Actions of n-alcohols on nicotinic acetylcholine receptor channels in cultured rat myotubes.

PubWeight™: 1.00‹?› | Rank: Top 15%

🔗 View Article (PMC 1180056)

Published in J Physiol on June 01, 1991

Authors

R D Murrell1, M S Braun, D A Haydon

Author Affiliations

1: Physiological Laboratory, University of Cambridge.

Articles cited by this

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch (1981) 134.60

Local anaesthetics transiently block currents through single acetylcholine-receptor channels. J Physiol (1978) 10.05

Fast events in single-channel currents activated by acetylcholine and its analogues at the frog muscle end-plate. J Physiol (1985) 9.25

Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance. Nature (1988) 6.35

Drug blockade of open end-plate channels. J Physiol (1976) 4.60

The charge carried by single-channel currents of rat cultured muscle cells in the presence of local anaesthetics. J Physiol (1983) 3.76

Ion channel block by acetylcholine, carbachol and suberyldicholine at the frog neuromuscular junction. Proc R Soc Lond B Biol Sci (1985) 2.64

Evidence that the M2 membrane-spanning region lines the ion channel pore of the nicotinic receptor. Science (1988) 2.31

An open-channel blocker interacts with adjacent turns of alpha-helices in the nicotinic acetylcholine receptor. Neuron (1990) 2.06

Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: serine-262 of the delta subunit is labeled by [3H]chlorpromazine. Proc Natl Acad Sci U S A (1986) 2.06

The nature of the site of general anesthesia. Int Rev Neurobiol (1985) 2.05

Location of a delta-subunit region determining ion transport through the acetylcholine receptor channel. Nature (1987) 1.99

Effects of some aliphatic alcohols on the conductance change caused by a quantum of acetylcholine at the toad end-plate. J Physiol (1975) 1.92

Acetylcholine-induced current in perfused rat myoballs. J Gen Physiol (1980) 1.92

Anaesthetic potencies of primary alkanols: implications for the molecular dimensions of the anaesthetic site. Br J Pharmacol (1989) 1.80

Block of acetylcholine-activated ion channels by an uncharged local anaesthetic. Nature (1981) 1.47

Single acetylcholine-activated channel currents in developing muscle cells. Dev Biol (1984) 1.38

Permeability of human red cells to a homologous series of aliphatic alcohols. Limitations of the continuous flow-tube method. J Gen Physiol (1983) 1.20

Kinetic differences between embryonic- and adult-type acetylcholine receptors in rat myotubes. J Physiol (1988) 1.14

Actions of general anesthetics on acetylcholine receptor-rich membranes from Torpedo californica. Anesthesiology (1986) 1.04

The actions of neutral anaesthetics on ion conductances of nerve membranes. Biochim Biophys Acta (1989) 0.95

Halothane shortens acetylcholine receptor channel kinetics without affecting conductance. Proc Natl Acad Sci U S A (1984) 0.89

Molecular sites of anesthetic action in postsynaptic nicotinic membranes. Trends Pharmacol Sci (1989) 0.86

The role of inactivation in the effects of n-alkanols on the sodium current of cultured rat sensory neurones. J Physiol (1989) 0.86

Articles by these authors

Ion transfer across lipid membranes in the presence of gramicidin A. I. Studies of the unit conductance channel. Biochim Biophys Acta (1972) 7.40

Ion transfer across lipid membranes in the presence of gramicidin A. II. The ion selectivity. Biochim Biophys Acta (1972) 4.35

Ion transport across thin lipid membranes: a critical discussion of mechanisms in selected systems. Q Rev Biophys (1972) 4.32

Discreteness of conductance change in bimolecular lipid membranes in the presence of certain antibiotics. Nature (1970) 4.22

Ion movements in gramicidin pores. An example of single-file transport. Biochim Biophys Acta (1980) 3.35

The effects of bilayer thickness and tension on gramicidin single-channel lifetime. Biochim Biophys Acta (1983) 2.97

Water permeability of lipid membranes. Physiol Rev (1980) 2.61

The unit conductance channel of alamethicin. Biochim Biophys Acta (1972) 2.56

Surface charge, surface dipoles and membrane conductance. Biochim Biophys Acta (1973) 2.51

Anaesthesia by the n-alkanes. A comparative study of nerve impulse blockage and the properties of black lipid bilayer membranes. Biochim Biophys Acta (1977) 1.91

Potential-dependent conductances in lipid membranes containing alamethicin. Philos Trans R Soc Lond B Biol Sci (1975) 1.81

The stability and properties of bimolecular lipid leaflets in aqueous solutions. J Theor Biol (1963) 1.80

Electron microscope studies of lipid bilayer membranes. J Mol Biol (1968) 1.78

The blockage of the electrical conductance in a pore-containing membrane by the n-alkanes. Biochim Biophys Acta (1978) 1.72

Some effects of aliphatic hydrocarbons on the electrical capacity and ionic currents of the squid giant axon membrane. J Physiol (1980) 1.68

The action of alcohols and other non-ionic surface active substances on the sodium current of the squid giant axon. J Physiol (1983) 1.64

The permeability to water of bimolecular lipid membranes. J Theor Biol (1966) 1.64

The variation of capacitance and conductance of bimolecular lipid membranes with area. J Theor Biol (1965) 1.62

Functions of the lipid in bilayer ion permeability. Ann N Y Acad Sci (1975) 1.57

Polar group orientation and the electrical properties of lecithin bimolecular leaflets. J Theor Biol (1965) 1.57

Some effects of n-pentane on the sodium and potassium currents of the squid giant axon. J Physiol (1981) 1.54

The influence of lipid composition and of some adsorbed proteins on the capacitance of black hydrocarbon membranes. J Theor Biol (1965) 1.51

Influence of temperature and membrane composition on the water permeability of lipid bilayers. J Theor Biol (1969) 1.47

Problem of boundary layers in the exchange diffusion of water across bimolecular lipid membranes. J Theor Biol (1969) 1.45

The effects of some inhalation anaesthetics on the sodium current of the squid giant axon. J Physiol (1983) 1.43

The kinetics of ion movements in the gramicidin channel. Fed Proc (1978) 1.39

Electrical capacitance of a lipid membrane separating two aqueous phases. J Theor Biol (1968) 1.38

The action of hydrocarbons and carbon tetrachloride on the sodium current of the squid giant axon. J Physiol (1983) 1.35

The thickness, composition and structure of some lipid bilayers and natural membranes. J Membr Biol (1971) 1.32

Tensions and free energies of formation of "solventless" lipid bilayers. Measurement of high contact angles. Biophys J (1983) 1.32

The interaction of n-octanol with black lipid bilayer membranes. Biochim Biophys Acta (1979) 1.26

Kinetics and stability of alamethicin conducting channels in lipid bilayers. Biochim Biophys Acta (1976) 1.26

A mean-field model of the alkane-saturated lipid bilayer above its phase transition. II. Results and comparison with experiment. Biophys J (1981) 1.19

The water permeability of artificial bimolecular leaflets: a comparison of radio-tracer and osmotic methods. Ann N Y Acad Sci (1966) 1.15

The molecular mechanisms of anaesthesia. Nature (1977) 1.13

Electrokinetic studies on the ultrastructure of the human erythrocyte. I. Electrophoresis at high ionic strengths--the cell as a polyanion. Arch Biochem Biophys (1967) 1.12

The actions of some general anaesthetics on the potassium current of the squid giant axon. J Physiol (1986) 1.05

The asymmetrical effects of some ionized n-octyl derivatives on the sodium current of the giant axon of Loligo forbesi. J Physiol (1984) 0.98

The adsorption of nonpolar molecules into lipid bilayer membranes. Biophys J (1980) 0.98

Nerve impulse blockage in squid axons by n-alkanes: the effect of axon diameter. J Physiol (1982) 0.96

Influence of diffusion layers during osmotic flow across bimolecular lipid membranes. J Theor Biol (1969) 0.95

The actions of neutral anaesthetics on ion conductances of nerve membranes. Biochim Biophys Acta (1989) 0.95

The admittance of the squid giant axon at radio frequencies and its relation to membrane structure. J Physiol (1985) 0.92

Mapping of general anaesthetic target sites. Nature (1986) 0.92

Surface potential changes in lipid monolayers and the 'cut-off' in anaesthetic effects of N-alkanols. Biochim Biophys Acta (1986) 0.91

The influence of n-alkanols and cholesterol on the duration and conductance of gramicidin single channels in monoolein bilayers. Biochim Biophys Acta (1982) 0.91

Further evidence that membrane thickness influences voltage-gated sodium channels. Biophys J (1985) 0.90

The actions of halogenated ethers on the ionic currents of the squid giant axon. Proc R Soc Lond B Biol Sci (1987) 0.88

Dual effects of internal n-alkyltrimethylammonium ions on the sodium current of the squid giant axon. J Physiol (1985) 0.86

Prostacyclin rather than nitric oxide lowers human umbilical artery tone in vitro. Eur J Obstet Gynecol Reprod Biol (1992) 0.86

A quantitative explanation of the effects of some alcohols on gramicidin single-channel lifetime. Biochim Biophys Acta (1985) 0.85

Anaesthetic action of esters and ketones: evidence for an interaction with the sodium channel protein in squid axons. J Physiol (1984) 0.83

Fluorescence spectroscopy of planar black lipid membranes. Probe adsorption and quantum yield determination. Biochim Biophys Acta (1973) 0.82

Some effects of n-pentane on the capacity and ionic currents of the squid giant axon membrane [proceedings]. J Physiol (1979) 0.82

Ultrastructure of membranes: biomolecular organization. Br Med Bull (1968) 0.82

Local anaesthetic effects of benzene and structurally related molecules, including benzocaine, on the squid giant axon. Pflugers Arch (1987) 0.79

The effects of homologous series of anaesthetics on a resting potassium conductance of the squid giant axon. Biochim Biophys Acta (1989) 0.79

The influence of n-alkanols on the capacity per unit area of planar lipid bilayers. Biochim Biophys Acta (1984) 0.79

The mechanisms of sodium current inhibition by benzocaine in the squid giant axon. Pflugers Arch (1987) 0.78

Inactivation of the sodium current in squid giant axons by hydrocarbons. Biophys J (1985) 0.78

Local anesthetic action of carboxylic esters: evidence for the significance of molecular volume and for the number of sites involved. J Membr Biol (1987) 0.78

Properties of lipid bilayers at a water-water interface. J Am Oil Chem Soc (1968) 0.77

Actions of n-alcohols on nicotinic acetylcholine receptor ion channels in cultured rat muscle cells. Ann N Y Acad Sci (1991) 0.77

Fusion of photoreceptor membrane vesicles. J Membr Biol (1979) 0.76

The blockage of the nervous impulse by n-alkanes [proceedings]. J Physiol (1977) 0.76

The adsorption of lysine vasopressin at ionized interfaces. Biochim Biophys Acta (1976) 0.75

Impedance measurement as an indication of membrane thickness change in the squid giant axon [proceedings]. J Physiol (1979) 0.75

Effects of anesthetics and convulsants on the resting potassium conductance in squid nerve. Ann N Y Acad Sci (1991) 0.75

The effects of short-chain phospholipids on the acetylcholine-activated ion channel. Pflugers Arch (1991) 0.75

The action of lysine vasopressin on artificial lipid bilayers. J Physiol (1972) 0.75

The action of serratamolide on ion movement in lipid bilayers and biomembranes. Biochim Biophys Acta (1973) 0.75