BRCA1 is regulated by Chk2 in response to spindle damage.

Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide]. J Pharmacol Exp Ther (2009) 1.11

CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. Cancer Res (2011) 1.04

Profiling of the BRCA1 transcriptome through microarray and ChIP-chip analysis. Nucleic Acids Res (2011) 1.02

Elevated cyclin G2 expression intersects with DNA damage checkpoint signaling and is required for a potent G2/M checkpoint arrest response to doxorubicin. J Biol Chem (2012) 0.97

DNA-PKcs activates the Chk2-Brca1 pathway during mitosis to ensure chromosomal stability. Oncogenesis (2014) 0.90

ATM-mediated Mad1 Serine 214 phosphorylation regulates Mad1 dimerization and the spindle assembly checkpoint. Carcinogenesis (2014) 0.88

Rad9A is required for G2 decatenation checkpoint and to prevent endoreduplication in response to topoisomerase II inhibition. J Biol Chem (2010) 0.85

Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection. Cell Cycle (2015) 0.81

WISP-1 contributes to fractionated irradiation-induced radioresistance in esophageal carcinoma cell lines and mice. PLoS One (2014) 0.79

Polo-like kinase 1 mediates BRCA1 phosphorylation and recruitment at DNA double-strand breaks. Oncotarget (2016) 0.78

X-ray structures of checkpoint kinase 2 in complex with inhibitors that target its gatekeeper-dependent hydrophobic pocket. FEBS Lett (2011) 0.77

Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining. Oncotarget (2015) 0.77

The when and wheres of CDC25 phosphatases. Curr Opin Cell Biol (2006) 2.28

Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2-M transition. J Cell Sci (2004) 1.93

OPA1 cleavage depends on decreased mitochondrial ATP level and bivalent metals. Exp Cell Res (2007) 1.55

CDC25B phosphorylation by Aurora-A occurs at the G2/M transition and is inhibited by DNA damage. Cell Cycle (2005) 1.18

CHK1 phosphorylates CDC25B during the cell cycle in the absence of DNA damage. J Cell Sci (2006) 1.16

Mitochondrial proteomic approach reveals galectin-7 as a novel BCL-2 binding protein in human cells. Mol Biol Cell (2011) 0.95

Resistance to the antibiotic Zeocin by stable expression of the Sh ble gene does not fully suppress Zeocin-induced DNA cleavage in human cells. Mutagenesis (2005) 0.88

NanoLC-MS/MS analysis provides new insights into the phosphorylation pattern of Cdc25B in vivo: full overlap with sites of phosphorylation by Chk1 and Cdk1/cycB kinases in vitro. J Proteome Res (2008) 0.82

Identification of N-terminally truncated stable nuclear isoforms of CDC25B that are specifically involved in G2/M checkpoint recovery. Cancer Res (2011) 0.79

CDC25B associates with a centrin 2-containing complex and is involved in maintaining centrosome integrity. Biol Cell (2011) 0.78

Overexpression of metallothionein-II sensitizes rodent cells to apoptosis induced by DNA cross-linking agent through inhibition of NF-kappa B activation. J Biol Chem (2001) 0.78

Bcl-2 is an integral component of mitotic chromosomes. Cell Biol Int (2009) 0.77