Published in Drug Metab Rev on January 01, 2008
Genes that confer the identity of the renin cell. J Am Soc Nephrol (2011) 1.52
An initial map of chromosomal segmental copy number variations in the chicken. BMC Genomics (2010) 1.24
Aldo-keto reductase (AKR) superfamily: genomics and annotation. Hum Genomics (2009) 1.16
Aldose reductase: a novel therapeutic target for inflammatory pathologies. Int J Biochem Cell Biol (2009) 1.00
Effect of graded Nrf2 activation on phase-I and -II drug metabolizing enzymes and transporters in mouse liver. PLoS One (2012) 0.99
Smoking-induced upregulation of AKR1B10 expression in the airway epithelium of healthy individuals. Chest (2010) 0.98
Biological role of aldo-keto reductases in retinoic Acid biosynthesis and signaling. Front Pharmacol (2012) 0.95
Aldo-Keto Reductase 1B10 and Its Role in Proliferation Capacity of Drug-Resistant Cancers. Front Pharmacol (2012) 0.95
CRYPTOCHROME-mediated phototransduction by modulation of the potassium ion channel β-subunit redox sensor. Proc Natl Acad Sci U S A (2015) 0.95
Genomic alterations in breast cancer patients in betel quid and non betel quid chewers. PLoS One (2012) 0.94
Aldo-keto reductase family 1 B10 protein detoxifies dietary and lipid-derived alpha, beta-unsaturated carbonyls at physiological levels. Biochem Biophys Res Commun (2009) 0.93
Human aldo-keto reductases 1B1 and 1B10: a comparative study on their enzyme activity toward electrophilic carbonyl compounds. Chem Biol Interact (2011) 0.93
SINGLET OXYGEN RESISTANT 1 links reactive electrophile signaling to singlet oxygen acclimation in Chlamydomonas reinhardtii. Proc Natl Acad Sci U S A (2012) 0.92
AKR1B10 induces cell resistance to daunorubicin and idarubicin by reducing C13 ketonic group. Toxicol Appl Pharmacol (2011) 0.92
Overview of extracellular microvesicles in drug metabolism. Expert Opin Drug Metab Toxicol (2010) 0.91
Interactions between the C-terminus of Kv1.5 and Kvβ regulate pyridine nucleotide-dependent changes in channel gating. Pflugers Arch (2012) 0.91
Hepatic xenobiotic metabolizing enzyme and transporter gene expression through the life stages of the mouse. PLoS One (2011) 0.89
Expanding xylose metabolism in yeast for plant cell wall conversion to biofuels. Elife (2015) 0.88
Functional expression of novel human and murine AKR1B genes. Chem Biol Interact (2011) 0.87
Proteomics of muscle chronological ageing in post-menopausal women. BMC Genomics (2014) 0.86
Host Plant Compatibility Shapes the Proteogenome of Frankia coriariae. Front Microbiol (2017) 0.85
High expression of aldo-keto reductase 1B10 is an independent predictor of favorable prognosis in patients with hepatocellular carcinoma. Gut Liver (2014) 0.84
Regulation of aldo-keto reductases in human diseases. Front Pharmacol (2012) 0.84
Expression of aldo-keto reductase family 1 member b10 in the early stages of human hepatocarcinogenesis. Int J Mol Sci (2014) 0.84
Functional analysis of insect molting fluid proteins on the protection and regulation of ecdysis. J Biol Chem (2014) 0.84
Enzymes of the AKR1B and AKR1C Subfamilies and Uterine Diseases. Front Pharmacol (2012) 0.84
Overexpression of aldo-keto-reductase in azole-resistant clinical isolates of Candida glabrata determined by cDNA-AFLP. Daru (2013) 0.83
Exclusion of aldose reductase as a mediator of ERG deficits in a mouse model of diabetic eye disease. Vis Neurosci (2012) 0.83
Aldo-Keto Reductases 1B in Endocrinology and Metabolism. Front Pharmacol (2012) 0.83
Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors. Eur J Med Chem (2014) 0.82
N-Benzoyl anthranilic acid derivatives as selective inhibitors of aldo-keto reductase AKR1C3. Bioorg Med Chem Lett (2012) 0.81
Alternative splicing in the aldo-keto reductase superfamily: implications for protein nomenclature. Chem Biol Interact (2013) 0.79
Evidence for functional convergence in genes upregulated by herbivores ingesting plant secondary compounds. BMC Ecol (2014) 0.79
Human and rodent aldo-keto reductases from the AKR1B subfamily and their specificity with retinaldehyde. Chem Biol Interact (2011) 0.79
Design of an amide N-glycoside derivative of β-glucogallin: a stable, potent, and specific inhibitor of aldose reductase. J Med Chem (2013) 0.79
Crystal packing modifies ligand binding affinity: the case of aldose reductase. Proteins (2012) 0.79
A Novel Aldo-Keto Reductase (AKR17A1) of Anabaena sp. PCC 7120 Degrades the Rice Field Herbicide Butachlor and Confers Tolerance to Abiotic Stresses in E. coli. PLoS One (2015) 0.78
Genes of the de novo and Salvage Biosynthesis Pathways of Vitamin B6 are Regulated under Oxidative Stress in the Plant Pathogen Rhizoctonia solani. Front Microbiol (2016) 0.77
The role of cytochromes p450 and aldo-keto reductases in prognosis of breast carcinoma patients. Medicine (Baltimore) (2014) 0.77
The roles of AKR1C1 and AKR1C2 in ethyl-3,4-dihydroxybenzoate induced esophageal squamous cell carcinoma cell death. Oncotarget (2016) 0.77
Catalytic reduction of carbonyl groups in oxidized PAPC by Kvβ2 (AKR6). Chem Biol Interact (2011) 0.77
Substrate Specificity, Inhibitor Selectivity and Structure-Function Relationships of Aldo-Keto Reductase 1B15: A Novel Human Retinaldehyde Reductase. PLoS One (2015) 0.77
Aldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto reductase with activity toward steroids and 3-keto-acyl-CoA conjugates. J Biol Chem (2015) 0.77
Estrogen receptor β and its domains interact with casein kinase 2, phosphokinase C, and N-myristoylation sites of mitochondrial and nuclear proteins in mouse brain. J Biol Chem (2012) 0.76
Differential gene expression in Pycnoporus coccineus during interspecific mycelial interactions with different competitors. Appl Environ Microbiol (2013) 0.76
Detoxifying Enzymes at the Cross-Roads of Inflammation, Oxidative Stress, and Drug Hypersensitivity: Role of Glutathione Transferase P1-1 and Aldose Reductase. Front Pharmacol (2016) 0.76
Aldo-Keto Reductase Family 1 Member B10 Inhibitors: Potential Drugs for Cancer Treatment. Recent Pat Anticancer Drug Discov (2016) 0.76
Using a Label Free Quantitative Proteomics Approach to Identify Changes in Protein Abundance in Multidrug-Resistant Mycobacterium tuberculosis. Indian J Microbiol (2015) 0.76
Alterations in estrogen signalling pathways upon acquisition of anthracycline resistance in breast tumor cells. PLoS One (2017) 0.75
High expression of AKR1B10 predicts low risk of early tumor recurrence in patients with hepatitis B virus-related hepatocellular carcinoma. Sci Rep (2017) 0.75
Biochemical and pharmacological characterization of AZD1981, an orally available selective DP2 antagonist in clinical development for asthma. Br J Pharmacol (2013) 0.75
Aldo-Keto Reductases 1B in Adrenal Cortex Physiology. Front Endocrinol (Lausanne) (2016) 0.75
Novel Aldo-Keto Reductases for the Biocatalytic Conversion of 3-Hydroxybutanal to 1,3-Butanediol: Structural and Biochemical Studies. Appl Environ Microbiol (2017) 0.75
Structure of the His269Arg mutant of the rat aldose reductase-like protein AKR1B14 complexed with NADPH. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.75
Renoprotective Effects of Aldose Reductase Inhibitor Epalrestat against High Glucose-Induced Cellular Injury. Biomed Res Int (2017) 0.75
Aldo-Keto Reductase AKR1C1-AKR1C4: Functions, Regulation, and Intervention for Anti-cancer Therapy. Front Pharmacol (2017) 0.75
Dual-color immunofluorescent labeling with quantum dots of the diabetes-associated proteins aldose reductase and Toll-like receptor 4 in the kidneys of diabetic rats. Int J Nanomedicine (2015) 0.75
The Coptotermes gestroi aldo-keto reductase: a multipurpose enzyme for biorefinery applications. Biotechnol Biofuels (2017) 0.75
Aldo-keto reductase family 1 member B8 is secreted via non-classical pathway. Int J Clin Exp Pathol (2014) 0.75
Loss of glyoxalase 1 induces compensatory mechanism to achieve dicarbonyl detoxification in mammalian Schwann cells. J Biol Chem (2016) 0.75
Metabolism of F18, a Derivative of Calanolide A, in Human Liver Microsomes and Cytosol. Front Pharmacol (2017) 0.75
Aldose reductase interacts with AKT1 to augment hepatic AKT/mTOR signaling and promote hepatocarcinogenesis. Oncotarget (2017) 0.75
Identification and functional characterization of four novel aldo/keto reductases in Anabaena sp. PCC 7120 by integrating wet lab with in silico approaches. Funct Integr Genomics (2017) 0.75
Biochemistry and molecular cell biology of diabetic complications. Nature (2001) 25.43
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med (1991) 16.01
Atherosclerosis. the road ahead. Cell (2001) 11.88
Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer. Cancer Res (2006) 9.87
Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes (1999) 5.96
Short-chain dehydrogenases/reductases (SDR). Biochemistry (1995) 5.34
Inactivation properties of voltage-gated K+ channels altered by presence of beta-subunit. Nature (1994) 4.38
Structural identification by mass spectrometry of oxidized phospholipids in minimally oxidized low density lipoprotein that induce monocyte/endothelial interactions and evidence for their presence in vivo. J Biol Chem (1997) 3.91
The relationship between protein structure and function: a comprehensive survey with application to the yeast genome. J Mol Biol (1999) 3.46
Short-chain dehydrogenases/reductases (SDR): the 2002 update. Chem Biol Interact (2003) 3.46
Minimally modified low density lipoprotein stimulates monocyte endothelial interactions. J Clin Invest (1990) 3.40
Comparative anatomy of the aldo-keto reductase superfamily. Biochem J (1997) 3.39
Diabetes and advanced glycation endproducts. J Intern Med (2002) 3.38
The anthracyclines: will we ever find a better doxorubicin? Semin Oncol (1992) 3.28
The power to reduce: pyridine nucleotides--small molecules with a multitude of functions. Biochem J (2007) 3.11
Overexpression of the aldo-keto reductase family protein AKR1B10 is highly correlated with smokers' non-small cell lung carcinomas. Clin Cancer Res (2005) 2.97
Extracellular matrix metabolism in diabetic nephropathy. J Am Soc Nephrol (2003) 2.85
beta-Amyloid-mediated vasoactivity and vascular endothelial damage. Nature (1996) 2.82
Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins. J Clin Invest (1999) 2.81
Short-chain dehydrogenases/reductases (SDRs). Eur J Biochem (2002) 2.62
Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose. Biochem J (1999) 2.61
Vitamin C. Biosynthesis, recycling and degradation in mammals. FEBS J (2007) 2.55
Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options. Endocr Rev (2005) 2.42
An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications. Science (1992) 2.37
Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels. Science (2000) 2.29
Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts. Arch Biochem Biophys (2003) 2.08
Beta subunits promote K+ channel surface expression through effects early in biosynthesis. Neuron (1996) 2.05
A new nomenclature for the aldo-keto reductase superfamily. Biochem Pharmacol (1997) 1.99
Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis. J Clin Invest (1998) 1.90
Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors. Br J Pharmacol (2007) 1.90
Aldo-keto reductases and bioactivation/detoxication. Annu Rev Pharmacol Toxicol (2007) 1.86
Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: a possible mechanism through which age is a risk factor for osteoarthritis. Arthritis Rheum (2002) 1.85
Glycation products and the pathogenesis of diabetic complications. Diabetes Care (1992) 1.84
Identification and characterization of a novel human aldose reductase-like gene. J Biol Chem (1998) 1.82
Kv beta 1 subunit binding specific for shaker-related potassium channel alpha subunits. Neuron (1996) 1.80
A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels. Science (2003) 1.76
Aldose reductase in glucose toxicity: a potential target for the prevention of diabetic complications. Pharmacol Rev (1998) 1.75
Human aldo-keto reductases: Function, gene regulation, and single nucleotide polymorphisms. Arch Biochem Biophys (2007) 1.75
Subunit composition determines Kv1 potassium channel surface expression. J Biol Chem (2000) 1.75
Determinants of bioactivity of oxidized phospholipids. Specific oxidized fatty acyl groups at the sn-2 position. Arterioscler Thromb Vasc Biol (2000) 1.74
Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase. J Biol Chem (1981) 1.72
Structure of a voltage-dependent K+ channel beta subunit. Cell (1999) 1.64
Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase. Structure (1997) 1.63
Delta 4-3-oxosteroid 5 beta-reductase deficiency described in identical twins with neonatal hepatitis. A new inborn error in bile acid synthesis. J Clin Invest (1988) 1.62
Sorbitol pathway: presence in nerve and cord with substrate accumulation in diabetes. Science (1966) 1.60
Cigarette smoke condensate induces cytochromes P450 and aldo-keto reductases in oral cancer cells. Toxicol Lett (2006) 1.59
Arginine 276 controls the directional preference of AKR1C9 (rat liver 3alpha-hydroxysteroid dehydrogenase) in human embryonic kidney 293 cells. Endocrinology (2005) 1.58
Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity. J Biochem (1998) 1.57
Transformation of prostaglandin D2 to 9 alpha, 11 beta-(15S)-trihydroxyprosta-(5Z,13E)-dien-1-oic acid (9 alpha, 11 beta-prostaglandin F2): a unique biologically active prostaglandin produced enzymatically in vivo in humans. Proc Natl Acad Sci U S A (1985) 1.55
Short-chain dehydrogenase/reductase (SDR) relationships: a large family with eight clusters common to human, animal, and plant genomes. Protein Sci (2002) 1.54
Polyol pathway and diabetic peripheral neuropathy. Int Rev Neurobiol (2002) 1.53
Molecular endocrinology of hydroxysteroid dehydrogenases. Endocr Rev (1997) 1.53
Structurally similar oxidized phospholipids differentially regulate endothelial binding of monocytes and neutrophils. Proc Natl Acad Sci U S A (1999) 1.53
Reduced K+ channel inactivation, spike broadening, and after-hyperpolarization in Kvbeta1.1-deficient mice with impaired learning. Learn Mem (1999) 1.51
Aldose reductase mediates mitogenic signaling in vascular smooth muscle cells. J Biol Chem (2002) 1.51
Directed evolution of a (beta alpha)8-barrel enzyme to catalyze related reactions in two different metabolic pathways. Proc Natl Acad Sci U S A (2000) 1.51
Mutagenesis of 3 alpha-hydroxysteroid dehydrogenase reveals a "push-pull" mechanism for proton transfer in aldo-keto reductases. Biochemistry (1998) 1.49
Modulation of voltage-dependent Shaker family potassium channels by an aldo-keto reductase. J Biol Chem (2006) 1.48
Development of nonsteroidal anti-inflammatory drug analogs and steroid carboxylates selective for human aldo-keto reductase isoforms: potential antineoplastic agents that work independently of cyclooxygenase isozymes. Mol Pharmacol (2004) 1.48
A meta-analysis of trials on aldose reductase inhibitors in diabetic peripheral neuropathy. The Italian Study Group. The St. Vincent Declaration. Diabet Med (1996) 1.46
Alterations in nonenzymatic biochemistry in uremia: origin and significance of "carbonyl stress" in long-term uremic complications. Kidney Int (1999) 1.46
Aldose reductase mediates the lipopolysaccharide-induced release of inflammatory mediators in RAW264.7 murine macrophages. J Biol Chem (2006) 1.46
Reduction of trioses by NADPH-dependent aldo-keto reductases. Aldose reductase, methylglyoxal, and diabetic complications. J Biol Chem (1992) 1.45
Demonstration that polyol accumulation is responsible for diabetic cataract by the use of transgenic mice expressing the aldose reductase gene in the lens. Proc Natl Acad Sci U S A (1995) 1.43
Tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: enzyme kinetics and crystal structure of the Y48H mutant enzyme. Biochemistry (1994) 1.43
Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism. Biochem J (2003) 1.42
Naltrexone. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in the management of opioid dependence. Drugs (1988) 1.41
Hyperglycemia, polyol metabolism, and complications of diabetes mellitus. Annu Rev Med (1975) 1.41
Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10. Proc Natl Acad Sci U S A (2007) 1.41
Protein cross-linking by the Maillard reaction. Isolation, characterization, and in vivo detection of a lysine-lysine cross-link derived from methylglyoxal. J Biol Chem (1996) 1.41
Selective reduction of AKR1C2 in prostate cancer and its role in DHT metabolism. Prostate (2003) 1.40
Structure of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase complexed with NADP+. Biochemistry (1996) 1.39
Succinic semialdehyde dehydrogenase deficiency: GABAB receptor-mediated function. Brain Res (2006) 1.37
4-Hydroxybutyric acid and the clinical phenotype of succinic semialdehyde dehydrogenase deficiency, an inborn error of GABA metabolism. Neuropediatrics (1998) 1.37
Human aldose reductase: rate constants for a mechanism including interconversion of ternary complexes by recombinant wild-type enzyme. Biochemistry (1995) 1.36
Functional and molecular aspects of voltage-gated K+ channel beta subunits. Ann N Y Acad Sci (1999) 1.34
Chemoprotection by organosulfur inducers of phase 2 enzymes: dithiolethiones and dithiins. Drug Metabol Drug Interact (2000) 1.34
Inflammation, bioactive lipids and atherosclerosis: potential roles of a lipoprotein-associated phospholipase A2, platelet activating factor-acetylhydrolase. Atheroscler Suppl (2002) 1.34
Structural and kinetic determinants of aldehyde reduction by aldose reductase. Biochemistry (1999) 1.34
Involvement of cysteine residues in catalysis and inhibition of human aldose reductase. Site-directed mutagenesis of Cys-80, -298, and -303. J Biol Chem (1992) 1.33
Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids. Biochem J (2006) 1.33
Activation of nuclear factor-kappaB by hyperglycemia in vascular smooth muscle cells is regulated by aldose reductase. Diabetes (2004) 1.33
The ubiquitous aldehyde reductase (AKR1A1) oxidizes proximate carcinogen trans-dihydrodiols to o-quinones: potential role in polycyclic aromatic hydrocarbon activation. Biochemistry (2001) 1.31
Glucose, glycation, and RAGE: implications for amplification of cellular dysfunction in diabetic nephropathy. J Am Soc Nephrol (2003) 1.30
Expression of human aldose and aldehyde reductases. Site-directed mutagenesis of a critical lysine 262. J Biol Chem (1991) 1.29
Inhibition of a major NAD(P)-linked oxidoreductase from rat liver cytosol by steroidal and nonsteroidal anti-inflammatory agents and by prostaglandins. Proc Natl Acad Sci U S A (1983) 1.29
Potassium channel alpha and beta subunits assemble in the endoplasmic reticulum. J Biol Chem (1997) 1.29
Multiple steps determine the overall rate of the reduction of 5alpha-dihydrotestosterone catalyzed by human type 3 3alpha-hydroxysteroid dehydrogenase: implications for the elimination of androgens. Biochemistry (2006) 1.28
Requirement of aldose reductase for the hyperglycemic activation of protein kinase C and formation of diacylglycerol in vascular smooth muscle cells. Diabetes (2005) 1.26
Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members. Biochem J (1999) 1.26
Prostaglandins and adenosine in the regulation of sleep and wakefulness. Curr Opin Pharmacol (2006) 1.25
Aldose reductase is an obligatory mediator of the late phase of ischemic preconditioning. Circ Res (2002) 1.25
cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family. J Biol Chem (1993) 1.24
A novel K+ channel beta-subunit (hKv beta 1.3) is produced via alternative mRNA splicing. J Biol Chem (1995) 1.24
Mutations in SRD5B1 (AKR1D1), the gene encoding delta(4)-3-oxosteroid 5beta-reductase, in hepatitis and liver failure in infancy. Gut (2003) 1.24
Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation (2010) 19.30
Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options. Endocr Rev (2005) 2.42
Cardiac myocyte-specific expression of inducible nitric oxide synthase protects against ischemia/reperfusion injury by preventing mitochondrial permeability transition. Circulation (2008) 2.37
Cardioprotection by N-acetylglucosamine linkage to cellular proteins. Circulation (2008) 2.11
Electronic cigarettes: a policy statement from the American Heart Association. Circulation (2014) 1.87
Episodic exposure to fine particulate air pollution decreases circulating levels of endothelial progenitor cells. Circ Res (2010) 1.86
Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice. FASEB J (2011) 1.72
Cardioprotective and antiapoptotic effects of heme oxygenase-1 in the failing heart. Circulation (2010) 1.64
Prenatal exposure to cigarette smoke induces diet- and sex-dependent dyslipidemia and weight gain in adult murine offspring. Environ Health Perspect (2009) 1.57
Aldose reductase mediates mitogenic signaling in vascular smooth muscle cells. J Biol Chem (2002) 1.51
Unsaturated lipid peroxidation-derived aldehydes activate autophagy in vascular smooth-muscle cells. Biochem J (2008) 1.49
Deficiency of the leukotriene B4 receptor, BLT-1, protects against systemic insulin resistance in diet-induced obesity. J Immunol (2011) 1.41
Mechanisms of acrolein-induced myocardial dysfunction: implications for environmental and endogenous aldehyde exposure. Am J Physiol Heart Circ Physiol (2007) 1.39
Assessment of immunoreactive synthetic peptides from the structural proteins of severe acute respiratory syndrome coronavirus. Clin Chem (2003) 1.34
Protein glutathiolation by nitric oxide: an intracellular mechanism regulating redox protein modification. FASEB J (2006) 1.34
Activation of nuclear factor-kappaB by hyperglycemia in vascular smooth muscle cells is regulated by aldose reductase. Diabetes (2004) 1.33
NALP-3 inflammasome silencing attenuates ceramide-induced transepithelial permeability. J Cell Physiol (2012) 1.32
Aldose reductase protects against early atherosclerotic lesion formation in apolipoprotein E-null mice. Circ Res (2009) 1.32
Glutathione-S-transferase P protects against endothelial dysfunction induced by exposure to tobacco smoke. Am J Physiol Heart Circ Physiol (2009) 1.30
Proresolution therapy for the treatment of delayed healing of diabetic wounds. Diabetes (2012) 1.27
Requirement of aldose reductase for the hyperglycemic activation of protein kinase C and formation of diacylglycerol in vascular smooth muscle cells. Diabetes (2005) 1.26
Aldose reductase is an obligatory mediator of the late phase of ischemic preconditioning. Circ Res (2002) 1.25
The heme oxygenase 1 inducer (CoPP) protects human cardiac stem cells against apoptosis through activation of the extracellular signal-regulated kinase (ERK)/NRF2 signaling pathway and cytokine release. J Biol Chem (2012) 1.24
Could dirty air cause diabetes? Circulation (2009) 1.23
Lipid peroxidation-derived aldehydes and oxidative stress in the failing heart: role of aldose reductase. Am J Physiol Heart Circ Physiol (2002) 1.18
A highly sensitive and accurate method to quantify absolute numbers of c-kit+ cardiac stem cells following transplantation in mice. Basic Res Cardiol (2013) 1.17
Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition. Circulation (2006) 1.17
Mitochondrial matrix metalloproteinase activation decreases myocyte contractility in hyperhomocysteinemia. Am J Physiol Heart Circ Physiol (2008) 1.17
Cardiovascular pathophysiology of environmental pollutants. Am J Physiol Heart Circ Physiol (2004) 1.17
Differential regulation of voltage-gated K+ channels by oxidized and reduced pyridine nucleotide coenzymes. Am J Physiol Cell Physiol (2004) 1.16
Lipid peroxidation product 4-hydroxy-trans-2-nonenal causes endothelial activation by inducing endoplasmic reticulum stress. J Biol Chem (2012) 1.16
Myocardial ischaemia inhibits mitochondrial metabolism of 4-hydroxy-trans-2-nonenal. Biochem J (2009) 1.15
Redox activation of aldose reductase in the ischemic heart. J Biol Chem (2006) 1.15
Aldose reductase mediates cytotoxic signals of hyperglycemia and TNF-alpha in human lens epithelial cells. FASEB J (2002) 1.15
Substrate specificity and catalytic efficiency of aldo-keto reductases with phospholipid aldehydes. Biochem J (2007) 1.14
Human cardiac stem cells isolated from atrial appendages stably express c-kit. PLoS One (2011) 1.14
Contribution of aldose reductase to diabetic hyperproliferation of vascular smooth muscle cells. Diabetes (2006) 1.13
Acrolein inhalation prevents vascular endothelial growth factor-induced mobilization of Flk-1+/Sca-1+ cells in mice. Arterioscler Thromb Vasc Biol (2011) 1.13
Protein modification by acrolein: formation and stability of cysteine adducts. Chem Res Toxicol (2009) 1.11
Overexpression of endothelial nitric oxide synthase prevents diet-induced obesity and regulates adipocyte phenotype. Circ Res (2012) 1.11
Aldose reductase-catalyzed reduction of aldehyde phospholipids. J Biol Chem (2004) 1.10
Aldose reductase inhibition suppresses oxidative stress-induced inflammatory disorders. Chem Biol Interact (2011) 1.09
Inhibition of aldose reductase attenuates TNF-alpha-induced expression of adhesion molecules in endothelial cells. FASEB J (2004) 1.09
Acrolein consumption exacerbates myocardial ischemic injury and blocks nitric oxide-induced PKCepsilon signaling and cardioprotection. J Mol Cell Cardiol (2008) 1.09
PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress. Biochem J (2013) 1.07
Role of endoplasmic reticulum stress in acrolein-induced endothelial activation. Toxicol Appl Pharmacol (2008) 1.07
Nitric oxide prevents aldose reductase activation and sorbitol accumulation during diabetes. Diabetes (2002) 1.06
Increased sensitivity of glutathione S-transferase P-null mice to cyclophosphamide-induced urinary bladder toxicity. J Pharmacol Exp Ther (2009) 1.03
Polychlorinated biphenyl 153 is a diet-dependent obesogen that worsens nonalcoholic fatty liver disease in male C57BL6/J mice. J Nutr Biochem (2013) 1.02
Acrolein activates matrix metalloproteinases by increasing reactive oxygen species in macrophages. Toxicol Appl Pharmacol (2009) 1.02
Environmental risk factors for heart disease. Rev Environ Health (2009) 1.02
Aldose reductase regulates high glucose-induced ectodomain shedding of tumor necrosis factor (TNF)-alpha via protein kinase C-delta and TNF-alpha converting enzyme in vascular smooth muscle cells. Endocrinology (2008) 1.01
Catalytic mechanism and substrate specificity of the beta-subunit of the voltage-gated potassium channel. Biochemistry (2008) 1.01
Role of nitric oxide in regulating aldose reductase activation in the ischemic heart. J Biol Chem (2008) 1.01
NADPH binding to beta-subunit regulates inactivation of voltage-gated K(+) channels. Biochem Biophys Res Commun (2007) 1.00
Protein S-glutathiolation: redox-sensitive regulation of protein function. J Mol Cell Cardiol (2011) 0.99
Aldose reductase regulates TNF-alpha-induced cell signaling and apoptosis in vascular endothelial cells. FEBS Lett (2004) 0.99
Protein O-GlcNAcylation is a novel cytoprotective signal in cardiac stem cells. Stem Cells (2013) 0.99
Exposure to ambient air fine particulate matter prevents VEGF-induced mobilization of endothelial progenitor cells from the bone marrow. Environ Health Perspect (2012) 0.98
Oral exposure to acrolein exacerbates atherosclerosis in apoE-null mice. Atherosclerosis (2011) 0.97
Exposure to acrolein by inhalation causes platelet activation. Toxicol Appl Pharmacol (2010) 0.97
Aldose reductase-regulated tumor necrosis factor-alpha production is essential for high glucose-induced vascular smooth muscle cell growth. Endocrinology (2007) 0.96
Postischemic deactivation of cardiac aldose reductase: role of glutathione S-transferase P and glutaredoxin in regeneration of reduced thiols from sulfenic acids. J Biol Chem (2010) 0.95
Measurement and identification of S-glutathiolated proteins. Methods Enzymol (2010) 0.94
Chronic oral exposure to the aldehyde pollutant acrolein induces dilated cardiomyopathy. Am J Physiol Heart Circ Physiol (2011) 0.94
Regulation of ion channels by pyridine nucleotides. Circ Res (2013) 0.94
Role of glutathiolation in preservation, restoration and regulation of protein function. IUBMB Life (2007) 0.94
Reductive metabolism of AGE precursors: a metabolic route for preventing AGE accumulation in cardiovascular tissue. Diabetes (2009) 0.94
Role of aldose reductase in the metabolism and detoxification of carnosine-acrolein conjugates. J Biol Chem (2013) 0.93
An analysis of the proteomic profile for Thermoanaerobacter tengcongensis under optimal culture conditions. Proteomics (2004) 0.92
Overview of pyridine nucleotides review series. Circ Res (2012) 0.92
Acrolein consumption induces systemic dyslipidemia and lipoprotein modification. Toxicol Appl Pharmacol (2009) 0.92
Exposure to Fine Particulate Air Pollution Causes Vascular Insulin Resistance by Inducing Pulmonary Oxidative Stress. Environ Health Perspect (2016) 0.91
PKCepsilon plays a causal role in acute ethanol-induced steatosis. Arch Biochem Biophys (2008) 0.91
Differences in transient outward current properties between neonatal and adult human atrial myocytes. J Mol Cell Cardiol (2003) 0.91
Interactions between the C-terminus of Kv1.5 and Kvβ regulate pyridine nucleotide-dependent changes in channel gating. Pflugers Arch (2012) 0.91
MicroRNA-301a mediated regulation of Kv4.2 in diabetes: identification of key modulators. PLoS One (2013) 0.91
Pentaerythritol tetranitrate improves angiotensin II-induced vascular dysfunction via induction of heme oxygenase-1. Hypertension (2010) 0.91
Transient receptor potential ion channels: powerful regulators of cell function. Ann Surg (2014) 0.91
Acrolein-induced vasomotor responses of rat aorta. Am J Physiol Heart Circ Physiol (2003) 0.90
Cardiomyocyte-restricted overexpression of extracellular superoxide dismutase increases nitric oxide bioavailability and reduces infarct size after ischemia/reperfusion. Basic Res Cardiol (2012) 0.90
Evidence-Based Policy Making: Assessment of the American Heart Association's Strategic Policy Portfolio: A Policy Statement From the American Heart Association. Circulation (2016) 0.90
Structure of a glutathione conjugate bound to the active site of aldose reductase. Proteins (2006) 0.89
Increased saturated fatty acids in obesity alter resolution of inflammation in part by stimulating prostaglandin production. J Immunol (2013) 0.88
Calcium transients in infant human atrial myocytes. Pediatr Res (2004) 0.88
Cytochromes P450 catalyze oxidation of alpha,beta-unsaturated aldehydes. Arch Biochem Biophys (2007) 0.88
Nitric oxide regulates the polyol pathway of glucose metabolism in vascular smooth muscle cells. FASEB J (2003) 0.88
Functional expression of novel human and murine AKR1B genes. Chem Biol Interact (2011) 0.87
L-Arginine prevents metabolic effects of high glucose in diabetic mice. FEBS Lett (2008) 0.87
Posttranslational glutathiolation of aldose reductase (AKR1B1): a possible mechanism of protein recovery from S-nitrosylation. Chem Biol Interact (2008) 0.86
Synthesis, quantification, characterization, and signaling properties of glutathionyl conjugates of enals. Methods Enzymol (2010) 0.85
Comparative measurements of multicomponent phospholipid mixtures by electrospray mass spectroscopy: relating ion intensity to concentration. Anal Biochem (2002) 0.85
Inhibition of fiber cell globulization and hyperglycemia-induced lens opacification by aminopeptidase inhibitor bestatin. Invest Ophthalmol Vis Sci (2002) 0.83
Identification of Bone Marrow Cell Subpopulations Associated With Improved Functional Outcomes in Patients With Chronic Left Ventricular Dysfunction: An Embedded Cohort Evaluation of the FOCUS-CCTRN Trial. Cell Transplant (2015) 0.83
Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System: A Scientific Statement From the American Heart Association. Circ Res (2016) 0.83
Beyond reactive oxygen species: aldehydes as arbitrators of alarm and adaptation. Circ Res (2009) 0.82
Role of aldose reductase in TNF-alpha-induced apoptosis of vascular endothelial cells. Chem Biol Interact (2003) 0.82