PubRank

Michael K Rosen

Author PubWeight™ 79.86‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Phase transitions in the assembly of multivalent signalling proteins. Nature 2012 3.49
2 Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain. Nature 2005 3.31
3 Hierarchical regulation of WASP/WAVE proteins. Mol Cell 2008 2.86
4 A conserved amphipathic helix in WASP/Scar proteins is essential for activation of Arp2/3 complex. Nat Struct Biol 2003 2.77
5 Estimation of the available free energy in a LOV2-J alpha photoswitch. Nat Chem Biol 2008 2.63
6 Structure and control of the actin regulatory WAVE complex. Nature 2010 2.25
7 Physical mechanisms of signal integration by WASP family proteins. Annu Rev Biochem 2010 2.18
8 Structural basis of Rho GTPase-mediated activation of the formin mDia1. Mol Cell 2005 2.16
9 Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nat Struct Mol Biol 2004 2.11
10 Genetically encoded photoswitching of actin assembly through the Cdc42-WASP-Arp2/3 complex pathway. Proc Natl Acad Sci U S A 2008 2.06
11 Arp2/3-independent assembly of actin by Vibrio type III effector VopL. Proc Natl Acad Sci U S A 2007 2.05
12 Autoinhibition regulates cellular localization and actin assembly activity of the diaphanous-related formins FRLalpha and mDia1. J Cell Biol 2006 1.99
13 Internal dynamics control activation and activity of the autoinhibited Vav DH domain. Nat Struct Mol Biol 2008 1.93
14 The WAVE regulatory complex is inhibited. Nat Struct Mol Biol 2009 1.83
15 Mechanism of actin filament nucleation by the bacterial effector VopL. Nat Struct Mol Biol 2011 1.80
16 Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP. Mol Cell 2003 1.77
17 Rationally improving LOV domain-based photoswitches. Nat Methods 2010 1.72
18 WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes. Proc Natl Acad Sci U S A 2010 1.71
19 Arp2/3 complex is bound and activated by two WASP proteins. Proc Natl Acad Sci U S A 2011 1.70
20 Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6. EMBO J 2003 1.60
21 Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1. Cell 2010 1.51
22 Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP. Curr Biol 2003 1.47
23 Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation. Proc Natl Acad Sci U S A 2009 1.46
24 Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspF(U). Nature 2008 1.43
25 Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer. Mol Biol Cell 2012 1.38
26 Determination of protein complex stoichiometry through multisignal sedimentation velocity experiments. Anal Biochem 2010 1.36
27 Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP. J Biol Chem 2005 1.35
28 Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination. Cell 2013 1.32
29 Signal transduction pathway of TonB-dependent transporters. Proc Natl Acad Sci U S A 2006 1.32
30 A two-state allosteric model for autoinhibition rationalizes WASP signal integration and targeting. J Mol Biol 2004 1.32
31 The nucleotide switch in Cdc42 modulates coupling between the GTPase-binding and allosteric equilibria of Wiskott-Aldrich syndrome protein. Proc Natl Acad Sci U S A 2005 1.31
32 Uncoupling Kapbeta2 substrate dissociation and ran binding. Biochemistry 2002 1.26
33 Three-color single molecule imaging shows WASP detachment from Arp2/3 complex triggers actin filament branch formation. Elife 2013 1.18
34 NMR analyses of the activation of the Arp2/3 complex by neuronal Wiskott-Aldrich syndrome protein. Biochemistry 2005 1.16
35 Specific patterns of Cdc42 activity are related to distinct elements of T cell polarization. J Immunol 2006 1.14
36 Rational design of genetically encoded fluorescence resonance energy transfer-based sensors of cellular Cdc42 signaling. Biochemistry 2003 1.14
37 Repetitive N-WASP-binding elements of the enterohemorrhagic Escherichia coli effector EspF(U) synergistically activate actin assembly. PLoS Pathog 2008 1.08
38 The bacterial effector VopL organizes actin into filament-like structures. Cell 2013 1.04
39 Acidic region tyrosines provide access points for allosteric activation of the autoinhibited Vav1 Dbl homology domain. Biochemistry 2005 1.03
40 A large kindred with X-linked neutropenia with an I294T mutation of the Wiskott-Aldrich syndrome gene. Br J Haematol 2008 1.03
41 Biochemical properties and inhibitors of (N-)WASP. Methods Enzymol 2006 1.02
42 A novel mechanism of actin filament processive capping by formin: solution of the rotation paradox. J Cell Biol 2005 1.01
43 Measurement and analysis of in vitro actin polymerization. Methods Mol Biol 2013 0.97
44 Crystal structure of the Formin mDia1 in autoinhibited conformation. PLoS One 2010 0.96
45 Ignition of a cellular machine. Nat Cell Biol 2002 0.89
46 NMR analysis of methyl groups at 100-500 kDa: model systems and Arp2/3 complex. Biochemistry 2003 0.88
47 Enlightening molecular mechanisms through study of protein interactions. J Mol Cell Biol 2012 0.88
48 Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes. J Exp Med 2010 0.87
49 The feasibility of parameterizing four-state equilibria using relaxation dispersion measurements. J Biomol NMR 2011 0.81
50 Purification of Arp2/3 complex from Saccharomyces cerevisiae. Methods Mol Biol 2013 0.80
51 Purification of native Arp2/3 complex from bovine thymus. Methods Mol Biol 2013 0.79
52 [Structure and function of Formin homology 2 domain]. Tanpakushitsu Kakusan Koso 2005 0.77
53 Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris. J Biomol NMR 2015 0.77
54 The Haemophilus ducreyi LspA1 protein inhibits phagocytosis by using a new mechanism involving activation of C-terminal Src kinase. MBio 2014 0.76
55 Correction: Fat2 acts through the WAVE regulatory complex to drive collective cell migration during tissue rotation. J Cell Biol 2016 0.75