Published in Clin Exp Pharmacol Physiol on September 10, 2008
Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice. Br J Pharmacol (2010) 0.95
Emodin, a Naturally Occurring Anthraquinone Derivative, Ameliorates Dyslipidemia by Activating AMP-Activated Protein Kinase in High-Fat-Diet-Fed Rats. Evid Based Complement Alternat Med (2012) 0.82
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Screening of a natural compound library identifies emodin, a natural compound from Rheum palmatum Linn that inhibits DPP4. PeerJ (2017) 0.75
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Identification of an acquired JAK2 mutation in polycythemia vera. J Biol Chem (2005) 5.58
Digital RNA allelotyping reveals tissue-specific and allele-specific gene expression in human. Nat Methods (2009) 4.38
A public resource facilitating clinical use of genomes. Proc Natl Acad Sci U S A (2012) 3.72
Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype. Blood (2005) 3.32
Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development. Dev Cell (2013) 3.31
A robust approach to identifying tissue-specific gene expression regulatory variants using personalized human induced pluripotent stem cells. PLoS Genet (2009) 2.78
TALEN-mediated precise genome modification by homologous recombination in zebrafish. Nat Methods (2013) 2.64
NANOG-dependent function of TET1 and TET2 in establishment of pluripotency. Nature (2013) 2.63
Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain. Neuron (2006) 2.60
A subpopulation of nociceptors specifically linked to itch. Nat Neurosci (2012) 2.41
Genetic correction and analysis of induced pluripotent stem cells from a patient with gyrate atrophy. Proc Natl Acad Sci U S A (2011) 2.41
miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia. Genes Dev (2010) 2.05
Statistical inference of chromosomal homology based on gene colinearity and applications to Arabidopsis and rice. BMC Bioinformatics (2006) 1.91
ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients. Genes Dev (2013) 1.87
Mammalian Kinesin-3 motors are dimeric in vivo and move by processive motility upon release of autoinhibition. PLoS Biol (2009) 1.66
Blocking IL-17A promotes the resolution of pulmonary inflammation and fibrosis via TGF-beta1-dependent and -independent mechanisms. J Immunol (2011) 1.65
Anti-apoptotic effects of a calpain inhibitor on cardiomyocytes in a canine rapid atrial fibrillation model. Cardiovasc Drugs Ther (2009) 1.46
Increased expression of calcium-sensing receptors induced by ox-LDL amplifies apoptosis of cardiomyocytes during simulated ischaemia-reperfusion. Clin Exp Pharmacol Physiol (2010) 1.45
GATA-2 reinforces megakaryocyte development in the absence of GATA-1. Mol Cell Biol (2009) 1.44
Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis. Genes Dev (2010) 1.42
Mechanisms of itch evoked by β-alanine. J Neurosci (2012) 1.40
1-(4-Amino-phen-yl)-3-[2-(trifluoro-meth-yl)phen-yl]prop-2-en-1-one. Acta Crystallogr Sect E Struct Rep Online (2010) 1.34
Reciprocal repression between microRNA-133 and calcineurin regulates cardiac hypertrophy: a novel mechanism for progressive cardiac hypertrophy. Hypertension (2010) 1.28
Rapid identification of heterozygous mutations in Drosophila melanogaster using genomic capture sequencing. Genome Res (2010) 1.26
Alterations of white matter integrity in adults with major depressive disorder: a magnetic resonance imaging study. J Psychiatry Neurosci (2008) 1.15
Whole-exome sequencing identifies ALMS1, IQCB1, CNGA3, and MYO7A mutations in patients with Leber congenital amaurosis. Hum Mutat (2011) 1.13
Preso1 dynamically regulates group I metabotropic glutamate receptors. Nat Neurosci (2012) 1.12
Analysis of protein-coding mutations in hiPSCs and their possible role during somatic cell reprogramming. Nat Commun (2013) 1.12
TLR4 activity is required in the resolution of pulmonary inflammation and fibrosis after acute and chronic lung injury. Am J Pathol (2011) 1.12
T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFbeta dosage. Blood (2006) 1.11
Carbon monoxide stimulates the Ca2(+)-activated big conductance k channels in cultured human endothelial cells. Hypertension (2007) 1.11
miR-99a/100~125b tricistrons regulate hematopoietic stem and progenitor cell homeostasis by shifting the balance between TGFβ and Wnt signaling. Genes Dev (2014) 1.11
Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome. Blood (2010) 1.08
Bone morphogenetic protein-4 mediates cardiac hypertrophy, apoptosis, and fibrosis in experimentally pathological cardiac hypertrophy. Hypertension (2012) 1.08
Allogeneic head and body reconstruction: mouse model. CNS Neurosci Ther (2014) 1.06
MicroRNA transport: a new way in cell communication. J Cell Physiol (2013) 1.06
Health-related quality of life and long-term care needs among elderly individuals living alone: a cross-sectional study in rural areas of Shaanxi Province, China. BMC Public Health (2013) 1.06
Matrine inhibits breast cancer growth via miR-21/PTEN/Akt pathway in MCF-7 cells. Cell Physiol Biochem (2012) 1.05
ABCG2/V-ATPase was associated with the drug resistance and tumor metastasis of esophageal squamous cancer cells. Diagn Pathol (2012) 1.05
A new alternative for bony chest wall reconstruction using biomaterial artificial rib and pleura: animal experiment and clinical application. Eur J Cardiothorac Surg (2011) 1.03
Mirror image DNA nanostructures for chiral supramolecular assemblies. Nano Lett (2009) 1.03
Tailoring the porosity and pore size of electrospun synthetic human elastin scaffolds for dermal tissue engineering. Biomaterials (2011) 1.03
Studies of inactivation of encephalomyocarditis virus, M13 bacteriophage, and Salmonella typhimurium by using a visible femtosecond laser: insight into the possible inactivation mechanisms. J Biomed Opt (2011) 1.02
Immobilization and one-dimensional arrangement of virus capsids with nanoscale precision using DNA origami. Nano Lett (2010) 1.02
The presenilin-1 ΔE9 mutation results in reduced γ-secretase activity, but not total loss of PS1 function, in isogenic human stem cells. Cell Rep (2013) 1.00
WebLab: a data-centric, knowledge-sharing bioinformatic platform. Nucleic Acids Res (2009) 1.00
Prevalence of metabolic syndrome among urban community residents in China. BMC Public Health (2013) 1.00
Post-conditioning protects cardiomyocytes from apoptosis via PKC(epsilon)-interacting with calcium-sensing receptors to inhibit endo(sarco)plasmic reticulum-mitochondria crosstalk. Mol Cell Biochem (2010) 0.99
Morphological stability and performance of polymer-fullerene solar cells under thermal stress: the impact of photoinduced PC60BM oligomerization. ACS Nano (2014) 0.99
Primary human dermal fibroblast interactions with open weave three-dimensional scaffolds prepared from synthetic human elastin. Biomaterials (2009) 0.99
Nitric oxide promotes MPK6-mediated caspase-3-like activation in cadmium-induced Arabidopsis thaliana programmed cell death. Plant Cell Environ (2012) 0.99
Biochemical mechanism of HIV-1 resistance to rilpivirine. J Biol Chem (2012) 0.99
MicroRNAs and apoptosis: implications in the molecular therapy of human disease. Clin Exp Pharmacol Physiol (2009) 0.98
Therapeutic effects of neuregulin-1 in diabetic cardiomyopathy rats. Cardiovasc Diabetol (2011) 0.98
Electrophysiological and neuroanatomical evidence of sexual dimorphism in aortic baroreceptor and vagal afferents in rat. Am J Physiol Regul Integr Comp Physiol (2008) 0.97
Possible roles of Runx1 and Sox9 in incipient intramembranous ossification. J Bone Miner Res (2004) 0.96
Antagonism or synergism. Role of tyrosine phosphatases SHP-1 and SHP-2 in growth factor signaling. J Biol Chem (2006) 0.95
[Study on pharmacokinetics of PVP coated beta-elemene liposome in rats]. Zhong Yao Cai (2006) 0.94
Effects of vegetative-periodic-induced rhizosphere variation on the uptake and translocation of metals in Phragmites australis (Cav.) Trin ex. Steudel growing in the Sun Island Wetland. Ecotoxicology (2013) 0.94
Microtubule-dependent retrograde transport of bovine immunodeficiency virus. Cell Microbiol (2010) 0.93
Transcriptional and post-transcriptional mechanisms for oncogenic overexpression of ether à go-go K+ channel. PLoS One (2011) 0.93
Targeting acute myeloid leukemia with a proapoptotic peptide conjugated to a Toll-like receptor 2-mediated cell-penetrating peptide. Int J Cancer (2013) 0.93
Opportunistic decision making and complexity in emergency care. J Biomed Inform (2011) 0.92
Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice. Pharm Res (2013) 0.92
Functionalized bacterial cellulose derivatives and nanocomposites. Carbohydr Polym (2013) 0.92
The metabolic syndrome and DYRK1B. N Engl J Med (2014) 0.92
MicroRNA-195 protects against dementia induced by chronic brain hypoperfusion via its anti-amyloidogenic effect in rats. J Neurosci (2013) 0.91
Mitochondrially localized EGFR is independent of its endocytosis and associates with cell viability. Acta Biochim Biophys Sin (Shanghai) (2010) 0.91
Gli inhibitor GANT61 causes apoptosis in myeloid leukemia cells and acts in synergy with rapamycin. Leuk Res (2012) 0.91
Role of polyamines in myocardial ischemia/reperfusion injury and their interactions with nitric oxide. Eur J Pharmacol (2007) 0.91
Enhancing fullerene-based solar cell lifetimes by addition of a fullerene dumbbell. Angew Chem Int Ed Engl (2014) 0.91
In vivo cancer targeting and imaging-guided surgery with near infrared-emitting quantum dot bioconjugates. Theranostics (2012) 0.90
beta-Ionone suppresses mammary carcinogenesis, proliferative activity and induces apoptosis in the mammary gland of the Sprague-Dawley rat. Int J Cancer (2008) 0.90
Mutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunit. J Biol Chem (2003) 0.90
Choline produces antiarrhythmic actions in animal models by cardiac M3 receptors: improvement of intracellular Ca2+ handling as a common mechanism. Can J Physiol Pharmacol (2008) 0.90
Without its N-finger, the main protease of severe acute respiratory syndrome coronavirus can form a novel dimer through its C-terminal domain. J Virol (2008) 0.90
Involvement of calcium-sensing receptor in cardiac hypertrophy-induced by angiotensinII through calcineurin pathway in cultured neonatal rat cardiomyocytes. Biochem Biophys Res Commun (2008) 0.90
Making sense: sensor-based investigation of clinician activities in complex critical care environments. J Biomed Inform (2011) 0.89
Arsenic trioxide induces the apoptosis in vascular smooth muscle cells via increasing intracellular calcium and ROS formation. Mol Biol Rep (2009) 0.89
Impaired PI3K/Akt signal pathway and hepatocellular injury in high-fat fed rats. World J Gastroenterol (2010) 0.89
Development of Wistar rat model of insulin resistance. World J Gastroenterol (2005) 0.89
AGR2 expression is regulated by HIF-1 and contributes to growth and angiogenesis of glioblastoma. Cell Biochem Biophys (2013) 0.88
The calcium-sensing receptor mediates hypoxia-induced proliferation of rat pulmonary artery smooth muscle cells through MEK1/ERK1,2 and PI3K pathways. Basic Clin Pharmacol Toxicol (2010) 0.88
The emergence of HIV-1 primary drug resistance genotypes among treatment-naïve men who have sex with men in high-prevalence areas in China. Arch Virol (2012) 0.88
17Beta-estradiol restores excitability of a sexually dimorphic subset of myelinated vagal afferents in ovariectomized rats. Am J Physiol Cell Physiol (2009) 0.88
Interleukin 17A inhibits autophagy through activation of PIK3CA to interrupt the GSK3B-mediated degradation of BCL2 in lung epithelial cells. Autophagy (2013) 0.88
Triple-layer Fabry-Perot absorber with near-perfect absorption in visible and near-infrared regime. Opt Express (2013) 0.88
Reactive oxygen species promote chloroplast dysfunction and salicylic acid accumulation in fumonisin B1-induced cell death. FEBS Lett (2013) 0.88
Pseudomonas pyocyanin inhibits wound repair by inducing premature cellular senescence: role for p38 mitogen-activated protein kinase. Burns (2009) 0.88
Eco-compensation in multi-district river networks in north Jiangsu, China. Environ Manage (2012) 0.88
Experimental study of Love-wave immunosensors based on ZnO/LiTaO3 structures. Ultrasonics (2009) 0.87
The application of poly (glycerol-sebacate) as biodegradable drug carrier. Biomaterials (2009) 0.87
Overexpression of microRNA-1 impairs cardiac contractile function by damaging sarcomere assembly. Cardiovasc Res (2012) 0.86
GM1 ganglioside contributes to retain the neuronal conduction and neuronal excitability in visceral and baroreceptor afferents. J Neurochem (2008) 0.86
Arsenic trioxide initiates ER stress responses, perturbs calcium signalling and promotes apoptosis in human lens epithelial cells. Exp Eye Res (2007) 0.86
The molecular basis for the inhibition of phosphodiesterase-4D by three natural resveratrol analogs. Isolation, molecular docking, molecular dynamics simulations, binding free energy, and bioassay. Biochim Biophys Acta (2013) 0.86