Published in Sci Signal on November 04, 2008
Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling. J Cell Biol (2009) 3.04
The two-pore channel TPCN2 mediates NAADP-dependent Ca(2+)-release from lysosomal stores. Pflugers Arch (2009) 2.35
Transfer of mitochondria from astrocytes to neurons after stroke. Nature (2016) 2.27
Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics. Biol Direct (2012) 2.05
An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals. J Biol Chem (2010) 1.74
TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+. J Biol Chem (2010) 1.74
Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP. Hum Mol Genet (2011) 1.68
Acidic calcium stores open for business: expanding the potential for intracellular Ca2+ signaling. Trends Cell Biol (2010) 1.67
Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore. Cardiovasc Res (2015) 1.47
Convergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinases. EMBO J (2014) 1.43
An ancestral deuterostome family of two-pore channels mediates nicotinic acid adenine dinucleotide phosphate-dependent calcium release from acidic organelles. J Biol Chem (2009) 1.42
Cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate (NAADP) as messengers for calcium mobilization. J Biol Chem (2012) 1.37
Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channels. J Biol Chem (2011) 1.32
NAADP-mediated Ca2+ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP antagonist. Proc Natl Acad Sci U S A (2009) 1.30
Photoaffinity labeling of high affinity nicotinic acid adenine dinucleotide phosphate (NAADP)-binding proteins in sea urchin egg. J Biol Chem (2011) 1.28
Two-pore channels: Regulation by NAADP and customized roles in triggering calcium signals. Cell Calcium (2010) 1.26
Nicotinic acid adenine dinucleotide phosphate (NAADP) regulates autophagy in cultured astrocytes. J Biol Chem (2011) 1.21
Direct mobilisation of lysosomal Ca2+ triggers complex Ca2+ signals. J Cell Sci (2012) 1.21
Membrane topology of NAADP-sensitive two-pore channels and their regulation by N-linked glycosylation. J Biol Chem (2010) 1.16
Isoform-specific targeting and interaction domains in human nicotinamide mononucleotide adenylyltransferases. J Biol Chem (2010) 1.15
TPC2 proteins mediate nicotinic acid adenine dinucleotide phosphate (NAADP)- and agonist-evoked contractions of smooth muscle. J Biol Chem (2010) 1.10
Gene flow and biological conflict systems in the origin and evolution of eukaryotes. Front Cell Infect Microbiol (2012) 1.04
Membrane potential regulates nicotinic acid adenine dinucleotide phosphate (NAADP) dependence of the pH- and Ca2+-sensitive organellar two-pore channel TPC1. J Biol Chem (2012) 1.04
The tissue-specific expression of TRPML2 (MCOLN-2) gene is influenced by the presence of TRPML1. Pflugers Arch (2009) 1.04
Acidic NAADP-sensitive calcium stores in the endothelium: agonist-specific recruitment and role in regulating blood pressure. J Biol Chem (2010) 1.02
Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist Ned-19 indicate two binding sites on the NAADP receptor. J Biol Chem (2009) 0.99
The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: role for the two-pore channels. Cell Calcium (2011) 0.97
NAADP receptors mediate calcium signaling stimulated by endothelin-1 and norepinephrine in renal afferent arterioles. Am J Physiol Renal Physiol (2009) 0.94
The intracellular Ca²⁺ channels of membrane traffic. Channels (Austin) (2012) 0.93
Questioning regulation of two-pore channels by NAADP. Messenger (Los Angel) (2013) 0.93
CD38-mediated Ca2+ signaling contributes to angiotensin II-induced activation of hepatic stellate cells: attenuation of hepatic fibrosis by CD38 ablation. J Biol Chem (2009) 0.93
Mechanism of cyclizing NAD to cyclic ADP-ribose by ADP-ribosyl cyclase and CD38. J Biol Chem (2009) 0.93
Domain assembly of NAADP-gated two-pore channels. Biochem J (2012) 0.92
In with the TRP channels: intracellular functions for TRPM1 and TRPM2. Sci Signal (2009) 0.91
The interdependence of endothelin-1 and calcium: a review. Clin Sci (Lond) (2010) 0.91
VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling. Proc Natl Acad Sci U S A (2014) 0.91
Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells. J Biol Chem (2015) 0.89
An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic β-cell. Islets (2010) 0.89
The role of CD38 in Fcγ receptor (FcγR)-mediated phagocytosis in murine macrophages. J Biol Chem (2012) 0.89
LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis. Exp Neurol (2014) 0.88
Nicotinic acid adenine dinucleotide phosphate (NAADP) activates global and heterogeneous local Ca2+ signals from NAADP- and ryanodine receptor-gated Ca2+ stores in pulmonary arterial myocytes. J Biol Chem (2013) 0.86
Deviant nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated Ca2+ signaling upon lysosome proliferation. J Biol Chem (2010) 0.86
8-Bromo-cyclic inosine diphosphoribose: towards a selective cyclic ADP-ribose agonist. Biochem J (2009) 0.86
A functional role for nicotinic acid adenine dinucleotide phosphate in oxytocin-mediated contraction of uterine smooth muscle from rat. J Pharmacol Exp Ther (2010) 0.86
Regulation of NAD+ metabolism, signaling and compartmentalization in the yeast Saccharomyces cerevisiae. DNA Repair (Amst) (2014) 0.85
NAD: not just a pawn on the board of plant-pathogen interactions. Plant Signal Behav (2012) 0.84
Inseparable tandem: evolution chooses ATP and Ca2+ to control life, death and cellular signalling. Philos Trans R Soc Lond B Biol Sci (2016) 0.82
Adenine Dinucleotide Second Messengers and T-lymphocyte Calcium Signaling. Front Immunol (2013) 0.82
A single residue in a novel ADP-ribosyl cyclase controls production of the calcium-mobilizing messengers cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate. J Biol Chem (2010) 0.81
Upstream deregulation of calcium signaling in Parkinson's disease. Front Mol Neurosci (2014) 0.81
Nicotinic acid adenine dinucleotide phosphate (NAADP) degradation by alkaline phosphatase. J Biol Chem (2012) 0.81
A Link between Autophagy and the Pathophysiology of LRRK2 in Parkinson's Disease. Parkinsons Dis (2012) 0.80
NAADP/TPC2/Ca(2+) Signaling Inhibits Autophagy. Commun Integr Biol (2014) 0.80
Autophagy maturation associated with CD38-mediated regulation of lysosome function in mouse glomerular podocytes. J Cell Mol Med (2013) 0.80
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger in muscarinic receptor-induced contraction of guinea pig trachea. J Biol Chem (2013) 0.78
Role of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) in Keratinocyte Differentiation. J Invest Dermatol (2015) 0.78
YCL047C/POF1 is a novel nicotinamide mononucleotide adenylyltransferase (NMNAT) in Saccharomyces cerevisiae. J Biol Chem (2014) 0.78
NO-Mediated [Ca2+]cyt Increases Depend on ADP-Ribosyl Cyclase Activity in Arabidopsis. Plant Physiol (2016) 0.77
Calcium Signalling Triggered by NAADP in T Cells Determines Cell Shape and Motility During Immune Synapse Formation. Messenger (Los Angel) (2015) 0.76
Less is more: Nutrient limitation induces cross-talk of nutrient sensing pathways with NAD(+) homeostasis and contributes to longevity. Front Biol (Beijing) (2015) 0.75
A novel cycling assay for cellular cADP-ribose with nanomolar sensitivity. Biochem J (2002) 1.55
Crystal structure of human CD38 extracellular domain. Structure (2005) 1.29
Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine nicotinic acid adenine dinucleotide phosphate (NAADP) synthesis and hydrolysis activities. J Biol Chem (2006) 1.13
Cyclic ADP-ribose is a second messenger in the lipopolysaccharide-stimulated proliferation of human peripheral blood mononuclear cells. Biochem J (2003) 1.06
The membrane-bound enzyme CD38 exists in two opposing orientations. Sci Signal (2012) 1.04
Structural basis for the mechanistic understanding of human CD38-controlled multiple catalysis. J Biol Chem (2006) 1.03
Ca(2+) signaling occurs via second messenger release from intraorganelle synthesis sites. Curr Biol (2008) 1.00
Covalent and noncovalent intermediates of an NAD utilizing enzyme, human CD38. Chem Biol (2008) 0.98
Evidence for a causal role of CD38 expression in granulocytic differentiation of human HL-60 cells. J Biol Chem (2002) 0.96
Regulation of nuclear Ca2+ signaling by translocation of the Ca2+ messenger synthesizing enzyme ADP-ribosyl cyclase during neuronal depolarization. J Biol Chem (2008) 0.95
Catalysis-associated conformational changes revealed by human CD38 complexed with a non-hydrolyzable substrate analog. J Biol Chem (2007) 0.95
A novel cycling assay for nicotinic acid-adenine dinucleotide phosphate with nanomolar sensitivity. Biochem J (2002) 0.95
Mechanism of cyclizing NAD to cyclic ADP-ribose by ADP-ribosyl cyclase and CD38. J Biol Chem (2009) 0.93
Autocrine/paracrine function of nicotinic acid adenine dinucleotide phosphate (NAADP) for glucose homeostasis in pancreatic β-cells and adipocytes. J Biol Chem (2013) 0.92
Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase. J Biol Chem (2009) 0.91
Mechanism-based small molecule probes for labeling CD38 on live cells. J Am Chem Soc (2009) 0.90
Structural basis for formation and hydrolysis of the calcium messenger cyclic ADP-ribose by human CD38. J Biol Chem (2006) 0.87
ADP-ribosyl cyclase; crystal structures reveal a covalent intermediate. Structure (2004) 0.86
Nuclear CD38 in retinoic acid-induced HL-60 cells. Exp Cell Res (2005) 0.86
CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5'-Diphosphate Ribose Template. PLoS One (2013) 0.84
Design, synthesis and biological characterization of novel inhibitors of CD38. Org Biomol Chem (2011) 0.83
Cytosolic CD38 protein forms intact disulfides and is active in elevating intracellular cyclic ADP-ribose. J Biol Chem (2011) 0.83
Emerging role of cyclic ADP-ribose (cADPR) in smooth muscle. Pharmacol Ther (2004) 0.82
Roles of cADPR and NAADP in pancreatic cells. Acta Biochim Biophys Sin (Shanghai) (2012) 0.81
Structural studies of intermediates along the cyclization pathway of Aplysia ADP-ribosyl cyclase. J Mol Biol (2011) 0.80
Cyclic ADP-ribose links metabolism to multiple fission in the dinoflagellate Crypthecodinium cohnii. Cell Calcium (2009) 0.79
High throughput fluorescence-based assays for cyclic ADP-ribose, NAADP, and their metabolic enzymes. Comb Chem High Throughput Screen (2003) 0.79
Hierarchical and helical self-assembly of ADP-ribosyl cyclase into large-scale protein microtubes. J Phys Chem B (2008) 0.78
Determination of ADP-ribosyl cyclase activity, cyclic ADP-ribose, and nicotinic acid adenine dinucleotide phosphate in tissue extracts. Methods Mol Biol (2013) 0.77
Conformational Closure of the Catalytic Site of Human CD38 Induced by Calcium (dagger) (double dagger). Biochemistry (2008) 0.77
Catalysis-based inhibitors of the calcium signaling function of CD38. Biochemistry (2011) 0.76
Identification of ADP-ribosylation sites of CD38 mutants by precursor ion scanning mass spectrometry. Anal Biochem (2012) 0.76
Conformational Closure of the Catalytic Site of Human CD38 Induced by Calcium. Biochemistry (2008) 0.75