Published in PLoS One on September 22, 2008
Post-translational modification and regulation of actin. Curr Opin Cell Biol (2012) 1.10
Analysis of isoaspartic Acid by selective proteolysis with Asp-N and electron transfer dissociation mass spectrometry. Anal Chem (2010) 1.05
Defective responses to oxidative stress in protein l-isoaspartyl repair-deficient Caenorhabditis elegans. Mech Ageing Dev (2009) 0.93
Protein L-isoaspartyl methyltransferase regulates p53 activity. Nat Commun (2012) 0.88
Control of cellular Bcl-xL levels by deamidation-regulated degradation. PLoS Biol (2013) 0.86
Integrated proteomic analysis of major isoaspartyl-containing proteins in the urine of wild type and protein L-isoaspartate O-methyltransferase-deficient mice. Anal Chem (2013) 0.85
PIMT prevents the apoptosis of endothelial cells in response to glycated low density lipoproteins and protective effects of grape seed procyanidin B2. PLoS One (2013) 0.82
Isoaspartyl protein damage and repair in mouse retina. Invest Ophthalmol Vis Sci (2014) 0.82
The microRNA 15a/16-1 cluster down-regulates protein repair isoaspartyl methyltransferase in hepatoma cells: implications for apoptosis regulation. J Biol Chem (2011) 0.81
Autoimmunity to isomerized histone H2B in systemic lupus erythematosus. Autoimmunity (2012) 0.81
Cancer metabolism and oxidative stress: Insights into carcinogenesis and chemotherapy via the non-dihydrofolate reductase effects of methotrexate. BBA Clin (2015) 0.81
Accelerated protein damage in brains of PIMT+/- mice; a possible model for the variability of cognitive decline in human aging. Neurobiol Aging (2014) 0.80
Homocysteinylated albumin promotes increased monocyte-endothelial cell adhesion and up-regulation of MCP1, Hsp60 and ADAM17. PLoS One (2012) 0.79
Insight of brain degenerative protein modifications in the pathology of neurodegeneration and dementia by proteomic profiling. Mol Brain (2016) 0.78
N52 monodeamidated Bcl‑xL shows impaired oncogenic properties in vivo and in vitro. Oncotarget (2016) 0.77
A comprehensive view of the epigenetic landscape. Part II: Histone post-translational modification, nucleosome level, and chromatin regulation by ncRNAs. Neurotox Res (2014) 0.77
Protein-L-isoaspartate (D-aspartate) O-methyltransferase protects cardiomyocytes against hypoxia induced apoptosis through inhibiting proapoptotic kinase Mst1. Int J Cardiol (2013) 0.77
Wortmannin reduces insulin signaling and death in seizure-prone Pcmt1-/- mice. PLoS One (2012) 0.76
Assessing analytical methods to monitor isoAsp formation in monoclonal antibodies. Front Pharmacol (2014) 0.75
Widespread occurrence of three sequence motifs in diverse S-adenosylmethionine-dependent methyltransferases suggests a common structure for these enzymes. Arch Biochem Biophys (1994) 4.06
Sequence of the D-aspartyl/L-isoaspartyl protein methyltransferase from human erythrocytes. Common sequence motifs for protein, DNA, RNA, and small molecule S-adenosylmethionine-dependent methyltransferases. J Biol Chem (1989) 3.16
Deamidation of glutaminyl and asparaginyl residues in peptides and proteins. Curr Top Cell Regul (1974) 2.75
Heat shock genes - integrating cell survival and death. J Biosci (2007) 2.43
"The stress of dying": the role of heat shock proteins in the regulation of apoptosis. J Cell Sci (2004) 2.29
Death versus survival: functional interaction between the apoptotic and stress-inducible heat shock protein pathways. J Clin Invest (2005) 2.06
Real-time PCR based on SYBR-Green I fluorescence: an alternative to the TaqMan assay for a relative quantification of gene rearrangements, gene amplifications and micro gene deletions. BMC Biotechnol (2003) 2.05
Extracellular heat shock protein 90: a role for a molecular chaperone in cell motility and cancer metastasis. Cancer Sci (2007) 1.96
Aging as war between chemical and biochemical processes: protein methylation and the recognition of age-damaged proteins for repair. Ageing Res Rev (2003) 1.90
Molecular clocks. Proc Natl Acad Sci U S A (2001) 1.88
Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma. Cancer Res (2007) 1.87
Nonenzymatic deamidation of asparaginyl and glutaminyl residues in proteins. Crit Rev Biochem Mol Biol (1991) 1.80
Deamidation and isoaspartate formation in proteins: unwanted alterations or surreptitious signals? Cell Mol Life Sci (2003) 1.78
Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage. Cell (2002) 1.76
Deficiency of a protein-repair enzyme results in the accumulation of altered proteins, retardation of growth, and fatal seizures in mice. Proc Natl Acad Sci U S A (1997) 1.75
DNA damage-induced Bcl-xL deamidation is mediated by NHE-1 antiport regulated intracellular pH. PLoS Biol (2007) 1.66
Acceleration of apoptotic cell death after the cleavage of Bcl-XL protein by caspase-3-like proteases. Oncogene (1998) 1.51
Isoaspartate in peptides and proteins: formation, significance, and analysis. J Pharm Biomed Anal (2000) 1.45
Spontaneous formation of L-isoaspartate and gain of function in fibronectin. J Biol Chem (2006) 1.39
Distinct hsp70 domains mediate apoptosis-inducing factor release and nuclear accumulation. J Biol Chem (2006) 1.21
Mass spectrometric detection of affinity purified crosslinked peptides. J Am Soc Mass Spectrom (2004) 1.14
Protein repair in the brain, proteomic analysis of endogenous substrates for protein L-isoaspartyl methyltransferase in mouse brain. J Biol Chem (2006) 1.11
Increased methyl esterification of altered aspartyl residues in erythrocyte membrane proteins in response to oxidative stress. Eur J Biochem (2000) 1.07
Suppression of Bcl-xL deamidation in human hepatocellular carcinomas. Cancer Res (2003) 1.05
Intracellular distribution of mammalian protein kinase A catalytic subunit altered by conserved Asn2 deamidation. J Cell Biol (2000) 1.04
Enzymatic methyl esterification of erythrocyte membrane proteins is impaired in chronic renal failure. Evidence for high levels of the natural inhibitor S-adenosylhomocysteine. J Clin Invest (1993) 1.02
Protein L-isoaspartyl methyltransferase repairs abnormal aspartyl residues accumulated in vivo in type-I collagen and restores cell migration. Exp Cell Res (2004) 1.00
Protein isoaspartyl methyltransferase protects from Bax-induced apoptosis. Gene (1999) 0.96
Expression and purification of a human recombinant methyltransferase that repairs damaged proteins. Protein Expr Purif (1995) 0.91
Overexpression of L-isoaspartate O-methyltransferase in Escherichia coli increases heat shock survival by a mechanism independent of methyltransferase activity. J Biol Chem (2003) 0.91
Protein damage and methylation-mediated repair in the erythrocyte. Biochem J (1995) 0.89
Protein methylation as a marker of aspartate damage in glucose-6-phosphate dehydrogenase-deficient erythrocytes: role of oxidative stress. Eur J Biochem (2002) 0.88
UVA irradiation induces L-isoaspartyl formation in melanoma cell proteins. Free Radic Biol Med (2001) 0.87
Inhibitors of cyclic nucleotide phosphodiesterases inhibit protein carboxyl methylation in intact blood platelets. J Biol Chem (1984) 0.85
Accumulation of altered aspartyl residues in erythrocyte proteins from patients with Down's syndrome. FEBS J (2007) 0.83
Degradation of structurally characterized proteins injected into HeLa cells. Tests of hypotheses. J Biol Chem (1988) 0.82
Identification of isoaspartyl-containing sequences in peptides and proteins that are usually poor substrates for the class II protein carboxyl methyltransferase. J Biol Chem (1990) 0.81
Enzymatic methyl esterification of synthetic tripeptides: structural requirements of the peptide substrate. Detection of the reaction products by fast-atom-bombardment mass spectrometry. Eur J Biochem (1988) 0.80
Injury-induced enzymatic methylation of aging collagen in the extracellular matrix of blood vessels. J Protein Chem (1997) 0.80
Structure of the human gene encoding the protein repair L-isoaspartyl (D-aspartyl) O-methyltransferase. Arch Biochem Biophys (1996) 0.79
Cytoskeletal behaviour in spectrin and in band 3 deficient spherocytic red cells: evidence for differentiated splenic conditioning role. Br J Haematol (1996) 0.79
Detection and characterization of a protein isoaspartyl methyltransferase which becomes trapped in the extracellular space during blood vessel injury. J Protein Chem (1997) 0.78
Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia. Lancet (2003) 2.39
C-reactive protein is released in the coronary circulation and causes endothelial dysfunction in patients with acute coronary syndromes. Int J Cardiol (2011) 2.14
Hyperhomocysteinemia and the MTHFR C677T polymorphism promote steatosis and fibrosis in chronic hepatitis C patients. Hepatology (2005) 1.74
SIRT1 contributes to telomere maintenance and augments global homologous recombination. J Cell Biol (2010) 1.48
p27Kip1 metabolism: a fascinating labyrinth. Cell Cycle (2007) 1.34
Von Hippel-Lindau-dependent polycythemia is endemic on the island of Ischia: identification of a novel cluster. Blood (2005) 1.26
Resveratrol: from basic science to the clinic. Cell Cycle (2007) 1.23
p21Cip1 gene expression is modulated by Egr1: a novel regulatory mechanism involved in the resveratrol antiproliferative effect. J Biol Chem (2003) 1.19
The N-terminal 11 amino acids of human erythrocyte band 3 are critical for aldolase binding and protein phosphorylation: implications for band 3 function. Blood (2005) 1.02
Oleuropein prevents oxidative myocardial injury induced by ischemia and reperfusion. J Nutr Biochem (2004) 1.01
A highly secreted sulphamidase engineered to cross the blood-brain barrier corrects brain lesions of mice with mucopolysaccharidoses type IIIA. EMBO Mol Med (2013) 1.00
Retinoic acid induces p27Kip1 nuclear accumulation by modulating its phosphorylation. Cancer Res (2006) 0.99
Allelic inactivation of the pseudoautosomal gene SYBL1 is controlled by epigenetic mechanisms common to the X and Y chromosomes. Hum Mol Genet (2002) 0.98
Resveratrol: from basic studies to bedside. Cancer Treat Res (2014) 0.94
Possible mechanisms of homocysteine toxicity. Kidney Int Suppl (2003) 0.92
Hydrogen sulphide-generating pathways in haemodialysis patients: a study on relevant metabolites and transcriptional regulation of genes encoding for key enzymes. Nephrol Dial Transplant (2009) 0.90
Influences on adherence to diet and physical activity recommendations in women and children: insights from six European studies. Ann Nutr Metab (2014) 0.90
[Emergency room services utilization in the province of Reggio Emilia: a comparison between immigrants and Italians]. Epidemiol Prev (2011) 0.90
Effect of reddening-ripening on the antioxidant activity of polyphenol extracts from cv. 'Annurca' apple fruits. J Agric Food Chem (2007) 0.90
In vivo effect of the natural antioxidant hydroxytyrosol on cyclosporine nephrotoxicity in rats. Nephrol Dial Transplant (2007) 0.88
Retinoic acid inhibits the growth of bone marrow mesenchymal stem cells and induces p27Kip1 and p16INK4A up-regulation. Mol Cell Biochem (2003) 0.88
Effects of immigrant status on Emergency Room (ER) utilisation by children under age one: a population-based study in the province of Reggio Emilia (Italy). BMC Health Serv Res (2013) 0.88
In vivo analysis of DNA methylation patterns recognized by specific proteins: coupling CHIP and bisulfite analysis. Biotechniques (2004) 0.88
Protein methylation as a marker of aspartate damage in glucose-6-phosphate dehydrogenase-deficient erythrocytes: role of oxidative stress. Eur J Biochem (2002) 0.88
The first agmatine/cadaverine aminopropyl transferase: biochemical and structural characterization of an enzyme involved in polyamine biosynthesis in the hyperthermophilic archaeon Pyrococcus furiosus. J Bacteriol (2007) 0.88
Hydroxytyrosol, a natural antioxidant from olive oil, prevents protein damage induced by long-wave ultraviolet radiation in melanoma cells. Free Radic Biol Med (2005) 0.87
Role of folic acid depletion on homocysteine serum level in children and adolescents with epilepsy and different MTHFR C677T genotypes. Seizure (2012) 0.87
Pediatrician-led motivational interviewing to treat overweight children: an RCT. Pediatrics (2013) 0.87
Homocysteine metabolism in renal failure. Curr Opin Clin Nutr Metab Care (2004) 0.86
Purification and characterization of 5'-methylthioadenosine phosphorylase from the hyperthermophilic archaeon Pyrococcus furiosus: substrate specificity and primary structure analysis. Extremophiles (2003) 0.85
Diverse effects of natural antioxidants on cyclosporin cytotoxicity in rat renal tubular cells. Nephrol Dial Transplant (2005) 0.84
Accumulation of altered aspartyl residues in erythrocyte proteins from patients with Down's syndrome. FEBS J (2007) 0.83
Methylthioadenosine phosphorylase from the archaeon Pyrococcus furiosus. Mechanism of the reaction and assignment of disulfide bonds. Eur J Biochem (2004) 0.83
MeCP2 dependent heterochromatin reorganization during neural differentiation of a novel Mecp2-deficient embryonic stem cell reporter line. PLoS One (2012) 0.82
Histone deacetylase inhibitors upregulate p57Kip2 level by enhancing its expression through Sp1 transcription factor. Carcinogenesis (2008) 0.82
Clinical, cytogenetic and molecular-cytogenetic characterization of a patient with a de novo tandem proximal-intermediate duplication of 16q and review of the literature. Am J Med Genet A (2011) 0.82
Hydrogen sulfide reduces cell adhesion and relevant inflammatory triggering by preventing ADAM17-dependent TNF-α activation. J Cell Biochem (2013) 0.82
The role of mental health problems and common psychotropic drug treatments in accidental injury at work: a case-control study. Occup Environ Med (2014) 0.81
Altered folate receptor 2 expression in uraemic patients on haemodialysis: implications for folate resistance. Nephrol Dial Transplant (2013) 0.81
Protective effect of the phenolic fraction from virgin olive oils against oxidative stress in human cells. J Agric Food Chem (2002) 0.81
The microRNA 15a/16-1 cluster down-regulates protein repair isoaspartyl methyltransferase in hepatoma cells: implications for apoptosis regulation. J Biol Chem (2011) 0.81
Antioxidants induce different phenotypes by a distinct modulation of signal transduction. FEBS Lett (2002) 0.81
Physiological and agonistic behavioural response of Procambarus clarkii to an acoustic stimulus. J Exp Biol (2012) 0.80
The underwater acoustic activities of the red swamp crayfish Procambarus clarkii. J Acoust Soc Am (2012) 0.80
Prenatal diagnosis of 46,XX testicular DSD. Molecular, cytogenetic, molecular-cytogenetic, and ultrasonographic evaluation. Prenat Diagn (2009) 0.80
Plasma protein aspartyl damage is increased in hemodialysis patients: studies on causes and consequences. J Am Soc Nephrol (2004) 0.80
Low hydrogen sulphide and chronic kidney disease: a dangerous liaison. Nephrol Dial Transplant (2012) 0.80
Hyperhomocysteinemia in uremia--a red flag in a disrupted circuit. Semin Dial (2009) 0.79
Homocysteinylated albumin promotes increased monocyte-endothelial cell adhesion and up-regulation of MCP1, Hsp60 and ADAM17. PLoS One (2012) 0.79
Biochemical and structural characterization of mammalian-like purine nucleoside phosphorylase from the Archaeon Pyrococcus furiosus. FEBS J (2007) 0.79
Olive oil phenolic compounds inhibit homocysteine-induced endothelial cell adhesion regardless of their different antioxidant activity. J Agric Food Chem (2009) 0.79
Impaired transmethylation potential in Parkinson's disease patients treated with L-Dopa. Neurosci Lett (2009) 0.78
Hydrogen sulfide, the third gaseous signaling molecule with cardiovascular properties, is decreased in hemodialysis patients. J Ren Nutr (2010) 0.78
Protective effect of polyphenols from Glycyrrhiza glabra against oxidative stress in Caco-2 cells. J Med Food (2009) 0.78
Hyperhomocysteinemia and macromolecule modifications in uremic patients. Clin Chem Lab Med (2005) 0.78
Therapy of hyperhomocysteinemia in hemodialysis patients: effects of folates and N-acetylcysteine. J Ren Nutr (2012) 0.78
Matrix metalloproteinases and their inhibitors as biomarkers for metal toxicity in vitro. Toxicol In Vitro (2006) 0.77
Homocysteine-induced endothelial cell adhesion is related to adenosine lowering and is not mediated by S-adenosylhomocysteine. FEBS Lett (2007) 0.77
The gasotransmitter hydrogen sulfide in hemodialysis patients. J Nephrol (2010) 0.77
Hydrogen sulfide, a toxic gas with cardiovascular properties in uremia: how harmful is it? Blood Purif (2011) 0.76
A novel hyperthermostable 5'-deoxy-5'-methylthioadenosine phosphorylase from the archaeon Sulfolobus solfataricus. FEBS J (2005) 0.76
Dupuytren's contracture and occupational exposure to hand-transmitted vibration. Occup Environ Med (2014) 0.76
Abnormal isoaspartyl residues in erythrocyte membranes from psoriatic patients. Arch Dermatol Res (2012) 0.76