Published in Dev Cell on September 01, 2007
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell (2010) 10.96
From endoplasmic-reticulum stress to the inflammatory response. Nature (2008) 7.17
The impact of the unfolded protein response on human disease. J Cell Biol (2012) 4.36
Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. J Clin Invest (2008) 4.30
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Dev Cell (2008) 4.26
Protein quality control in the early secretory pathway. EMBO J (2008) 3.59
The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes. Endocr Rev (2008) 3.56
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice. Cell Metab (2008) 3.45
Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells. Cell Metab (2009) 3.28
The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature (2009) 2.48
Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome. Mol Cell (2009) 2.47
Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells. J Clin Invest (2010) 2.22
Endoplasmic reticulum stress and type 2 diabetes. Annu Rev Biochem (2012) 2.10
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis. EMBO J (2011) 2.08
Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects. J Clin Endocrinol Metab (2008) 2.07
The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex. Cell Metab (2011) 2.02
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability. Proc Natl Acad Sci U S A (2009) 2.00
Methods for monitoring endoplasmic reticulum stress and the unfolded protein response. Int J Cell Biol (2010) 1.91
Protein kinase Ctheta is required for autophagy in response to stress in the endoplasmic reticulum. J Biol Chem (2008) 1.89
Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments. Cell Rep (2013) 1.87
Linking ER Stress to Autophagy: Potential Implications for Cancer Therapy. Int J Cell Biol (2010) 1.86
A review of the mammalian unfolded protein response. Biotechnol Bioeng (2011) 1.83
Measuring ER stress and the unfolded protein response using mammalian tissue culture system. Methods Enzymol (2011) 1.80
PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage. Oncogene (2010) 1.77
Selective activation of ATF6 and PERK endoplasmic reticulum stress signaling pathways prevent mutant rhodopsin accumulation. Invest Ophthalmol Vis Sci (2012) 1.74
The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress. Mol Biol Cell (2011) 1.73
Extensive pancreas regeneration following acinar-specific disruption of Xbp1 in mice. Gastroenterology (2011) 1.72
Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stress. Mol Biol Cell (2010) 1.70
Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. Proc Natl Acad Sci U S A (2009) 1.69
PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation. Proc Natl Acad Sci U S A (2008) 1.66
Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. FASEB J (2011) 1.65
Activation of calcium/calmodulin-dependent protein kinase II in obesity mediates suppression of hepatic insulin signaling. Cell Metab (2013) 1.61
Beta-cell failure as a complication of diabetes. Rev Endocr Metab Disord (2008) 1.60
Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion. Proc Natl Acad Sci U S A (2011) 1.59
Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease. J Biol Chem (2011) 1.58
ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulum. J Cell Sci (2009) 1.57
The Unfolded Protein Response Triggers Site-Specific Regulatory Ubiquitylation of 40S Ribosomal Proteins. Mol Cell (2015) 1.55
ATF6alpha-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo. Proc Natl Acad Sci U S A (2008) 1.54
From HLA-B27 to spondyloarthritis: a journey through the ER. Immunol Rev (2010) 1.52
Endoplasmic reticulum stress response in cancer: molecular mechanism and therapeutic potential. Am J Transl Res (2010) 1.47
The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells. PLoS Biol (2015) 1.47
The role of the unfolded protein response in the heart. J Mol Cell Cardiol (2007) 1.39
Protein misfolding in the endoplasmic reticulum as a conduit to human disease. Nature (2016) 1.37
Mechanisms of lipotoxicity in NAFLD and clinical implications. J Pediatr Gastroenterol Nutr (2011) 1.35
ER stress and its functional link to mitochondria: role in cell survival and death. Cold Spring Harb Perspect Biol (2011) 1.33
Identification and characterization of endoplasmic reticulum stress-induced apoptosis in vivo. Methods Enzymol (2008) 1.28
The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice. Gastroenterology (2013) 1.27
CHOP-independent apoptosis and pathway-selective induction of the UPR in developing plasma cells. Mol Immunol (2009) 1.26
Intersection of the unfolded protein response and hepatic lipid metabolism. Cell Mol Life Sci (2009) 1.24
Endoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes. Cold Spring Harb Perspect Med (2012) 1.23
Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration. Int Rev Cell Mol Biol (2013) 1.23
ATF6beta is a host cellular target of the Toxoplasma gondii virulence factor ROP18. J Exp Med (2011) 1.21
Coronavirus infection modulates the unfolded protein response and mediates sustained translational repression. J Virol (2008) 1.19
Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress. Biochem J (2011) 1.14
Deficiency of suppressor enhancer Lin12 1 like (SEL1L) in mice leads to systemic endoplasmic reticulum stress and embryonic lethality. J Biol Chem (2010) 1.14
The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in β-cells. Diabetes Obes Metab (2010) 1.14
Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice. J Clin Invest (2009) 1.13
Regulation of apoptosis by the unfolded protein response. Methods Mol Biol (2009) 1.12
Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia. Nat Genet (2015) 1.12
The endoplasmic reticulum stress sensor, ATF6α, protects against neurotoxin-induced dopaminergic neuronal death. J Biol Chem (2010) 1.09
Coxsackievirus B3 infection activates the unfolded protein response and induces apoptosis through downregulation of p58IPK and activation of CHOP and SREBP1. J Virol (2010) 1.08
Bacteria, the endoplasmic reticulum and the unfolded protein response: friends or foes? Nat Rev Microbiol (2014) 1.08
Multiple Mechanisms of Unfolded Protein Response-Induced Cell Death. Am J Pathol (2015) 1.08
Mechanisms and clinical implications of hepatocyte lipoapoptosis. Clin Lipidol (2010) 1.07
MicroRNA-30c-2* limits expression of proadaptive factor XBP1 in the unfolded protein response. J Cell Biol (2012) 1.05
Monitoring and manipulating mammalian unfolded protein response. Methods Enzymol (2011) 1.05
Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking. PLoS One (2012) 1.05
The unfolded protein response in neurodegenerative diseases: a neuropathological perspective. Acta Neuropathol (2015) 1.05
C/EBP homologous protein (CHOP) contributes to suppression of metabolic genes during endoplasmic reticulum stress in the liver. J Biol Chem (2012) 1.04
Fatty acids and the endoplasmic reticulum in nonalcoholic fatty liver disease. Biofactors (2010) 1.04
Endoplasmic reticulum stress as a pro-fibrotic stimulus. Biochim Biophys Acta (2012) 1.03
Endoplasmic reticulum stress and lipid metabolism: mechanisms and therapeutic potential. Biochem Res Int (2011) 1.03
Influenza A viral replication is blocked by inhibition of the inositol-requiring enzyme 1 (IRE1) stress pathway. J Biol Chem (2011) 1.01
IRE1alpha controls cyclin A1 expression and promotes cell proliferation through XBP-1. Cell Stress Chaperones (2009) 1.01
The stress-regulated transcription factor CHOP promotes hepatic inflammatory gene expression, fibrosis, and oncogenesis. PLoS Genet (2013) 1.01
p21(Cip1) protects against oxidative stress by suppressing ER-dependent activation of mitochondrial death pathways. Free Radic Biol Med (2008) 1.00
Gender differences control the susceptibility to ER stress-induced acute kidney injury. Am J Physiol Renal Physiol (2013) 1.00
Endoplasmic reticulum stress response in an INS-1 pancreatic beta-cell line with inducible expression of a folding-deficient proinsulin. BMC Cell Biol (2010) 1.00
A novel protein, Luman/CREB3 recruitment factor, inhibits Luman activation of the unfolded protein response. Mol Cell Biol (2008) 1.00
Potential for therapeutic manipulation of the UPR in disease. Semin Immunopathol (2013) 0.99
Endoplasmic reticulum stress in the β-cell pathogenesis of type 2 diabetes. Exp Diabetes Res (2011) 0.98
Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish. PLoS Genet (2014) 0.97
Protein disulfide isomerase A6 controls the decay of IRE1α signaling via disulfide-dependent association. Mol Cell (2014) 0.97
Inflammation and cellular stress: a mechanistic link between immune-mediated and metabolically driven pathologies. Eur J Nutr (2011) 0.97
Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis. EMBO J (2014) 0.96
Crosstalk Between Endoplasmic Reticulum Stress, Oxidative Stress, and Autophagy: Potential Therapeutic Targets for Acute CNS Injuries. Mol Neurobiol (2014) 0.95
Stressed to death: targeting endoplasmic reticulum stress response induced apoptosis in gliomas. Curr Pharm Des (2011) 0.95
BiP availability distinguishes states of homeostasis and stress in the endoplasmic reticulum of living cells. Mol Biol Cell (2010) 0.95
Myelin under stress. J Neurosci Res (2009) 0.94
A functional haplotype in EIF2AK3, an ER stress sensor, is associated with lower bone mineral density. J Bone Miner Res (2012) 0.93
Unfolded Protein Response (UPR) is activated during normal lens development. Gene Expr Patterns (2010) 0.93
Acute infection of mice with Clostridium difficile leads to eIF2α phosphorylation and pro-survival signalling as part of the mucosal inflammatory response. Immunology (2013) 0.93
ATF6 signaling is required for efficient West Nile virus replication by promoting cell survival and inhibition of innate immune responses. J Virol (2012) 0.92
Neuronal endoplasmic reticulum stress in axon injury and neurodegeneration. Ann Neurol (2013) 0.92
Defining hepatic dysfunction parameters in two models of fatty liver disease in zebrafish larvae. Zebrafish (2013) 0.91
Alcohol disrupts endoplasmic reticulum function and protein secretion in hepatocytes. Alcohol Clin Exp Res (2011) 0.91
Regulation of the transcriptome by ER stress: non-canonical mechanisms and physiological consequences. Front Genet (2013) 0.90
Endoplasmic reticulum stress impairs IL-4/IL-13 signaling through C/EBPβ-mediated transcriptional suppression. J Cell Sci (2013) 0.89
The unfolded protein response in retinal vascular diseases: implications and therapeutic potential beyond protein folding. Prog Retin Eye Res (2014) 0.89
Peroxisome deficiency causes a complex phenotype because of hepatic SREBP/Insig dysregulation associated with endoplasmic reticulum stress. J Biol Chem (2008) 0.89
The mammalian unfolded protein response. Annu Rev Biochem (2005) 16.31
Stress granules and processing bodies are dynamically linked sites of mRNP remodeling. J Cell Biol (2005) 9.25
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science (2005) 7.98
A trip to the ER: coping with stress. Trends Cell Biol (2004) 7.67
From endoplasmic-reticulum stress to the inflammatory response. Nature (2008) 7.17
Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins. PLoS Biol (2006) 6.45
ER stress and the unfolded protein response. Mutat Res (2005) 6.43
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes Dev (2002) 6.37
The endoplasmic reticulum and the unfolded protein response. Semin Cell Dev Biol (2007) 5.59
Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway. Proc Natl Acad Sci U S A (2001) 5.59
Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid Redox Signal (2007) 5.17
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell (2006) 5.10
A time-dependent phase shift in the mammalian unfolded protein response. Dev Cell (2003) 4.99
Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol (2003) 4.77
The impact of the unfolded protein response on human disease. J Cell Biol (2012) 4.36
Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. J Clin Invest (2008) 4.30
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Dev Cell (2008) 4.26
Endoplasmic reticulum stress in liver disease. J Hepatol (2010) 3.90
Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation. J Biol Chem (2003) 3.89
ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nat Cell Biol (2013) 3.84
ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. EMBO J (2005) 3.79
Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2. EMBO J (2004) 3.77
Antioxidants reduce endoplasmic reticulum stress and improve protein secretion. Proc Natl Acad Sci U S A (2008) 3.58
The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes. Endocr Rev (2008) 3.56
The unfolded protein response: a stress signaling pathway critical for health and disease. Neurology (2006) 3.46
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression. Mol Cell Biol (2006) 3.31
Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells. Cell Metab (2009) 3.28
That which does not kill me makes me stronger: adapting to chronic ER stress. Trends Biochem Sci (2007) 3.20
The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature (2004) 3.18
The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis. J Clin Invest (2005) 3.16
Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses. Mol Cell Biol (2003) 3.01
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Mol Cell Biol (2004) 3.00
The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response. Proc Natl Acad Sci U S A (2006) 2.90
Signaling the unfolded protein response from the endoplasmic reticulum. J Biol Chem (2004) 2.87
Heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and mediates survival upon arsenite exposure. J Biol Chem (2005) 2.85
Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation. Mol Biol Cell (2006) 2.84
Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis. Nat Med (2005) 2.83
Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation. J Cell Biol (2006) 2.76
mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice. J Clin Invest (2011) 2.72
Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II. J Biochem (2004) 2.62
Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway. Nat Cell Biol (2006) 2.58
The zipper model of translational control: a small upstream ORF is the switch that controls structural remodeling of an mRNA leader. Cell (2003) 2.50
Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control. EMBO J (2006) 2.41
Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome. Cell Metab (2012) 2.39
Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. PLoS Genet (2005) 2.33
Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response. J Biol Chem (2004) 2.29
Importance of eIF2alpha phosphorylation and stress granule assembly in alphavirus translation regulation. Mol Biol Cell (2005) 2.27
ER stress signaling by regulated splicing: IRE1/HAC1/XBP1. Methods (2005) 2.25
The role of p58IPK in protecting the stressed endoplasmic reticulum. Mol Biol Cell (2007) 2.20
PKR protects colonic epithelium against colitis through the unfolded protein response and prosurvival signaling. Inflamm Bowel Dis (2012) 2.20
ER stress controls iron metabolism through induction of hepcidin. Science (2009) 2.18
Endoplasmic reticulum stress and type 2 diabetes. Annu Rev Biochem (2012) 2.10
The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis. EMBO J (2011) 2.08
Activation of GCN2 in UV-irradiated cells inhibits translation. Curr Biol (2002) 2.02
The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex. Cell Metab (2011) 2.02
MT1-MMP-dependent control of skeletal stem cell commitment via a β1-integrin/YAP/TAZ signaling axis. Dev Cell (2013) 1.95
Protein kinase Ctheta is required for autophagy in response to stress in the endoplasmic reticulum. J Biol Chem (2008) 1.89
Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex. Nat Genet (2003) 1.82
Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS. Proc Natl Acad Sci U S A (2009) 1.78
Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa. J Biol Chem (2006) 1.78
Bioengineering of coagulation factor VIII for improved secretion. Blood (2004) 1.76
Inhibition of the ubiquitin-proteasome system induces stress granule formation. Mol Biol Cell (2007) 1.75
Reovirus induces and benefits from an integrated cellular stress response. J Virol (2006) 1.74
Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development. Proc Natl Acad Sci U S A (2009) 1.68
The unfolded protein response--a stress signaling pathway of the endoplasmic reticulum. J Chem Neuroanat (2004) 1.63
The protein kinase/endoribonuclease IRE1alpha that signals the unfolded protein response has a luminal N-terminal ligand-independent dimerization domain. J Biol Chem (2002) 1.63
TDAG51 is induced by homocysteine, promotes detachment-mediated programmed cell death, and contributes to the cevelopment of atherosclerosis in hyperhomocysteinemia. J Biol Chem (2003) 1.61
ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulum. J Cell Sci (2009) 1.57
IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis. Cell Metab (2012) 1.56
Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity. Cell Host Microbe (2010) 1.56
Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis. J Biol Chem (2006) 1.53
A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells. Sci Signal (2010) 1.52
Cytoplasmic IRE1alpha-mediated XBP1 mRNA splicing in the absence of nuclear processing and endoplasmic reticulum stress. J Biol Chem (2006) 1.52
Initiation of protein synthesis by hepatitis C virus is refractory to reduced eIF2.GTP.Met-tRNA(i)(Met) ternary complex availability. Mol Biol Cell (2006) 1.51
Divergent roles of IRE1alpha and PERK in the unfolded protein response. Curr Mol Med (2006) 1.50
Uncoupling stress granule assembly and translation initiation inhibition. Mol Biol Cell (2009) 1.49
Conservative mutations in the C2 domains of factor VIII and factor V alter phospholipid binding and cofactor activity. Blood (2012) 1.49
Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease. Antioxid Redox Signal (2014) 1.47
Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H. Hepatology (2008) 1.47
All roads lead to ATF4. Dev Cell (2003) 1.44
Unfolded protein response. Curr Biol (2012) 1.44
LMAN1 and MCFD2 form a cargo receptor complex and interact with coagulation factor VIII in the early secretory pathway. J Biol Chem (2005) 1.44
Adaptation of endoplasmic reticulum exit sites to acute and chronic increases in cargo load. EMBO J (2008) 1.41
Structure and intermolecular interactions of the luminal dimerization domain of human IRE1alpha. J Biol Chem (2003) 1.40
CAS P8 -652 6N del polymorphism and breast cancer risk: a systematic review and meta-analysis. Neth J Med (2014) 1.40