The use of peptones as medium additives for the production of a recombinant therapeutic protein in high density perfusion cultures of mammalian cells.

PubWeight™: 1.21‹?› | Rank: Top 10%

🔗 View Article (PMC 3449690)

Published in Cytotechnology on February 01, 2000

Authors

R Heidemann1, C Zhang, H Qi, J Larrick Rule, C Rozales, S Park, S Chuppa, M Ray, J Michaels, K Konstantinov, D Naveh

Author Affiliations

1: Bayer Corporation, 800 Dwight Way, P.O. Box 1686, Berkeley, CA, 94701, USA, rudiger.heidemann.b@bayer.com.

Articles citing this

The role of recombinant proteins in the development of serum-free media. Cytotechnology (2006) 1.57

Cell culture processes for monoclonal antibody production. MAbs (2010) 1.48

Characterization of yeastolate fractions that promote insect cell growth and recombinant protein production. Cytotechnology (2007) 1.06

Plant protein hydrolysates support CHO-320 cells proliferation and recombinant IFN-gamma production in suspension and inside microcarriers in protein-free media. Cytotechnology (2004) 0.95

A new seed-train expansion method for recombinant mammalian cell lines. Cytotechnology (2002) 0.89

Combination of yeast hydrolysates to improve CHO cell growth and IgG production. Cytotechnology (2012) 0.81

Optimization and control of perfusion cultures using a viable cell probe and cell specific perfusion rates. Cytotechnology (2003) 0.79

Chickpea protein hydrolysate as a substitute for serum in cell culture. Cytotechnology (2008) 0.78

The effect of nitrogen source on yield and glycosylation of a human cystatin C mutant expressed in Pichia pastoris. J Ind Microbiol Biotechnol (2004) 0.77

Peptone Supplementation of Culture Medium Has Variable Effects on the Productivity of CHO Cells. Int J Mol Cell Med (2014) 0.77

The Role of Different Supplements in Expression Level of Monoclonal Antibody against Human CD20. Avicenna J Med Biotechnol (2013) 0.77

Promoting effect of rapeseed proteins and peptides on Sf9 insect cell growth. Cytotechnology (2003) 0.77

Effects of Peptone Supplementation in Different Culture Media on Growth, Metabolic Pathway and Productivity of CHO DG44 Cells; a New Insight into Amino Acid Profiles. Iran Biomed J (2015) 0.76

A T-flask based screening platform for evaluating and identifying plant hydrolysates for a fed-batch cell culture process. Cytotechnology (2007) 0.75

Tracking dipeptides at work-uptake and intracellular fate in CHO culture. AMB Express (2016) 0.75

Articles cited by this

Metabolic flux analysis of hybridoma cells in different culture media using mass balances. Biotechnol Bioeng (1996) 2.01

The protein hydrolysate, Primatone RL, is a cost-effective multiple growth promoter of mammalian cell culture in serum-containing and serum-free media and displays anti-apoptosis properties. J Immunol Methods (1996) 1.43

Role of pH gradient and membrane potential in dipeptide transport in intestinal and renal brush-border membrane vesicles from the rabbit. Studies with L-carnosine and glycyl-L-proline. J Biol Chem (1983) 1.33

Separation of positional isomers of oligosaccharides and glycopeptides by high-performance anion-exchange chromatography with pulsed amperometric detection. Proc Natl Acad Sci U S A (1988) 1.24

Fermentor temperature as a tool for control of high-density perfusion cultures of mammalian cells. Biotechnol Bioeng (1997) 1.17

Optimization of serum-free fermentation processes for antibody production. Cytotechnology (1991) 1.14

Metabolism of peptide amino acids by Chinese hamster ovary cells grown in a complex medium. Biotechnol Bioeng (1999) 1.06

Peptone, a low-cost growth-promoting nutrient for intensive animal cell culture. Cytotechnology (1994) 1.03

Development of a serum-free culture medium for the large scale production of recombinant protein from a Chinese hamster ovary cell line. Cytotechnology (1995) 1.01

H+ gradient-driven dipeptide reabsorption in proximal tubule of rat kidney. Studies in vivo and in vitro. Am J Physiol (1987) 0.98

Carrier-mediated reabsorption of small peptides in renal proximal tubule. Am J Physiol (1986) 0.94

Effects of dissolved oxygen levels and the role of extra- and intracellular amino acid concentrations upon the metabolism of mammalian cell lines during batch and continuous cultures. Cytotechnology (1998) 0.89

Proton/peptide cotransporter (PEPT 2) from human kidney: functional characterization and chromosomal localization. Biochim Biophys Acta (1995) 0.89

Influence of Primatone RL supplementation on sialylation of recombinant human interferon-gamma produced by Chinese hamster ovary cell culture using serum-free media. Biotechnol Bioeng (1997) 0.88

Growth limitation in hybridoma cell cultures: the role of inhibitory or toxic metabolites. Cytotechnology (1991) 0.85

Gamma-interferon production and quality in stoichiometric fed-batch cultures of Chinese hamster ovary (CHO) cells under serum-free conditions. Biotechnol Bioeng (1997) 0.85

Effects of peptone on hybridoma growth and monoclonal antibody formation. Cytotechnology (1994) 0.85

Identification of a renal cell line that constitutively expresses the kidney-specific high-affinity H+/peptide cotransporter. FASEB J (1995) 0.85

Multiple carriers for dipeptide transport: carrier-mediated transport of glycyl-L-proline in renal BBMV. Am J Physiol (1991) 0.84

Re-use of spent cell culture medium in pilot scale and rapid preparative purification with membrane chromatography. J Biotechnol (1994) 0.83

Observations on the influence of glutamine, asparagine and peptone on growth and t-PA production of Chinese hamster ovary (CHO) cells. Cytotechnology (1994) 0.83

The medium cycle bioreactor (MCB): monoclonal antibody production in a new economic production system. Cytotechnology (1991) 0.82

H(+)-peptide cotransport in Madin-Darby canine kidney cells: expression and calmodulin-dependent regulation. Am J Physiol (1995) 0.81

Optimization of a membrane oxygenation system for cell culture in stirred tank reactors. Dev Biol Stand (1987) 0.79

Articles by these authors

(truncated to the top 100)

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell (1999) 19.48

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci U S A (1998) 16.04

Use of a cDNA microarray to analyse gene expression patterns in human cancer. Nat Genet (1996) 15.73

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development (1996) 9.58

Transcriptional control in the production of liver-specific mRNAs. Cell (1981) 9.35

Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature (1998) 7.43

Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha. Proc Natl Acad Sci U S A (1993) 4.99

Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy. Nat Med (1999) 4.81

Calibration of the dietary questionnaire for a multiethnic cohort in Hawaii and Los Angeles. Am J Epidemiol (2000) 4.46

Transgene and transposon silencing in Chlamydomonas reinhardtii by a DEAH-box RNA helicase. Science (2000) 3.84

A cytogenetic survey of 14,069 newborn infants. I. Incidence of chromosome abnormalities. Clin Genet (1975) 3.81

Singapore Chinese Health Study: development, validation, and calibration of the quantitative food frequency questionnaire. Nutr Cancer (2001) 3.77

Crystal structure of the anthrax lethal factor. Nature (2001) 3.75

A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site. Mol Cell Biol (1992) 3.63

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. Cell (1997) 3.47

Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A. J Biol Chem (2001) 3.38

The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers. Cell (1993) 3.35

Association of CYP2C9*2 with bosentan-induced liver injury. Clin Pharmacol Ther (2013) 3.29

A paracrine role for the epithelial progesterone receptor in mammary gland development. Proc Natl Acad Sci U S A (1998) 3.23

Inter-RNA interaction of phage phi29 pRNA to form a hexameric complex for viral DNA transportation. Mol Cell (1998) 3.21

Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset. Arthritis Res (2000) 3.03

The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-kappa B-mediated inhibition. Nature (1992) 2.95

Quantitative analysis of the viscoelastic properties of thin regions of fibroblasts using atomic force microscopy. Biophys J (2004) 2.89

Fatty acid oxidation enzyme gene expression is downregulated in the failing heart. Circulation (1996) 2.87

Synthetic zinc finger transcription factor action at an endogenous chromosomal site. Activation of the human erythropoietin gene. J Biol Chem (2000) 2.85

Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells. Pancreas (2004) 2.85

Increased incidence of congenital malformations in children with transient thyroid-stimulating hormone elevation on neonatal screening. J Pediatr (1998) 2.80

Cross-protective immunity can account for the alternating epidemic pattern of dengue virus serotypes circulating in Bangkok. Proc Natl Acad Sci U S A (2006) 2.77

FIERY1 encoding an inositol polyphosphate 1-phosphatase is a negative regulator of abscisic acid and stress signaling in Arabidopsis. Genes Dev (2001) 2.73

Intraglottal pressure profiles for a symmetric and oblique glottis with a divergence angle of 10 degrees. J Acoust Soc Am (2001) 2.72

Electric polarization reversal and memory in a multiferroic material induced by magnetic fields. Nature (2004) 2.72

Characterization of recombinant pig enamelysin activity and cleavage of recombinant pig and mouse amelogenins. J Dent Res (1999) 2.50

Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas. Oncogene (2012) 2.41

Impoverished counterfactual thinking is associated with schizophrenia. Psychiatry (2000) 2.40

Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast. Nature (2000) 2.34

Epidemiological link between exposure to poultry and all influenza A(H7N9) confirmed cases in Huzhou city, China, March to May 2013. Euro Surveill (2013) 2.34

Efficacy and safety of infliximab plus naproxen versus naproxen alone in patients with early, active axial spondyloarthritis: results from the double-blind, placebo-controlled INFAST study, Part 1. Ann Rheum Dis (2013) 2.32

An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing. J Neurosci (2001) 2.25

Upregulation of phosphodiesterase 1A1 expression is associated with the development of nitrate tolerance. Circulation (2001) 2.21

Chemical mapping of a single molecule by plasmon-enhanced Raman scattering. Nature (2013) 2.19

Randomised clinical trial: the effects of Helicobacter pylori eradication on glandular atrophy and intestinal metaplasia after subtotal gastrectomy for gastric cancer. Aliment Pharmacol Ther (2013) 2.17

Systematic review of the efficacy of cilostazol, naftidrofuryl oxalate and pentoxifylline for the treatment of intermittent claudication. Br J Surg (2012) 2.17

Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene. Mol Cell Biol (1997) 2.16

Reelin gene alleles and susceptibility to autism spectrum disorders. Mol Psychiatry (2002) 2.05

The immortalized UROtsa cell line as a potential cell culture model of human urothelium. Environ Health Perspect (2001) 2.03

Recovery from exercise-induced desaturation in the quadriceps muscles of elite competitive rowers. Am J Physiol (1992) 2.02

Bone marrow scintigraphy using technetium-99m-antigranulocyte antibody in hematologic disorders. J Nucl Med (1996) 2.01

Unnatural ligands for engineered proteins: new tools for chemical genetics. Annu Rev Biophys Biomol Struct (2000) 1.99

Phospholipase D1 is an effector of Rheb in the mTOR pathway. Proc Natl Acad Sci U S A (2008) 1.97

Eyelid reconstruction using a hard palate mucoperiosteal graft combined with a V-Y subcutaneously pedicled flap. Br J Plast Surg (2001) 1.96

Physical and functional interaction between WT1 and p53 proteins. Proc Natl Acad Sci U S A (1993) 1.96

Selective expression of the large neutral amino acid transporter at the blood-brain barrier. Proc Natl Acad Sci U S A (1999) 1.93

Reactions of electron-deficient alkynes and allenes under phosphine catalysis. Acc Chem Res (2001) 1.86

Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants. Mol Psychiatry (2012) 1.84

High-energy surface X-ray diffraction for fast surface structure determination. Science (2014) 1.84

Learning from the Arabidopsis experience. The next gene search paradigm. Plant Physiol (2001) 1.82

A retrospective study of the application on double-balloon enteroscopy in 378 patients with suspected small-bowel diseases. Endoscopy (2007) 1.81

Protein kinase C in the regulation of smooth muscle contraction. FASEB J (1987) 1.81

Overexpression of nef as a marker for restricted HIV-1 infection of astrocytes in postmortem pediatric central nervous tissues. Neurology (1994) 1.80

Familial occurrence of trisomy 22. Am J Hum Genet (1968) 1.78

Obese adults have visual attention bias for food cue images: evidence for altered reward system function. Int J Obes (Lond) (2009) 1.75

Protection against anthrax lethal toxin challenge by genetic immunization with a plasmid encoding the lethal factor protein. Infect Immun (2001) 1.75

Population attributable fraction of infection-related cancers in Korea. Ann Oncol (2010) 1.72

A population-based eye survey of older adults in a rural district of Rajasthan: II. Outcomes of cataract surgery. Ophthalmology (2001) 1.70

Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at square root of s = 7 TeV. Phys Rev Lett (2010) 1.67

Peptide and small molecule microarray for high throughput cell adhesion and functional assays. Bioconjug Chem (2001) 1.65

SETBP1 mutations in 658 patients with myelodysplastic syndromes, chronic myelomonocytic leukemia and secondary acute myeloid leukemias. Leukemia (2013) 1.65

The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction. Proc Natl Acad Sci U S A (1993) 1.63

Response to antiviral treatment in hepatitis C virus-associated marginal zone lymphomas. Leukemia (2004) 1.62

Natural history of acute upper GI bleeding due to tumours: short-term success and long-term recurrence with or without endoscopic therapy. Aliment Pharmacol Ther (2013) 1.61

Sharpin, a novel postsynaptic density protein that directly interacts with the shank family of proteins. Mol Cell Neurosci (2001) 1.61

A novel acidotropic pH indicator and its potential application in labeling acidic organelles of live cells. Chem Biol (1999) 1.61

The oncoprotein Bcl-3 can facilitate NF-kappa B-mediated transactivation by removing inhibiting p50 homodimers from select kappa B sites. EMBO J (1993) 1.61

Aminoglycoside-induced translational read-through in disease: overcoming nonsense mutations by pharmacogenetic therapy. Clin Pharmacol Ther (2007) 1.60

Sequence requirement for hand-in-hand interaction in formation of RNA dimers and hexamers to gear phi29 DNA translocation motor. RNA (1999) 1.58

Familial mental retardation in a family with an inherited chromosome rearrangement. J Med Genet (1974) 1.57

Percutaneous sacral third nerve root neurostimulation improves symptoms and normalizes urinary HB-EGF levels and antiproliferative activity in patients with interstitial cystitis. Urology (2000) 1.57

Activation of a high affinity Gi protein-coupled plasma membrane receptor by sphingosine-1-phosphate. J Biol Chem (1996) 1.56

Study of the mass and spin-parity of the Higgs boson candidate via its decays to Z boson pairs. Phys Rev Lett (2013) 1.56

Purification and characterization of a novel chitinase from the entomopathogenic fungus, Metarhizium anisopliae. J Invertebr Pathol (1999) 1.55

Cloning and characterization of a novel member of the transforming growth factor-beta/bone morphogenetic protein family. J Biol Chem (1998) 1.55

Flowering time quantitative trait Loci analysis of oilseed brassica in multiple environments and genomewide alignment with Arabidopsis. Genetics (2007) 1.55

Phenotypic correlations in patients with ring chromosome 22. Clin Genet (1977) 1.54

Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: activation of c-Jun NH(2)-terminal kinase and promoter response element. Blood (2000) 1.54

The role of NDR1 in avirulence gene-directed signaling and control of programmed cell death in Arabidopsis. Plant Physiol (2001) 1.53

High frequency of autoantibodies to insoluble cellular antigens in patients with chronic fatigue syndrome. Arthritis Rheum (1997) 1.53

Experimental autoimmune myocarditis in A/J mice is an interleukin-4-dependent disease with a Th2 phenotype. Am J Pathol (2001) 1.52

An interesting case of rifampicin-dependent/-enhanced multidrug-resistant tuberculosis. Int J Tuberc Lung Dis (2010) 1.52

Snail is a repressor of RKIP transcription in metastatic prostate cancer cells. Oncogene (2007) 1.50

Calcium influx induces neurite growth through a Src-Ras signaling cassette. Neuron (1995) 1.49

Mutagenesis of specificity and toxicity regions of a Bacillus thuringiensis protoxin gene. J Bacteriol (1995) 1.49

Hepatic radioembolization with Yttrium-90 glass microspheres for treatment of primary liver cancer. Chin Med J (Engl) (1999) 1.48

Rat pancreatic stellate cells secrete matrix metalloproteinases: implications for extracellular matrix turnover. Gut (2003) 1.47

WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A. J Biol Chem (2000) 1.47

Feedback equilibrium control during human standing. Biol Cybern (2005) 1.46

Functional role of mucoid exopolysaccharide (alginate) in antibiotic-induced and polymorphonuclear leukocyte-mediated killing of Pseudomonas aeruginosa. Infect Immun (1991) 1.46

Tethered Sir3p nucleates silencing at telomeres and internal loci in Saccharomyces cerevisiae. Mol Cell Biol (1996) 1.45

Modulation of nitric oxide bioavailability by erythrocytes. Proc Natl Acad Sci U S A (2001) 1.45

Clinical spectrum of 500 children with neurocysticercosis and response to albendazole therapy. J Child Neurol (2000) 1.45

Surface geochemistry of the clay minerals. Proc Natl Acad Sci U S A (1999) 1.45