Published in Cell on October 04, 2002
The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene (2007) 10.08
Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane. J Cell Biol (2003) 3.01
Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis. EMBO J (2004) 2.77
Integral role of Noxa in p53-mediated apoptotic response. Genes Dev (2003) 2.50
DNA damage-induced Bcl-xL deamidation is mediated by NHE-1 antiport regulated intracellular pH. PLoS Biol (2007) 1.66
c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL. Mol Cell Biol (2003) 1.59
Mitochondria: pharmacological manipulation of cell death. J Clin Invest (2005) 1.54
Viral pseudo-enzymes activate RIG-I via deamidation to evade cytokine production. Mol Cell (2015) 1.50
Identification of the major phosphorylation site in Bcl-xL induced by microtubule inhibitors and analysis of its functional significance. J Biol Chem (2008) 1.46
Emerging insights into the molecular pathogenesis of uveal melanoma. Future Oncol (2008) 1.44
Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission. Mol Cell (2010) 1.38
Mitochondrial signaling in cell death via the Bcl-2 family. Cancer Biol Ther (2010) 1.30
Structure-based prediction of asparagine and aspartate degradation sites in antibody variable regions. PLoS One (2014) 1.28
Mass spectrometric analysis of asparagine deamidation and aspartate isomerization in polypeptides. Electrophoresis (2010) 1.22
Regulation of expression of Bcl-2 protein family member Bim by T cell receptor triggering. Proc Natl Acad Sci U S A (2004) 1.20
Expanding circle of inhibition: small-molecule inhibitors of Bcl-2 as anticancer cell and antiangiogenic agents. J Clin Oncol (2008) 1.13
Coupling of caspase-9 to Apaf1 in response to loss of pRb or cytotoxic drugs is cell-type-specific. EMBO J (2004) 1.09
Intrinsically disordered proteins in bcl-2 regulated apoptosis. Int J Mol Sci (2010) 1.00
Protein isoaspartate methyltransferase prevents apoptosis induced by oxidative stress in endothelial cells: role of Bcl-Xl deamidation and methylation. PLoS One (2008) 1.00
Pin1 in neuronal apoptosis. Cell Cycle (2007) 0.94
Protein modification by deamidation indicates variations in joint extracellular matrix turnover. J Biol Chem (2011) 0.92
Getting away with murder: how does the BCL-2 family of proteins kill with immunity? Ann N Y Acad Sci (2013) 0.91
Mitochondrial and postmitochondrial survival signaling in cancer. Mitochondrion (2013) 0.90
Migfilin sensitizes cisplatin-induced apoptosis in human glioma cells in vitro. Acta Pharmacol Sin (2012) 0.90
Role of the ATM-checkpoint kinase 2 pathway in CDT-mediated apoptosis of gingival epithelial cells. PLoS One (2010) 0.89
Quantitative measurement of deamidation in lens betaB2-crystallin and peptides by direct electrospray injection and fragmentation in a Fourier transform mass spectrometer. Mol Vis (2005) 0.89
Protein L-isoaspartyl methyltransferase regulates p53 activity. Nat Commun (2012) 0.88
Elevated poly-(ADP-ribose)-polymerase activity sensitizes retinoblastoma-deficient cells to DNA damage-induced necrosis. Mol Cancer Res (2009) 0.88
The retinoblastoma protein (Rb) as an anti-apoptotic factor: expression of Rb is required for the anti-apoptotic function of BAG-1 protein in colorectal tumour cells. Cell Death Dis (2012) 0.87
Bcl-xL mediates therapeutic resistance of a mesenchymal breast cancer cell subpopulation. Oncotarget (2014) 0.86
Control of cellular Bcl-xL levels by deamidation-regulated degradation. PLoS Biol (2013) 0.86
Bcl-xl does not have to bind Bax to protect T cells from death. J Exp Med (2006) 0.85
The microRNA 15a/16-1 cluster down-regulates protein repair isoaspartyl methyltransferase in hepatoma cells: implications for apoptosis regulation. J Biol Chem (2011) 0.81
The V119I polymorphism in protein L-isoaspartate O-methyltransferase alters the substrate-binding interface. Protein Eng Des Sel (2009) 0.81
The liver's dance with death: two Bcl-2 guardian proteins from the abyss. Hepatology (2009) 0.80
Repair of isoaspartate formation modulates the interaction of deamidated 4E-BP2 with mTORC1 in brain. J Biol Chem (2010) 0.80
Widespread Occurrence of Non-Enzymatic Deamidations of Asparagine Residues in Yersinia pestis Proteins Resulting from Alkaline pH Membrane Extraction Conditions. Open Proteomics J (2008) 0.79
Cranberry proanthocyanidins inhibit esophageal adenocarcinoma in vitro and in vivo through pleiotropic cell death induction and PI3K/AKT/mTOR inactivation. Oncotarget (2015) 0.79
Biphasic regulation of InsP3 receptor gating by dual Ca2+ release channel BH3-like domains mediates Bcl-xL control of cell viability. Proc Natl Acad Sci U S A (2016) 0.78
A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation. Cell Host Microbe (2016) 0.77
N52 monodeamidated Bcl‑xL shows impaired oncogenic properties in vivo and in vitro. Oncotarget (2016) 0.77
JAK2 and genomic instability in the myeloproliferative neoplasms: a case of the chicken or the egg? Am J Hematol (2012) 0.77
Brain proteomics supports the role of glutamate metabolism and suggests other metabolic alterations in protein l-isoaspartyl methyltransferase (PIMT)-knockout mice. J Proteome Res (2013) 0.76
A cathepsin B inhibitor, E-64, improves the preimplantation development of bovine somatic cell nuclear transfer embryos. J Reprod Dev (2013) 0.76
Emerging Roles of Protein Deamidation in Innate Immune Signaling. J Virol (2016) 0.76
NOX5-L can stimulate proliferation and apoptosis depending on its levels and cellular context, determining cancer cell susceptibility to cisplatin. Oncotarget (2015) 0.76
Critical role of protein L-isoaspartyl methyltransferase in basic fibroblast growth factor-mediated neuronal cell differentiation. BMB Rep (2016) 0.75
Prediction of Spontaneous Protein Deamidation from Sequence-Derived Secondary Structure and Intrinsic Disorder. PLoS One (2015) 0.75
Biologically distinct conformations of Bcl-x can be resolved using 2D isoelectric focusing. Mol Immunol (2009) 0.75
Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL. J Clin Invest (2007) 5.38
Quantification of thyroglobulin, a low-abundance serum protein, by immunoaffinity peptide enrichment and tandem mass spectrometry. Clin Chem (2008) 3.23
Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. Am J Physiol Endocrinol Metab (2008) 2.86
Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy. Nat Med (2005) 2.78
ATP-binding cassette transporter A1: a cell cholesterol exporter that protects against cardiovascular disease. Physiol Rev (2005) 2.76
Mesp1 coordinately regulates cardiovascular fate restriction and epithelial-mesenchymal transition in differentiating ESCs. Cell Stem Cell (2008) 2.46
Bioluminescence imaging of myeloperoxidase activity in vivo. Nat Med (2009) 2.43
The myeloperoxidase product hypochlorous acid oxidizes HDL in the human artery wall and impairs ABCA1-dependent cholesterol transport. Proc Natl Acad Sci U S A (2004) 2.39
Regulation of mouse brain glycogen synthase kinase-3 by atypical antipsychotics. Int J Neuropsychopharmacol (2006) 2.19
Neonatal lethality in transgenic mice expressing prion protein with a deletion of residues 105-125. EMBO J (2007) 2.12
The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression. Mol Cell Biol (2008) 2.00
Myeloperoxidase impairs ABCA1-dependent cholesterol efflux through methionine oxidation and site-specific tyrosine chlorination of apolipoprotein A-I. J Biol Chem (2006) 1.95
Ethanol-induced caspase-3 activation in the in vivo developing mouse brain. Neurobiol Dis (2002) 1.92
Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent. Neuro Oncol (2010) 1.91
Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1. Proc Natl Acad Sci U S A (2012) 1.91
Strain-dependent neurodevelopmental abnormalities in caspase-3-deficient mice. J Neuropathol Exp Neurol (2002) 1.87
Cyclic distension of fibrin-based tissue constructs: evidence of adaptation during growth of engineered connective tissue. Proc Natl Acad Sci U S A (2008) 1.82
High-density lipoprotein suppresses the type I interferon response, a family of potent antiviral immunoregulators, in macrophages challenged with lipopolysaccharide. Circulation (2010) 1.80
Bafilomycin A1 inhibits chloroquine-induced death of cerebellar granule neurons. Mol Pharmacol (2006) 1.80
Monocyte chemoattractant protein deficiency fails to restrain macrophage infiltration into adipose tissue [corrected]. Diabetes (2008) 1.72
Tyrosine 192 in apolipoprotein A-I is the major site of nitration and chlorination by myeloperoxidase, but only chlorination markedly impairs ABCA1-dependent cholesterol transport. J Biol Chem (2004) 1.71
Oxidative modification of von Willebrand factor by neutrophil oxidants inhibits its cleavage by ADAMTS13. Blood (2009) 1.70
Human atherosclerotic intima and blood of patients with established coronary artery disease contain high density lipoprotein damaged by reactive nitrogen species. J Biol Chem (2004) 1.68
Methionine oxidation impairs reverse cholesterol transport by apolipoprotein A-I. Proc Natl Acad Sci U S A (2008) 1.63
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity. Mol Brain (2008) 1.61
Thematic review series: The immune system and atherogenesis. Lipoprotein-associated inflammatory proteins: markers or mediators of cardiovascular disease? J Lipid Res (2005) 1.61
Spectral index for assessment of differential protein expression in shotgun proteomics. J Proteome Res (2008) 1.55
Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis. J Neurosci (2007) 1.52
Role of caspase-3 in ethanol-induced developmental neurodegeneration. Neurobiol Dis (2005) 1.52
High-density lipoproteins: a consensus statement from the National Lipid Association. J Clin Lipidol (2013) 1.50
Myeloperoxidase-generated oxidants modulate left ventricular remodeling but not infarct size after myocardial infarction. Circulation (2005) 1.42
Identification of Trop-2 as an oncogene and an attractive therapeutic target in colon cancers. Mol Cancer Ther (2008) 1.41
Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice. J Neurosci (2005) 1.40
Prognostic value of 1p, 19q, 9p, 10q, and EGFR-FISH analyses in recurrent oligodendrogliomas. J Neuropathol Exp Neurol (2004) 1.39
Oxidative stress and endothelial dysfunction in vascular disease. Curr Diab Rep (2007) 1.39
Combined statin and niacin therapy remodels the high-density lipoprotein proteome. Circulation (2008) 1.38
Mechanisms for oxidative stress in diabetic cardiovascular disease. Antioxid Redox Signal (2007) 1.37
Bcl-2 family regulation of neuronal development and neurodegeneration. Biochim Biophys Acta (2004) 1.36
Autophagy, bafilomycin and cell death: the "a-B-cs" of plecomacrolide-induced neuroprotection. Autophagy (2006) 1.36
Myeloperoxidase produces nitrating oxidants in vivo. J Clin Invest (2002) 1.35
Lithium prevents and ameliorates experimental autoimmune encephalomyelitis. J Immunol (2008) 1.34
Transgenic rescue of ataxia mice with neuronal-specific expression of ubiquitin-specific protease 14. J Neurosci (2006) 1.33
N-acetylcysteine reduces the size and activity of von Willebrand factor in human plasma and mice. J Clin Invest (2011) 1.32
Expression of human myeloperoxidase by macrophages promotes atherosclerosis in mice. Circulation (2005) 1.32
The autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapy. Front Biosci (2008) 1.32
Selective involvement of BH3-only Bcl-2 family members Bim and Bad in neonatal hypoxia-ischemia. Brain Res (2006) 1.31
The Ajuba LIM domain protein is a corepressor for SNAG domain mediated repression and participates in nucleocytoplasmic Shuttling. Cancer Res (2007) 1.30
Myeloperoxidase: an inflammatory enzyme for generating dysfunctional high density lipoprotein. Curr Opin Cardiol (2006) 1.30
Type 1 diabetes promotes disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice. Proc Natl Acad Sci U S A (2008) 1.28
Myeloperoxidase targets apolipoprotein A-I, the major high density lipoprotein protein, for site-specific oxidation in human atherosclerotic lesions. J Biol Chem (2012) 1.28
Neuronal expression of myeloperoxidase is increased in Alzheimer's disease. J Neurochem (2004) 1.27
Lysine residues direct the chlorination of tyrosines in YXXK motifs of apolipoprotein A-I when hypochlorous acid oxidizes high density lipoprotein. J Biol Chem (2003) 1.27
Acrolein impairs ATP binding cassette transporter A1-dependent cholesterol export from cells through site-specific modification of apolipoprotein A-I. J Biol Chem (2005) 1.27
Myeloperoxidase: an oxidative pathway for generating dysfunctional high-density lipoprotein. Chem Res Toxicol (2010) 1.25
BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death. J Neurosci (2006) 1.24
The interplay between size, morphology, stability, and functionality of high-density lipoprotein subclasses. Biochemistry (2008) 1.24
Unique proteomic signatures distinguish macrophages and dendritic cells. PLoS One (2012) 1.24
A macrophage sterol-responsive network linked to atherogenesis. Cell Metab (2010) 1.23
Translation of high-density lipoprotein function into clinical practice: current prospects and future challenges. Circulation (2013) 1.23
Serum amyloid A3 does not contribute to circulating SAA levels. J Lipid Res (2009) 1.23
HDL, lipid peroxidation, and atherosclerosis. J Lipid Res (2009) 1.22
Human neutrophils use the myeloperoxidase-hydrogen peroxide-chloride system to chlorinate but not nitrate bacterial proteins during phagocytosis. J Biol Chem (2002) 1.22
Advanced glycation end product precursors impair ABCA1-dependent cholesterol removal from cells. Diabetes (2005) 1.22
S100A9 differentially modifies phenotypic states of neutrophils, macrophages, and dendritic cells: implications for atherosclerosis and adipose tissue inflammation. Circulation (2011) 1.20
Methionine oxidation contributes to bacterial killing by the myeloperoxidase system of neutrophils. Proc Natl Acad Sci U S A (2009) 1.20
Generation of intramolecular and intermolecular sulfenamides, sulfinamides, and sulfonamides by hypochlorous acid: a potential pathway for oxidative cross-linking of low-density lipoprotein by myeloperoxidase. Biochemistry (2002) 1.20
Modifying apolipoprotein A-I by malondialdehyde, but not by an array of other reactive carbonyls, blocks cholesterol efflux by the ABCA1 pathway. J Biol Chem (2010) 1.19
Clinical utility of fluorescence in situ hybridization (FISH) in morphologically ambiguous gliomas with hybrid oligodendroglial/astrocytic features. J Neuropathol Exp Neurol (2003) 1.18
Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease. Proc Natl Acad Sci U S A (2004) 1.18
CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress. PLoS One (2012) 1.18
Proteomic and computational analysis of bronchoalveolar proteins during the course of the acute respiratory distress syndrome. Am J Respir Crit Care Med (2008) 1.17
N-terminal truncation of antiapoptotic MCL1, but not G2/M-induced phosphorylation, is associated with stabilization and abundant expression in tumor cells. J Biol Chem (2007) 1.17
Lysosome dysfunction triggers Atg7-dependent neural apoptosis. J Biol Chem (2010) 1.16
Hyperlipidemia in concert with hyperglycemia stimulates the proliferation of macrophages in atherosclerotic lesions: potential role of glucose-oxidized LDL. Diabetes (2004) 1.14
Lipoproteomics: using mass spectrometry-based proteomics to explore the assembly, structure, and function of lipoproteins. J Lipid Res (2009) 1.11
Snail and the microRNA-200 family act in opposition to regulate epithelial-to-mesenchymal transition and germ layer fate restriction in differentiating ESCs. Stem Cells (2011) 1.11
Reactive carbonyls and polyunsaturated fatty acids produce a hydroxyl radical-like species: a potential pathway for oxidative damage of retinal proteins in diabetes. J Biol Chem (2005) 1.10
Hypertrophic neuropathies and malignant peripheral nerve sheath tumors in transgenic mice overexpressing glial growth factor beta3 in myelinating Schwann cells. J Neurosci (2003) 1.10
Oxidation of apolipoprotein A-I by myeloperoxidase impairs the initial interactions with ABCA1 required for signaling and cholesterol export. J Lipid Res (2010) 1.09
Myeloperoxidase plays critical roles in killing Klebsiella pneumoniae and inactivating neutrophil elastase: effects on host defense. J Immunol (2005) 1.09
Serum amyloid A facilitates the binding of high-density lipoprotein from mice injected with lipopolysaccharide to vascular proteoglycans. Arterioscler Thromb Vasc Biol (2011) 1.08
MMP-9 sheds the beta2 integrin subunit (CD18) from macrophages. Mol Cell Proteomics (2008) 1.08
Phagocytes produce 5-chlorouracil and 5-bromouracil, two mutagenic products of myeloperoxidase, in human inflammatory tissue. J Biol Chem (2003) 1.08
Kainic acid induces early and transient autophagic stress in mouse hippocampus. Neurosci Lett (2006) 1.07
Vitamin D status does not predict sustained virologic response or fibrosis stage in chronic hepatitis C genotype 1 infection. J Hepatol (2013) 1.07
Low-dose bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction. J Neurochem (2010) 1.07
Myeloperoxidase inactivates TIMP-1 by oxidizing its N-terminal cysteine residue: an oxidative mechanism for regulating proteolysis during inflammation. J Biol Chem (2007) 1.06
Role of reactive oxygen species and spinal cord apoptotic genes in the development of neuropathic pain. Pharmacol Res (2006) 1.05
Regulation of neuronal cell death and neurodegeneration by members of the Bcl-2 family: therapeutic implications. Curr Drug Targets CNS Neurol Disord (2005) 1.05