Published in Acta Crystallogr D Biol Crystallogr on November 27, 2003
The crystal structure of the Escherichia coli AmtB-GlnK complex reveals how GlnK regulates the ammonia channel. Proc Natl Acad Sci U S A (2007) 1.98
Inhibitory complex of the transmembrane ammonia channel, AmtB, and the cytosolic regulatory protein, GlnK, at 1.96 A. Proc Natl Acad Sci U S A (2006) 1.85
Structure of GlnK1 with bound effectors indicates regulatory mechanism for ammonia uptake. EMBO J (2007) 1.25
The crystal structure of the complex of PII and acetylglutamate kinase reveals how PII controls the storage of nitrogen as arginine. Proc Natl Acad Sci U S A (2007) 1.23
The PII superfamily revised: a novel group and evolutionary insights. J Mol Evol (2009) 1.12
Interactions between the nitrogen signal transduction protein PII and N-acetyl glutamate kinase in organisms that perform oxygenic photosynthesis. J Bacteriol (2004) 1.11
Mechanism of 2-oxoglutarate signaling by the Synechococcus elongatus PII signal transduction protein. Proc Natl Acad Sci U S A (2010) 1.09
Complex structure and biochemical characterization of the Staphylococcus aureus cyclic diadenylate monophosphate (c-di-AMP)-binding protein PstA, the founding member of a new signal transduction protein family. J Biol Chem (2014) 0.92
The 2.2 A resolution crystal structure of Bacillus cereus Nif3-family protein YqfO reveals a conserved dimetal-binding motif and a regulatory domain. Protein Sci (2007) 0.91
Identification of Rhodospirillum rubrum GlnB variants that are altered in their ability to interact with different targets in response to nitrogen status signals. J Bacteriol (2006) 0.89
Structural basis and target-specific modulation of ADP sensing by the Synechococcus elongatus PII signaling protein. J Biol Chem (2014) 0.86
From PII signaling to metabolite sensing: a novel 2-oxoglutarate sensor that details PII-NAGK complex formation. PLoS One (2013) 0.83
Structure of putative CutA1 from Homo sapiens determined at 2.05 A resolution. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.82
Crystal structures of the apo and ATP bound Mycobacterium tuberculosis nitrogen regulatory PII protein. Protein Sci (2010) 0.80
Structure of the PII signal transduction protein of Neisseria meningitidis at 1.85 A resolution. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.79
Population shift of binding pocket size and dynamic correlation analysis shed new light on the anticooperative mechanism of PII protein. Proteins (2013) 0.78
A PII-Like Protein Regulated by Bicarbonate: Structural and Biochemical Studies of the Carboxysome-Associated CPII Protein. J Mol Biol (2016) 0.75
Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a nearly minimal oxyphototrophic genome. Proc Natl Acad Sci U S A (2003) 3.55
Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing. Proc Natl Acad Sci U S A (2012) 3.26
Genomic epidemiology of a dengue virus epidemic in urban Singapore. J Virol (2009) 2.74
Crystal structure of the dengue virus RNA-dependent RNA polymerase catalytic domain at 1.85-angstrom resolution. J Virol (2007) 2.65
Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus. Nat Struct Mol Biol (2006) 2.55
A dengue fever viremia model in mice shows reduction in viral replication and suppression of the inflammatory response after treatment with antiviral drugs. J Infect Dis (2007) 2.22
Reduced expansion rate of abdominal aortic aneurysms in patients with diabetes may be related to aberrant monocyte-matrix interactions. Eur Heart J (2008) 2.21
Update on dengue: epidemiology, virus evolution, antiviral drugs, and vaccine development. Curr Infect Dis Rep (2010) 2.14
Association between osteopontin and human abdominal aortic aneurysm. Arterioscler Thromb Vasc Biol (2006) 2.14
Early Dengue infection and outcome study (EDEN) - study design and preliminary findings. Ann Acad Med Singapore (2006) 2.12
Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein. EMBO J (2008) 1.99
Decision tree algorithms predict the diagnosis and outcome of dengue fever in the early phase of illness. PLoS Negl Trop Dis (2008) 1.99
Structural basis for proofreading during replication of the Escherichia coli chromosome. Structure (2002) 1.98
The Synechococcus elongatus P signal transduction protein controls arginine synthesis by complex formation with N-acetyl-L-glutamate kinase. Mol Microbiol (2004) 1.97
Structure of the Dengue virus helicase/nucleoside triphosphatase catalytic domain at a resolution of 2.4 A. J Virol (2005) 1.96
Host gene expression profiling of dengue virus infection in cell lines and patients. PLoS Negl Trop Dis (2007) 1.86
Crystal structure of the NS3 protease-helicase from dengue virus. J Virol (2007) 1.84
Functional profiling of recombinant NS3 proteases from all four serotypes of dengue virus using tetrapeptide and octapeptide substrate libraries. J Biol Chem (2005) 1.70
Association of statin prescription with small abdominal aortic aneurysm progression. Am Heart J (2010) 1.67
Evaluation of the diagnostic and prognostic value of plasma D-dimer for abdominal aortic aneurysm. Eur Heart J (2010) 1.63
A small-molecule dengue virus entry inhibitor. Antimicrob Agents Chemother (2009) 1.59
The early clinical features of dengue in adults: challenges for early clinical diagnosis. PLoS Negl Trop Dis (2011) 1.52
A method for full genome sequencing of all four serotypes of the dengue virus. J Virol Methods (2010) 1.48
Role of T cells, cytokines and antibody in dengue fever and dengue haemorrhagic fever. Rev Med Virol (2006) 1.44
Acclimation of unicellular cyanobacteria to macronutrient deficiency: emergence of a complex network of cellular responses. Microbiology (2005) 1.42
Nuclear localization of dengue virus nonstructural protein 5 through its importin alpha/beta-recognized nuclear localization sequences is integral to viral infection. Traffic (2007) 1.41
Dengue virus serotype infection specifies the activation of the unfolded protein response. Virol J (2007) 1.41
Towards the design of antiviral inhibitors against flaviviruses: the case for the multifunctional NS3 protein from Dengue virus as a target. Antiviral Res (2008) 1.41
Regulatory links between carbon and nitrogen metabolism. Curr Opin Microbiol (2006) 1.40
Immune surveillance by mast cells during dengue infection promotes natural killer (NK) and NKT-cell recruitment and viral clearance. Proc Natl Acad Sci U S A (2011) 1.40
Dengue virus NS4B interacts with NS3 and dissociates it from single-stranded RNA. J Gen Virol (2006) 1.36
Interaction network in cyanobacterial nitrogen regulation: PipX, a protein that interacts in a 2-oxoglutarate dependent manner with PII and NtcA. Mol Microbiol (2006) 1.34
The interdomain region of dengue NS5 protein that binds to the viral helicase NS3 contains independently functional importin beta 1 and importin alpha/beta-recognized nuclear localization signals. J Biol Chem (2002) 1.31
Obesity, adipokines, and abdominal aortic aneurysm: Health in Men study. Circulation (2007) 1.31
Peptide inhibitors of Dengue virus NS3 protease. Part 1: Warhead. Bioorg Med Chem Lett (2005) 1.30
Finding new medicines for flaviviral targets. Novartis Found Symp (2006) 1.29
Construction and characterization of a stable subgenomic dengue virus type 2 replicon system for antiviral compound and siRNA testing. Antiviral Res (2007) 1.27
Alpha/beta hydrolase fold: an update. Protein Pept Lett (2009) 1.26
Ligation of Fc gamma receptor IIB inhibits antibody-dependent enhancement of dengue virus infection. Proc Natl Acad Sci U S A (2011) 1.24
The crystal structure of the complex of PII and acetylglutamate kinase reveals how PII controls the storage of nitrogen as arginine. Proc Natl Acad Sci U S A (2007) 1.23
Periodic re-emergence of endemic strains with strong epidemic potential-a proposed explanation for the 2004 Indonesian dengue epidemic. Infect Genet Evol (2007) 1.23
Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors. Bioorg Med Chem Lett (2005) 1.22
Genomes of Stigonematalean cyanobacteria (subsection V) and the evolution of oxygenic photosynthesis from prokaryotes to plastids. Genome Biol Evol (2013) 1.22
The gas vesicle gene cluster from Microcystis aeruginosa and DNA rearrangements that lead to loss of cell buoyancy. J Bacteriol (2004) 1.17
Structural basis for the regulation of NtcA-dependent transcription by proteins PipX and PII. Proc Natl Acad Sci U S A (2010) 1.15
Comparing the organophosphorus and carbamate insecticide resistance mutations in cholin- and carboxyl-esterases. Chem Biol Interact (2005) 1.15
Complex formation and catalytic activation by the PII signaling protein of N-acetyl-L-glutamate kinase from Synechococcus elongatus strain PCC 7942. J Biol Chem (2004) 1.14
Assessment of a serum assay for quantification of abdominal aortic calcification. Arterioscler Thromb Vasc Biol (2006) 1.14
Flexibility between the protease and helicase domains of the dengue virus NS3 protein conferred by the linker region and its functional implications. J Biol Chem (2010) 1.14
Anomalous scattering analysis of Agrobacterium radiobacter phosphotriesterase: the prominent role of iron in the heterobinuclear active site. Biochem J (2006) 1.14
Structural analysis of the PP2C phosphatase tPphA from Thermosynechococcus elongatus: a flexible flap subdomain controls access to the catalytic site. J Mol Biol (2007) 1.14
Mutagenesis of the dengue virus type 2 NS5 methyltransferase domain. J Biol Chem (2008) 1.14
Hydrolysis of the 5'-p-nitrophenyl ester of TMP by the proofreading exonuclease (epsilon) subunit of Escherichia coli DNA polymerase III. Biochemistry (2002) 1.14
On a mouse monoclonal antibody that neutralizes all four dengue virus serotypes. J Gen Virol (2009) 1.11
Celgosivir treatment misfolds dengue virus NS1 protein, induces cellular pro-survival genes and protects against lethal challenge mouse model. Antiviral Res (2011) 1.11
Dengue virus regulates type I interferon signalling in a strain-dependent manner in human cell lines. J Gen Virol (2008) 1.10
Mechanism of 2-oxoglutarate signaling by the Synechococcus elongatus PII signal transduction protein. Proc Natl Acad Sci U S A (2010) 1.09
In crystallo capture of a Michaelis complex and product-binding modes of a bacterial phosphotriesterase. J Mol Biol (2007) 1.09
Depletion of macrophages in mice results in higher dengue virus titers and highlights the role of macrophages for virus control. Eur J Immunol (2009) 1.08
Genotyping of axenic and non-axenic isolates of the genus Prochlorococcus and the OMF-'Synechococcus' clade by size, sequence analysis or RFLP of the Internal Transcribed Spacer of the ribosomal operon. Microbiology (2002) 1.08
rDNA analyses of planktonic heterocystous cyanobacteria, including members of the genera Anabaenopsis and Cyanospira. Microbiology (2002) 1.08
The structure and function of a novel glycerophosphodiesterase from Enterobacter aerogenes. J Mol Biol (2007) 1.07
Plasticity and evolution of aeruginosin biosynthesis in cyanobacteria. Appl Environ Microbiol (2009) 1.06
Metabolic and transcriptomic phenotyping of inorganic carbon acclimation in the Cyanobacterium Synechococcus elongatus PCC 7942. Plant Physiol (2011) 1.06
RuBisCO-like proteins as the enolase enzyme in the methionine salvage pathway: functional and evolutionary relationships between RuBisCO-like proteins and photosynthetic RuBisCO. J Exp Bot (2008) 1.05
Growth of Escherichia coli coexpressing phosphotriesterase and glycerophosphodiester phosphodiesterase, using paraoxon as the sole phosphorus source. Appl Environ Microbiol (2004) 1.05
Signal transduction protein P(II) is required for NtcA-regulated gene expression during nitrogen deprivation in the cyanobacterium Synechococcus elongatus strain PCC 7942. J Bacteriol (2003) 1.04
Association of obesity and metabolic syndrome with the severity and outcome of intermittent claudication. J Vasc Surg (2006) 1.04
Horizontal gene transfer of two cytoskeletal elements from a eukaryote to a cyanobacterium. Curr Biol (2007) 1.04
A fluorescence quenching assay to discriminate between specific and nonspecific inhibitors of dengue virus protease. Anal Biochem (2009) 1.03
DengueInfo: A web portal to dengue information resources. Infect Genet Evol (2007) 1.03
Dose- and schedule-dependent protective efficacy of celgosivir in a lethal mouse model for dengue virus infection informs dosing regimen for a proof of concept clinical trial. Antiviral Res (2012) 1.03
A scintillation proximity assay for dengue virus NS5 2'-O-methyltransferase-kinetic and inhibition analyses. Antiviral Res (2008) 1.03
Interaction of the membrane-bound GlnK-AmtB complex with the master regulator of nitrogen metabolism TnrA in Bacillus subtilis. J Biol Chem (2006) 1.03
The novel protein phosphatase PphA from Synechocystis PCC 6803 controls dephosphorylation of the signalling protein PII. Mol Microbiol (2002) 1.02
Structure-based mutational analysis of the NS3 helicase from dengue virus. J Virol (2006) 1.01
The morphogene AmiC2 is pivotal for multicellular development in the cyanobacterium Nostoc punctiforme. Mol Microbiol (2011) 1.00
Halogenase genes in nonribosomal peptide synthetase gene clusters of Microcystis (cyanobacteria): sporadic distribution and evolution. Mol Biol Evol (2008) 1.00
PII-regulated arginine synthesis controls accumulation of cyanophycin in Synechocystis sp. strain PCC 6803. J Bacteriol (2006) 1.00
A multi-step strategy to obtain crystals of the dengue virus RNA-dependent RNA polymerase that diffract to high resolution. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 1.00
The effects of substrate orientation on the mechanism of a phosphotriesterase. Org Biomol Chem (2005) 0.98
Transcript profiling reveals new insights into the acclimation of the mesophilic fresh-water cyanobacterium Synechococcus elongatus PCC 7942 to iron starvation. Plant Physiol (2008) 0.98
Requirement of the nitrogen starvation-induced protein Sll0783 for polyhydroxybutyrate accumulation in Synechocystis sp. strain PCC 6803. Appl Environ Microbiol (2010) 0.97
Structure and function of an insect α-carboxylesterase (αEsterase7) associated with insecticide resistance. Proc Natl Acad Sci U S A (2013) 0.97
Ammonia triggers photodamage of photosystem II in the cyanobacterium Synechocystis sp. strain PCC 6803. Plant Physiol (2008) 0.97
Structure of the N-terminal domain of Escherichia coli glutamine synthetase adenylyltransferase. Structure (2004) 0.96
Improving a natural enzyme activity through incorporation of unnatural amino acids. J Am Chem Soc (2010) 0.96
The structure of an enzyme-product complex reveals the critical role of a terminal hydroxide nucleophile in the bacterial phosphotriesterase mechanism. Biochim Biophys Acta (2005) 0.96
Carbon-source-dependent nitrogen regulation in Escherichia coli is mediated through glutamine-dependent GlnB signalling. Microbiology (2003) 0.95
A human PrM antibody that recognizes a novel cryptic epitope on dengue E glycoprotein. PLoS One (2012) 0.95