Published in Antiviral Res on September 20, 2008
Structure and functionality in flavivirus NS-proteins: perspectives for drug design. Antiviral Res (2009) 1.87
Small molecule inhibitors that selectively block dengue virus methyltransferase. J Biol Chem (2010) 1.40
A crystal structure of the Dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication. PLoS Pathog (2015) 1.16
Flavivirus RNA cap methyltransferase: structure, function, and inhibition. Front Biol (Beijing) (2010) 0.97
Crystal structure of the dengue virus methyltransferase bound to a 5'-capped octameric RNA. PLoS One (2010) 0.96
Molecular basis for specific viral RNA recognition and 2'-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5). Proc Natl Acad Sci U S A (2015) 0.91
Selective inhibition of the West Nile virus methyltransferase by nucleoside analogs. Antiviral Res (2012) 0.90
Structure-based and ligand-based virtual screening of novel methyltransferase inhibitors of the dengue virus. BMC Bioinformatics (2011) 0.89
Flexibility of NS5 Methyltransferase-Polymerase Linker Region Is Essential for Dengue Virus Replication. J Virol (2015) 0.88
S-adenosyl-homocysteine is a weakly bound inhibitor for a flaviviral methyltransferase. PLoS One (2013) 0.87
Novel Broad Spectrum Inhibitors Targeting the Flavivirus Methyltransferase. PLoS One (2015) 0.83
Identification and Characterization of Novel Broad-Spectrum Inhibitors of the Flavivirus Methyltransferase. ACS Infect Dis (2015) 0.78
Designing cyclopentapeptide inhibitor as potential antiviral drug for dengue virus ns5 methyltransferase. Bioinformation (2012) 0.78
Dengue Virus Non-Structural Protein 5. Viruses (2017) 0.75
Modification of S-Adenosyl-l-Homocysteine as Inhibitor of Nonstructural Protein 5 Methyltransferase Dengue Virus Through Molecular Docking and Molecular Dynamics Simulation. Drug Target Insights (2017) 0.75
Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformation. EMBO J (2004) 4.05
Genomic epidemiology of a dengue virus epidemic in urban Singapore. J Virol (2009) 2.74
Crystal structure of the dengue virus RNA-dependent RNA polymerase catalytic domain at 1.85-angstrom resolution. J Virol (2007) 2.65
Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus. Nat Struct Mol Biol (2006) 2.55
A dengue fever viremia model in mice shows reduction in viral replication and suppression of the inflammatory response after treatment with antiviral drugs. J Infect Dis (2007) 2.22
Update on dengue: epidemiology, virus evolution, antiviral drugs, and vaccine development. Curr Infect Dis Rep (2010) 2.14
Early Dengue infection and outcome study (EDEN) - study design and preliminary findings. Ann Acad Med Singapore (2006) 2.12
Structure and interactions at the viral surface of the envelope protein E1 of Semliki Forest virus. Structure (2006) 2.05
Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein. EMBO J (2008) 1.99
Decision tree algorithms predict the diagnosis and outcome of dengue fever in the early phase of illness. PLoS Negl Trop Dis (2008) 1.99
Structure of the Dengue virus helicase/nucleoside triphosphatase catalytic domain at a resolution of 2.4 A. J Virol (2005) 1.96
Host gene expression profiling of dengue virus infection in cell lines and patients. PLoS Negl Trop Dis (2007) 1.86
Crystal structure of the NS3 protease-helicase from dengue virus. J Virol (2007) 1.84
Ten years of dengue drug discovery: progress and prospects. Antiviral Res (2013) 1.84
The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes. PLoS Pathog (2011) 1.78
Functional profiling of recombinant NS3 proteases from all four serotypes of dengue virus using tetrapeptide and octapeptide substrate libraries. J Biol Chem (2005) 1.70
Conventional and unconventional mechanisms for capping viral mRNA. Nat Rev Microbiol (2011) 1.61
A small-molecule dengue virus entry inhibitor. Antimicrob Agents Chemother (2009) 1.59
The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription. PLoS Pathog (2010) 1.57
The early clinical features of dengue in adults: challenges for early clinical diagnosis. PLoS Negl Trop Dis (2011) 1.52
A method for full genome sequencing of all four serotypes of the dengue virus. J Virol Methods (2010) 1.48
Role of T cells, cytokines and antibody in dengue fever and dengue haemorrhagic fever. Rev Med Virol (2006) 1.44
Nuclear localization of dengue virus nonstructural protein 5 through its importin alpha/beta-recognized nuclear localization sequences is integral to viral infection. Traffic (2007) 1.41
Dengue virus serotype infection specifies the activation of the unfolded protein response. Virol J (2007) 1.41
Towards the design of antiviral inhibitors against flaviviruses: the case for the multifunctional NS3 protein from Dengue virus as a target. Antiviral Res (2008) 1.41
Small molecule inhibitors that selectively block dengue virus methyltransferase. J Biol Chem (2010) 1.40
Immune surveillance by mast cells during dengue infection promotes natural killer (NK) and NKT-cell recruitment and viral clearance. Proc Natl Acad Sci U S A (2011) 1.40
The functional role of a conserved loop in EAL domain-based cyclic di-GMP-specific phosphodiesterase. J Bacteriol (2009) 1.39
Dengue virus NS4B interacts with NS3 and dissociates it from single-stranded RNA. J Gen Virol (2006) 1.36
The flavivirus polymerase as a target for drug discovery. Antiviral Res (2008) 1.36
Structure of the functional form of the mosquito larvicidal Cry4Aa toxin from Bacillus thuringiensis at a 2.8-angstrom resolution. J Bacteriol (2006) 1.35
The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket. J Virol (2009) 1.32
The interdomain region of dengue NS5 protein that binds to the viral helicase NS3 contains independently functional importin beta 1 and importin alpha/beta-recognized nuclear localization signals. J Biol Chem (2002) 1.31
Peptide inhibitors of Dengue virus NS3 protease. Part 1: Warhead. Bioorg Med Chem Lett (2005) 1.30
Finding new medicines for flaviviral targets. Novartis Found Symp (2006) 1.29
Functional analysis of two cavities in flavivirus NS5 polymerase. J Biol Chem (2011) 1.28
Construction and characterization of a stable subgenomic dengue virus type 2 replicon system for antiviral compound and siRNA testing. Antiviral Res (2007) 1.27
Antibodies targeting the PfRH1 binding domain inhibit invasion of Plasmodium falciparum merozoites. PLoS Pathog (2008) 1.27
Biochemical and structural analysis of Helix pomatia agglutinin. A hexameric lectin with a novel fold. J Biol Chem (2006) 1.25
Ligation of Fc gamma receptor IIB inhibits antibody-dependent enhancement of dengue virus infection. Proc Natl Acad Sci U S A (2011) 1.24
Periodic re-emergence of endemic strains with strong epidemic potential-a proposed explanation for the 2004 Indonesian dengue epidemic. Infect Genet Evol (2007) 1.23
Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors. Bioorg Med Chem Lett (2005) 1.22
X-ray structures of the N- and C-terminal domains of a coronavirus nucleocapsid protein: implications for nucleocapsid formation. J Virol (2006) 1.22
Biochemical and genetic characterization of dengue virus methyltransferase. Virology (2010) 1.21
The structures of the PII proteins from the cyanobacteria Synechococcus sp. PCC 7942 and Synechocystis sp. PCC 6803. Acta Crystallogr D Biol Crystallogr (2003) 1.16
The crystal structure of the plexin-semaphorin-integrin domain/hybrid domain/I-EGF1 segment from the human integrin beta2 subunit at 1.8-A resolution. J Biol Chem (2005) 1.16
CRIM1 regulates the rate of processing and delivery of bone morphogenetic proteins to the cell surface. J Biol Chem (2003) 1.15
The nucleocapsid protein of coronavirus infectious bronchitis virus: crystal structure of its N-terminal domain and multimerization properties. Structure (2005) 1.15
Mutagenesis of the dengue virus type 2 NS5 methyltransferase domain. J Biol Chem (2008) 1.14
Flexibility between the protease and helicase domains of the dengue virus NS3 protein conferred by the linker region and its functional implications. J Biol Chem (2010) 1.14
Novel inhibitors of dengue virus methyltransferase: discovery by in vitro-driven virtual screening on a desktop computer grid. J Med Chem (2010) 1.13
Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2'-O-methyltransferase nsp10/nsp16 complex. PLoS Pathog (2011) 1.13
A structural hypothesis for the transition between bent and extended conformations of the leukocyte beta2 integrins. J Biol Chem (2007) 1.12
On a mouse monoclonal antibody that neutralizes all four dengue virus serotypes. J Gen Virol (2009) 1.11
Celgosivir treatment misfolds dengue virus NS1 protein, induces cellular pro-survival genes and protects against lethal challenge mouse model. Antiviral Res (2011) 1.11
Dengue virus regulates type I interferon signalling in a strain-dependent manner in human cell lines. J Gen Virol (2008) 1.10
The role of TBK1 and IKKε in the expression and activation of Pellino 1. Biochem J (2011) 1.10
Depletion of macrophages in mice results in higher dengue virus titers and highlights the role of macrophages for virus control. Eur J Immunol (2009) 1.08
A fluorescence quenching assay to discriminate between specific and nonspecific inhibitors of dengue virus protease. Anal Biochem (2009) 1.03
Structure and catalytic mechanism of the thioesterase CalE7 in enediyne biosynthesis. J Biol Chem (2009) 1.03
Dose- and schedule-dependent protective efficacy of celgosivir in a lethal mouse model for dengue virus infection informs dosing regimen for a proof of concept clinical trial. Antiviral Res (2012) 1.03
DengueInfo: A web portal to dengue information resources. Infect Genet Evol (2007) 1.03
A crystal structure of the dengue virus non-structural protein 5 (NS5) polymerase delineates interdomain amino acid residues that enhance its thermostability and de novo initiation activities. J Biol Chem (2013) 1.03
Structure-based mutational analysis of the NS3 helicase from dengue virus. J Virol (2006) 1.01
A multi-step strategy to obtain crystals of the dengue virus RNA-dependent RNA polymerase that diffract to high resolution. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 1.00
Products of the iterative polyketide synthases in 9- and 10-membered enediyne biosynthesis. Chem Commun (Camb) (2009) 0.98
Amino acid residues critical for RNA-binding in the N-terminal domain of the nucleocapsid protein are essential determinants for the infectivity of coronavirus in cultured cells. Nucleic Acids Res (2006) 0.97
Higher catalytic efficiency of N-7-methylation is responsible for processive N-7 and 2'-O methyltransferase activity in dengue virus. Virology (2010) 0.97
Conformational flexibility of the Dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor. J Virol (2013) 0.97
Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis. J Biol Chem (2012) 0.97
Crystal structure of the dengue virus methyltransferase bound to a 5'-capped octameric RNA. PLoS One (2010) 0.96
Structure of the N-terminal domain of Escherichia coli glutamine synthetase adenylyltransferase. Structure (2004) 0.96
Dimerization of flavivirus NS4B protein. J Virol (2014) 0.95
Patterning of the vertebrate ventral spinal cord. Int J Dev Biol (2002) 0.95
A human PrM antibody that recognizes a novel cryptic epitope on dengue E glycoprotein. PLoS One (2012) 0.95
N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase. J Med Chem (2009) 0.95
Establishment of a robust dengue virus NS3-NS5 binding assay for identification of protein-protein interaction inhibitors. Antiviral Res (2012) 0.95
The magnitude of dengue virus NS1 protein secretion is strain dependent and does not correlate with severe pathologies in the mouse infection model. J Virol (2012) 0.95
Differential unfolded protein response during Chikungunya and Sindbis virus infection: CHIKV nsP4 suppresses eIF2α phosphorylation. Virol J (2013) 0.94
Peptide inhibitors of West Nile NS3 protease: SAR study of tetrapeptide aldehyde inhibitors. J Med Chem (2006) 0.94
Structure of human Rack1 protein at a resolution of 2.45 Å. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.91
The yin and yang of amyloid: insights from α-synuclein and repeat domain of Pmel17. Phys Chem Chem Phys (2011) 0.90
18F-FDG as an inflammation biomarker for imaging dengue virus infection and treatment response. JCI Insight (2017) 0.89