Published in Free Radic Biol Med on October 07, 2008
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The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress. Mol Cell Biol (2007) 2.07
Identification of the functional domain of p21(WAF1/CIP1) that protects cells from cisplatin cytotoxicity. Am J Physiol Renal Physiol (2005) 1.74
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The cyclin-dependent kinase inhibitor p21 protects the lung from oxidative stress. Am J Respir Cell Mol Biol (2001) 1.41
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Endoplasmic reticulum chaperones inhibit the production of amyloid-beta peptides. Biochem J (2007) 1.24
Hyperoxia-induced signal transduction pathways in pulmonary epithelial cells. Free Radic Biol Med (2007) 1.16
Bcl-2 protects against hyperoxia-induced apoptosis through inhibition of the mitochondria-dependent pathway. Free Radic Biol Med (2007) 1.14
Multiple alternate p21 transcripts are regulated by p53 in human cells. Oncogene (2006) 1.09
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Downregulation of PCNA potentiates p21-mediated growth inhibition in response to hyperoxia. Am J Physiol Lung Cell Mol Physiol (2006) 1.00
Brap2 functions as a cytoplasmic retention protein for p21 during monocyte differentiation. Mol Cell Biol (2004) 0.95
The Cdk and PCNA domains on p21Cip1 both function to inhibit G1/S progression during hyperoxia. Am J Physiol Lung Cell Mol Physiol (2003) 0.93
p21Cip1 protection against hyperoxia requires Bcl-XL and is uncoupled from its ability to suppress growth. Am J Pathol (2006) 0.91
Endothelial Akt activation by hyperoxia: role in cell survival. Free Radic Biol Med (2005) 0.90
PUMA inactivation protects against oxidative stress through p21/Bcl-XL inhibition of bax death. Free Radic Biol Med (2007) 0.89
Identification of the nuclear localization signal of p21(cip1) and consequences of its mutation on cell proliferation. FEBS Lett (2002) 0.88
p21(Cip1/Waf1/Sdi1) protects against hyperoxia by maintaining expression of Bcl-X(L). Free Radic Biol Med (2006) 0.87
Analysis of cellular response to protein overexpression. Syst Biol (Stevenage) (2005) 0.87
Hyperoxia alters the expression and phosphorylation of multiple factors regulating translation initiation. Am J Physiol Lung Cell Mol Physiol (2004) 0.83
p21WAF1/CIP1 regulates the p300 sumoylation motif CRD1 through a C-terminal domain independently of cyclin/CDK binding. Cell Cycle (2005) 0.82
Identification of the region required for the antiapoptotic function of the cyclin kinase inhibitor, p21. Arch Biochem Biophys (2004) 0.80
p21(Waf1/Cip1) regulates proliferation and apoptosis in airway epithelial cells and alternative forms have altered binding activities. Exp Lung Res (2004) 0.80
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Type II epithelial cells are critical target for hyperoxia-mediated impairment of postnatal lung development. Am J Physiol Lung Cell Mol Physiol (2006) 1.58
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In vivo exposure to hyperoxia induces DNA damage in a population of alveolar type II epithelial cells. Am J Physiol Lung Cell Mol Physiol (2004) 1.08
Hyperoxic ventilated premature baboons have increased p53, oxidant DNA damage and decreased VEGF expression. Pediatr Res (2005) 1.07
The role of hyperoxia in the pathogenesis of experimental BPD. Semin Perinatol (2013) 1.02
Downregulation of PCNA potentiates p21-mediated growth inhibition in response to hyperoxia. Am J Physiol Lung Cell Mol Physiol (2006) 1.00
Increased epithelial cell proliferation in very premature baboons with chronic lung disease. Am J Physiol Lung Cell Mol Physiol (2002) 0.98
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Lung development and the host response to influenza A virus are altered by different doses of neonatal oxygen in mice. Am J Physiol Lung Cell Mol Physiol (2012) 0.95
The Cdk and PCNA domains on p21Cip1 both function to inhibit G1/S progression during hyperoxia. Am J Physiol Lung Cell Mol Physiol (2003) 0.93
p21Cip1 protection against hyperoxia requires Bcl-XL and is uncoupled from its ability to suppress growth. Am J Pathol (2006) 0.91
Neonatal hyperoxia alters the host response to influenza A virus infection in adult mice through multiple pathways. Am J Physiol Lung Cell Mol Physiol (2013) 0.91
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The RNA surveillance protein SMG1 activates p53 in response to DNA double-strand breaks but not exogenously oxidized mRNA. Cell Cycle (2011) 0.90
Parenchymal cell TNF receptors contribute to inflammatory cell recruitment and respiratory failure in Pneumocystis carinii-induced pneumonia. J Immunol (2008) 0.90
Growth arrest in G1 protects against oxygen-induced DNA damage and cell death. J Cell Physiol (2002) 0.89
Transdifferentiation of alveolar epithelial type II to type I cells is controlled by opposing TGF-β and BMP signaling. Am J Physiol Lung Cell Mol Physiol (2013) 0.89
PUMA inactivation protects against oxidative stress through p21/Bcl-XL inhibition of bax death. Free Radic Biol Med (2007) 0.89
Neonatal hyperoxia stimulates the expansion of alveolar epithelial type II cells. Am J Respir Cell Mol Biol (2014) 0.88
Hyperoxia augments ER-stress-induced cell death independent of BiP loss. Free Radic Biol Med (2009) 0.88
Activation of the G2 cell cycle checkpoint enhances survival of epithelial cells exposed to hyperoxia. Am J Physiol Lung Cell Mol Physiol (2002) 0.88
p21(Cip1/Waf1/Sdi1) protects against hyperoxia by maintaining expression of Bcl-X(L). Free Radic Biol Med (2006) 0.87
p53 modulates radiation sensitivity independent of p21 transcriptional activation. Am J Clin Oncol (2005) 0.86
Epithelial ablation of Bcl-XL increases sensitivity to oxygen without disrupting lung development. Am J Respir Cell Mol Biol (2009) 0.85
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Bcl-X(L) is the primary mediator of p21 protection against hyperoxia-induced cell death. Exp Lung Res (2010) 0.81
Loss of Gadd45a does not modify the pulmonary response to oxidative stress. Am J Physiol Lung Cell Mol Physiol (2005) 0.80
Neonatal oxygen exposure alters airway hyper-responsiveness but not the response to allergen challenge in adult mice. Pediatr Allergy Immunol (2014) 0.80
Selective ablation of lung epithelial IKK2 impairs pulmonary Th17 responses and delays the clearance of Pneumocystis. J Immunol (2013) 0.79
Murine mechanical ventilation stimulates alveolar epithelial cell proliferation. Exp Lung Res (2010) 0.76
Carbonic anhydrase XII mRNA encodes a hydratase that is differentially expressed along the rabbit nephron. Am J Physiol Renal Physiol (2002) 0.75
p21(Cip1/WAF1/Sdi1) does not affect expression of base excision DNA repair enzymes during chronic oxidative stress. Antioxid Redox Signal (2005) 0.75
Macroarray analysis reveals a strain-induced oxidant response in pulmonary epithelial cells. Exp Lung Res (2004) 0.75