Saccharomyces cerevisiae. ACS Chem Biol (2014) 0.85
Complexin is able to bind to SNARE core complexes in different assembled states with distinct affinity. Biochem Biophys Res Commun (2006) 0.85
Tailored delivery of active keratinocyte growth factor from biodegradable polymer formulations. J Biomed Mater Res A (2003) 0.85
Effects of DNA mismatches on binding affinity and kinetics of polymerase-DNA complexes as revealed by surface plasmon resonance biosensor. Analyst (2003) 0.85
Rule generation for protein secondary structure prediction with support vector machines and decision tree. IEEE Trans Nanobioscience (2006) 0.84
Three-dimensional architecture of phycobilisomes from Nostoc flagelliforme revealed by single particle electron microscopy. FEBS Lett (2005) 0.84
Association between sleep quality and cardiovascular damage in pre-dialysis patients with chronic kidney disease. BMC Nephrol (2014) 0.84
Effects of selective hypothermia on blood-brain barrier integrity and tight junction protein expression levels after intracerebral hemorrhage in rats. Biol Chem (2013) 0.84
The structure of SecB/OmpA as visualized by electron microscopy: The mature region of the precursor protein binds asymmetrically to SecB. Biochem Biophys Res Commun (2010) 0.83
Stable sensors with tunable sensitivities based on class II xerogels. Anal Chem (2006) 0.83
Dimeric SecA couples the preprotein translocation in an asymmetric manner. PLoS One (2011) 0.83