Published in Proc Natl Acad Sci U S A on May 24, 2010
Retromer-mediated endosomal protein sorting: all WASHed up! Trends Cell Biol (2013) 2.77
Sorting nexins provide diversity for retromer-dependent trafficking events. Nat Cell Biol (2011) 2.32
Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms. Acta Neuropathol (2013) 2.30
New insights into the regulation and cellular functions of the ARP2/3 complex. Nat Rev Mol Cell Biol (2012) 2.25
Structure and control of the actin regulatory WAVE complex. Nature (2010) 2.25
The retromer complex - endosomal protein recycling and beyond. J Cell Sci (2012) 2.08
ER contact sites define the position and timing of endosome fission. Cell (2014) 1.92
Mutation in VPS35 associated with Parkinson's disease impairs WASH complex association and inhibits autophagy. Nat Commun (2014) 1.61
New mechanisms and functions of actin nucleation. Curr Opin Cell Biol (2010) 1.45
Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer. Mol Biol Cell (2012) 1.38
Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks. Mol Biol Cell (2012) 1.36
Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination. Cell (2013) 1.32
WASH inhibits autophagy through suppression of Beclin 1 ubiquitination. EMBO J (2013) 1.32
Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia. J Cell Biol (2013) 1.28
Phase transitions of multivalent proteins can promote clustering of membrane receptors. Elife (2014) 1.22
Capping protein regulators fine-tune actin assembly dynamics. Nat Rev Mol Cell Biol (2014) 1.17
WASH knockout T cells demonstrate defective receptor trafficking, proliferation, and effector function. Mol Cell Biol (2012) 1.10
The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIα. Mol Biol Cell (2013) 1.08
The hereditary spastic paraplegia protein strumpellin: characterisation in neurons and of the effect of disease mutations on WASH complex assembly and function. Biochim Biophys Acta (2012) 1.08
Bacterial subversion of host actin dynamics at the plasma membrane. Cell Microbiol (2011) 1.07
Dedicator of cytokinesis 8 interacts with talin and Wiskott-Aldrich syndrome protein to regulate NK cell cytotoxicity. J Immunol (2013) 1.05
T cell antigen receptor activation and actin cytoskeleton remodeling. Biochim Biophys Acta (2013) 1.03
Under lock and key: spatiotemporal regulation of WASP family proteins coordinates separate dynamic cellular processes. Semin Cell Dev Biol (2013) 1.01
Physiology and pathology of endosome-to-Golgi retrograde sorting. Traffic (2011) 0.99
Dysbindin-containing complexes and their proposed functions in brain: from zero to (too) many in a decade. ASN Neuro (2011) 0.97
Function and regulation of the endosomal fusion and fission machineries. Cold Spring Harb Perspect Biol (2014) 0.96
WASH is required for lysosomal recycling and efficient autophagic and phagocytic digestion. Mol Biol Cell (2013) 0.95
PI(3,5)P2 controls endosomal branched actin dynamics by regulating cortactin-actin interactions. J Cell Biol (2015) 0.94
Evolution of the eukaryotic ARP2/3 activators of the WASP family: WASP, WAVE, WASH, and WHAMM, and the proposed new family members WAWH and WAML. BMC Res Notes (2012) 0.94
Actin polymerization controls the organization of WASH domains at the surface of endosomes. PLoS One (2012) 0.94
COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. Mol Biol Cell (2014) 0.93
The actin nucleation factor JMY is a negative regulator of neuritogenesis. Mol Biol Cell (2011) 0.93
Regulation of integrin trafficking, cell adhesion, and cell migration by WASH and the Arp2/3 complex. Cytoskeleton (Hoboken) (2012) 0.92
Interactions of isolated C-terminal fragments of neural Wiskott-Aldrich syndrome protein (N-WASP) with actin and Arp2/3 complex. J Biol Chem (2012) 0.92
WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner. J Exp Med (2014) 0.91
Structural insights into WHAMM-mediated cytoskeletal coordination during membrane remodeling. J Cell Biol (2012) 0.91
USP7 Acts as a Molecular Rheostat to Promote WASH-Dependent Endosomal Protein Recycling and Is Mutated in a Human Neurodevelopmental Disorder. Mol Cell (2015) 0.90
ARP2/3-dependent growth in the plant kingdom: SCARs for life. Front Plant Sci (2013) 0.88
Control of polarized assembly of actin filaments in cell motility. Cell Mol Life Sci (2015) 0.88
Phosphoinositides in the mammalian endo-lysosomal network. Subcell Biochem (2012) 0.87
Mutations in the BLOC-1 subunits dysbindin and muted generate divergent and dosage-dependent phenotypes. J Biol Chem (2014) 0.85
WASH complex regulates Arp2/3 complex for actin-based polar body extrusion in mouse oocytes. Sci Rep (2014) 0.83
Actin on trafficking: could actin guide directed receptor transport? Cell Adh Migr (2012) 0.82
Nuclear FAM21 participates in NF-κB-dependent gene regulation in pancreatic cancer cells. J Cell Sci (2014) 0.81
The role of the retromer complex in aging-related neurodegeneration: a molecular and genomic review. Mol Genet Genomics (2014) 0.81
Actin engine in immunological synapse. Immune Netw (2012) 0.81
Autophagosome-lysosome fusion in neurons requires INPP5E, a protein associated with Joubert syndrome. EMBO J (2016) 0.81
Systems-wide Studies Uncover Commander, a Multiprotein Complex Essential to Human Development. Cell Syst (2017) 0.81
FAM21 directs SNX27-retromer cargoes to the plasma membrane by preventing transport to the Golgi apparatus. Nat Commun (2016) 0.80
Wiskott-Aldrich syndrome proteins in the nucleus: aWASH with possibilities. Nucleus (2015) 0.78
Neurodevelopmental disorders: mechanisms and boundary definitions from genomes, interactomes and proteomes. Transl Psychiatry (2013) 0.78
Structural and mechanistic insights into regulation of the retromer coat by TBC1d5. Nat Commun (2016) 0.78
Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling. J Cell Biol (2015) 0.77
Wash functions downstream of Rho1 GTPase in a subset of Drosophila immune cell developmental migrations. Mol Biol Cell (2015) 0.77
Dendritic cells utilize the evolutionarily conserved WASH and retromer complexes to promote MHCII recycling and helper T cell priming. PLoS One (2014) 0.76
WASH has a critical role in NK cell cytotoxicity through Lck-mediated phosphorylation. Cell Death Dis (2016) 0.76
The spectrum of KIAA0196 variants, and characterization of a murine knockout: implications for the mutational mechanism in hereditary spastic paraplegia type SPG8. Orphanet J Rare Dis (2015) 0.76
WASH drives early recycling from macropinosomes and phagosomes to maintain surface phagocytic receptors. Proc Natl Acad Sci U S A (2016) 0.75
Role of the Retromer Complex in Neurodegenerative Diseases. Front Aging Neurosci (2016) 0.75
Strumpellin and Spartin, Hereditary Spastic Paraplegia Proteins, are Binding Partners. J Exp Neurosci (2015) 0.75
MoCAP proteins regulated by MoArk1-mediated phosphorylation coordinate endocytosis and actin dynamics to govern development and virulence of Magnaporthe oryzae. PLoS Genet (2017) 0.75
Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour. Pigment Cell Melanoma Res (2016) 0.75
An evolutionary balance: conservation vs innovation in ciliate membrane trafficking. Traffic (2016) 0.75
Retromer/WASH dependent sorting of nutrient transporters requires a multivalent interaction network with ANKRD50. J Cell Sci (2016) 0.75
Cellular functions of WASP family proteins at a glance. J Cell Sci (2017) 0.75
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res (1997) 665.31
Basic local alignment search tool. J Mol Biol (1990) 659.07
Predicting coiled coils from protein sequences. Science (1991) 38.18
EMAN: semiautomated software for high-resolution single-particle reconstructions. J Struct Biol (1999) 27.52
The HHpred interactive server for protein homology detection and structure prediction. Nucleic Acids Res (2005) 21.68
A map of the interactome network of the metazoan C. elegans. Science (2004) 15.60
The tandem affinity purification (TAP) method: a general procedure of protein complex purification. Methods (2001) 15.37
Membrane lipids: where they are and how they behave. Nat Rev Mol Cell Biol (2008) 13.77
Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature (2002) 6.26
The WASP-WAVE protein network: connecting the membrane to the cytoskeleton. Nat Rev Mol Cell Biol (2007) 6.00
A FAM21-containing WASH complex regulates retromer-dependent sorting. Dev Cell (2009) 4.89
New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet (2005) 4.18
Abi1 is essential for the formation and activation of a WAVE2 signalling complex. Nat Cell Biol (2004) 4.04
The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex. Dev Cell (2009) 4.00
Hereditary spastic paraplegia: clinical features and pathogenetic mechanisms. Lancet Neurol (2008) 3.49
Mechanism of actin network attachment to moving membranes: barbed end capture by N-WASP WH2 domains. Cell (2007) 3.04
Capping protein increases the rate of actin-based motility by promoting filament nucleation by the Arp2/3 complex. Cell (2008) 3.00
Protein complexes regulating Arp2/3-mediated actin assembly. Curr Opin Cell Biol (2005) 2.63
Human subtelomeric WASH genes encode a new subclass of the WASP family. PLoS Genet (2007) 2.43
New insights into mechanism and regulation of actin capping protein. Int Rev Cell Mol Biol (2008) 2.11
Arp2/3-independent assembly of actin by Vibrio type III effector VopL. Proc Natl Acad Sci U S A (2007) 2.05
Mutations in the KIAA0196 gene at the SPG8 locus cause hereditary spastic paraplegia. Am J Hum Genet (2006) 1.92
The WAVE regulatory complex is inhibited. Nat Struct Mol Biol (2009) 1.83
Wash functions downstream of Rho and links linear and branched actin nucleation factors. Development (2009) 1.66
Abl interactor 1 (Abi-1) wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and wave-1 levels. Mol Cell Biol (2004) 1.38
The Wave complex is intrinsically inactive. Cell Motil Cytoskeleton (2009) 1.37
The nucleotide switch in Cdc42 modulates coupling between the GTPase-binding and allosteric equilibria of Wiskott-Aldrich syndrome protein. Proc Natl Acad Sci U S A (2005) 1.31
The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ. Biochem J (2005) 1.20
Recent advances in the biology of WASP and WIP. Immunol Res (2009) 1.19
Sra-1 interacts with Kette and Wasp and is required for neuronal and bristle development in Drosophila. Development (2004) 1.15
HKL-3000: the integration of data reduction and structure solution--from diffraction images to an initial model in minutes. Acta Crystallogr D Biol Crystallogr (2006) 13.29
A FAM21-containing WASH complex regulates retromer-dependent sorting. Dev Cell (2009) 4.89
Phase transitions in the assembly of multivalent signalling proteins. Nature (2012) 3.49
Highly conserved protective epitopes on influenza B viruses. Science (2012) 3.47
A new generation of crystallographic validation tools for the protein data bank. Structure (2011) 3.41
Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain. Nature (2005) 3.31
Regulation of T-cell activation by the cytoskeleton. Nat Rev Immunol (2007) 3.19
Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse. Immunity (2007) 3.14
Hierarchical regulation of WASP/WAVE proteins. Mol Cell (2008) 2.86
A conserved amphipathic helix in WASP/Scar proteins is essential for activation of Arp2/3 complex. Nat Struct Biol (2003) 2.77
Retromer-mediated endosomal protein sorting: all WASHed up! Trends Cell Biol (2013) 2.77
Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells. Cancer Res (2005) 2.72
Estimation of the available free energy in a LOV2-J alpha photoswitch. Nat Chem Biol (2008) 2.63
VAV proteins as signal integrators for multi-subunit immune-recognition receptors. Nat Rev Immunol (2002) 2.57
Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase. Mol Cell (2006) 2.32
Structure and control of the actin regulatory WAVE complex. Nature (2010) 2.25
HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse. Immunity (2006) 2.23
Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis. J Clin Invest (2003) 2.21
The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation. Curr Biol (2006) 2.20
Physical mechanisms of signal integration by WASP family proteins. Annu Rev Biochem (2010) 2.18
Structural basis of Rho GTPase-mediated activation of the formin mDia1. Mol Cell (2005) 2.16
Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity. Mol Cell Biol (2003) 2.15
Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nat Struct Mol Biol (2004) 2.11
Deregulated GSK3beta activity in colorectal cancer: its association with tumor cell survival and proliferation. Biochem Biophys Res Commun (2005) 2.08
Genetically encoded photoswitching of actin assembly through the Cdc42-WASP-Arp2/3 complex pathway. Proc Natl Acad Sci U S A (2008) 2.06
Arp2/3-independent assembly of actin by Vibrio type III effector VopL. Proc Natl Acad Sci U S A (2007) 2.05
Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35. Nat Struct Mol Biol (2010) 2.01
Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis. Cancer Cell (2005) 2.01
Autoinhibition regulates cellular localization and actin assembly activity of the diaphanous-related formins FRLalpha and mDia1. J Cell Biol (2006) 1.99
The structural genomics experimental pipeline: insights from global target lists. Proteins (2004) 1.98
Secondary structure of Huntingtin amino-terminal region. Structure (2009) 1.98
Internal dynamics control activation and activity of the autoinhibited Vav DH domain. Nat Struct Mol Biol (2008) 1.93
[20] Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol (1997) 1.92
Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse. Nat Immunol (2005) 1.90
The WAVE regulatory complex is inhibited. Nat Struct Mol Biol (2009) 1.83
Mechanism of actin filament nucleation by the bacterial effector VopL. Nat Struct Mol Biol (2011) 1.80
NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells. Nat Immunol (2006) 1.78
Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP. Mol Cell (2003) 1.77
Rationally improving LOV domain-based photoswitches. Nat Methods (2010) 1.72
Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6. J Med Chem (2008) 1.70
Arp2/3 complex is bound and activated by two WASP proteins. Proc Natl Acad Sci U S A (2011) 1.70
The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis. J Biol Chem (2004) 1.64
Measurement errors and their consequences in protein crystallography. Acta Crystallogr D Biol Crystallogr (2003) 1.62
T cell activation and the cytoskeleton: you can't have one without the other. Adv Immunol (2008) 1.62
Aberrant nuclear accumulation of glycogen synthase kinase-3beta in human pancreatic cancer: association with kinase activity and tumor dedifferentiation. Clin Cancer Res (2006) 1.61
Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6. EMBO J (2003) 1.60
SLP-76 coordinates Nck-dependent Wiskott-Aldrich syndrome protein recruitment with Vav-1/Cdc42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site. J Immunol (2003) 1.58
Vasodilator-stimulated phosphoprotein promotes activation of hepatic stellate cells by regulating Rab11-dependent plasma membrane targeting of transforming growth factor beta receptors. Hepatology (2014) 1.55
Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton. J Immunol (2005) 1.54
Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1. Cell (2010) 1.51
Targeting GSK-3: a promising approach for cancer therapy? Future Oncol (2006) 1.50
Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP. Curr Biol (2003) 1.47
Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation. Proc Natl Acad Sci U S A (2009) 1.46
Methodology and applications of automatic electron-density map interpretation by six-dimensional rotational and translational search for molecular fragments. Acta Crystallogr D Biol Crystallogr (2002) 1.44
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes. Mol Cell Biol (2003) 1.44
Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspF(U). Nature (2008) 1.43
Molecular architecture of the chick vestibular hair bundle. Nat Neurosci (2013) 1.43
Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen. J Biol Chem (2004) 1.40
Regulation of pancreatic tumor cell proliferation and chemoresistance by the histone methyltransferase enhancer of zeste homologue 2. Clin Cancer Res (2008) 1.39
Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy. Nat Struct Mol Biol (2012) 1.38
Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer. Mol Biol Cell (2012) 1.38
Determination of protein complex stoichiometry through multisignal sedimentation velocity experiments. Anal Biochem (2010) 1.36
Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks. Mol Biol Cell (2012) 1.36
Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP. J Biol Chem (2005) 1.35
High-resolution timing of cell cycle-regulated gene expression. Proc Natl Acad Sci U S A (2007) 1.35
Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination. Cell (2013) 1.32
Signal transduction pathway of TonB-dependent transporters. Proc Natl Acad Sci U S A (2006) 1.32
A two-state allosteric model for autoinhibition rationalizes WASP signal integration and targeting. J Mol Biol (2004) 1.32
The nucleotide switch in Cdc42 modulates coupling between the GTPase-binding and allosteric equilibria of Wiskott-Aldrich syndrome protein. Proc Natl Acad Sci U S A (2005) 1.31
Protein kinase D1 and the beta 1 integrin cytoplasmic domain control beta 1 integrin function via regulation of Rap1 activation. Immunity (2005) 1.29
Human immunodeficiency virus-induced apoptosis of human hepatocytes via CXCR4. J Infect Dis (2003) 1.28
Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line. EMBO J (2002) 1.28
Diffraction data analysis in the presence of radiation damage. Acta Crystallogr D Biol Crystallogr (2010) 1.27
Uncoupling Kapbeta2 substrate dissociation and ran binding. Biochemistry (2002) 1.26
The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1. J Cell Biol (2008) 1.23
WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse. Mol Cell Biol (2007) 1.21
Three-color single molecule imaging shows WASP detachment from Arp2/3 complex triggers actin filament branch formation. Elife (2013) 1.18
Structural basis for Marburg virus VP35-mediated immune evasion mechanisms. Proc Natl Acad Sci U S A (2012) 1.18
Structural genomics: keeping up with expanding knowledge of the protein universe. Curr Opin Struct Biol (2007) 1.17
NMR analyses of the activation of the Arp2/3 complex by neuronal Wiskott-Aldrich syndrome protein. Biochemistry (2005) 1.16
Rational design of genetically encoded fluorescence resonance energy transfer-based sensors of cellular Cdc42 signaling. Biochemistry (2003) 1.14
Specific patterns of Cdc42 activity are related to distinct elements of T cell polarization. J Immunol (2006) 1.14
Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis. J Hepatol (2010) 1.13
Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element. Mol Cell Biol (2006) 1.13
The many faces of radiation-induced changes. J Synchrotron Radiat (2006) 1.13