Published in FASEB J on December 17, 2002
Prevention of hepatocarcinogenesis and increased susceptibility to acetaminophen-induced liver failure in transaldolase-deficient mice by N-acetylcysteine. J Clin Invest (2009) 1.75
Aldose reductase inhibition prevents endotoxin-induced uveitis in rats. Invest Ophthalmol Vis Sci (2007) 1.61
Diabetic complications and dysregulated innate immunity. Front Biosci (2008) 1.28
Inhibition of aldose reductase prevents experimental allergic airway inflammation in mice. PLoS One (2009) 1.11
Aldose reductase deficiency in mice prevents azoxymethane-induced colonic preneoplastic aberrant crypt foci formation. Carcinogenesis (2008) 1.10
Aldose reductase, oxidative stress, and diabetic mellitus. Front Pharmacol (2012) 1.10
Aldose reductase inhibition suppresses oxidative stress-induced inflammatory disorders. Chem Biol Interact (2011) 1.09
Prevention of posterior capsular opacification through aldose reductase inhibition. Invest Ophthalmol Vis Sci (2008) 1.07
Mediation of aldose reductase in lipopolysaccharide-induced inflammatory signals in mouse peritoneal macrophages. Cytokine (2006) 1.05
Aldose reductase: a novel therapeutic target for inflammatory pathologies. Int J Biochem Cell Biol (2009) 1.00
Aldose reductase mediates endotoxin-induced production of nitric oxide and cytotoxicity in murine macrophages. Free Radic Biol Med (2007) 1.00
Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells. Cancer Lett (2007) 0.98
Inhibition of aldose reductase prevents endotoxin-induced inflammation by regulating the arachidonic acid pathway in murine macrophages. Free Radic Biol Med (2011) 0.92
Osmotic stress, not aldose reductase activity, directly induces growth factors and MAPK signaling changes during sugar cataract formation. Exp Eye Res (2012) 0.92
Lens epithelial cell apoptosis initiates diabetic cataractogenesis in the Zucker diabetic fatty rat. Graefes Arch Clin Exp Ophthalmol (2010) 0.89
Understanding the role of aldose reductase in ocular inflammation. Curr Mol Med (2010) 0.85
A simple method for establishing adherent ex vivo explant cultures from human eye pathologies for use in subsequent calcium imaging and inflammatory studies. J Immunol Res (2014) 0.82
Taurine reduces nitrosative stress and nitric oxide synthase expression in high glucose-exposed human Schwann cells. Exp Neurol (2011) 0.82
Impact of diabetes mellitus on bladder uroepithelial cells. Am J Physiol Regul Integr Comp Physiol (2012) 0.81
Oxidative stress as a common mediator for apoptosis induced-cardiac damage in diabetic rats. Open Cardiovasc Med J (2008) 0.80
Aldose reductase expression as a risk factor for cataract. Chem Biol Interact (2014) 0.80
Inhibition of aldose reductase attenuates endotoxin signals in human non-pigmented ciliary epithelial cells. Exp Eye Res (2010) 0.79
KIOM-79 Prevents Lens Epithelial Cell Apoptosis and Lens Opacification in Zucker Diabetic Fatty Rats. Evid Based Complement Alternat Med (2010) 0.76
Prevention of VEGF-induced growth and tube formation in human retinal endothelial cells by aldose reductase inhibition. J Diabetes Complications (2012) 0.76
Investigation of synergistic mechanism and identification of interaction site of aldose reductase with the combination of gigantol and syringic acid for prevention of diabetic cataract. BMC Complement Altern Med (2016) 0.75
Nanoceria Attenuated High Glucose-Induced Oxidative Damage in HepG2 Cells. Cell J (2016) 0.75
Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation (2010) 19.30
Role of aldose reductase and oxidative damage in diabetes and the consequent potential for therapeutic options. Endocr Rev (2005) 2.42
Cardiac myocyte-specific expression of inducible nitric oxide synthase protects against ischemia/reperfusion injury by preventing mitochondrial permeability transition. Circulation (2008) 2.37
Cardioprotection by N-acetylglucosamine linkage to cellular proteins. Circulation (2008) 2.11
Electronic cigarettes: a policy statement from the American Heart Association. Circulation (2014) 1.87
Episodic exposure to fine particulate air pollution decreases circulating levels of endothelial progenitor cells. Circ Res (2010) 1.86
The aldo-keto reductase superfamily and its role in drug metabolism and detoxification. Drug Metab Rev (2008) 1.80
Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice. FASEB J (2011) 1.72
Cardioprotective and antiapoptotic effects of heme oxygenase-1 in the failing heart. Circulation (2010) 1.64
Aldose reductase inhibition prevents endotoxin-induced uveitis in rats. Invest Ophthalmol Vis Sci (2007) 1.61
Prenatal exposure to cigarette smoke induces diet- and sex-dependent dyslipidemia and weight gain in adult murine offspring. Environ Health Perspect (2009) 1.57
Aldose reductase mediates mitogenic signaling in vascular smooth muscle cells. J Biol Chem (2002) 1.51
Unsaturated lipid peroxidation-derived aldehydes activate autophagy in vascular smooth-muscle cells. Biochem J (2008) 1.49
Aldose reductase mediates the lipopolysaccharide-induced release of inflammatory mediators in RAW264.7 murine macrophages. J Biol Chem (2006) 1.46
Deficiency of the leukotriene B4 receptor, BLT-1, protects against systemic insulin resistance in diet-induced obesity. J Immunol (2011) 1.41
Mechanisms of acrolein-induced myocardial dysfunction: implications for environmental and endogenous aldehyde exposure. Am J Physiol Heart Circ Physiol (2007) 1.39
Assessment of immunoreactive synthetic peptides from the structural proteins of severe acute respiratory syndrome coronavirus. Clin Chem (2003) 1.34
Protein glutathiolation by nitric oxide: an intracellular mechanism regulating redox protein modification. FASEB J (2006) 1.34
Activation of nuclear factor-kappaB by hyperglycemia in vascular smooth muscle cells is regulated by aldose reductase. Diabetes (2004) 1.33
Aldose reductase protects against early atherosclerotic lesion formation in apolipoprotein E-null mice. Circ Res (2009) 1.32
Glutathione-S-transferase P protects against endothelial dysfunction induced by exposure to tobacco smoke. Am J Physiol Heart Circ Physiol (2009) 1.30
Proresolution therapy for the treatment of delayed healing of diabetic wounds. Diabetes (2012) 1.27
Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cells. Cancer Res (2006) 1.27
Requirement of aldose reductase for the hyperglycemic activation of protein kinase C and formation of diacylglycerol in vascular smooth muscle cells. Diabetes (2005) 1.26
Aldose reductase is an obligatory mediator of the late phase of ischemic preconditioning. Circ Res (2002) 1.25
The heme oxygenase 1 inducer (CoPP) protects human cardiac stem cells against apoptosis through activation of the extracellular signal-regulated kinase (ERK)/NRF2 signaling pathway and cytokine release. J Biol Chem (2012) 1.24
Could dirty air cause diabetes? Circulation (2009) 1.23
Lipid peroxidation-derived aldehydes and oxidative stress in the failing heart: role of aldose reductase. Am J Physiol Heart Circ Physiol (2002) 1.18
A highly sensitive and accurate method to quantify absolute numbers of c-kit+ cardiac stem cells following transplantation in mice. Basic Res Cardiol (2013) 1.17
Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition. Circulation (2006) 1.17
Cardiovascular pathophysiology of environmental pollutants. Am J Physiol Heart Circ Physiol (2004) 1.17
Differential regulation of voltage-gated K+ channels by oxidized and reduced pyridine nucleotide coenzymes. Am J Physiol Cell Physiol (2004) 1.16
Lipid peroxidation product 4-hydroxy-trans-2-nonenal causes endothelial activation by inducing endoplasmic reticulum stress. J Biol Chem (2012) 1.16
Redox activation of aldose reductase in the ischemic heart. J Biol Chem (2006) 1.15
Myocardial ischaemia inhibits mitochondrial metabolism of 4-hydroxy-trans-2-nonenal. Biochem J (2009) 1.15
Substrate specificity and catalytic efficiency of aldo-keto reductases with phospholipid aldehydes. Biochem J (2007) 1.14
Human cardiac stem cells isolated from atrial appendages stably express c-kit. PLoS One (2011) 1.14
Acrolein inhalation prevents vascular endothelial growth factor-induced mobilization of Flk-1+/Sca-1+ cells in mice. Arterioscler Thromb Vasc Biol (2011) 1.13
Contribution of aldose reductase to diabetic hyperproliferation of vascular smooth muscle cells. Diabetes (2006) 1.13
Overexpression of endothelial nitric oxide synthase prevents diet-induced obesity and regulates adipocyte phenotype. Circ Res (2012) 1.11
Protein modification by acrolein: formation and stability of cysteine adducts. Chem Res Toxicol (2009) 1.11
Inhibition of aldose reductase prevents experimental allergic airway inflammation in mice. PLoS One (2009) 1.11
Aldose reductase deficiency in mice prevents azoxymethane-induced colonic preneoplastic aberrant crypt foci formation. Carcinogenesis (2008) 1.10
Aldose reductase-catalyzed reduction of aldehyde phospholipids. J Biol Chem (2004) 1.10
Aldose reductase inhibition suppresses oxidative stress-induced inflammatory disorders. Chem Biol Interact (2011) 1.09
Inhibition of aldose reductase attenuates TNF-alpha-induced expression of adhesion molecules in endothelial cells. FASEB J (2004) 1.09
Inhibition of aldose reductase prevents growth factor-induced G1-S phase transition through the AKT/phosphoinositide 3-kinase/E2F-1 pathway in human colon cancer cells. Mol Cancer Ther (2010) 1.09
Acrolein consumption exacerbates myocardial ischemic injury and blocks nitric oxide-induced PKCepsilon signaling and cardioprotection. J Mol Cell Cardiol (2008) 1.09
PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress. Biochem J (2013) 1.07
Role of endoplasmic reticulum stress in acrolein-induced endothelial activation. Toxicol Appl Pharmacol (2008) 1.07
Prevention of posterior capsular opacification through aldose reductase inhibition. Invest Ophthalmol Vis Sci (2008) 1.07
Nitric oxide prevents aldose reductase activation and sorbitol accumulation during diabetes. Diabetes (2002) 1.06
Mediation of aldose reductase in lipopolysaccharide-induced inflammatory signals in mouse peritoneal macrophages. Cytokine (2006) 1.05
Increased sensitivity of glutathione S-transferase P-null mice to cyclophosphamide-induced urinary bladder toxicity. J Pharmacol Exp Ther (2009) 1.03
Carotenoid derived aldehydes-induced oxidative stress causes apoptotic cell death in human retinal pigment epithelial cells. Exp Eye Res (2007) 1.03
Polychlorinated biphenyl 153 is a diet-dependent obesogen that worsens nonalcoholic fatty liver disease in male C57BL6/J mice. J Nutr Biochem (2013) 1.02
Acrolein activates matrix metalloproteinases by increasing reactive oxygen species in macrophages. Toxicol Appl Pharmacol (2009) 1.02
Environmental risk factors for heart disease. Rev Environ Health (2009) 1.02
Aldose reductase regulates high glucose-induced ectodomain shedding of tumor necrosis factor (TNF)-alpha via protein kinase C-delta and TNF-alpha converting enzyme in vascular smooth muscle cells. Endocrinology (2008) 1.01
Inhibition of aldose reductase prevents lipopolysaccharide-induced inflammatory response in human lens epithelial cells. Invest Ophthalmol Vis Sci (2006) 1.01
Catalytic mechanism and substrate specificity of the beta-subunit of the voltage-gated potassium channel. Biochemistry (2008) 1.01
Role of nitric oxide in regulating aldose reductase activation in the ischemic heart. J Biol Chem (2008) 1.01
Aldose reductase: a novel therapeutic target for inflammatory pathologies. Int J Biochem Cell Biol (2009) 1.00
NADPH binding to beta-subunit regulates inactivation of voltage-gated K(+) channels. Biochem Biophys Res Commun (2007) 1.00
Aldose reductase mediates endotoxin-induced production of nitric oxide and cytotoxicity in murine macrophages. Free Radic Biol Med (2007) 1.00
Aldose reductase regulates TNF-alpha-induced cell signaling and apoptosis in vascular endothelial cells. FEBS Lett (2004) 0.99
Protein S-glutathiolation: redox-sensitive regulation of protein function. J Mol Cell Cardiol (2011) 0.99
Protein O-GlcNAcylation is a novel cytoprotective signal in cardiac stem cells. Stem Cells (2013) 0.99
Exposure to ambient air fine particulate matter prevents VEGF-induced mobilization of endothelial progenitor cells from the bone marrow. Environ Health Perspect (2012) 0.98
Aldose reductase regulates TNF-alpha-induced PGE2 production in human colon cancer cells. Cancer Lett (2007) 0.98
Oral exposure to acrolein exacerbates atherosclerosis in apoE-null mice. Atherosclerosis (2011) 0.97
Exposure to acrolein by inhalation causes platelet activation. Toxicol Appl Pharmacol (2010) 0.97
Aldose reductase-regulated tumor necrosis factor-alpha production is essential for high glucose-induced vascular smooth muscle cell growth. Endocrinology (2007) 0.96
Aldose reductase inhibition suppresses the expression of Th2 cytokines and airway inflammation in ovalbumin-induced asthma in mice. J Immunol (2009) 0.95
Inhibition of aldose reductase prevents angiogenesis in vitro and in vivo. Angiogenesis (2011) 0.95
A critical role for CD63 in HIV replication and infection of macrophages and cell lines. Virology (2008) 0.95
Postischemic deactivation of cardiac aldose reductase: role of glutathione S-transferase P and glutaredoxin in regeneration of reduced thiols from sulfenic acids. J Biol Chem (2010) 0.95
Reductive metabolism of AGE precursors: a metabolic route for preventing AGE accumulation in cardiovascular tissue. Diabetes (2009) 0.94
Regulation of ion channels by pyridine nucleotides. Circ Res (2013) 0.94
Measurement and identification of S-glutathiolated proteins. Methods Enzymol (2010) 0.94
Role of glutathiolation in preservation, restoration and regulation of protein function. IUBMB Life (2007) 0.94
Chronic oral exposure to the aldehyde pollutant acrolein induces dilated cardiomyopathy. Am J Physiol Heart Circ Physiol (2011) 0.94
Aldose reductase deficiency protects sugar-induced lens opacification in rats. Chem Biol Interact (2011) 0.93