Phage-display derived single-chain fragment variable (scFv) antibodies recognizing conformational epitopes of Escherichia coli heat-labile enterotoxin B-subunit.

PubWeight™: 0.82‹?›

🔗 View Article (PMID 18786540)

Published in J Immunol Methods on September 09, 2008

Authors

Wen Yuan Chung1, Markus Sack, Rachel Carter, Holger Spiegel, Rainer Fischer, Timothy R Hirst, Neil A Williams, Roger F L James

Author Affiliations

1: Royal College of Surgeons, Department of Surgery, Connolly Hospital, Blanchardstown, D15, Ireland.

Articles by these authors

Autophagy promotes MHC class II presentation of peptides from intracellular source proteins. Proc Natl Acad Sci U S A (2005) 3.75

A comprehensive model for the cellular uptake of cationic cell-penetrating peptides. Traffic (2007) 3.01

Uptake of a fluorescent marker in plant cells is sensitive to brefeldin A and wortmannin. Plant Cell (2002) 1.83

Plant-derived pharmaceuticals--the road forward. Trends Plant Sci (2005) 1.82

Molecular farming in plants: host systems and expression technology. Trends Biotechnol (2003) 1.78

Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes. Proc Natl Acad Sci U S A (2008) 1.74

Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium. Blood (2004) 1.61

Fusion proteins comprising a Fusarium-specific antibody linked to antifungal peptides protect plants against a fungal pathogen. Nat Biotechnol (2004) 1.59

Emphysematous gastritis caused by Sarcina ventriculi. Gastrointest Endosc (2010) 1.54

Cholera toxin: a paradigm for multi-functional engagement of cellular mechanisms (Review). Mol Membr Biol (2004) 1.49

Molecular farming for new drugs and vaccines. Current perspectives on the production of pharmaceuticals in transgenic plants. EMBO Rep (2005) 1.45

Effect of antivirals on human herpesvirus 6 replication in hematopoietic stem cell transplant recipients. Clin Infect Dis (2001) 1.40

Plant cell cultures for the production of recombinant proteins. Nat Biotechnol (2004) 1.27

Sowing the seeds of success: pharmaceutical proteins from plants. Curr Opin Biotechnol (2005) 1.26

Cost-effective production of a vaginal protein microbicide to prevent HIV transmission. Proc Natl Acad Sci U S A (2008) 1.23

Unexpected deposition patterns of recombinant proteins in post-endoplasmic reticulum compartments of wheat endosperm. Plant Physiol (2004) 1.22

Simultaneous occurrence of Hodgkin's lymphoma and eosinophilic granuloma: a potential pitfall in positron emission tomography imaging. Clin Lymphoma (2002) 1.21

Genetic determinants of Pseudomonas aeruginosa biofilm establishment. Microbiology (2009) 1.19

Loss of CTL function among high-avidity tumor-specific CD8+ T cells following tumor infiltration. Cancer Res (2008) 1.19

Preliminary X-ray analysis of a human V(H) fragment at 1.8 A resolution. Acta Crystallogr D Biol Crystallogr (2004) 1.18

Evolution of a regulatory framework for pharmaceuticals derived from genetically modified plants. Trends Biotechnol (2008) 1.18

Transgenic plants in the biopharmaceutical market. Expert Opin Emerg Drugs (2005) 1.18

Endosperm-specific co-expression of recombinant soybean ferritin and Aspergillus phytase in maize results in significant increases in the levels of bioavailable iron. Plant Mol Biol (2005) 1.17

Psychopathic traits in females and males across the globe. Behav Sci Law (2012) 1.14

The structure of the dizinc subclass B2 metallo-beta-lactamase CphA reveals that the second inhibitory zinc ion binds in the histidine site. Antimicrob Agents Chemother (2009) 1.14

Recombinant antibody 2G12 produced in maize endosperm efficiently neutralizes HIV-1 and contains predominantly single-GlcNAc N-glycans. Plant Biotechnol J (2007) 1.13

Polyphenoloxidase silencing affects latex coagulation in Taraxacum species. Plant Physiol (2009) 1.11

Potato virus X as a novel platform for potential biomedical applications. Nano Lett (2010) 1.08

T cell memory response to pneumococcal protein antigens in an area of high pneumococcal carriage and disease. J Infect Dis (2009) 1.08

Spatial and temporal regulation of the forisome gene for1 in the phloem during plant development. Plant Mol Biol (2007) 1.06

An unusual internal ribosomal entry site of inverted symmetry directs expression of a potato leafroll polerovirus replication-associated protein. Proc Natl Acad Sci U S A (2003) 1.06

Biochemical and functional characterization of anti-HIV antibody-ELP fusion proteins from transgenic plants. Plant Biotechnol J (2008) 1.05

The potential of plant virus vectors for vaccine production. Drugs R D (2006) 1.03

Granzyme B-H22(scFv), a human immunotoxin targeting CD64 in acute myeloid leukemia of monocytic subtypes. Mol Cancer Ther (2008) 1.03

Perforin-like protein PPLP2 permeabilizes the red blood cell membrane during egress of Plasmodium falciparum gametocytes. Cell Microbiol (2014) 1.02

Acquisition of pneumococci specific effector and regulatory Cd4+ T cells localising within human upper respiratory-tract mucosal lymphoid tissue. PLoS Pathog (2011) 1.02

Deteriorating pneumococcal-specific B-cell memory in minimally symptomatic African children with HIV infection. J Infect Dis (2011) 1.01

Cationic cell-penetrating peptides interfere with TNF signalling by induction of TNF receptor internalization. J Cell Sci (2005) 1.01

Plant molecular pharming for the treatment of chronic and infectious diseases. Annu Rev Plant Biol (2014) 1.00

Impaired CD4 T cell memory response to Streptococcus pneumoniae precedes CD4 T cell depletion in HIV-infected Malawian adults. PLoS One (2011) 1.00

Characterization of rubber particles and rubber chain elongation in Taraxacum koksaghyz. BMC Biochem (2010) 1.00

Molecular farming of pharmaceutical proteins using plant suspension cell and tissue cultures. Curr Pharm Des (2013) 1.00

Defective pneumococcal-specific Th1 responses in HIV-infected adults precedes a loss of control of pneumococcal colonization. Clin Infect Dis (2012) 1.00

Parenteral influenza vaccination influences mucosal and systemic T cell-mediated immunity in healthy adults. J Infect Dis (2004) 1.00

Cellulases for biomass degradation: comparing recombinant cellulase expression platforms. Trends Biotechnol (2013) 0.99

Development of viral nanoparticles for efficient intracellular delivery. Nanoscale (2012) 0.99

Mucosal immunity in resource-limited setting: is the battle ground different? Trends Microbiol (2010) 0.98

ELPylated anti-human TNF therapeutic single-domain antibodies for prevention of lethal septic shock. Plant Biotechnol J (2011) 0.98

Influence of elastin-like peptide fusions on the quantity and quality of a tobacco-derived human immunodeficiency virus-neutralizing antibody. Plant Biotechnol J (2009) 0.98

Rapid high-level production of functional HIV broadly neutralizing monoclonal antibodies in transient plant expression systems. PLoS One (2013) 0.98

Rapid transient production in plants by replicating and non-replicating vectors yields high quality functional anti-HIV antibody. PLoS One (2010) 0.98

Proteins from the FLOWERING LOCUS T-like subclade of the PEBP family act antagonistically to regulate floral initiation in tobacco. Plant J (2012) 0.97

Recombinant anti-hCG antibodies retained in the endoplasmic reticulum of transformed plants lack core-xylose and core-alpha(1,3)-fucose residues. Plant Biotechnol J (2004) 0.97

Functional analysis of the broadly neutralizing human anti-HIV-1 antibody 2F5 produced in transgenic BY-2 suspension cultures. FASEB J (2007) 0.97

Opportunities for recombinant antigen and antibody expression in transgenic plants--technology assessment. Vaccine (2005) 0.97

Monoclonal tobacco cell lines with enhanced recombinant protein yields can be generated from heterogeneous cell suspension cultures by flow sorting. Plant Biotechnol J (2012) 0.97

Design of protein membrane interaction inhibitors by virtual ligand screening, proof of concept with the C2 domain of factor V. Proc Natl Acad Sci U S A (2007) 0.96

Do multiple concurrent infections in African children cause irreversible immunological damage? Immunology (2012) 0.96

Evidence for naturally acquired T cell-mediated mucosal immunity to Neisseria meningitidis. J Immunol (2003) 0.96

Viroid-induced RNA silencing of GFP-viroid fusion transgenes does not induce extensive spreading of methylation or transitive silencing. Plant J (2004) 0.96

The intracellular fate of a recombinant protein is tissue dependent. Plant Physiol (2006) 0.96

Plantibodies: applications, advantages and bottlenecks. Curr Opin Biotechnol (2002) 0.96

Escherichia coli heat-labile enterotoxin B subunit prevents autoimmune arthritis through induction of regulatory CD4+ T cells. Arthritis Rheum (2002) 0.96

A CD14 domain with lipopolysaccharide-binding and -neutralizing activity. Chembiochem (2006) 0.95

Production of Desmodus rotundus salivary plasminogen activator alpha1 (DSPAalpha1) in tobacco is hampered by proteolysis. Biotechnol Bioeng (2005) 0.95

With or without sugar? (A)glycosylation of therapeutic antibodies. Mol Biotechnol (2013) 0.95

Restrictive cardiomyopathy in a patient with primary hyperoxaluria type II. Clin Res Cardiol (2006) 0.94

Harmonine, a defence compound from the harlequin ladybird, inhibits mycobacterial growth and demonstrates multi-stage antimalarial activity. Biol Lett (2011) 0.94

Detailed functional characterization of glycosylated and nonglycosylated variants of malaria vaccine candidate PfAMA1 produced in Nicotiana benthamiana and analysis of growth inhibitory responses in rabbits. Plant Biotechnol J (2014) 0.94

Small cleavable adapters enhance the specific cytotoxicity of a humanized immunotoxin directed against CD64-positive cells. J Immunother (2008) 0.94

A recombinant multimeric immunoglobulin expressed in rice shows assembly-dependent subcellular localization in endosperm cells. Plant Biotechnol J (2005) 0.93

Malaria parasites co-opt human factor H to prevent complement-mediated lysis in the mosquito midgut. Cell Host Microbe (2013) 0.93

Suppression of human T-cell responses to beta-cells by activation of B7-H4 pathway. Cell Transplant (2006) 0.92

Immune modulation by the cholera-like enterotoxins. Expert Rev Mol Med (2002) 0.92

Optimizing the yield of recombinant pharmaceutical proteins in plants. Curr Pharm Des (2013) 0.92

A cell-penetrating peptide derived from human lactoferrin with conformation-dependent uptake efficiency. J Biol Chem (2009) 0.92

A mechanistic basis for the co-evolution of chicken tapasin and major histocompatibility complex class I (MHC I) proteins. J Biol Chem (2013) 0.92

Modulation of human monocytes by Escherichia coli heat-labile enterotoxin B-subunit; altered cytokine production and its functional consequences. Immunology (2002) 0.92

Regulation of Th-1 T cell-dominated immunity to Neisseria meningitidis within the human mucosa. Cell Microbiol (2006) 0.92

Isolation and characterization of isochorismate synthase and cinnamate 4-hydroxylase during salinity stress, wounding, and salicylic acid treatment in Carthamus tinctorius. Plant Signal Behav (2013) 0.92

Absence of mucosal immunity in the human upper respiratory tract to the commensal bacteria Neisseria lactamica but not pathogenic Neisseria meningitidis during the peak age of nasopharyngeal carriage. J Immunol (2009) 0.91

Optimization of BY-2 cell suspension culture medium for the production of a human antibody using a combination of fractional factorial designs and the response surface method. Plant Biotechnol J (2013) 0.91

Flow cytometry-based ultra-high-throughput screening assay for cellulase activity. Anal Biochem (2012) 0.91

Histone acetylation mediates epigenetic regulation of transcriptional reprogramming in insects during metamorphosis, wounding and infection. Front Zool (2012) 0.90

Recombinant CD64-specific single chain immunotoxin exhibits specific cytotoxicity against acute myeloid leukemia cells. Cancer Res (2003) 0.90

Contribution of the ADP-ribosylating and receptor-binding properties of cholera-like enterotoxins in modulating cytokine secretion by human intestinal epithelial cells. Microbiology (2002) 0.90

Mutant Escherichia coli heat-labile toxin B subunit that separates toxoid-mediated signaling and immunomodulatory action from trafficking and delivery functions. Infect Immun (2003) 0.89

Scaled-up manufacturing of recombinant antibodies produced by plant cells in a 200-L orbitally-shaken disposable bioreactor. Biotechnol Bioeng (2014) 0.89