Published in Clin Pharmacol Ther on October 15, 2008
Unrecognized acetaminophen toxicity as a cause of indeterminate acute liver failure. Hepatology (2011) 2.61
Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure. Drug Metab Dispos (2009) 1.95
Acetaminophen-cysteine adducts during therapeutic dosing and following overdose. BMC Gastroenterol (2011) 1.26
Acetaminophen protein adduct formation following low-dose acetaminophen exposure: comparison of immediate-release vs extended-release formulations. Eur J Clin Pharmacol (2012) 1.06
Potential of extracellular microRNAs as biomarkers of acetaminophen toxicity in children. Toxicol Appl Pharmacol (2015) 0.98
Targeted liquid chromatography-mass spectrometry analysis of serum acylcarnitines in acetaminophen toxicity in children. Biomark Med (2014) 0.93
Prolonged Acetaminophen-Protein Adduct Elimination During Renal Failure, Lack of Adduct Removal by Hemodiafiltration, and Urinary Adduct Concentrations After Acetaminophen Overdose. J Med Toxicol (2015) 0.85
Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells. Xenobiotica (2015) 0.83
Acute liver failure after recommended doses of acetaminophen in patients with myopathies. Crit Care Med (2011) 0.83
Target biomarker profile for the clinical management of paracetamol overdose. Br J Clin Pharmacol (2015) 0.82
Acetaminophen Adducts Detected in Serum of Pediatric Patients With Acute Liver Failure. J Pediatr Gastroenterol Nutr (2015) 0.80
Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity. PLoS One (2015) 0.80
Clinical pharmacology of paracetamol in neonates: a review. Curr Ther Res Clin Exp (2014) 0.79
Paracetamol (acetaminophen) protein adduct concentrations during therapeutic dosing. Br J Clin Pharmacol (2016) 0.78
Low rates of hepatotoxicity among Asian patients with paracetamol overdose: a review of 1024 cases. BMC Pharmacol Toxicol (2012) 0.77
Retinoid regulation of antiviral innate immunity in hepatocytes. Hepatology (2016) 0.76
Confirming the Causative Role of Acetaminophen in Indeterminate Acute Liver Failure Using Acetaminophen-Cysteine Adducts. J Med Toxicol (2015) 0.75
Targeted metabolomic profiling indicates structure-based perturbations in serum phospholipids in children with acetaminophen overdose. Toxicol Rep (2016) 0.75
Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatology (2005) 10.66
Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985) N Engl J Med (1988) 5.38
Acute liver necrosis following overdose of paracetamol. Br Med J (1966) 4.75
Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. J Pharmacol Exp Ther (1973) 4.40
Measurement of serum acetaminophen-protein adducts in patients with acute liver failure. Gastroenterology (2006) 3.85
AGA technical review on the evaluation of liver chemistry tests. Gastroenterology (2002) 3.74
Acetaminophen-induced hepatotoxicity. Drug Metab Dispos (2003) 3.22
Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group. J Pediatr (2006) 3.03
Therapeutic misadventures with acetaminophen: hepatoxicity after multiple doses in children. J Pediatr (1998) 3.02
Detection of acetaminophen protein adducts in children with acute liver failure of indeterminate cause. Pediatrics (2006) 2.96
Acetaminophen poisoning and toxicity. Pediatrics (1975) 2.71
2001 Annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med (2002) 2.47
Determination of acetaminophen-protein adducts in mouse liver and serum and human serum after hepatotoxic doses of acetaminophen using high-performance liquid chromatography with electrochemical detection. Drug Metab Dispos (2002) 2.34
Acetaminophen overdose. 662 cases with evaluation of oral acetylcysteine treatment. Arch Intern Med (1981) 2.15
The changing face of teenage drug abuse--the trend toward prescription drugs. N Engl J Med (2006) 1.92
Pediatric acetaminophen overdose: risk factors associated with hepatocellular injury. Arch Pediatr Adolesc Med (2000) 1.80
The clinical significance of transaminase activities of serum. Am J Med (1959) 1.69
Immunohistochemical localization and quantification of the 3-(cystein-S-yl)-acetaminophen protein adduct in acetaminophen hepatotoxicity. Am J Pathol (1991) 1.57
In vivo mechanisms of tissue-selective drug toxicity: effects of liver-specific knockout of the NADPH-cytochrome P450 reductase gene on acetaminophen toxicity in kidney, lung, and nasal mucosa. Mol Pharmacol (2004) 1.30
Acetaminophen overdose with therapeutic intent. J Pediatr (1998) 1.29
Immunochemical quantitation of 3-(cystein-S-yl)acetaminophen adducts in serum and liver proteins of acetaminophen-treated mice. J Pharmacol Exp Ther (1989) 1.28
Role of inflammation in the mechanism of acetaminophen-induced hepatotoxicity. Expert Opin Drug Metab Toxicol (2005) 1.24
A sensitive immunochemical assay for acetaminophen-protein adducts. J Pharmacol Exp Ther (1987) 1.13
The value of plasma acetaminophen half-life in antidote-treated acetaminophen overdosage. Clin Pharmacol Ther (2002) 1.10
Acetaminophen-induced hepatotoxicity. Life Sci (1981) 1.09
Acetaminophen overdose in children and adolescents. Pediatr Clin North Am (1986) 1.04
Immunohistochemical localization of acetaminophen in target tissues of the CD-1 mouse: correspondence of covalent binding with toxicity. Fundam Appl Toxicol (1995) 1.02
Measurement of acetaminophen-protein adducts in children and adolescents with acetaminophen overdoses. . J Clin Pharmacol (2001) 0.98
Mechanism of paracetamol toxicity. Lancet (1990) 0.97
Identification of the major covalent adduct formed in vitro and in vivo between acetaminophen and mouse liver proteins. Mol Pharmacol (1985) 0.96
Acetaminophen overdose as a suicidal gesture: a survey of adolescents' knowledge of its potential for toxicity. J Am Acad Child Adolesc Psychiatry (1992) 0.95
Mechanisms of acetaminophen toxicity: immunochemical detection of drug-protein adducts. Drug Metab Rev (1995) 0.94
Adolescents' misperceptions of the dangerousness of acetaminophen in overdose. Suicide Life Threat Behav (1997) 0.88
Pharmacokinetic effects of diphenhydramine or oxycodone in simulated acetaminophen overdose. Acad Emerg Med (2005) 0.83
Late increase in acetaminophen concentration after overdose of Tylenol Extended Relief. Ann Emerg Med (1996) 0.83
Acetaminophen and protein thiol modification. Adv Exp Med Biol (1991) 0.82
Formation of chemically reactive metabolites of phenacetin and acetaminophen. Adv Exp Med Biol (1981) 0.82
Estimated risk of hepatotoxicity after an acute acetaminophen overdose in alcoholics. Alcohol (2008) 0.79
Cross-linking of protein molecules by the reactive metabolite of acetaminophen, N-acetyl-p-benzoquinone imine, and related quinoid compounds. Adv Exp Med Biol (1986) 0.78
Structure of the gene encoding the immunodominant surface antigen on the sporozoite of the human malaria parasite Plasmodium falciparum. Science (1984) 8.18
Spatial targeting of interventions against malaria. Bull World Health Organ (2003) 5.51
IS10 transposition is regulated by DNA adenine methylation. Cell (1985) 4.41
Why patients choose paracetamol for self poisoning and their knowledge of its dangers. BMJ (1995) 3.86
Excess number of bladder cancers in workers exposed to ortho-toluidine and aniline. J Natl Cancer Inst (1991) 3.40
Paracetamol self-poisoning. Characteristics, prevention and harm reduction. Br J Psychiatry (1996) 3.07
Smoking during pregnancy and its effects on the fetus. J Obstet Gynaecol Br Commonw (1972) 2.91
Factors contributing to outbreaks of food poisoning in England and Wales 1970-1979. J Hyg (Lond) (1982) 2.87
Xylem embolism in response to freeze-thaw cycles and water stress in ring-porous, diffuse-porous, and conifer species. Plant Physiol (1992) 2.79
Platelet thrombospondin modulates endothelial cell adhesion, motility, and growth: a potential angiogenesis regulatory factor. J Cell Biol (1990) 2.69
Dispensing by the community pharmacist: an unstoppable decline? J R Coll Gen Pract (1988) 2.69
The relationship of phenotype changes in Pseudomonas aeruginosa to the clinical condition of patients with cystic fibrosis. Am Rev Respir Dis (1983) 2.68
Prescribing indicators for UK general practice: Delphi consultation study. BMJ (2000) 2.68
Extracorporeal membrane oxygenation and early-onset group B streptococcal sepsis. Pediatrics (1992) 2.67
Intravenous gamma-globulin treatment and retreatment in Kawasaki disease. US/Canadian Kawasaki Syndrome Study Group. Pediatr Infect Dis J (1998) 2.53
Pyocyanin and 1-hydroxyphenazine produced by Pseudomonas aeruginosa inhibit the beating of human respiratory cilia in vitro. J Clin Invest (1987) 2.40
On the use of nucleic acid sequences to infer early branchings in the tree of life. Mol Biol Evol (1995) 2.36
A Rsc3/Rsc30 zinc cluster dimer reveals novel roles for the chromatin remodeler RSC in gene expression and cell cycle control. Mol Cell (2001) 2.30
The pharmacokinetics of colistin in patients with cystic fibrosis. J Clin Pharmacol (2001) 2.18
Ontogeny of dextromethorphan O- and N-demethylation in the first year of life. Clin Pharmacol Ther (2007) 2.17
The isolation of salmonellas from British pork sausages and sausage meat. J Hyg (Lond) (1975) 2.08
Low Temperature Development Induces a Specific Decrease in trans-Delta-Hexadecenoic Acid Content which Influences LHCII Organization. Plant Physiol (1987) 2.07
Evidence of gentamicin nephrotoxicity in patients with renal allografts. Br Med J (1975) 2.05
Myocardial perforation associated with the use of the Gensini ventriculography catheter. Int J Cardiol (1996) 2.04
Vascular and hepatocellular peroxynitrite formation during acetaminophen toxicity: role of mitochondrial oxidant stress. Toxicol Sci (2001) 2.00
Pharmacokinetic studies in paediatric patients. Clinical and ethical considerations. Clin Pharmacokinet (1992) 1.94
Molecular fingerprinting defines a strain of Salmonella enterica serotype Anatum responsible for an international outbreak associated with formula-dried milk. Epidemiol Infect (1998) 1.87
Dispensing doctors. BMJ (1992) 1.87
Pediatric acetaminophen overdose: risk factors associated with hepatocellular injury. Arch Pediatr Adolesc Med (2000) 1.80
Glucuronidation in humans. Pharmacogenetic and developmental aspects. Clin Pharmacokinet (1999) 1.79
Effect of bacterial products on human ciliary function in vitro. Thorax (1985) 1.78
Growth phase variation of integration host factor level in Escherichia coli. J Bacteriol (1994) 1.70
Variation in therapy and outcome for pediatric head trauma patients. Crit Care Med (2001) 1.69
Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatotoxicity and the formation of reactive oxygen and nitrogen species. Hepatology (1999) 1.68
Population pharmacokinetics of fluconazole in young infants. Antimicrob Agents Chemother (2008) 1.68
Cytochrome P450 3A: ontogeny and drug disposition. Clin Pharmacokinet (1999) 1.67
Selective protein covalent binding and target organ toxicity. Toxicol Appl Pharmacol (1997) 1.66
Information data bases. Lancet (1990) 1.63
Syndrome of inappropriate antidiuretic hormone secretion in children following spinal fusion. Crit Care Med (1999) 1.60
Immunohistochemical localization and quantification of the 3-(cystein-S-yl)-acetaminophen protein adduct in acetaminophen hepatotoxicity. Am J Pathol (1991) 1.57
Optimized conditions for the growth of human epidermal cells in culture. J Invest Dermatol (1980) 1.57
Assessing distress in pediatric intensive care environments: the COMFORT scale. J Pediatr Psychol (1992) 1.56
Fracture liaison services for the evaluation and management of patients with osteoporotic fracture: a cost-effectiveness evaluation based on data collected over 8 years of service provision. Osteoporos Int (2011) 1.55
Intercellular adhesion molecule-1 and CD36 synergize to mediate adherence of Plasmodium falciparum-infected erythrocytes to cultured human microvascular endothelial cells. J Clin Invest (1997) 1.55
Acute hepatic failure associated with the use of sodium valproate. N Engl J Med (1979) 1.55
Bradycardia during anesthesia in infants. An epidemiologic study. Anesthesiology (1994) 1.53
Indinavir population pharmacokinetics in plasma and cerebrospinal fluid. The HIV Neurobehavioral Research Center Group. Antimicrob Agents Chemother (2000) 1.52
An isotopic assay for thymidylate synthetase. Biochemistry (1966) 1.52
Squamous cell carcinoma of the tongue in young adults: increasing incidence and factors that predict treatment outcomes. Otolaryngol Head Neck Surg (2000) 1.51
Factors determining maintenance of sinus rhythm after chronic atrial fibrillation with left atrial dilatation. Am J Cardiol (1989) 1.50
A method for noninvasive determination of inspiratory resistance during proportional assist ventilation. Am J Respir Crit Care Med (2001) 1.48
Development of a PCR-based line probe assay for identification of fungal pathogens. J Clin Microbiol (2000) 1.48
In utero infection due to Pasteurella multocida in the first trimester of pregnancy: case report and review. Clin Infect Dis (1992) 1.47
Clinical pharmacology: a discipline called to action for maternal and child health. Clin Pharmacol Ther (2007) 1.46
Video-EEG monitoring in newborns with hypoxic-ischemic encephalopathy treated with hypothermia. Neurology (2011) 1.45
DSS4-1 is a dominant suppressor of sec4-8 that encodes a nucleotide exchange protein that aids Sec4p function. Nature (1993) 1.45
An outbreak of Salmonella dublin infection in England and Wales associated with a soft unpasteurized cows' milk cheese. Epidemiol Infect (1992) 1.44
Mechanical ventilators optimized for pediatric use decrease work of breathing and oxygen consumption during pressure-support ventilation. Crit Care Med (1994) 1.44
Cardiac toxicity associated with intravenous erythromycin lactobionate: two case reports and a review of the literature. Pediatr Infect Dis J (1993) 1.43
A national outbreak of Salmonella typhimurium DT 124 caused by contaminated salami sticks. Epidemiol Infect (1989) 1.43
Computerized dynamic visual acuity test in the assessment of vestibular deficits. Am J Otol (1998) 1.43
Studies on the growth of Vibrio cholerae biotype eltor and biotype classical in foods. J Hyg (Lond) (1982) 1.42
A pro forma and review process for the assessment of standards of care in stillbirths. BJOG (2011) 1.41
Extracapsular spread. A significant predictor of treatment failure in patients with squamous cell carcinoma of the tongue. Cancer (2001) 1.40
Ethical and practical considerations of withdrawal of treatment in the intensive care unit. Can J Anaesth (1999) 1.40
Intraoperative assessement of coronary flow and coronary vascular resistance during coronary bypass surgery. Scand Cardiovasc J (1999) 1.39
Arctic willy. BMJ (1990) 1.39
BLOOD-BORNE PYOGENIC INFECTIONS OF BONES AND JOINTS. Ann Surg (1940) 1.39
Methotrexate and cytosine arabinoside modulation of thymidylate synthetase activity in CCRF-CEM cells. Cancer Res (1971) 1.39
Application of pharmacokinetics in the diagnosis of chemical abuse in Münchausen syndrome by proxy. Clin Pediatr (Phila) (1988) 1.38
Investigating relationships between a range of potential indicators of general practice prescribing: an observational study. J Clin Pharm Ther (1998) 1.38
Paraproteinaemia after allo-SCT, association with alemtuzumab-based conditioning and CMV reactivation. Bone Marrow Transplant (2010) 1.38
Efficacy of antiperspirants on feet. Mil Med (1992) 1.37
Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data. Pharmacogenetics (1999) 1.36
A mammalian guanine-nucleotide-releasing protein enhances function of yeast secretory protein Sec4. Nature (1993) 1.34
Identification and preliminary characterization of protein-cysteine farnesyltransferase. Proc Natl Acad Sci U S A (1990) 1.33
Permanent pacemaker insertion after CoreValve transcatheter aortic valve implantation: incidence and contributing factors (the UK CoreValve Collaborative). Circulation (2011) 1.30
A double-blind pilot study of risperidone in the treatment of conduct disorder. J Am Acad Child Adolesc Psychiatry (2000) 1.30
Acetaminophen overdose with therapeutic intent. J Pediatr (1998) 1.29
Immunochemical quantitation of 3-(cystein-S-yl)acetaminophen adducts in serum and liver proteins of acetaminophen-treated mice. J Pharmacol Exp Ther (1989) 1.28
Biochemical characterization and deletion analysis of recombinant human protein phosphatase 2C alpha. Biochem J (1996) 1.27
Guidelines for the microbiological quality of some ready-to-eat foods sampled at the point of sale. PHLS Advisory Committee for Food and Dairy Products. Commun Dis Public Health (2000) 1.27
Determination of imipenem and cilastatin in serum by high-pressure liquid chromatography. Antimicrob Agents Chemother (1984) 1.27
Examination of raw beef products for the presence of Vero cytotoxin producing Escherichia coli, particularly those of serogroup O157. J Appl Bacteriol (1993) 1.26
Merkel cell carcinoma of the head and neck: effect of surgical excision and radiation on recurrence and survival. Arch Otolaryngol Head Neck Surg (2001) 1.26
Immediate action needed to improve labeling of prescription drugs for pediatric patients. Ann Pharmacother (1997) 1.25
Informing prescribing allocations at district level in England. J Health Serv Res Policy (1997) 1.25
Molecular mechanisms of sequestration in malaria. Parasitology (1994) 1.25
Proportional assist ventilation. Results of an initial clinical trial. Am Rev Respir Dis (1992) 1.24
Infertile or childless by choice? A multipractice survey of women aged 35 and 50. Br Med J (Clin Res Ed) (1987) 1.23
Physiotherapy exercises and back pain. BMJ (1991) 1.22
Role of cell-generated hydrogen peroxide in granulocyte-mediated killing of schistosomula of Schistosoma mansoni in vitro. J Clin Invest (1981) 1.22
Principles of drug biodisposition in the neonate. A critical evaluation of the pharmacokinetic-pharmacodynamic interface (Part I). Clin Pharmacokinet (1988) 1.22
Developmental pharmacodynamics of cyclosporine. Clin Pharmacol Ther (1999) 1.22
Review of knee proprioception and the relation to extremity function after an anterior cruciate ligament rupture. J Orthop Sports Phys Ther (2001) 1.22
Randomized placebo-controlled trial of a 42-Day tapering course of dexamethasone to reduce the duration of ventilator dependency in very low birth weight infants. Pediatrics (1999) 1.21
Cefotaxime and desacetylcefotaxime pharmacokinetics in infants and children with meningitis. Antimicrob Agents Chemother (1985) 1.20