Iron, the substantia nigra and related neurological disorders.

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. BMC Med Genomics (2009) 2.36

Substantia nigra hyperechogenicity is a risk marker of Parkinson's disease: no. J Neural Transm (Vienna) (2010) 2.07

The perplexing paradox of paraquat: the case for host-based susceptibility and postulated neurodegenerative effects. J Biochem Mol Toxicol (2014) 2.03

The oral iron chelator deferiprone protects against iron overload-induced retinal degeneration. Invest Ophthalmol Vis Sci (2011) 1.37

Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice. Invest Ophthalmol Vis Sci (2011) 1.32

Identification of a fluorescent general anesthetic, 1-aminoanthracene. Proc Natl Acad Sci U S A (2009) 1.29

Using high-resolution MR imaging at 7T to evaluate the anatomy of the midbrain dopaminergic system. AJNR Am J Neuroradiol (2010) 1.13

Neurodegeneration in an animal model of Parkinson's disease is exacerbated by a high-fat diet. Am J Physiol Regul Integr Comp Physiol (2010) 1.01

Different susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1. PLoS One (2010) 0.99

Systems genetic analysis of the effects of iron deficiency in mouse brain. Neurogenetics (2012) 0.98

Mitochondrial ferritin in the substantia nigra in restless legs syndrome. J Neuropathol Exp Neurol (2009) 0.97

Bmp6 regulates retinal iron homeostasis and has altered expression in age-related macular degeneration. Am J Pathol (2011) 0.92

The iron regulatory capability of the major protein participants in prevalent neurodegenerative disorders. Front Pharmacol (2014) 0.91

Mapping brain metals to evaluate therapies for neurodegenerative disease. CNS Neurosci Ther (2010) 0.91

Dexras1, a small GTPase, is required for glutamate-NMDA neurotoxicity. J Neurosci (2013) 0.90

Systems genetics analysis of iron regulation in the brain. Biochimie (2009) 0.89

Iron chelation and neuroprotection in neurodegenerative diseases. J Neural Transm (Vienna) (2010) 0.89

Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice. Proc Natl Acad Sci U S A (2016) 0.89

Human L-ferritin deficiency is characterized by idiopathic generalized seizures and atypical restless leg syndrome. J Exp Med (2013) 0.86

Iron deficiency alters expression of dopamine-related genes in the ventral midbrain in mice. Neuroscience (2013) 0.85

A multicontrast approach for comprehensive imaging of substantia nigra. Neuroimage (2015) 0.84

The potential for transition metal-mediated neurodegeneration in amyotrophic lateral sclerosis. Front Aging Neurosci (2014) 0.84

Possible association between vitamin D deficiency and restless legs syndrome. Neuropsychiatr Dis Treat (2014) 0.82

1B/(-)IRE DMT1 expression during brain ischemia contributes to cell death mediated by NF-κB/RelA acetylation at Lys310. PLoS One (2012) 0.82

Association study between four polymorphisms in the HFE, TF and TFR genes and Parkinson's disease in southern Italy. Neurol Sci (2011) 0.82

Pooled analysis of iron-related genes in Parkinson's disease: association with transferrin. Neurobiol Dis (2013) 0.81

Inhibition of Sirtuin 2 exerts neuroprotection in aging rats with increased neonatal iron intake. Neural Regen Res (2014) 0.80

Aconitase causes iron toxicity in Drosophila pink1 mutants. PLoS Genet (2013) 0.80

Toward an In Vivo Neuroimaging Template of Human Brainstem Nuclei of the Ascending Arousal, Autonomic, and Motor Systems. Brain Connect (2015) 0.78

Brain Iron Metabolism Dysfunction in Parkinson's Disease. Mol Neurobiol (2016) 0.77

Inhibition of the Fe(III)-catalyzed dopamine oxidation by ATP and its relevance to oxidative stress in Parkinson's disease. ACS Chem Neurosci (2013) 0.77

Parkinson's Disease: The Mitochondria-Iron Link. Parkinsons Dis (2016) 0.76

Lysosomal iron modulates NMDA receptor-mediated excitation via small GTPase, Dexras1. Mol Brain (2016) 0.75

Levodopa Responsive Parkinsonism in Patients with Hemochromatosis: Case Presentation and Literature Review. Case Rep Neurol Med (2017) 0.75

Time- and cell-type specific changes in iron, ferritin, and transferrin in the gerbil hippocampal CA1 region after transient forebrain ischemia. Neural Regen Res (2016) 0.75

Melanin-based coatings as lead-binding agents. Bioinorg Chem Appl (2012) 0.75

Iron, brain ageing and neurodegenerative disorders. Nat Rev Neurosci (2004) 5.37

Iron status and neural functioning. Annu Rev Nutr (2003) 2.63

A diet-induced mouse model for glutaric aciduria type I. Brain (2006) 2.31

Persistent neurochemical and behavioral abnormalities in adulthood despite early iron supplementation for perinatal iron deficiency anemia in rats. Behav Brain Res (2006) 2.02

Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system. J Biol Chem (2005) 1.95

Oligodendrocytes and myelination: the role of iron. Glia (2009) 1.90

Ferritin subunits in CSF are decreased in restless legs syndrome. J Lab Clin Med (2006) 1.67

Pre- and postweaning iron deficiency alters myelination in Sprague-Dawley rats. Dev Neurosci (2003) 1.51

Moderate iron deficiency in infancy: biology and behavior in young rats. Behav Brain Res (2006) 1.43

Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice. Invest Ophthalmol Vis Sci (2011) 1.32

Detection of cancer cells in the cerebrospinal fluid: current methods and future directions. Fluids Barriers CNS (2011) 1.32

Brain iron uptake and homeostatic mechanisms: an overview. Biometals (2003) 1.21

MRI and histological analysis of beta-amyloid plaques in both human Alzheimer's disease and APP/PS1 transgenic mice. J Magn Reson Imaging (2009) 1.18

Developmental changes in the expression of iron regulatory proteins and iron transport proteins in the perinatal rat brain. J Neurosci Res (2002) 1.18

The significance of ferritin in cancer: anti-oxidation, inflammation and tumorigenesis. Biochim Biophys Acta (2013) 1.17

Iron deficiency alters iron regulatory protein and iron transport protein expression in the perinatal rat brain. Pediatr Res (2003) 1.15

Perinatal nutritional iron deficiency permanently impairs hippocampus-dependent trace fear conditioning in rats. Nutr Neurosci (2005) 1.12

Regulation, mechanisms and proposed function of ferritin translocation to cell nuclei. J Cell Sci (2002) 1.10

Plasma biomarkers associated with ALS and their relationship to iron homeostasis. Muscle Nerve (2010) 1.09

Interleukin-13 receptor-targeted nanovesicles are a potential therapy for glioblastoma multiforme. Mol Cancer Ther (2006) 1.08

Ferritin stimulates breast cancer cells through an iron-independent mechanism and is localized within tumor-associated macrophages. Breast Cancer Res Treat (2013) 1.07

Mechanism of age-dependent susceptibility and novel treatment strategy in glutaric acidemia type I. J Clin Invest (2007) 1.07

Tim-2 is the receptor for H-ferritin on oligodendrocytes. J Neurochem (2008) 1.06

Efficacy of interleukin-13 receptor-targeted liposomal doxorubicin in the intracranial brain tumor model. Mol Cancer Ther (2009) 1.04

Genetic heterogeneity of amyotrophic lateral sclerosis: implications for clinical practice and research. Muscle Nerve (2014) 1.03

Gene expression of transferrin and transferrin receptor in brains of control vs. iron-deficient rats. Nutr Neurosci (2003) 1.02

HFE gene variants affect iron in the brain. J Nutr (2011) 1.00

Behavior and monoamine deficits in prenatal and perinatal iron deficiency are not corrected by early postnatal moderate-iron or high-iron diets in rats. J Nutr (2012) 0.99

Direct magnetic resonance imaging of histological tissue samples at 3.0T. Magn Reson Med (2007) 0.97

Mitochondrial ferritin in the substantia nigra in restless legs syndrome. J Neuropathol Exp Neurol (2009) 0.97

Is ferroportin-hepcidin signaling altered in restless legs syndrome? J Neurol Sci (2006) 0.97

Nuclear ferritin: A new role for ferritin in cell biology. Biochim Biophys Acta (2010) 0.96

The dopaminergic neurons of the A11 system in RLS autopsy brains appear normal. Sleep Med (2009) 0.96

H-ferritin is the major source of iron for oligodendrocytes. Glia (2011) 0.96

Functional roles of transferrin in the brain. Biochim Biophys Acta (2011) 0.96

Gender and iron genes may modify associations between brain iron and memory in healthy aging. Neuropsychopharmacology (2011) 0.96

Mutant HFE H63D protein is associated with prolonged endoplasmic reticulum stress and increased neuronal vulnerability. J Biol Chem (2011) 0.95

Olfactory deficit detected by fMRI in early Alzheimer's disease. Brain Res (2010) 0.95

Consequences of expressing mutants of the hemochromatosis gene (HFE) into a human neuronal cell line lacking endogenous HFE. FASEB J (2006) 0.95

Characterization of nuclear ferritin and mechanism of translocation. Biochem J (2005) 0.95

Cytokine toxicity to oligodendrocyte precursors is mediated by iron. Glia (2005) 0.93

Myelination and motor coordination are increased in transferrin transgenic mice. J Neurosci Res (2003) 0.92

Ferritin levels in the cerebrospinal fluid and restless legs syndrome: effects of different clinical phenotypes. Sleep (2005) 0.92

Brain iron uptake in hypotransferrinemic mice: influence of systemic iron status. J Neurosci Res (2004) 0.91

Abnormally increased CSF 3-Ortho-methyldopa (3-OMD) in untreated restless legs syndrome (RLS) patients indicates more severe disease and possibly abnormally increased dopamine synthesis. Sleep Med (2008) 0.91

Differential expression of genes in amyotrophic lateral sclerosis revealed by profiling the post mortem cortex. Amyotroph Lateral Scler (2006) 0.91

Regulation of the profile of iron-management proteins in brain microvasculature. J Cereb Blood Flow Metab (2004) 0.90

Heavy chain ferritin siRNA delivered by cationic liposomes increases sensitivity of cancer cells to chemotherapeutic agents. Cancer Res (2011) 0.90

Influence of HFE variants and cellular iron on monocyte chemoattractant protein-1. J Neuroinflammation (2009) 0.89

Interactions and reactions of ferritin with DNA. J Biol Chem (2004) 0.89

Redox metals in Alzheimer's disease. Ann N Y Acad Sci (2004) 0.88

HFE polymorphisms influence the response to chemotherapeutic agents via induction of p16INK4A. Int J Cancer (2011) 0.86

Quantitative proteomic analyses of cerebrospinal fluid using iTRAQ in a primate model of iron deficiency anemia. Dev Neurosci (2012) 0.86

Prevalent iron metabolism gene variants associated with increased brain ferritin iron in healthy older men. J Alzheimers Dis (2010) 0.86

The mechanism of vanadium-mediated developmental hypomyelination is related to destruction of oligodendrocyte progenitors through a relationship with ferritin and iron. Neurotox Res (2010) 0.86

Alteration of iron regulatory proteins (IRP1 and IRP2) and ferritin in the brains of scrapie-infected mice. Neurosci Lett (2007) 0.85

Subcellular localization of iron regulatory proteins to Golgi and ER membranes. J Cell Sci (2005) 0.85

A mutation in the HFE gene is associated with altered brain iron profiles and increased oxidative stress in mice. Biochim Biophys Acta (2013) 0.84

CSF proteomic analysis reveals persistent iron deficiency-induced alterations in non-human primate infants. J Neurochem (2007) 0.84

Metabolic analysis of mouse brains that have compromised iron storage. Metab Brain Dis (2006) 0.83

Increased cellular iron levels affect matrix metalloproteinase expression and phagocytosis in activated microglia. Neurosci Lett (2011) 0.82

H and L ferritin subunit mRNA expression differs in brains of control and iron-deficient rats. J Nutr (2002) 0.82

Gene-environment interactions: neurodegeneration in non-mammals and mammals. Neurotoxicology (2010) 0.81

The lipophilic iron compound TMH-ferrocene [(3,5,5-trimethylhexanoyl)ferrocene] increases iron concentrations, neuronal L-ferritin, and heme oxygenase in brains of BALB/c mice. Biol Trace Elem Res (2002) 0.81

Nitric oxide protects astrocytes from oxidative stress. Ann N Y Acad Sci (2002) 0.81

Mechanism of metabolic stroke and spontaneous cerebral hemorrhage in glutaric aciduria type I. Acta Neuropathol Commun (2014) 0.80

HFE polymorphisms affect cellular glutamate regulation. Neurobiol Aging (2009) 0.80

Adaptive endoplasmic reticulum stress alters cellular responses to the extracellular milieu. J Neurosci Res (2015) 0.80

The Deterioration Seen in Myelin Related Morphophysiology in Vanadium Exposed Rats is Partially Protected by Concurrent Iron Deficiency. Niger J Physiol Sci (2016) 0.79

Proteomic analysis of the cerebrospinal fluid of patients with restless legs syndrome/Willis-Ekbom disease. Fluids Barriers CNS (2013) 0.79

Maturational and aging effects on human brain apparent transverse relaxation. PLoS One (2012) 0.79

HFE polymorphisms affect survival of brain tumor patients. J Neurooncol (2014) 0.78

The effect of iron in MRI and transverse relaxation of amyloid-beta plaques in Alzheimer's disease. NMR Biomed (2014) 0.78

Abnormal iron delivery to the bone marrow in neonatal hypotransferrinemic mice. Biometals (2002) 0.78

Upregulation of iron regulatory proteins and divalent metal transporter-1 isoforms in the rat hippocampus after kainate induced neuronal injury. Exp Brain Res (2005) 0.78

Young coconut juice, a potential therapeutic agent that could significantly reduce some pathologies associated with Alzheimer's disease: novel findings. Br J Nutr (2010) 0.78

The impact of host iron homeostasis on disease. Preface. Biochim Biophys Acta (2009) 0.78

H63D HFE polymorphisms are associated with increased disease duration and decreased muscle superoxide dismutase-1 expression in amyotrophic lateral sclerosis patients. Muscle Nerve (2013) 0.78

Iron and ER stress in neurodegenerative disease. Biometals (2012) 0.78

Development of a fluorescent reporter to assess iron regulatory protein activity in living cells. Biochim Biophys Acta (2004) 0.78

Serum ferritin is elevated in amyotrophic lateral sclerosis patients. Amyotroph Lateral Scler Frontotemporal Degener (2014) 0.78

The H63D HFE gene variant promotes activation of the intrinsic apoptotic pathway via mitochondria dysfunction following β-amyloid peptide exposure. J Neurosci Res (2010) 0.77

A light and electron microscopic study of divalent metal transporter-1 distribution in the rat hippocampus, after kainate-induced neuronal injury. Exp Neurol (2002) 0.77

Regulation of Hfe by stress factors in BV-2 cells. Neurobiol Aging (2005) 0.77

Histological-MRI correlation in the primary motor cortex of patients with amyotrophic lateral sclerosis. J Magn Reson Imaging (2014) 0.77

Expression of the HFE allelic variant H63D in SH-SY5Y cells affects tau phosphorylation at serine residues. Neurobiol Aging (2009) 0.77

Prolyl-peptidyl isomerase, Pin1, phosphorylation is compromised in association with the expression of the HFE polymorphic allele, H63D. Biochim Biophys Acta (2010) 0.76

Regional and cellular distribution of mitochondrial ferritin in the mouse brain. J Neurosci Res (2010) 0.76

New insights for glutaric aciduria type I. Brain (2006) 0.75

Altered eyeblink reflex conditioning in restless legs syndrome patients. Sleep Med (2010) 0.75

Introduction to cells comprising the nervous system. Adv Neurobiol (2014) 0.75

Microscopic R2* mapping of reduced brain iron in the Belgrade rat. Ann Neurol (2002) 0.75

CSF ferritin predicts CSF Aβ decline in biomarker-determined Alzheimer's disease. J Neurol Neurosurg Psychiatry (2017) 0.75