Published in PLoS One on November 13, 2008
HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism. Nat Struct Mol Biol (2012) 1.25
Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange. Proc Natl Acad Sci U S A (2011) 1.23
Conformational variation in structures of classical and non-classical MHCII proteins and functional implications. Immunol Rev (2012) 1.00
HLA-DM constrains epitope selection in the human CD4 T cell response to vaccinia virus by favoring the presentation of peptides with longer HLA-DM-mediated half-lives. J Immunol (2012) 0.97
HLA-DM and HLA-DO, key regulators of MHC-II processing and presentation. Curr Opin Immunol (2013) 0.92
DM influences the abundance of major histocompatibility complex class II alleles with low affinity for class II-associated invariant chain peptides via multiple mechanisms. Immunology (2010) 0.91
A Peptide/MHCII conformer generated in the presence of exchange peptide is substrate for HLA-DM editing. Sci Rep (2012) 0.86
Susceptibility to HLA-DM protein is determined by a dynamic conformation of major histocompatibility complex class II molecule bound with peptide. J Biol Chem (2014) 0.84
Evaluating the Role of HLA-DM in MHC Class II-Peptide Association Reactions. J Immunol (2015) 0.81
A novel method to measure HLA-DM-susceptibility of peptides bound to MHC class II molecules based on peptide binding competition assay and differential IC(50) determination. J Immunol Methods (2014) 0.79
HLA-DM: arbiter conformationis. Immunology (2013) 0.78
Measurement of Peptide Binding to MHC Class II Molecules by Fluorescence Polarization. Curr Protoc Immunol (2014) 0.78
The Thermodynamic Mechanism of Peptide-MHC Class II Complex Formation Is a Determinant of Susceptibility to HLA-DM. J Immunol (2015) 0.77
HLA-DM Focuses on Conformational Flexibility Around P1 Pocket to Catalyze Peptide Exchange. Front Immunol (2013) 0.77
Structural Insights Into HLA-DM Mediated MHC II Peptide Exchange. Curr Top Biochem Res (2011) 0.76
A step-by-step overview of the dynamic process of epitope selection by major histocompatibility complex class II for presentation to helper T cells. F1000Res (2016) 0.76
Thermodynamics of Peptide-MHC Class II Interactions: Not all Complexes are Created Equal. Front Immunol (2013) 0.75
Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature (1994) 7.13
HLA-DM induces CLIP dissociation from MHC class II alpha beta dimers and facilitates peptide loading. Cell (1995) 3.64
Mediation by HLA-DM of dissociation of peptides from HLA-DR. Nature (1995) 3.40
Strategy for analysing the co-operativity of intramolecular interactions in peptides and proteins. J Mol Biol (1990) 3.40
The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3. Nature (1995) 2.90
The human class II MHC protein HLA-DR1 assembles as empty alpha beta heterodimers in the absence of antigenic peptide. Cell (1992) 2.79
Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM. Science (1996) 2.68
Antigen presentation and T cell development in H2-M-deficient mice. Science (1996) 2.07
Tetraspan microdomains distinct from lipid rafts enrich select peptide-MHC class II complexes. Nat Immunol (2001) 2.04
Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells. Immunity (1994) 1.87
HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules. J Exp Med (1996) 1.77
Editing of the HLA-DR-peptide repertoire by HLA-DM. EMBO J (1996) 1.74
Co-operative interactions during protein folding. J Mol Biol (1992) 1.68
HLA-DM recognizes the flexible conformation of major histocompatibility complex class II. J Exp Med (2000) 1.56
HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH. Immunity (1997) 1.45
Interaction of HLA-DR with an acidic face of HLA-DM disrupts sequence-dependent interactions with peptides. Immunity (2003) 1.43
HLA-DM targets the hydrogen bond between the histidine at position beta81 and peptide to dissociate HLA-DR-peptide complexes. Nat Immunol (2006) 1.41
The optimization of peptide cargo bound to MHC class I molecules by the peptide-loading complex. Immunol Rev (2005) 1.30
The kinetic basis of peptide exchange catalysis by HLA-DM. Proc Natl Acad Sci U S A (2001) 1.24
Identification of the lateral interaction surfaces of human histocompatibility leukocyte antigen (HLA)-DM with HLA-DR1 by formation of tethered complexes that present enhanced HLA-DM catalysis. J Exp Med (2002) 1.23
Cutting edge: TCR contacts as anchors: effects on affinity and HLA-DM stability. J Immunol (2003) 1.20
Empty class II major histocompatibility complex created by peptide photolysis establishes the role of DM in peptide association. J Biol Chem (2007) 1.16
Enhanced catalytic action of HLA-DM on the exchange of peptides lacking backbone hydrogen bonds between their N-terminal region and the MHC class II alpha-chain. J Immunol (2004) 1.15
Conformational isomers of a class II MHC-peptide complex in solution. J Mol Biol (1999) 1.10
Small molecules that enhance the catalytic efficiency of HLA-DM. J Immunol (2006) 1.10
Energy transfer between two peptides bound to one MHC class II molecule. Science (1991) 1.08
Cutting edge: a single, essential hydrogen bond controls the stability of peptide-MHC class II complexes. J Immunol (1999) 1.07
Cooperativity of hydrophobic anchor interactions: evidence for epitope selection by MHC class II as a folding process. J Immunol (2007) 1.07
Pathways of antigen processing and presentation. Rev Immunogenet (1999) 1.03
How HLA-DM edits the MHC class II peptide repertoire: survival of the fittest? Immunol Today (1997) 1.02
Energetic asymmetry among hydrogen bonds in MHC class II*peptide complexes. Proc Natl Acad Sci U S A (2001) 1.01
Kinetics and specificity of peptide-MHC class II complex displacement reactions. J Immunol (1994) 0.97
Structural principles of MHC class II antigen presentation. Rev Immunogenet (1999) 0.95
Kinetic isomers of a class II MHC-peptide complex. Biochemistry (1998) 0.94
Cooperativity during the formation of peptide/MHC class II complexes. Biochemistry (2005) 0.94
Formation of two peptide/MHC II isomers is catalyzed differentially by HLA-DM. Biochemistry (2003) 0.90
Catalysis of peptide dissociation from class II MHC-peptide complexes. Proc Natl Acad Sci U S A (1999) 0.85
Exploration of the P6/P7 region of the peptide-binding site of the human class II major histocompatability complex protein HLA-DR1. J Biol Chem (2003) 0.85
Interpretation of biphasic dissociation kinetics for isomeric class II major histocompatibility complex-peptide complexes. Biophys J (1999) 0.83
The intracellular transport of MHC class II molecules in the absence of HLA-DM. J Immunol (1995) 0.80
A europium fluoroimmunoassay for measuring peptide binding to MHC class I molecules. J Immunol Methods (1998) 0.79
Evidence for cobinding of self- and allopeptides to human class II major histocompatibility antigen DR1 by energy transfer. Proc Natl Acad Sci U S A (1993) 0.78
A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. Immunity (2011) 3.76
Differential interaction of spin-labeled arrestin with inactive and active phosphorhodopsin. Proc Natl Acad Sci U S A (2006) 1.94
Factor VIII ectopically targeted to platelets is therapeutic in hemophilia A with high-titer inhibitory antibodies. J Clin Invest (2006) 1.69
Structure and function of the visual arrestin oligomer. EMBO J (2007) 1.66
Both maltose-binding protein and ATP are required for nucleotide-binding domain closure in the intact maltose ABC transporter. Proc Natl Acad Sci U S A (2008) 1.59
Long-term results of bone marrow transplantation in complete DiGeorge syndrome. J Allergy Clin Immunol (2007) 1.54
Arrestin mobilizes signaling proteins to the cytoskeleton and redirects their activity. J Mol Biol (2007) 1.52
Emergence of T cells that recognize nonpolymorphic antigens during graft-versus- host disease. Blood (2012) 1.48
Maltose-binding protein is open in the catalytic transition state for ATP hydrolysis during maltose transport. J Biol Chem (2004) 1.48
Visual arrestin binding to microtubules involves a distinct conformational change. J Biol Chem (2006) 1.41
A model for the solution structure of the rod arrestin tetramer. Structure (2008) 1.37
Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance. J Exp Med (2010) 1.32
A fractal clonotype distribution in the CD8+ memory T cell repertoire could optimize potential for immune responses. J Immunol (2003) 1.32
Few residues within an extensive binding interface drive receptor interaction and determine the specificity of arrestin proteins. J Biol Chem (2011) 1.30
Cutting edge: TCR contacts as anchors: effects on affinity and HLA-DM stability. J Immunol (2003) 1.20
Re-establishing peripheral tolerance in the absence of CTLA-4: complementation by wild-type T cells points to an indirect role for CTLA-4. J Immunol (2002) 1.19
Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking Gimap5. Blood (2008) 1.19
Complex T cell memory repertoires participate in recall responses at extremes of antigenic load. J Immunol (2006) 1.11
Arrestin binding to calmodulin: a direct interaction between two ubiquitous signaling proteins. J Mol Biol (2006) 1.11
The role of arrestin alpha-helix I in receptor binding. J Mol Biol (2009) 1.10
Concentration by centrifugation for gas exchange EPR oximetry measurements with loop-gap resonators. J Magn Reson (2005) 1.09
Cooperativity of hydrophobic anchor interactions: evidence for epitope selection by MHC class II as a folding process. J Immunol (2007) 1.07
Detection of cytomegalovirus drug resistance mutations by next-generation sequencing. J Clin Microbiol (2013) 1.04
Gamma delta T cell regulation of IFN-gamma production by central nervous system-infiltrating encephalitogenic T cells: correlation with recovery from experimental autoimmune encephalomyelitis. J Immunol (2004) 1.04
Cutting edge: HLA-DM-mediated peptide exchange functions normally on MHC class II-peptide complexes that have been weakened by elimination of a conserved hydrogen bond. J Immunol (2009) 1.02
A polymorphic pocket at the P10 position contributes to peptide binding specificity in class II MHC proteins. Chem Biol (2004) 1.01
Resting state conformation of the MsbA homodimer as studied by site-directed spin labeling. Biochemistry (2004) 1.00
A molecular marker for thymocyte-positive selection: selection of CD4 single-positive thymocytes with shorter TCRB CDR3 during T cell development. J Immunol (2002) 0.99
Two compensatory pathways maintain long-term stability and diversity in CD8 T cell memory repertoires. J Immunol (2009) 0.96
Peptide-MHC class II complex stability governs CD4 T cell clonal selection. J Immunol (2009) 0.96
Concentration-dependent oligomerization and oligomeric arrangement of LptA. Protein Sci (2011) 0.95
Enthalpy-entropy compensation and cooperativity as thermodynamic epiphenomena of structural flexibility in ligand-receptor interactions. J Mol Biol (2012) 0.95
Cooperativity during the formation of peptide/MHC class II complexes. Biochemistry (2005) 0.94
A clonotype nomenclature for T cell receptors. Immunogenetics (2009) 0.93
Characterization of the Walker A motif of MsbA using site-directed spin labeling electron paramagnetic resonance spectroscopy. Biochemistry (2005) 0.93
Crystallographic structure of the human leukocyte antigen DRA, DRB3*0101: models of a directional alloimmune response and autoimmunity. J Mol Biol (2007) 0.93
Characterization of D-cyclin proteins in hematolymphoid neoplasms: lack of specificity of cyclin-D2 and D3 expression in lymphoma subtypes. Mod Pathol (2010) 0.92
Functional dichotomy between NKG2D and CD28-mediated co-stimulation in human CD8+ T cells. PLoS One (2010) 0.92
Functionally important ATP binding and hydrolysis sites in Escherichia coli MsbA. Biochemistry (2008) 0.90
Sensitization from transfusion in patients awaiting primary kidney transplant. Nephrol Dial Transplant (2013) 0.90
Selective T cell expansion during aging of CD8 memory repertoires to influenza revealed by modeling. J Immunol (2011) 0.89
T cell receptor CDR3 loop length repertoire is determined primarily by features of the V(D)J recombination reaction. Eur J Immunol (2003) 0.89
Characterization of the E506Q and H537A dysfunctional mutants in the E. coli ABC transporter MsbA. Biochemistry (2011) 0.89
Characterization of the LSGGQ and H motifs from the Escherichia coli lipid A transporter MsbA. Biochemistry (2006) 0.88
Purification and characterization of the L-Ara4N transferase protein ArnT from Salmonella typhimurium. Protein Expr Purif (2005) 0.88
EPR spectroscopy of MolB2C2-a reveals mechanism of transport for a bacterial type II molybdate importer. J Biol Chem (2013) 0.87
Site-directed spin labeling reveals pentameric ligand-gated ion channel gating motions. PLoS Biol (2013) 0.87
C-terminal anchoring of a peptide to class II MHC via the P10 residue is compatible with a peptide bulge. J Immunol (2002) 0.86
A Peptide/MHCII conformer generated in the presence of exchange peptide is substrate for HLA-DM editing. Sci Rep (2012) 0.86
Naive T cell repertoire skewing in HLA-A2 individuals by a specialized rearrangement mechanism results in public memory clonotypes. J Immunol (2011) 0.85
Selective elimination of alloreactive donor T cells attenuates graft-versus-host disease and enhances T-cell reconstitution. Biol Blood Marrow Transplant (2003) 0.85
Effects of the L511P and D512G mutations on the Escherichia coli ABC transporter MsbA. Biochemistry (2011) 0.85
Disproportional effects in populations of concern for pandemic influenza: insights from seasonal epidemics in Wisconsin, 1967-2004. Influenza Other Respir Viruses (2010) 0.84
The TCR repertoires of regulatory and conventional T cells specific for the same foreign antigen are distinct. J Immunol (2012) 0.84
Disruption of LptA oligomerization and affinity of the LptA-LptC interaction. Protein Sci (2013) 0.83
The functional CD8 T cell memory recall repertoire responding to the influenza A M1(58-66) epitope is polyclonal and shows a complex clonotype distribution. Hum Immunol (2013) 0.82
The transcription factor RFX protects MHC class II genes against epigenetic silencing by DNA methylation. J Immunol (2009) 0.82
High-throughput detection method for influenza virus. J Vis Exp (2012) 0.82
Cross-reactivity of T cells and its role in the immune system. Crit Rev Immunol (2012) 0.80
Cross-reactive responses to modified M1₅₈-₆₆ peptides by CD8⁺ T cells that use noncanonical BV genes can describe unknown repertoires. Eur J Immunol (2012) 0.79
Elimination of leukemia in the absence of lethal graft-versus-host disease after allogenic bone marrow transplantation. J Immunol (2003) 0.79
Evidence for preferred MHC class II-TCR recognition independent of the source of bound peptide. Eur J Immunol (2002) 0.79
Identification of a functionally important loop in Salmonella typhimurium ArnT. Biochemistry (2010) 0.79
Self-association of arrestin family members. Handb Exp Pharmacol (2014) 0.78
Simulation studies for a multistage dynamic process of immune memory response to influenza: experiment in silico. Ann Zool Fennici (2008) 0.78
Quantitative measurement of pathogen-specific human memory T cell repertoire diversity using a CDR3 beta-specific microarray. BMC Genomics (2007) 0.77
An accessible micro-capillary electrophoresis device using surface-tension-driven flow. Electrophoresis (2009) 0.76
Developmental dynamics of post-selection thymic DN iNKT. PLoS One (2012) 0.75
Spin-labeled lipid A. Anal Biochem (2008) 0.75
Overlap of direct and indirect alloreactive T-cell repertoires when MHC polymorphism is limited to the peptide binding groove. Hum Immunol (2002) 0.75
Reactive lymphoid hyperplasia of the terminal ileum: a benign (lymphoma-like) condition that may harbor aberrant immunohistochemical patterns or clonal immunoglobulin heavy chain gene rearrangements. Appl Immunohistochem Mol Morphol (2014) 0.75