Improved splicing of adeno-associated viral (AAV) capsid protein-supplying pre-mRNAs leads to increased recombinant AAV vector production.

Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain. Nat Biotechnol (2016) 1.11

Adeno-associated virus type 5 utilizes alternative translation initiation to encode a small Rep40-like protein. J Virol (2009) 0.80

Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus. J Virol (1998) 7.76

Studies of small DNA viruses found in various adenovirus preparations: physical, biological, and immunological characteristics. Proc Natl Acad Sci U S A (1966) 7.35

Site-specific integration by adeno-associated virus. Proc Natl Acad Sci U S A (1990) 7.06

Targeted integration of adeno-associated virus (AAV) into human chromosome 19. EMBO J (1991) 6.13

Insect cells as a factory to produce adeno-associated virus type 2 vectors. Hum Gene Ther (2002) 3.92

Nonsense mutations inhibit splicing of MVM RNA in cis when they interrupt the reading frame of either exon of the final spliced product. Genes Dev (1992) 3.26

Transfection of mammalian cells using linear polyethylenimine is a simple and effective means of producing recombinant adeno-associated virus vectors. J Virol Methods (2006) 2.36

Role for highly regulated rep gene expression in adeno-associated virus vector production. J Virol (1997) 2.19

Accumulation of MVM gene products is differentially regulated by transcription initiation, RNA processing and protein stability. Virology (1991) 2.18

Isolation of adenovirus-associated viruses from man. Proc Natl Acad Sci U S A (1967) 2.10

Alternate mRNA splicing is required for synthesis of adeno-associated virus VP1 capsid protein. J Virol (1988) 2.03

Synthesis of adeno-associated virus structural proteins requires both alternative mRNA splicing and alternative initiations from a single transcript. J Virol (1988) 1.89

Characterization of the transcription profile of adeno-associated virus type 5 reveals a number of unique features compared to previously characterized adeno-associated viruses. J Virol (2002) 1.64

The adeno-associated virus type 2 Rep protein regulates RNA processing via interaction with the transcription template. Mol Cell Biol (2002) 1.51

Identification and elimination of replication-competent adeno-associated virus (AAV) that can arise by nonhomologous recombination during AAV vector production. J Virol (1997) 1.35

Electron microscopy of adenovirus-associated virus (AAV) in cell cultures. Virology (1966) 1.35

Analysis of recombinant adeno-associated virus packaging and requirements for rep and cap gene products. J Virol (1997) 1.21

Inhibition of PrKX, a novel protein kinase, and the cyclic AMP-dependent protein kinase PKA by the regulatory proteins of adeno-associated virus type 2. Mol Cell Biol (1998) 1.20

Adeno-associated virus RNAs appear in a temporal order and their splicing is stimulated during coinfection with adenovirus. J Virol (2000) 1.14

High-titer, wild-type free recombinant adeno-associated virus vector production using intron-containing helper plasmids. J Virol (2000) 1.12

PKA/PrKX activity is a modulator of AAV/adenovirus interaction. EMBO J (2003) 1.08

Characterization of wild-type adeno-associated virus type 2-like particles generated during recombinant viral vector production and strategies for their elimination. J Virol (1998) 1.06

Effects of adeno-associated virus on adenovirus replication and gene expression during coinfection. J Virol (2006) 1.05

Quantitation of encapsidated recombinant adeno-associated virus DNA in crude cell lysates and tissue culture medium by quantitative, real-time PCR. J Virol Methods (2006) 1.01

Inhibition of adenovirus cytotoxicity, replication, and E2a gene expression by adeno-associated virus. Virology (2001) 0.93

Efficient expression of the adeno-associated virus type 5 p41 capsid gene promoter in 293 cells does not require Rep. J Virol (2006) 0.92

Strategies for manufacturing recombinant adeno-associated virus vectors for gene therapy applications exploiting baculovirus technology. Brief Funct Genomic Proteomic (2008) 0.91

Replication competent helper functions for recombinant AAV vector generation. Gene Ther (2002) 0.87

Serotype-specific replicating AAV helper constructs increase recombinant AAV type 2 vector production. Virology (2005) 0.87

Characterization of adeno-associated virus rep protein inhibition of adenovirus E2a gene expression. Virology (2002) 0.86

Construction of adeno-associated virus packaging plasmids and cells that directly select for AAV helper functions. J Virol Methods (2003) 0.78

Self-amplification system for recombinant adeno-associated virus production. Biochem Biophys Res Commun (2000) 0.78

Transfection of mammalian cells using linear polyethylenimine is a simple and effective means of producing recombinant adeno-associated virus vectors. J Virol Methods (2006) 2.36

The family Parvoviridae. Arch Virol (2013) 2.12

Deaminase-independent inhibition of parvoviruses by the APOBEC3A cytidine deaminase. PLoS Pathog (2009) 1.65

Characterization of the transcription profile of adeno-associated virus type 5 reveals a number of unique features compared to previously characterized adeno-associated viruses. J Virol (2002) 1.64

The adeno-associated virus type 2 Rep protein regulates RNA processing via interaction with the transcription template. Mol Cell Biol (2002) 1.51

Block to the production of full-length B19 virus transcripts by internal polyadenylation is overcome by replication of the viral genome. J Virol (2008) 1.26

Interaction between parvovirus NS2 protein and nuclear export factor Crm1 is important for viral egress from the nucleus of murine cells. J Virol (2002) 1.24

Comparison of the transcription profile of simian parvovirus with that of the human erythrovirus B19 reveals a number of unique features. J Virol (2004) 1.21

Trans-splicing adeno-associated viral vector-mediated gene therapy is limited by the accumulation of spliced mRNA but not by dual vector coinfection efficiency. Hum Gene Ther (2004) 1.16

Alternative polyadenylation of adeno-associated virus type 5 RNA within an internal intron is governed by the distance between the promoter and the intron and is inhibited by U1 small nuclear RNP binding to the intervening donor. J Biol Chem (2004) 1.12

Alternative polyadenylation of adeno-associated virus type 5 RNA within an internal intron is governed by both a downstream element within the intron 3' splice acceptor and an element upstream of the P41 initiation site. J Virol (2004) 1.08

Minute virus of mice NS1 interacts with the SMN protein, and they colocalize in novel nuclear bodies induced by parvovirus infection. J Virol (2002) 1.08

Parvovirus minute virus of mice induces a DNA damage response that facilitates viral replication. PLoS Pathog (2010) 1.03

Quantitation of encapsidated recombinant adeno-associated virus DNA in crude cell lysates and tissue culture medium by quantitative, real-time PCR. J Virol Methods (2006) 1.01

Identification and characterization of two internal cleavage and polyadenylation sites of parvovirus B19 RNA. J Virol (2006) 1.00

Positive and negative effects of adenovirus type 5 helper functions on adeno-associated virus type 5 (AAV5) protein accumulation govern AAV5 virus production. J Virol (2006) 0.97

Human circovirus TT virus genotype 6 expresses six proteins following transfection of a full-length clone. J Virol (2005) 0.96

The choice of translation initiation site of the rep proteins from goose parvovirus P9-generated mRNA is governed by splicing and the nature of the excised intron. J Virol (2009) 0.95

E4Orf6-E1B-55k-dependent degradation of de novo-generated adeno-associated virus type 5 Rep52 and capsid proteins employs a cullin 5-containing E3 ligase complex. J Virol (2008) 0.95

Expression profiles of bovine adeno-associated virus and avian adeno-associated virus display significant similarity to that of adeno-associated virus type 5. J Virol (2006) 0.94

Efficient expression of the adeno-associated virus type 5 p41 capsid gene promoter in 293 cells does not require Rep. J Virol (2006) 0.92

Characterization of the nonstructural proteins of the bocavirus minute virus of canines. J Virol (2012) 0.92

Adeno-associated viruses can induce phosphorylation of eIF2alpha via PKR activation, which can be overcome by helper adenovirus type 5 virus-associated RNA. J Virol (2007) 0.87

Minute virus of mice small nonstructural protein NS2 interacts and colocalizes with the Smn protein. J Virol (2002) 0.86

Adeno-associated virus small rep proteins are modified with at least two types of polyubiquitination. J Virol (2009) 0.85

RNAse mapping and quantitation of RNA isoforms. Methods Mol Biol (2012) 0.84

Minute virus of mice small non-structural protein NS2 localizes within, but is not required for the formation of, Smn-associated autonomous parvovirus-associated replication bodies. J Gen Virol (2005) 0.83

Molecular characterization of three newly recognized rat parvoviruses. J Gen Virol (2002) 0.81

Adeno-associated virus type 5 utilizes alternative translation initiation to encode a small Rep40-like protein. J Virol (2009) 0.80

Replication of minute virus of mice in murine cells is facilitated by virally induced depletion of p21. J Virol (2012) 0.80

Upstream AP1- and CREB-binding sites confer high basal activity on the adeno-associated virus type 5 capsid gene promoter. J Virol (2007) 0.79

The adeno-associated virus type 5 small rep proteins expressed via internal translation initiation are functional. J Virol (2012) 0.78

Splicing of goose parvovirus pre-mRNA influences cytoplasmic translation of the processed mRNA. Virology (2012) 0.77

The transcription strategy of bovine adeno-associated virus (B-AAV) combines features of both adeno-associated virus type 2 (AAV2) and type 5 (AAV5). Virology (2007) 0.75