Retinoids regulate TGFbeta signaling at the level of Smad2 phosphorylation and nuclear accumulation.

PubWeight™: 0.85‹?›

🔗 View Article (PMC 2596883)

Published in Biochim Biophys Acta on August 13, 2008

Authors

Loretta L Hoover1, Elizabeth G Burton, Megan L O'Neill, Bonnie A Brooks, Shilpa Sreedharan, Nineveh A Dawson, Steven W Kubalak

Author Affiliations

1: Department of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Medical University of South Carolina, 173 Ashley Avenue Suite 601BSB Charleston, SC 29425, USA.

Articles cited by this

Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell (2003) 25.94

Specificity and versatility in tgf-beta signaling through Smads. Annu Rev Cell Dev Biol (2005) 11.18

A decade of molecular biology of retinoic acid receptors. FASEB J (1996) 9.70

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol (2002) 8.89

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling. Nature (1997) 7.69

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation. Mol Cell (2000) 6.69

An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct. Anal Biochem (1994) 6.31

PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling. Cell (2006) 5.28

SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. Cell (1998) 4.51

Ubiquitin-dependent degradation of TGF-beta-activated smad2. Nat Cell Biol (1999) 3.25

The TGF beta receptor activation process: an inhibitor- to substrate-binding switch. Mol Cell (2001) 2.87

International Union of Pharmacology. LXIII. Retinoid X receptors. Pharmacol Rev (2006) 2.22

Elevated transforming growth factor beta2 enhances apoptosis and contributes to abnormal outflow tract and aortic sac development in retinoic X receptor alpha knockout embryos. Development (2002) 2.20

Cross-talk between ERK MAP kinase and Smad signaling pathways enhances TGF-beta-dependent responses in human mesangial cells. FASEB J (2003) 2.15

Microtubule binding to Smads may regulate TGF beta activity. Mol Cell (2000) 2.09

Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus. Mol Cell (2002) 2.05

International Union of Pharmacology. LX. Retinoic acid receptors. Pharmacol Rev (2006) 2.04

Ski/Sno and TGF-beta signaling. Cytokine Growth Factor Rev (2001) 1.71

Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways. J Biol Chem (2006) 1.63

Multiple modes of repression by the Smad transcriptional corepressor TGIF. J Biol Chem (1999) 1.61

The Smad transcriptional corepressor TGIF recruits mSin3. Cell Growth Differ (2001) 1.36

Fine tuning and cross-talking of TGF-beta signal by inhibitory Smads. J Biochem Mol Biol (2005) 1.35

Integration of the TGF-beta pathway into the cellular signalling network. Cell Signal (2002) 1.23

Retinoid X receptor dominates the nuclear import and export of the unliganded vitamin D receptor. Mol Endocrinol (2002) 1.20

c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity. Proc Natl Acad Sci U S A (2001) 1.17

Retinoic acid receptors interfere with the TGF-beta/Smad signaling pathway in a ligand-specific manner. Oncogene (2003) 1.15

Discrete roles for peroxisome proliferator-activated receptor gamma and retinoid X receptor in recruiting nuclear receptor coactivators. Mol Cell Biol (2000) 1.15

Cx43 mediates TGF-beta signaling through competitive Smads binding to microtubules. Mol Biol Cell (2007) 1.10

Analysis of the proepicardium-epicardium transition during the malformation of the RXRalpha-/- epicardium. Dev Dyn (2005) 1.09

Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor. EMBO J (2001) 1.05

Vitamin A regulation of gene expression: molecular mechanism of a prototype gene. J Nutr Biochem (2007) 1.04

Levels of phospho-Smad2/3 are sensors of the interplay between effects of TGF-beta and retinoic acid on monocytic and granulocytic differentiation of HL-60 cells. Blood (2002) 1.02

Nuclear import of the retinoid X receptor, the vitamin D receptor, and their mutual heterodimer. J Biol Chem (2005) 0.97

Meeting report: signaling schemes for TGF-beta. Sci STKE (2001) 0.92

The retinoid X receptor ligand restores defective signalling by the vitamin D receptor. EMBO Rep (2006) 0.87

The expanding role for retinoid signaling in heart development. ScientificWorldJournal (2008) 0.87

The molecular genetics of retinoic acid receptors: cardiovascular and limb development. Biochem Soc Symp (1996) 0.81

Glucose-mediated transforming growth factor-beta1 release in human mesothelial cells is endothelin independent. J Cardiovasc Pharmacol (2004) 0.78