Published in J Med Microbiol on February 01, 2005
Clostridium difficile infection: new developments in epidemiology and pathogenesis. Nat Rev Microbiol (2009) 7.89
Clostridium difficile PCR ribotypes in calves, Canada. Emerg Infect Dis (2006) 2.12
Clostridium difficile associated infection, diarrhea and colitis. World J Gastroenterol (2009) 1.97
Possible seasonality of Clostridium difficile in retail meat, Canada. Emerg Infect Dis (2009) 1.55
Laboratory diagnosis of Clostridium difficile infection can molecular amplification methods move us out of uncertainty? J Mol Diagn (2011) 1.41
Crystal structure of receptor-binding C-terminal repeats from Clostridium difficile toxin A. Proc Natl Acad Sci U S A (2005) 1.35
Truncation in the tcdC region of the Clostridium difficile PathLoc of clinical isolates does not predict increased biological activity of Toxin B or Toxin A. BMC Infect Dis (2009) 1.10
Comparative efficacies of rifaximin and vancomycin for treatment of Clostridium difficile-associated diarrhea and prevention of disease recurrence in hamsters. Antimicrob Agents Chemother (2008) 1.05
Automated detection of toxigenic Clostridium difficile in clinical samples: isothermal tcdB amplification coupled to array-based detection. J Clin Microbiol (2012) 1.00
The host immune response to Clostridium difficile infection. Ther Adv Infect Dis (2013) 0.96
Genetic relatedness of Clostridium difficile isolates from various origins determined by triple-locus sequence analysis based on toxin regulatory genes tcdC, tcdR, and cdtR. J Clin Microbiol (2008) 0.96
Clostridium difficile: New Insights into the Evolution of the Pathogenicity Locus. Sci Rep (2015) 0.88
Recent developments on the role of Clostridium difficile in inflammatory bowel disease. World J Gastroenterol (2008) 0.86
Isolation of RNA polymerase from Clostridium difficile and characterization of glutamate dehydrogenase and rRNA gene promoters in vitro and in vivo. J Bacteriol (2006) 0.82
Production of Clostridium difficile toxin in a medium totally free of both animal and dairy proteins or digests. Proc Natl Acad Sci U S A (2009) 0.82
Differential stress transcriptome landscape of historic and recently emerged hypervirulent strains of Clostridium difficile strains determined using RNA-seq. PLoS One (2013) 0.80
Effects of Clostridium difficile toxin A and B on human T lymphocyte migration. Toxins (Basel) (2013) 0.79
DNA-Microarray-based Genotyping of Clostridium difficile. BMC Microbiol (2015) 0.75
Current knowledge on the laboratory diagnosis of Clostridium difficile infection. World J Gastroenterol (2017) 0.75
An epidemic, toxin gene-variant strain of Clostridium difficile. N Engl J Med (2005) 18.10
Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA). Infect Control Hosp Epidemiol (2010) 17.99
Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship. Clin Infect Dis (2006) 14.63
Burden of Clostridium difficile infection in the United States. N Engl J Med (2015) 8.17
The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome. Nat Genet (2006) 8.02
Clostridium difficile infection: new developments in epidemiology and pathogenesis. Nat Rev Microbiol (2009) 7.89
Treatment with monoclonal antibodies against Clostridium difficile toxins. N Engl J Med (2010) 7.37
The complete genome sequence of Francisella tularensis, the causative agent of tularemia. Nat Genet (2005) 6.22
Toxin B is essential for virulence of Clostridium difficile. Nature (2009) 5.49
Emergence and global spread of epidemic healthcare-associated Clostridium difficile. Nat Genet (2012) 4.10
N-linked glycosylation in Campylobacter jejuni and its functional transfer into E. coli. Science (2002) 4.04
Protein glycosylation in bacterial mucosal pathogens. Nat Rev Microbiol (2005) 3.75
Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium. Genome Biol (2009) 3.66
A mouse model of Clostridium difficile-associated disease. Gastroenterology (2008) 3.65
Bile salts and glycine as cogerminants for Clostridium difficile spores. J Bacteriol (2008) 3.37
Antibiotic treatment of clostridium difficile carrier mice triggers a supershedder state, spore-mediated transmission, and severe disease in immunocompromised hosts. Infect Immun (2009) 3.36
The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081. PLoS Genet (2006) 3.33
Clinical recognition and diagnosis of Clostridium difficile infection. Clin Infect Dis (2008) 3.32
Management of Clostridium difficile infection: thinking inside and outside the box. Clin Infect Dis (2010) 3.31
Clostridium difficile infection caused by the epidemic BI/NAP1/027 strain. Gastroenterology (2009) 3.29
Evolutionary dynamics of Clostridium difficile over short and long time scales. Proc Natl Acad Sci U S A (2010) 3.18
Bacterial pathogenomics. Nature (2007) 3.16
Interruption of recurrent Clostridium difficile-associated diarrhea episodes by serial therapy with vancomycin and rifaximin. Clin Infect Dis (2007) 3.15
Strategies to prevent central line-associated bloodstream infections in acute care hospitals. Infect Control Hosp Epidemiol (2008) 3.13
Outcome of metronidazole therapy for Clostridium difficile disease and correlation with a scoring system. J Infect (2007) 2.84
Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens. Genome Res (2006) 2.84
Epidemiology of community-associated Clostridium difficile infection, 2009 through 2011. JAMA Intern Med (2013) 2.78
An outbreak of eosinophilic meningitis caused by Angiostrongylus cantonensis in travelers returning from the Caribbean. N Engl J Med (2002) 2.76
Genome reduction in Leptospira borgpetersenii reflects limited transmission potential. Proc Natl Acad Sci U S A (2006) 2.71
Construction and analysis of chromosomal Clostridium difficile mutants. Mol Microbiol (2006) 2.65
Additional targets of the Bacillus subtilis global regulator CodY identified by chromatin immunoprecipitation and genome-wide transcript analysis. J Bacteriol (2003) 2.65
Binary bacterial toxins: biochemistry, biology, and applications of common Clostridium and Bacillus proteins. Microbiol Mol Biol Rev (2004) 2.60
Multilocus variable-number tandem-repeat analysis for investigation of Clostridium difficile transmission in Hospitals. J Clin Microbiol (2006) 2.52
Application of DNA microarrays to study the evolutionary genomics of Yersinia pestis and Yersinia pseudotuberculosis. Genome Res (2003) 2.51
In vitro activities of 15 antimicrobial agents against 110 toxigenic clostridium difficile clinical isolates collected from 1983 to 2004. Antimicrob Agents Chemother (2007) 2.43
Genome sequence of the saprophyte Leptospira biflexa provides insights into the evolution of Leptospira and the pathogenesis of leptospirosis. PLoS One (2008) 2.35
A compendium of strategies to prevent healthcare-associated infections in acute care hospitals. Infect Control Hosp Epidemiol (2008) 2.32
Impact of strain type on detection of toxigenic Clostridium difficile: comparison of molecular diagnostic and enzyme immunoassay approaches. J Clin Microbiol (2010) 2.32
Expression and prognostic relevance of annexin A3 in prostate cancer. Eur Urol (2008) 2.32
Re-annotation and re-analysis of the Campylobacter jejuni NCTC11168 genome sequence. BMC Genomics (2007) 2.31
Strategies to prevent catheter-associated urinary tract infections in acute care hospitals. Infect Control Hosp Epidemiol (2008) 2.30
Human hypervirulent Clostridium difficile strains exhibit increased sporulation as well as robust toxin production. J Bacteriol (2010) 2.29
Discovery and validation of new protein biomarkers for urothelial cancer: a prospective analysis. Lancet Oncol (2006) 2.29
Repression of Clostridium difficile toxin gene expression by CodY. Mol Microbiol (2007) 2.28
Clostridium difficile testing: after 20 years, still challenging. J Clin Microbiol (2003) 2.24
NetB, a new toxin that is associated with avian necrotic enteritis caused by Clostridium perfringens. PLoS Pathog (2008) 2.23
Strategies to prevent surgical site infections in acute care hospitals. Infect Control Hosp Epidemiol (2008) 2.22
Bacterial epidemiology and biology--lessons from genome sequencing. Genome Biol (2011) 2.18
Functional analysis of the Campylobacter jejuni N-linked protein glycosylation pathway. Mol Microbiol (2005) 2.16
Autocatalytic cleavage of Clostridium difficile toxin B. Nature (2007) 2.11
Campylobacter--a tale of two protein glycosylation systems. Trends Microbiol (2003) 2.10
Clostridium difficile toxin expression is inhibited by the novel regulator TcdC. Mol Microbiol (2007) 2.05
Comparative phylogenomics of the food-borne pathogen Campylobacter jejuni reveals genetic markers predictive of infection source. Proc Natl Acad Sci U S A (2005) 2.04
The Clostridium difficile spo0A gene is a persistence and transmission factor. Infect Immun (2012) 2.02
Construction of an alpha toxin gene knockout mutant of Clostridium perfringens type A by use of a mobile group II intron. Appl Environ Microbiol (2005) 2.01
Binary toxin-producing, large clostridial toxin-negative Clostridium difficile strains are enterotoxic but do not cause disease in hamsters. J Infect Dis (2006) 1.99
Toxinotype V Clostridium difficile in humans and food animals. Emerg Infect Dis (2008) 1.98
Clindamycin, cephalosporins, fluoroquinolones, and Clostridium difficile-associated diarrhea: this is an antimicrobial resistance problem. Clin Infect Dis (2004) 1.98
A hospital outbreak of Clostridium difficile disease associated with isolates carrying binary toxin genes. Clin Infect Dis (2004) 1.96
Activation of the Bacillus subtilis global regulator CodY by direct interaction with branched-chain amino acids. Mol Microbiol (2004) 1.96
Decreased cure and increased recurrence rates for Clostridium difficile infection caused by the epidemic C. difficile BI strain. Clin Infect Dis (2012) 1.96
Staphylococcus aureus CodY negatively regulates virulence gene expression. J Bacteriol (2007) 1.88
Metabolism of bile salts in mice influences spore germination in Clostridium difficile. PLoS One (2010) 1.87
Serum anti-toxin B antibody correlates with protection from recurrent Clostridium difficile infection (CDI). Vaccine (2009) 1.85
Strategies to prevent clostridium difficile infections in acute care hospitals. Infect Control Hosp Epidemiol (2008) 1.84
Rifampin and rifaximin resistance in clinical isolates of Clostridium difficile. Antimicrob Agents Chemother (2008) 1.84
A novel paralogous gene family involved in phase-variable flagella-mediated motility in Campylobacter jejuni. Microbiology (2002) 1.84
Parallel independent evolution of pathogenicity within the genus Yersinia. Proc Natl Acad Sci U S A (2014) 1.83
Inhibiting the initiation of Clostridium difficile spore germination using analogs of chenodeoxycholic acid, a bile acid. J Bacteriol (2010) 1.82
Strategies to prevent ventilator-associated pneumonia in acute care hospitals. Infect Control Hosp Epidemiol (2008) 1.81
Analysis of Campylobacter jejuni capsular loci reveals multiple mechanisms for the generation of structural diversity and the ability to form complex heptoses. Mol Microbiol (2005) 1.79
Beta toxin is essential for the intestinal virulence of Clostridium perfringens type C disease isolate CN3685 in a rabbit ileal loop model. Mol Microbiol (2008) 1.78
Adaptation of Campylobacter jejuni NCTC11168 to high-level colonization of the avian gastrointestinal tract. Infect Immun (2004) 1.77
Direct targets of CodY in Staphylococcus aureus. J Bacteriol (2010) 1.76
Structural insights into the molecular organization of the S-layer from Clostridium difficile. Mol Microbiol (2009) 1.71
Efficient sporulation in Clostridium difficile requires disruption of the sigmaK gene. Mol Microbiol (2003) 1.71
Characterization of relA and codY mutants of Listeria monocytogenes: identification of the CodY regulon and its role in virulence. Mol Microbiol (2007) 1.69
Colonization for the prevention of Clostridium difficile disease in hamsters. J Infect Dis (2002) 1.68