Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining.

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Published in Oncotarget on September 29, 2015

Authors

Jason M Beckta1,2, Seth M Dever1,2, Nisha Gnawali1, Ashraf Khalil1, Amrita Sule1,2, Sarah E Golding1, Elizabeth Rosenberg1, Aarthi Narayanan3, Kylene Kehn-Hall3, Bo Xu4, Lawrence F Povirk5, Kristoffer Valerie1,2,6

Author Affiliations

1: Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA 23298, USA.
2: Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA 23298, USA.
3: National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA 20110, USA.
4: Cancer Research Department, Southern Research Institute, Birmingham, AL 35205, USA.
5: Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298, USA.
6: Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.

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