Published in Exp Cell Res on September 25, 2008
Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway. J Exp Med (2009) 1.85
Anti-Ro52 autoantibodies from patients with Sjögren's syndrome inhibit the Ro52 E3 ligase activity by blocking the E3/E2 interface. J Biol Chem (2011) 0.93
Autoantigen TRIM21/Ro52 as a Possible Target for Treatment of Systemic Lupus Erythematosus. Int J Rheumatol (2012) 0.85
Toll-like receptor 3 stimulation promotes Ro52/TRIM21 synthesis and nuclear redistribution in salivary gland epithelial cells, partially via type I interferon pathway. Clin Exp Immunol (2014) 0.84
Interaction between innate immunity and Ro52-induced antibody causes Sjögren's syndrome-like disorder in mice. Ann Rheum Dis (2015) 0.83
Tyrosine phosphorylation of the E3 ubiquitin ligase TRIM21 positively regulates interaction with IRF3 and hence TRIM21 activity. PLoS One (2012) 0.82
Comprehensively surveying structure and function of RING domains from Drosophila melanogaster. PLoS One (2011) 0.78
The cellular protein La functions in enhancement of virus release through lipid rafts facilitated by murine leukemia virus glycosylated Gag. MBio (2011) 0.78
Precocious detection on amphibian oocyte lampbrush chromosomes of subtle changes in the cellular localisation of the Ro52 protein induced by in vitro culture. Chromosome Res (2012) 0.75
Signs of first-degree heart block occur in one-third of fetuses of pregnant women with anti-SSA/Ro 52-kd antibodies. Arthritis Rheum (2004) 2.58
Cellular basis of ectopic germinal center formation and autoantibody production in the target organ of patients with Sjögren's syndrome. Arthritis Rheum (2003) 2.03
Induction of interferon-alpha by immune complexes or liposomes containing systemic lupus erythematosus autoantigen- and Sjögren's syndrome autoantigen-associated RNA. Arthritis Rheum (2006) 1.86
Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway. J Exp Med (2009) 1.85
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. Nat Genet (2013) 1.79
High Ro52 expression in spontaneous and UV-induced cutaneous inflammation. J Invest Dermatol (2009) 1.53
Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies. J Clin Invest (2015) 1.51
Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands. Nat Genet (2005) 1.43
Increased expression of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in skin lesions of patients with lupus erythematosus. Arthritis Rheum (2005) 1.39
A serologic marker for fetal risk of congenital heart block. Arthritis Rheum (2002) 1.38
The complexity of Sjögren's syndrome: novel aspects on pathogenesis. Immunol Lett (2011) 1.35
Differential effects on BAFF and APRIL levels in rituximab-treated patients with systemic lupus erythematosus and rheumatoid arthritis. Arthritis Res Ther (2006) 1.34
Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block. J Exp Med (2005) 1.31
The Sjogren's syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death. J Immunol (2006) 1.30
The immunobiology of Ro52 (TRIM21) in autoimmunity: a critical review. J Autoimmun (2012) 1.21
Interferon-alpha induces up-regulation and nuclear translocation of the Ro52 autoantigen as detected by a panel of novel Ro52-specific monoclonal antibodies. J Clin Immunol (2008) 1.20
Pivotal advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis. J Leukoc Biol (2008) 1.12
NCR3/NKp30 contributes to pathogenesis in primary Sjogren's syndrome. Sci Transl Med (2013) 1.12
Neurogenesis in the adult spinal cord in an experimental model of multiple sclerosis. Eur J Neurosci (2006) 1.11
Increased extracellular levels of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in minor salivary glands of patients with Sjögren's syndrome. Arthritis Rheum (2006) 1.11
Self protection from anti-viral responses--Ro52 promotes degradation of the transcription factor IRF7 downstream of the viral Toll-Like receptors. PLoS One (2010) 1.10
IL-17: a new actor in IFN-driven systemic autoimmune diseases. Eur J Immunol (2012) 1.07
Structural, functional and immunologic characterization of folded subdomains in the Ro52 protein targeted in Sjögren's syndrome. Mol Immunol (2006) 1.06
Structural organization and Zn2+-dependent subdomain interactions involving autoantigenic epitopes in the Ring-B-box-coiled-coil (RBCC) region of Ro52. J Biol Chem (2005) 1.04
Congenital heart block: evidence for a pathogenic role of maternal autoantibodies. Arthritis Res Ther (2012) 1.03
Gender and the treatment of immune-mediated chronic inflammatory diseases: rheumatoid arthritis, inflammatory bowel disease and psoriasis: an observational study. BMC Med (2012) 1.03
Antibiotic-resistant Propionibacterium acnes on the skin of patients with moderate to severe acne in Stockholm. Anaerobe (2004) 0.96
Expression of Ccl11 associates with immune response modulation and protection against neuroinflammation in rats. PLoS One (2012) 0.95
A serology-based approach combined with clinical examination of 125 Ro/SSA-positive patients to define incidence and prevalence of subacute cutaneous lupus erythematosus. Arthritis Rheum (2007) 0.95
The ketogenic diet influences the levels of excitatory and inhibitory amino acids in the CSF in children with refractory epilepsy. Epilepsy Res (2005) 0.94
Enhanced interferon regulatory factor 3 binding to the interleukin-23p19 promoter correlates with enhanced interleukin-23 expression in systemic lupus erythematosus. Arthritis Rheum (2012) 0.93
Anti-Ro52 autoantibodies from patients with Sjögren's syndrome inhibit the Ro52 E3 ligase activity by blocking the E3/E2 interface. J Biol Chem (2011) 0.93
Development of heart block in children of SSA/SSB-autoantibody-positive women is associated with maternal age and displays a season-of-birth pattern. Ann Rheum Dis (2011) 0.93
Late development of complete atrioventricular block may be immune mediated and congenital in origin. Acta Paediatr (2013) 0.91
Expression of the immune regulator tripartite-motif 21 is controlled by IFN regulatory factors. J Immunol (2013) 0.90
Association between genetic variants in the tumour necrosis factor/lymphotoxin α/lymphotoxin β locus and primary Sjogren's syndrome in Scandinavian samples. Ann Rheum Dis (2012) 0.90
Lipids and lipid-reactive antibodies as biomarkers for multiple sclerosis. J Neuroimmunol (2012) 0.88
Cloning and characterization of two human Ro52-specific monoclonal autoantibodies directed towards a domain associated with congenital heart block. J Autoimmun (2004) 0.88
Local production of Ro/SSA and La/SSB autoantibodies in the target organ coincides with high levels of circulating antibodies in sera of patients with Sjögren's syndrome. Scand J Rheumatol (2003) 0.88
Polymorphisms of the ITGAM gene confer higher risk of discoid cutaneous than of systemic lupus erythematosus. PLoS One (2010) 0.87
Anti-Ro52 monoclonal antibodies specific for amino acid 200-239, but not other Ro52 epitopes, induce congenital heart block in a rat model. Ann Rheum Dis (2011) 0.87
Maternal MHC regulates generation of pathogenic antibodies and fetal MHC-encoded genes determine susceptibility in congenital heart block. J Immunol (2010) 0.87
Ultraviolet radiation-B-induced cataract in albino rats: maximum tolerable dose and ascorbate consumption. Acta Ophthalmol Scand (2006) 0.87
Clinical follow-up of 102 anti-Ro/SSA-positive patients with dermatological manifestations. Acta Derm Venereol (2008) 0.86
Serial analysis of Ro/SSA and La/SSB antibody levels and correlation with clinical disease activity in patients with systemic lupus erythematosus. Scand J Rheumatol (2002) 0.86
Phase I, randomized, double-blind, placebo-controlled, multiple intravenous, dose-ascending study of sirukumab in cutaneous or systemic lupus erythematosus. Arthritis Rheum (2013) 0.86
Genetic associations to germinal centre formation in primary Sjogren's syndrome. Ann Rheum Dis (2013) 0.86
Association of genes in the NF-κB pathway with antibody-positive primary Sjögren's syndrome. Scand J Immunol (2013) 0.85
Update on the immunobiology of Sjögren's syndrome. Curr Opin Rheumatol (2015) 0.85
Outcome and growth of infants fetally exposed to heart block-associated maternal anti-Ro52/SSA autoantibodies. Pediatrics (2008) 0.84
Potential association of muscarinic receptor 3 gene variants with primary Sjogren's syndrome. Ann Rheum Dis (2011) 0.83
Drinking water supplementation with ascorbate is not protective against UVR-B-induced cataract in the guinea pig. Acta Ophthalmol (2007) 0.82
Electrical impedance spectroscopy as a potential adjunct diagnostic tool for cutaneous melanoma. Skin Res Technol (2013) 0.81
Ascorbate in the rat lens: dependence on dietary intake. Ophthalmic Res (2005) 0.80
A possible genetic association with chronic fatigue in primary Sjögren's syndrome: a candidate gene study. Rheumatol Int (2013) 0.80
Oxidative stress increases neurogenesis and oligodendrogenesis in adult neural progenitor cells. Stem Cells Dev (2014) 0.79
Serologic follow-up of children born to mothers with Ro/SSA autoantibodies. Lupus (2009) 0.79
Patients' views on care and treatment after phototherapy for psoriasis and atopic eczema including a gender perspective. J Dermatolog Treat (2008) 0.79
Nitric oxide-induced neuronal to glial lineage fate-change depends on NRSF/REST function in neural progenitor cells. Stem Cells (2014) 0.79
Minor salivary gland immunohistology in the diagnosis of primary Sjögren's syndrome. J Oral Pathol Med (2008) 0.78
Photoprovocation in cutaneous lupus erythematosus: a multicenter study evaluating a standardized protocol. J Invest Dermatol (2011) 0.78
Ro52 autoantibody-positive women's experience of being pregnant and giving birth to a child with congenital heart block. Midwifery (2011) 0.78
[The laundry-basket project--gender differences to the very skin. Different treatment of some common skin diseases in men and women]. Lakartidningen (2005) 0.77
Progression to first-degree heart block in preschool children exposed in utero to maternal anti-SSA/Ro52 autoantibodies. Acta Paediatr (2012) 0.77
Gene-environment interaction in induction of autoimmunity. Semin Immunol (2011) 0.77
Neurodevelopment in children with and without congenital heart block born to anti-Ro/SSA-positive mothers. Acta Paediatr (2012) 0.76
Killers come to the rescue. Nat Biotechnol (2002) 0.75
Risk Factors for De Novo Squamous Cell Carcinoma (SCC) Development in Renal Transplant Recipients with a Previous SCC. Acta Derm Venereol (2017) 0.75
Immunological contribution to the pathogenesis of congenital heart block. Scand J Immunol (2010) 0.75
Ascorbate in the guinea pig lens: dependence on drinking water supplementation. Acta Ophthalmol Scand (2005) 0.75
[Kidney transplanted persons with malignant tumors is a growing patient group]. Lakartidningen (2012) 0.75
A database analysis of cutaneous lupus erythematosus with the EUSCLE Core Set Questionnaire. Acta Derm Venereol (2010) 0.75
[Challenges and opportunities for the next generation in global health]. Lakartidningen (2015) 0.75
3rd Nordic Meeting on Genetics and Pathogenesis of Inflammatory Diseases. Scand J Immunol (2012) 0.75
The experiences of pregnancy in women with SSA/Ro52 autoantibodies. Musculoskeletal Care (2010) 0.75
Long-term growth of children with autoantibody-mediated congenital heart block. Acta Paediatr (2013) 0.75
The effects of PBN (phenyl-butyl-nitrone) on GLT-1 levels and on the extracellular levels of amino acids and energy metabolites in a model of iron-induced posttraumatic epilepsy. Epilepsy Res (2003) 0.75
Development of systemic lupus erythematosus in a patient with congenital heart block. Arthritis Rheum (2003) 0.75