Published in Biochemistry on February 26, 1991
The metabolic serine hydrolases and their functions in mammalian physiology and disease. Chem Rev (2011) 1.89
Comparative biochemical analysis of three bacterial prolyl endopeptidases: implications for coeliac sprue. Biochem J (2004) 1.63
A cytosolic serine endopeptidase from Trypanosoma cruzi is required for the generation of Ca2+ signaling in mammalian cells. J Cell Biol (1997) 1.44
Loss of a prolyl oligopeptidase confers resistance to lithium by elevation of inositol (1,4,5) trisphosphate. EMBO J (1999) 1.41
A new family of serine-type peptidases related to prolyl oligopeptidase. Biochem J (1991) 1.40
Structural and mechanistic analysis of two prolyl endopeptidases: role of interdomain dynamics in catalysis and specificity. Proc Natl Acad Sci U S A (2005) 1.27
Comparative genomics of gene expression in the parasitic and free-living nematodes Strongyloides stercoralis and Caenorhabditis elegans. Genome Res (2004) 1.20
Catalysis of serine oligopeptidases is controlled by a gating filter mechanism. EMBO Rep (2000) 1.08
Prolyl endopeptidase catalysis. A physical rather than a chemical step is rate-limiting. Biochem J (1992) 1.08
Molecular, functional and structural properties of the prolyl oligopeptidase of Trypanosoma cruzi (POP Tc80), which is required for parasite entry into mammalian cells. Biochem J (2005) 1.06
Inactivation of prolyl endopeptidase by a peptidylchloromethane. Kinetics of inactivation and identification of sites of modification. Biochem J (1991) 1.03
Posttranslational processing of a new class of hydroxyproline-containing proteins. Prolyl hydroxylation and C-terminal cleavage of tobacco (Nicotiana tabacum) vacuolar chitinase. Plant Physiol (1993) 0.95
Proline-specific endopeptidases from microbial sources: isolation of an enzyme from a Xanthomonas sp. J Bacteriol (1992) 0.89
Targeted modification of wheat grain protein to reduce the content of celiac causing epitopes. Funct Integr Genomics (2012) 0.88
Overexpression and characterization of a prolyl endopeptidase from the hyperthermophilic archaeon Pyrococcus furiosus. J Bacteriol (1997) 0.88
Peptidyldiazomethanes. A novel mechanism of interaction with prolyl endopeptidase. Biochem J (1992) 0.87
Structural analysis of prolyl oligopeptidases using molecular docking and dynamics: insights into conformational changes and ligand binding. PLoS One (2011) 0.87
Substrate- and pH-dependent contribution of oxyanion binding site to the catalysis of prolyl oligopeptidase, a paradigm of the serine oligopeptidase family. Protein Sci (2000) 0.86
OsPOP5, a prolyl oligopeptidase family gene from rice confers abiotic stress tolerance in Escherichia coli. Int J Mol Sci (2013) 0.82
Effects of ionic strength on the catalysis and stability of prolyl oligopeptidase. Biochem J (1995) 0.81
Benzyloxycarbonylprolylprolinal, a transition-state analogue for prolyl oligopeptidase, forms a tetrahedral adduct with catalytic serine, not a reactive cysteine. Biochem J (1997) 0.80
Slow-binding inhibitors of prolyl oligopeptidase with different functional groups at the P1 site. Biochem J (2004) 0.75
Location of the protease II gene (ptrB) on the physical map of the Escherichia coli chromosome. J Bacteriol (1992) 0.75
New nucleotide sequence data on the EMBL File Server. Nucleic Acids Res (1991) 0.75
Localization and subcellular distribution of prolyl oligopeptidase in the mouse placenta. J Mol Histol (2011) 0.75
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature (1996) 26.30
Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J (1996) 16.68
Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways. Proc Natl Acad Sci U S A (2000) 9.02
Role of translocation in the activation and function of protein kinase B. J Biol Chem (1997) 7.29
The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc Natl Acad Sci U S A (1998) 6.98
Ten years of protein kinase B signalling: a hard Akt to follow. Trends Biochem Sci (2001) 6.66
Phosphorylation and activation of p70s6k by PDK1. Science (1998) 6.53
Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase. FEBS Lett (1996) 6.16
Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol Cell Biol (2001) 5.78
Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. Proc Natl Acad Sci U S A (1991) 4.66
The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment. EMBO J (1989) 4.49
Regulation of protein kinase cascades by protein phosphatase 2A. Trends Biochem Sci (1999) 4.42
Mutant defective in processing of an enzyme located in the lysosome-like vacuole of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1981) 4.20
The crystal structure of human eukaryotic release factor eRF1--mechanism of stop codon recognition and peptidyl-tRNA hydrolysis. Cell (2000) 3.92
Protein phosphatase-1 and protein phosphatase-2A from rabbit skeletal muscle. Methods Enzymol (1988) 3.88
Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors. Proc Natl Acad Sci U S A (1996) 3.50
Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway. EMBO J (1999) 3.41
Molecular cloning of cDNAs encoding two isoforms of the catalytic subunit of protein phosphatase 2A. Biochemistry (1987) 3.31
Serine/threonine protein phosphatases. Biochem J (1995) 3.11
Pleckstrin domain homology. Nature (1993) 3.03
The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs. Cell (1999) 2.89
High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/protein kinase B and their influence on kinase activity. J Biol Chem (1997) 2.88
Evidence for N- and C-terminal processing of a plant defense-related enzyme: Primary structure of tobacco prepro-beta-1,3-glucanase. Proc Natl Acad Sci U S A (1988) 2.86
Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta. J Biol Chem (1997) 2.70
Physiological roles of PKB/Akt isoforms in development and disease. Biochem Soc Trans (2007) 2.70
90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1. J Biol Chem (1999) 2.61
Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin. J Biol Chem (1997) 2.40
Kinetics of the inhibition of thrombin by hirudin. Biochemistry (1986) 2.33
The 55 kd regulatory subunit of Drosophila protein phosphatase 2A is required for anaphase. Cell (1993) 2.26
Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane. Science (2001) 2.11
Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase. Proc Natl Acad Sci U S A (1998) 2.09
Constitutive activation of protein kinase B and phosphorylation of p47phox by a membrane-targeted phosphoinositide 3-kinase. Curr Biol (1996) 2.07
alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure. Biochemistry (1990) 2.03
Tenascin: cDNA cloning and induction by TGF-beta. EMBO J (1988) 2.01
Physiological functions of protein kinase B/Akt. Biochem Soc Trans (2004) 2.00
Developmental regulation of expression and activity of multiple forms of the Drosophila RAC protein kinase. J Biol Chem (1995) 1.91
Thrombin functions as an inflammatory mediator through activation of its receptor. J Exp Med (1996) 1.87
Raf-1-associated protein phosphatase 2A as a positive regulator of kinase activation. J Biol Chem (2000) 1.87
AUH, a gene encoding an AU-specific RNA binding protein with intrinsic enoyl-CoA hydratase activity. Proc Natl Acad Sci U S A (1995) 1.80
Drosophila mutants in the 55 kDa regulatory subunit of protein phosphatase 2A show strongly reduced ability to dephosphorylate substrates of p34cdc2. J Cell Sci (1994) 1.79
The catalytic subunits of protein phosphatase-1 and protein phosphatase 2A are distinct gene products. Eur J Biochem (1984) 1.76
Correct folding of circularly permuted variants of a beta alpha barrel enzyme in vivo. Science (1989) 1.76
Identification of the 40 S ribosomal protein S6 phosphorylation sites induced by cycloheximide. J Biol Chem (1988) 1.72
Mitogen-activated 70K S6 kinase. Identification of in vitro 40 S ribosomal S6 phosphorylation sites. J Biol Chem (1991) 1.70
Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform. Biochemistry (1991) 1.69
Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation. Mol Cell Biol (1999) 1.69
Crystal structure of the thrombin-hirudin complex: a novel mode of serine protease inhibition. EMBO J (1990) 1.65
Molecular cloning of a second form of rac protein kinase. Cell Regul (1991) 1.63
Purification of glycogen synthase kinase 3 from rabbit skeletal muscle. Copurification with the activating factor (FA) of the (Mg-ATP) dependent protein phosphatase. Eur J Biochem (1981) 1.63
Protein phosphatase 2A--a 'ménage à trois'. Trends Cell Biol (1994) 1.62
p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1). J Biol Chem (2000) 1.61
Quantitative evaluation of the contribution of ionic interactions to the formation of the thrombin-hirudin complex. Biochemistry (1989) 1.61
Thrombin causes neurite retraction in neuronal cells through activation of cell surface receptors. Neuron (1992) 1.60
Purification and characterization of a soluble beta-fructofuranosidase from Daucus carota. Eur J Biochem (1992) 1.59
A recombinant calcitonin receptor independently stimulates 3',5'-cyclic adenosine monophosphate and Ca2+/inositol phosphate signaling pathways. Mol Endocrinol (1992) 1.59
Characterisation of a reconstituted Mg-ATP-dependent protein phosphatase. Eur J Biochem (1983) 1.58
Amino acid sequence of the ribonuclease inhibitor from porcine liver reveals the presence of leucine-rich repeats. Biochemistry (1988) 1.55
Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing. J Biol Chem (1993) 1.54
A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain. J Biol Chem (1999) 1.54
The interaction of thrombin with fibrinogen. A structural basis for its specificity. Eur J Biochem (1992) 1.53
Reconstitution of a Mg-ATP-dependent protein phosphatase and its activation through a phosphorylation mechanism. FEBS Lett (1982) 1.51
Phosphorylation of the type-II regulatory subunit of cyclic-AMP-dependent protein kinase by glycogen synthase kinase 3 and glycogen synthase kinase 5. Eur J Biochem (1982) 1.50
Effect of the Z mutation on the physical and inhibitory properties of alpha 1-antitrypsin. Biochemistry (1993) 1.49
The repressor MDBP-2 is a member of the histone H1 family that binds preferentially in vitro and in vivo to methylated nonspecific DNA sequences. Proc Natl Acad Sci U S A (1992) 1.49
Protein C-mannosylation is enzyme-catalysed and uses dolichyl-phosphate-mannose as a precursor. Mol Biol Cell (1998) 1.49
Differential methylation and altered conformation of cytoplasmic and nuclear forms of protein phosphatase 2A during cell cycle progression. J Cell Biol (1995) 1.46
Calcium regulation of Ndr protein kinase mediated by S100 calcium-binding proteins. EMBO J (1998) 1.43
Molecular cloning and characterization of a conserved nuclear serine(threonine) protein kinase. Proc Natl Acad Sci U S A (1995) 1.42
The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo. J Biol Chem (1994) 1.42
Inactivation and dephosphorylation of protein kinase Balpha (PKBalpha) promoted by hyperosmotic stress. EMBO J (1998) 1.41
Ndr protein kinase is regulated by phosphorylation on two conserved sequence motifs. J Biol Chem (1999) 1.41
The catalytic subunit of protein phosphatase 2A associates with the translation termination factor eRF1. EMBO J (1996) 1.36
Functional expression of human PP2Ac in yeast permits the identification of novel C-terminal and dominant-negative mutant forms. J Biol Chem (1999) 1.35
Vimentin dephosphorylation by protein phosphatase 2A is modulated by the targeting subunit B55. Mol Biol Cell (1999) 1.35
Identification of regions in polyomavirus middle T and small t antigens important for association with protein phosphatase 2A. J Virol (1995) 1.34
Ligation of the T cell co-stimulatory receptor CD28 activates the serine-threonine protein kinase protein kinase B. Eur J Immunol (1997) 1.33
Proteinase-activated receptor-2: expression by human neutrophils. J Cell Sci (1997) 1.33
Separation and characterisation of glycogen synthase kinase 3, glycogen synthase kinase 4 and glycogen synthase kinase 5 from rabbit skeletal muscle. Eur J Biochem (1982) 1.33
Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation. Mol Cell Biol (2000) 1.32
Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex. Curr Biol (1999) 1.32
Protein chemical and kinetic characterization of recombinant porcine ribonuclease inhibitor expressed in Saccharomyces cerevisiae. Biochemistry (1990) 1.32
Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 and their role in regulating kinase activity. J Biol Chem (2001) 1.30
Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice. J Biol Chem (2001) 1.30
Effects of mutations in the hinge region of serpins. Biochemistry (1993) 1.29
Tissue-specific expression of mRNAs encoding alpha- and beta-catalytic subunits of protein phosphatase 2A. FEBS Lett (1988) 1.29