Published in J Mol Biol on October 07, 2008
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Aromatic small molecules remodel toxic soluble oligomers of amyloid beta through three independent pathways. J Biol Chem (2010) 1.20
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Structure-based design of conformation- and sequence-specific antibodies against amyloid β. Proc Natl Acad Sci U S A (2011) 1.05
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Isolation and characterization of antibody fragments selective for specific protein morphologies from nanogram antigen samples. Biotechnol Prog (2013) 0.85
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Novel amyloid-beta specific scFv and VH antibody fragments from human and mouse phage display antibody libraries. J Neuroimmunol (2010) 0.80
Restricted V gene usage and VH/VL pairing of mouse humoral response against the N-terminal immunodominant epitope of the amyloid β peptide. Mol Immunol (2010) 0.80
Novel atomic force microscopy based biopanning for isolation of morphology specific reagents against TDP-43 variants in amyotrophic lateral sclerosis. J Vis Exp (2015) 0.80
Effects of an amyloid-beta 1-42 oligomers antibody screened from a phage display library in APP/PS1 transgenic mice. Brain Res (2016) 0.78
Construction of human Fab library and screening of a single-domain antibody of amyloid-beta 42 oligomers. Neural Regen Res (2013) 0.77
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Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models. FASEB J (2006) 1.32
Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42. Neurobiol Dis (2005) 1.26
Isolation of a human single chain antibody fragment against oligomeric alpha-synuclein that inhibits aggregation and prevents alpha-synuclein-induced toxicity. J Mol Biol (2007) 1.24
A human single-chain Fv intrabody blocks aberrant cellular effects of overexpressed alpha-synuclein. Mol Ther (2004) 1.22
Inhibiting aggregation of alpha-synuclein with human single chain antibody fragments. Biochemistry (2004) 1.12
Residues 17-20 and 30-35 of beta-amyloid play critical roles in aggregation. J Neurosci Res (2004) 1.11
Detecting morphologically distinct oligomeric forms of alpha-synuclein. J Biol Chem (2009) 1.06
CSF levels of oligomeric alpha-synuclein and beta-amyloid as biomarkers for neurodegenerative disease. Integr Biol (Camb) (2011) 1.03
Isolating recombinant antibodies against specific protein morphologies using atomic force microscopy and phage display technologies. Protein Eng Des Sel (2006) 1.01
Curcumin reduces alpha-synuclein induced cytotoxicity in Parkinson's disease cell model. BMC Neurosci (2010) 1.01
Conformational targeting of fibrillar polyglutamine proteins in live cells escalates aggregation and cytotoxicity. PLoS One (2009) 1.01
Single chain variable fragments against beta-amyloid (Abeta) can inhibit Abeta aggregation and prevent abeta-induced neurotoxicity. Biochemistry (2004) 1.01
Physico-chemical determinants of soluble intrabody expression in mammalian cell cytoplasm. Protein Eng Des Sel (2010) 0.95
Intracellular targeting and clearance of oligomeric alpha-synuclein alleviates toxicity in mammalian cells. Neurosci Lett (2009) 0.94
Quantification of cytokines involved in wound healing using surface plasmon resonance. Anal Chem (2005) 0.93
Characterizing antibody specificity to different protein morphologies by AFM. Langmuir (2009) 0.90
Trimeric tau is toxic to human neuronal cells at low nanomolar concentrations. Int J Cell Biol (2013) 0.89
Single chain Fv antibodies against the 25-35 Abeta fragment inhibit aggregation and toxicity of Abeta42. Biochemistry (2006) 0.86
Nanobody specific for oligomeric β-amyloid stabilizes nontoxic form. Neurobiol Aging (2010) 0.86
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Proteolytic antibody light chains alter beta-amyloid aggregation and prevent cytotoxicity. Biochemistry (2004) 0.85
Single-molecule selection and recovery of structure-specific antibodies using atomic force microscopy. Nanomedicine (2007) 0.84
Cyclodextrins promote protein aggregation posing risks for therapeutic applications. Biochem Biophys Res Commun (2009) 0.82
Inhibiting β-secretase activity in Alzheimer's disease cell models with single-chain antibodies specifically targeting APP. J Mol Biol (2010) 0.82
A sensitive phage-based capture ELISA for sub-femtomolar detection of protein variants directly from biological samples. Biotechnol Prog (2014) 0.81
Degradation of beta-amyloid by proteolytic antibody light chains. Biochemistry (2003) 0.81
Identification and repair of positive binding antibodies containing randomly generated amber codons from synthetic phage display libraries. Biotechnol Prog (2006) 0.79
Engineered proteolytic nanobodies reduce Abeta burden and ameliorate Abeta-induced cytotoxicity. Biochemistry (2010) 0.79
Bispecific tandem single chain antibody simultaneously inhibits β-secretase and promotes α-secretase processing of AβPP. J Alzheimers Dis (2012) 0.79
Anti-oligomeric single chain variable domain antibody differentially affects huntingtin and alpha-synuclein aggregates. FEBS Lett (2008) 0.78
Generation and Characterization of an scFv Directed against Site II of Rabies Glycoprotein. Biotechnol Res Int (2011) 0.77
Human α4β2 nicotinic acetylcholine receptor as a novel target of oligomeric α-synuclein. PLoS One (2013) 0.76
Characterization of an antibody scFv that recognizes fibrillar insulin and beta-amyloid using atomic force microscopy. Nanomedicine (2008) 0.75
Antifibrillizing agents catalyze the formation of unstable intermediate aggregates of beta-amyloid. Biotechnol Prog (2010) 0.75
3D-printed microfluidic chips with patterned, cell-laden hydrogel constructs. Biofabrication (2016) 0.75