| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
An epidemic, toxin gene-variant strain of Clostridium difficile.
|
N Engl J Med
|
2005
|
18.10
|
|
2
|
Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA).
|
Infect Control Hosp Epidemiol
|
2010
|
17.99
|
|
3
|
Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship.
|
Clin Infect Dis
|
2006
|
14.63
|
|
4
|
Burden of Clostridium difficile infection in the United States.
|
N Engl J Med
|
2015
|
8.17
|
|
5
|
Clostridium difficile infection: new developments in epidemiology and pathogenesis.
|
Nat Rev Microbiol
|
2009
|
7.89
|
|
6
|
Treatment with monoclonal antibodies against Clostridium difficile toxins.
|
N Engl J Med
|
2010
|
7.37
|
|
7
|
Toxin B is essential for virulence of Clostridium difficile.
|
Nature
|
2009
|
5.49
|
|
8
|
Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium.
|
Genome Biol
|
2009
|
3.66
|
|
9
|
A mouse model of Clostridium difficile-associated disease.
|
Gastroenterology
|
2008
|
3.65
|
|
10
|
Comparison of seven techniques for typing international epidemic strains of Clostridium difficile: restriction endonuclease analysis, pulsed-field gel electrophoresis, PCR-ribotyping, multilocus sequence typing, multilocus variable-number tandem-repeat analysis, amplified fragment length polymorphism, and surface layer protein A gene sequence typing.
|
J Clin Microbiol
|
2007
|
3.60
|
|
11
|
Clinical recognition and diagnosis of Clostridium difficile infection.
|
Clin Infect Dis
|
2008
|
3.32
|
|
12
|
Clostridium difficile infection caused by the epidemic BI/NAP1/027 strain.
|
Gastroenterology
|
2009
|
3.29
|
|
13
|
Interruption of recurrent Clostridium difficile-associated diarrhea episodes by serial therapy with vancomycin and rifaximin.
|
Clin Infect Dis
|
2007
|
3.15
|
|
14
|
Strategies to prevent central line-associated bloodstream infections in acute care hospitals.
|
Infect Control Hosp Epidemiol
|
2008
|
3.13
|
|
15
|
Outcome of metronidazole therapy for Clostridium difficile disease and correlation with a scoring system.
|
J Infect
|
2007
|
2.84
|
|
16
|
Epidemiology of community-associated Clostridium difficile infection, 2009 through 2011.
|
JAMA Intern Med
|
2013
|
2.78
|
|
17
|
Multilocus variable-number tandem-repeat analysis for investigation of Clostridium difficile transmission in Hospitals.
|
J Clin Microbiol
|
2006
|
2.52
|
|
18
|
In vitro activities of 15 antimicrobial agents against 110 toxigenic clostridium difficile clinical isolates collected from 1983 to 2004.
|
Antimicrob Agents Chemother
|
2007
|
2.43
|
|
19
|
A compendium of strategies to prevent healthcare-associated infections in acute care hospitals.
|
Infect Control Hosp Epidemiol
|
2008
|
2.32
|
|
20
|
Impact of strain type on detection of toxigenic Clostridium difficile: comparison of molecular diagnostic and enzyme immunoassay approaches.
|
J Clin Microbiol
|
2010
|
2.32
|
|
21
|
Strategies to prevent catheter-associated urinary tract infections in acute care hospitals.
|
Infect Control Hosp Epidemiol
|
2008
|
2.30
|
|
22
|
Human hypervirulent Clostridium difficile strains exhibit increased sporulation as well as robust toxin production.
|
J Bacteriol
|
2010
|
2.29
|
|
23
|
Strategies to prevent surgical site infections in acute care hospitals.
|
Infect Control Hosp Epidemiol
|
2008
|
2.22
|
|
24
|
Binary toxin-producing, large clostridial toxin-negative Clostridium difficile strains are enterotoxic but do not cause disease in hamsters.
|
J Infect Dis
|
2006
|
1.99
|
|
25
|
Toxinotype V Clostridium difficile in humans and food animals.
|
Emerg Infect Dis
|
2008
|
1.98
|
|
26
|
Clindamycin, cephalosporins, fluoroquinolones, and Clostridium difficile-associated diarrhea: this is an antimicrobial resistance problem.
|
Clin Infect Dis
|
2004
|
1.98
|
|
27
|
A hospital outbreak of Clostridium difficile disease associated with isolates carrying binary toxin genes.
|
Clin Infect Dis
|
2004
|
1.96
|
|
28
|
Decreased cure and increased recurrence rates for Clostridium difficile infection caused by the epidemic C. difficile BI strain.
|
Clin Infect Dis
|
2012
|
1.96
|
|
29
|
Serum anti-toxin B antibody correlates with protection from recurrent Clostridium difficile infection (CDI).
|
Vaccine
|
2009
|
1.85
|
|
30
|
Strategies to prevent clostridium difficile infections in acute care hospitals.
|
Infect Control Hosp Epidemiol
|
2008
|
1.84
|
|
31
|
Rifampin and rifaximin resistance in clinical isolates of Clostridium difficile.
|
Antimicrob Agents Chemother
|
2008
|
1.84
|
|
32
|
Strategies to prevent ventilator-associated pneumonia in acute care hospitals.
|
Infect Control Hosp Epidemiol
|
2008
|
1.81
|
|
33
|
Colonization for the prevention of Clostridium difficile disease in hamsters.
|
J Infect Dis
|
2002
|
1.68
|
|
34
|
Strategies to prevent transmission of methicillin-resistant Staphylococcus aureus in acute care hospitals.
|
Infect Control Hosp Epidemiol
|
2008
|
1.66
|
|
35
|
Comparison of strain typing results for Clostridium difficile isolates from North America.
|
J Clin Microbiol
|
2011
|
1.65
|
|
36
|
Staphylococcus aureus and Clostridium difficile cause distinct pseudomembranous intestinal diseases.
|
Clin Infect Dis
|
2004
|
1.58
|
|
37
|
Distribution of Clostridium difficile variant toxinotypes and strains with binary toxin genes among clinical isolates in an American hospital.
|
J Med Microbiol
|
2004
|
1.52
|
|
38
|
Effectiveness of alcohol-based hand rubs for removal of Clostridium difficile spores from hands.
|
Infect Control Hosp Epidemiol
|
2010
|
1.51
|
|
39
|
Distribution of Clostridium difficile strains from a North American, European and Australian trial of treatment for C. difficile infections: 2005-2007.
|
Anaerobe
|
2009
|
1.47
|
|
40
|
Frequency of binary toxin genes among Clostridium difficile strains that do not produce large clostridial toxins.
|
J Clin Microbiol
|
2003
|
1.43
|
|
41
|
Relapse versus reinfection: recurrent Clostridium difficile infection following treatment with fidaxomicin or vancomycin.
|
Clin Infect Dis
|
2012
|
1.42
|
|
42
|
Predictors of death after Clostridium difficile infection: a report on 128 strain-typed cases from a teaching hospital in the United Kingdom.
|
Clin Infect Dis
|
2010
|
1.41
|
|
43
|
Molecular epidemiology of Clostridium difficile over the course of 10 years in a tertiary care hospital.
|
Clin Infect Dis
|
2009
|
1.39
|
|
44
|
Comparative susceptibilities to fidaxomicin (OPT-80) of isolates collected at baseline, recurrence, and failure from patients in two phase III trials of fidaxomicin against Clostridium difficile infection.
|
Antimicrob Agents Chemother
|
2011
|
1.33
|
|
45
|
NAP1 strain type predicts outcomes from Clostridium difficile infection.
|
Clin Infect Dis
|
2014
|
1.31
|
|
46
|
Infection of hamsters with historical and epidemic BI types of Clostridium difficile.
|
J Infect Dis
|
2007
|
1.29
|
|
47
|
Revised nomenclature of Clostridium difficile toxins and associated genes.
|
J Med Microbiol
|
2005
|
1.28
|
|
48
|
International typing study of toxin A-negative, toxin B-positive Clostridium difficile variants.
|
J Clin Microbiol
|
2003
|
1.23
|
|
49
|
Metronidazole for Clostridium difficile-associated disease: is it okay for Mom?
|
Clin Infect Dis
|
2005
|
1.21
|
|
50
|
Multilocus variable-number tandem-repeat analysis and multilocus sequence typing reveal genetic relationships among Clostridium difficile isolates genotyped by restriction endonuclease analysis.
|
J Clin Microbiol
|
2009
|
1.21
|
|
51
|
Rifaximin Redux: treatment of recurrent Clostridium difficile infections with rifaximin immediately post-vancomycin treatment.
|
Anaerobe
|
2009
|
1.15
|
|
52
|
Difference in the incidence of Clostridium difficile among patients infected with human immunodeficiency virus admitted to a public hospital and a private hospital.
|
Infect Control Hosp Epidemiol
|
2002
|
1.15
|
|
53
|
Predominance of a single restriction endonuclease analysis group with intrahospital subgroup diversity among Clostridium difficile isolates at two Chicago hospitals.
|
Infect Control Hosp Epidemiol
|
2002
|
1.14
|
|
54
|
Prevention of fatal Clostridium difficile-associated disease during continuous administration of clindamycin in hamsters.
|
J Infect Dis
|
2003
|
1.14
|
|
55
|
Evaluation of an oral suspension of VP20621, spores of nontoxigenic Clostridium difficile strain M3, in healthy subjects.
|
Antimicrob Agents Chemother
|
2012
|
1.13
|
|
56
|
Onset of symptoms and time to diagnosis of Clostridium difficile-associated disease following discharge from an acute care hospital.
|
Infect Control Hosp Epidemiol
|
2007
|
1.03
|
|
57
|
Effect of nucleic acid amplification testing on population-based incidence rates of Clostridium difficile infection.
|
Clin Infect Dis
|
2013
|
1.03
|
|
58
|
Clostridium difficile infection among children across diverse US geographic locations.
|
Pediatrics
|
2014
|
1.01
|
|
59
|
Surface-layer protein A (SlpA) is a major contributor to host-cell adherence of Clostridium difficile.
|
PLoS One
|
2013
|
1.00
|
|
60
|
Does infection with specific Clostridium difficile strains or clades influence clinical outcome?
|
Clin Infect Dis
|
2013
|
0.99
|
|
61
|
New approach to the management of Clostridium difficile infection: colonisation with non-toxigenic C. difficile during daily ampicillin or ceftriaxone administration.
|
Int J Antimicrob Agents
|
2009
|
0.98
|
|
62
|
Fourteen-genome comparison identifies DNA markers for severe-disease-associated strains of Clostridium difficile.
|
J Clin Microbiol
|
2011
|
0.98
|
|
63
|
New definitions will help, but cultures are critical for resolving unanswered questions about Clostridium difficile.
|
Infect Control Hosp Epidemiol
|
2007
|
0.95
|
|
64
|
Strategies to prevent Clostridium difficile infections in acute care hospitals: 2014 Update.
|
Infect Control Hosp Epidemiol
|
2014
|
0.94
|
|
65
|
Fidaxomicin "chaser" regimen following vancomycin for patients with multiple Clostridium difficile recurrences.
|
Clin Infect Dis
|
2012
|
0.92
|
|
66
|
Susceptibility of hamsters to human pathogenic Clostridium difficile strain B1 following clindamycin, ampicillin or ceftriaxone administration.
|
Anaerobe
|
2003
|
0.92
|
|
67
|
Nontoxigenic Clostridium difficile protects hamsters against challenge with historic and epidemic strains of toxigenic BI/NAP1/027 C. difficile.
|
Antimicrob Agents Chemother
|
2013
|
0.91
|
|
68
|
Vaccination with parenteral toxoid B protects hamsters against lethal challenge with toxin A-negative, toxin B-positive clostridium difficile but does not prevent colonization.
|
J Infect Dis
|
2011
|
0.87
|
|
69
|
Renal failure and leukocytosis are predictors of a complicated course of Clostridium difficile infection if measured on day of diagnosis.
|
Clin Infect Dis
|
2012
|
0.87
|
|
70
|
Utility of a commercial PCR assay and a clinical prediction rule for detection of toxigenic Clostridium difficile in asymptomatic carriers.
|
J Clin Microbiol
|
2013
|
0.86
|
|
71
|
Measuring the severity of Clostridium difficile infection: implications for management and drug development.
|
Expert Rev Anti Infect Ther
|
2008
|
0.86
|
|
72
|
Multihospital outbreak of Clostridium difficile infection, Cleveland, Ohio, USA.
|
Emerg Infect Dis
|
2010
|
0.85
|
|
73
|
Strategies to prevent Clostridium difficile infections in acute care hospitals: 2014 update.
|
Infect Control Hosp Epidemiol
|
2014
|
0.84
|
|
74
|
Effectiveness of hand hygiene for removal of Clostridium difficile spores from hands.
|
Infect Control Hosp Epidemiol
|
2013
|
0.84
|
|
75
|
Protection from Clostridium difficile infection in CD4 T Cell- and polymeric immunoglobulin receptor-deficient mice.
|
Infect Immun
|
2013
|
0.83
|
|
76
|
Susceptibility of hamsters to infection by historic and epidemic BI Clostridium difficile strains during daily administration of three fluoroquinolones.
|
Anaerobe
|
2011
|
0.83
|
|
77
|
Epidemiology and outcome of Clostridium difficile infection and diarrhea in HIV infected inpatients.
|
Diagn Microbiol Infect Dis
|
2002
|
0.83
|
|
78
|
A simulation-based assessment of strategies to control Clostridium difficile transmission and infection.
|
PLoS One
|
2013
|
0.82
|
|
79
|
Workshop on immunizations in older adults: identifying future research agendas.
|
J Am Geriatr Soc
|
2010
|
0.82
|
|
80
|
Clostridium difficile infection and limitations of markers for severity in patients with hematologic malignancy.
|
Infect Control Hosp Epidemiol
|
2012
|
0.82
|
|
81
|
Clinical and Microbiologic Assessment of Cases of Pediatric Community-associated Clostridium difficile Infection Reveals Opportunities for Improved Testing Decisions.
|
Pediatr Infect Dis J
|
2016
|
0.81
|
|
82
|
Clostridium difficile infection rates and spectrum of disease among peripartum women at one hospital from 2003 to 2007 with molecular typing analysis of recovered Clostridium difficile isolates.
|
Am J Infect Control
|
2010
|
0.80
|
|
83
|
A compendium of strategies to prevent healthcare-associated infections in acute care hospitals: 2014 updates.
|
Infect Control Hosp Epidemiol
|
2014
|
0.80
|
|
84
|
Sustained clinical response as an endpoint in treatment trials of Clostridium difficile-associated diarrhea.
|
Antimicrob Agents Chemother
|
2012
|
0.79
|
|
85
|
Clostridium difficile-associated disease treatment response depends on definition of cure.
|
Clin Infect Dis
|
2007
|
0.79
|
|
86
|
Antimotility agents for the treatment of Clostridium difficile infection: is the juice worth the squeeze?
|
Clin Infect Dis
|
2009
|
0.79
|
|
87
|
Is pediatric Clostridium difficile infection associated with prior antibiotic exposure?
|
Future Microbiol
|
2014
|
0.78
|
|
88
|
Genotypic and phenotypic analysis of Clostridium difficile correlated with previous antibiotic exposure.
|
Microb Drug Resist
|
2006
|
0.78
|
|
89
|
A compendium of strategies to prevent healthcare-associated infections in acute care hospitals: 2014 updates.
|
Infect Control Hosp Epidemiol
|
2014
|
0.78
|
|
90
|
Introduction to "A Compendium of Strategies To Prevent Healthcare-Associated Infections in Acute Care Hospitals: 2014 updates".
|
Infect Control Hosp Epidemiol
|
2014
|
0.76
|
|
91
|
Community-associated Clostridium difficile infection among veterans with spinal cord injury and disorder.
|
Infect Control Hosp Epidemiol
|
2014
|
0.75
|
|
92
|
Introduction to "A compendium of strategies to prevent healthcare-associated infections in acute care hospitals: 2014 updates".
|
Infect Control Hosp Epidemiol
|
2014
|
0.75
|
|
93
|
Introduction to the special issue on Clostridium difficile.
|
Anaerobe
|
2009
|
0.75
|