Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM.

PubWeight™: 2.68‹?› | Rank: Top 1%

🔗 View Article (PMID 8849454)

Published in Science on October 25, 1996

Authors

D A Weber1, B D Evavold, P E Jensen

Author Affiliations

1: Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.

Articles citing this

HLA-DM recognizes the flexible conformation of major histocompatibility complex class II. J Exp Med (2000) 1.56

A dominant-negative clathrin mutant differentially affects trafficking of molecules with distinct sorting motifs in the class II major histocompatibility complex (MHC) pathway. J Cell Biol (1998) 1.53

HLA-DM targets the hydrogen bond between the histidine at position beta81 and peptide to dissociate HLA-DR-peptide complexes. Nat Immunol (2006) 1.41

HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptide. Nat Immunol (2010) 1.38

CTCF controls expression and chromatin architecture of the human major histocompatibility complex class II locus. Mol Cell Biol (2010) 1.26

HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism. Nat Struct Mol Biol (2012) 1.25

The kinetic basis of peptide exchange catalysis by HLA-DM. Proc Natl Acad Sci U S A (2001) 1.24

Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange. Proc Natl Acad Sci U S A (2011) 1.23

Identification of the lateral interaction surfaces of human histocompatibility leukocyte antigen (HLA)-DM with HLA-DR1 by formation of tethered complexes that present enhanced HLA-DM catalysis. J Exp Med (2002) 1.23

Crystal structure of the HLA-DM-HLA-DR1 complex defines mechanisms for rapid peptide selection. Cell (2012) 1.21

The impact of DM on MHC class II-restricted antigen presentation can be altered by manipulation of MHC-peptide kinetic stability. J Exp Med (2006) 1.18

Lysosomal cathepsin B plays an important role in antigen processing, while cathepsin D is involved in degradation of the invariant chain inovalbumin-immunized mice. Immunology (2000) 1.18

Empty class II major histocompatibility complex created by peptide photolysis establishes the role of DM in peptide association. J Biol Chem (2007) 1.16

DM determines the cryptic and immunodominant fate of T cell epitopes. J Exp Med (2000) 1.16

Characteristics of carbohydrate antigen binding to the presentation protein HLA-DR. Glycobiology (2008) 1.14

Retention of empty MHC class I molecules by tapasin is essential to reconstitute antigen presentation in invertebrate cells. EMBO J (1999) 1.13

A role for HLA-DO as a co-chaperone of HLA-DM in peptide loading of MHC class II molecules. EMBO J (1998) 1.13

Identification of the transcriptional response of human intestinal mucosa to Lactobacillus plantarum WCFS1 in vivo. BMC Genomics (2008) 1.12

Small molecules that enhance the catalytic efficiency of HLA-DM. J Immunol (2006) 1.10

Cutting edge: HLA-DM functions through a mechanism that does not require specific conserved hydrogen bonds in class II MHC-peptide complexes. J Immunol (2009) 1.10

Complexes of two cohorts of CLIP peptides and HLA-DQ2 of the autoimmune DR3-DQ2 haplotype are poor substrates for HLA-DM. J Immunol (2008) 1.10

pH-dependent peptide binding properties of the type I diabetes-associated I-Ag7 molecule: rapid release of CLIP at an endosomal pH. J Exp Med (1999) 1.08

Modulation of the major histocompatibility complex class II-associated peptide repertoire by human histocompatibility leukocyte antigen (HLA)-DO. J Exp Med (2000) 1.07

A pH-sensitive histidine residue as control element for ligand release from HLA-DR molecules. Proc Natl Acad Sci U S A (2002) 1.07

The peptide-receptive transition state of MHC class I molecules: insight from structure and molecular dynamics. J Immunol (2012) 1.05

Interaction between HLA-DM and HLA-DR involves regions that undergo conformational changes at lysosomal pH. Proc Natl Acad Sci U S A (1997) 1.02

Transporters associated with antigen processing (TAP)-independent presentation of soluble insulin to alpha/beta T cells by the class Ib gene product, Qa-1(b). J Exp Med (1998) 1.02

Energetic asymmetry among hydrogen bonds in MHC class II*peptide complexes. Proc Natl Acad Sci U S A (2001) 1.01

Regulated expression of human histocompatibility leukocyte antigen (HLA)-DO during antigen-dependent and antigen-independent phases of B cell development. J Exp Med (2002) 1.00

Conformational variation in structures of classical and non-classical MHCII proteins and functional implications. Immunol Rev (2012) 1.00

The convergent roles of tapasin and HLA-DM in antigen presentation. Trends Immunol (2008) 0.99

HLA-DM mediates epitope selection by a "compare-exchange" mechanism when a potential peptide pool is available. PLoS One (2008) 0.97

Comprehensive analysis of MHC class II genes in teleost fish genomes reveals dispensability of the peptide-loading DM system in a large part of vertebrates. BMC Evol Biol (2013) 0.97

Mapping the HLA-DO/HLA-DM complex by FRET and mutagenesis. Proc Natl Acad Sci U S A (2012) 0.97

The mechanism of HLA-DM induced peptide exchange in the MHC class II antigen presentation pathway. Curr Opin Immunol (2011) 0.95

MHC class II antigen presentation and immunological abnormalities due to deficiency of MHC class II and its associated genes. Exp Mol Pathol (2008) 0.95

Stability of empty and peptide-loaded class II major histocompatibility complex molecules at neutral and endosomal pH: comparison to class I proteins. Proc Natl Acad Sci U S A (1997) 0.95

Efficient loading of HLA-DR with a T helper epitope by genetic exchange of CLIP. Proc Natl Acad Sci U S A (1997) 0.94

DM influences the abundance of major histocompatibility complex class II alleles with low affinity for class II-associated invariant chain peptides via multiple mechanisms. Immunology (2010) 0.91

DNA methylation dysregulates and silences the HLA-DQ locus by altering chromatin architecture. Genes Immun (2011) 0.91

Functional HLA-DM on the surface of B cells and immature dendritic cells. EMBO J (2000) 0.90

Mechanisms of peptide repertoire selection by HLA-DM. Trends Immunol (2013) 0.89

Enhanced intracellular dissociation of major histocompatibility complex class I-associated peptides: a mechanism for optimizing the spectrum of cell surface-presented cytotoxic T lymphocyte epitopes. J Exp Med (1997) 0.89

Ubiquitination of human leukocyte antigen (HLA)-DM by different membrane-associated RING-CH (MARCH) protein family E3 ligases targets different endocytic pathways. J Biol Chem (2012) 0.88

HLA-DM mediates peptide exchange by interacting transiently and repeatedly with HLA-DR1. Mol Immunol (2009) 0.88

Immunodominance of CD4 T cells to foreign antigens is peptide intrinsic and independent of molecular context: implications for vaccine design. J Immunol (2008) 0.87

Distinct intracellular compartments involved in invariant chain degradation and antigenic peptide loading of major histocompatibility complex (MHC) class II molecules. J Cell Biol (1997) 0.87

The control of the specificity of CD4 T cell responses: thresholds, breakpoints, and ceilings. Front Immunol (2013) 0.87

Re-Directing CD4(+) T Cell Responses with the Flanking Residues of MHC Class II-Bound Peptides: The Core is Not Enough. Front Immunol (2013) 0.84

Determinants of immunodominance for CD4 T cells. Curr Opin Immunol (2015) 0.84

HLA-DO as the optimizer of epitope selection for MHC class II antigen presentation. PLoS One (2013) 0.84

Susceptibility to HLA-DM protein is determined by a dynamic conformation of major histocompatibility complex class II molecule bound with peptide. J Biol Chem (2014) 0.84

MHC class II antigen presentation by dendritic cells regulated through endosomal sorting. Cold Spring Harb Perspect Biol (2013) 0.83

Purification of intracellular compartments involved in antigen processing: a new method based on magnetic sorting. Biochem J (1999) 0.83

Out damned CLIP! Out, I say! Science (1996) 0.82

Processing of the DRB1*1103-restricted measles virus nucleoprotein determinant 185-199 in the endosomal compartment. Clin Exp Immunol (1998) 0.82

An MHC class II restriction bias in CD4 T cell responses toward I-A is altered to I-E in DM-deficient mice. J Immunol (2008) 0.82

Specific T cell recognition of kinetic isomers in the binding of peptide to class II major histocompatibility complex. Proc Natl Acad Sci U S A (1997) 0.82

Evaluating the Role of HLA-DM in MHC Class II-Peptide Association Reactions. J Immunol (2015) 0.81

Disruption of hydrogen bonds between major histocompatibility complex class II and the peptide N-terminus is not sufficient to form a human leukocyte antigen-DM receptive state of major histocompatibility complex class II. PLoS One (2013) 0.80

TLR-mediated B cell activation results in ectopic CLIP expression that promotes B cell-dependent inflammation. J Leukoc Biol (2010) 0.80

Structural Characteristics of HLA-DQ that May Impact DM Editing and Susceptibility to Type-1 Diabetes. Front Immunol (2013) 0.80

The melting pot of the MHC II peptidome. Curr Opin Immunol (2016) 0.80

Evidence for a human leucocyte antigen-DM-induced structural change in human leucocyte antigen-DObeta. Immunology (2008) 0.79

A novel method to measure HLA-DM-susceptibility of peptides bound to MHC class II molecules based on peptide binding competition assay and differential IC(50) determination. J Immunol Methods (2014) 0.79

HLA-DM: arbiter conformationis. Immunology (2013) 0.78

HLA-DM Focuses on Conformational Flexibility Around P1 Pocket to Catalyze Peptide Exchange. Front Immunol (2013) 0.77

Protective response to Leishmania major in BALB/c mice requires antigen processing in the absence of DM. J Immunol (2009) 0.77

Type 1 diabetes associated HLA-DQ2 and DQ8 molecules are relatively resistant to HLA-DM mediated release of invariant chain-derived CLIP peptides. Eur J Immunol (2016) 0.76

Structural Insights Into HLA-DM Mediated MHC II Peptide Exchange. Curr Top Biochem Res (2011) 0.76

Destabilization of peptide:MHC interaction induces IL-2 resistant anergy in diabetogenic T cells. J Autoimmun (2013) 0.76

Novel mutants define genes required for the expression of human histocompatibility leukocyte antigen DM: evidence for loci on human chromosome 6p. J Exp Med (1997) 0.75

Thermodynamics of Peptide-MHC Class II Interactions: Not all Complexes are Created Equal. Front Immunol (2013) 0.75

Human leukocyte Antigen-DM polymorphisms in autoimmune diseases. Open Biol (2016) 0.75

Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation. Front Immunol (2017) 0.75

Articles by these authors

Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells. Nature (1993) 3.83

Formation of plant RNA virus replication complexes on membranes: role of an endoplasmic reticulum-targeted viral protein. EMBO J (1997) 2.99

Mouse CD94/NKG2A is a natural killer cell receptor for the nonclassical major histocompatibility complex (MHC) class I molecule Qa-1(b). J Exp Med (1998) 2.57

DO11.10 and OT-II T cells recognize a C-terminal ovalbumin 323-339 epitope. J Immunol (2000) 2.50

DM enhances peptide binding to class II MHC by release of invariant chain-derived peptide. Immunity (1995) 2.10

The PSI-H subunit of photosystem I is essential for state transitions in plant photosynthesis. Nature (2000) 1.77

Molecular interaction of CD1b with lipoglycan antigens. Immunity (1998) 1.60

Balance of power: a view of the mechanism of photosynthetic state transitions. Trends Plant Sci (2001) 1.49

Delayed antigen presentation by epidermal Langerhans cells to cloned T h1 and T h2 cells. J Invest Dermatol (1990) 1.41

Th2 cell clonal anergy as a consequence of partial activation. J Exp Med (1994) 1.34

Early motion of the ankle after operative treatment of a rupture of the Achilles tendon. A prospective, randomized clinical and radiographic study. J Bone Joint Surg Am (1999) 1.29

Antimicrobial properties of porphyrins. Expert Opin Investig Drugs (2001) 1.28

Role of subunits in eukaryotic Photosystem I. Biochim Biophys Acta (2001) 1.28

Genetic evidence for an essential role for potyvirus CI protein in cell-to-cell movement. Plant J (1998) 1.28

A putative Mg chelatase subunit from Arabidopsis thaliana cv C24. Sequence and transcript analysis of the gene, import of the protein into chloroplasts, and in situ localization of the transcript and protein. Plant Physiol (1996) 1.26

Cloning, sequencing and functional assignment of the chlorophyll biosynthesis gene, chlP, of Synechocystis sp. PCC 6803. FEBS Lett (1996) 1.24

Supermolecular organization of photosystem II and its associated light-harvesting antenna in Arabidopsis thaliana. Eur J Biochem (2001) 1.24

Analysis of Qa-1(b) peptide binding specificity and the capacity of CD94/NKG2A to discriminate between Qa-1-peptide complexes. J Exp Med (2000) 1.23

Green plant photosystem I binds light-harvesting complex I on one side of the complex. Biochemistry (2001) 1.17

Regulatory mechanisms in immune responses to heterologous insulins. II. Suppressor T cell activation associated with nonresponsiveness in H-2b mice. J Exp Med (1984) 1.12

Skiing injuries in children and adolescents. J Trauma (1996) 1.11

Modulation of T cell development by an endogenous altered peptide ligand. J Exp Med (1995) 1.08

Magnesium chelatase from Rhodobacter sphaeroides: initial characterization of the enzyme using purified subunits and evidence for a BchI-BchD complex. Biochem J (1999) 1.07

Minor role for direct adrenoceptor-mediated calcium entry in rat mesenteric small arteries. J Vasc Res (1995) 1.07

Cutting edge: dueling TCRs: peptide antagonism of CD4+ T cells with dual antigen specificities. J Immunol (1999) 1.03

Genetics of insulin-specific helper and suppressor T cells in nonresponder mice. J Immunol (1985) 1.03

Transporters associated with antigen processing (TAP)-independent presentation of soluble insulin to alpha/beta T cells by the class Ib gene product, Qa-1(b). J Exp Med (1998) 1.02

Structure and expression of a nitrite reductase gene from bean (Phaseolus vulgaris) and promoter analysis in transgenic tobacco. Plant Mol Biol (1995) 1.02

Reconstitution of an active magnesium chelatase enzyme complex from the bchI, -D, and -H gene products of the green sulfur bacterium Chlorobium vibrioforme expressed in Escherichia coli. J Bacteriol (1998) 1.02

Congenital anomalies of the optic disk. Am J Ophthalmol (1976) 1.01

Malignant phyllodes tumor of the prostate. A case report with immunohistochemical and ultrastructural studies. Arch Pathol Lab Med (1992) 1.00

Transmembrane domain-mediated colocalization of HLA-DM and HLA-DR is required for optimal HLA-DM catalytic activity. J Immunol (2001) 0.98

A structural transition in class II major histocompatibility complex proteins at mildly acidic pH. J Exp Med (1996) 0.97

Persistence of peptide-induced CD4+ T cell anergy in vitro. J Exp Med (1998) 0.96

Effect of acidosis on tension and [Ca2+]i in rat cerebral arteries: is there a role for membrane potential? Am J Physiol (1998) 0.94

Traumatic transdiaphragmatic intercostal hernia secondary to coughing: case report and review of the literature. J Trauma (1996) 0.93

The unimportance of being (protein kinase C) epsilon. FASEB J (1998) 0.93

Bystander help in primary immune responses in vivo. J Exp Med (1986) 0.90

Unresponsiveness to a self-peptide of mouse lysozyme owing to hindrance of T cell receptor-major histocompatibility complex/peptide interaction caused by flanking epitopic residues. J Exp Med (1996) 0.90

An insulin peptide that binds an alternative site in class II major histocompatibility complex. J Exp Med (1996) 0.89

Effect of decreased O2 supply to tissue on the lactate: pyruvate ratio in blood. J Clin Invest (1969) 0.88

Inefficient peptide binding by cell-surface class II MHC molecules. Cell Immunol (1997) 0.87

Primary structure of human alpha 2-macroglobulin. Complete disulfide bridge assignment and localization of two interchain bridges in the dimeric proteinase binding unit. J Biol Chem (1986) 0.86

Reduction of traumatic secondary shoulder dislocations with lidocaine. Arch Orthop Trauma Surg (1995) 0.86

Effects of tyrosine kinase inhibitors on the contractility of rat mesenteric resistance arteries. Br J Pharmacol (1995) 0.86

Requirements for simian immunodeficiency virus antigen-specific in vitro proliferation of T cells from infected rhesus macaques and sooty mangabeys. AIDS (1990) 0.86

CD4+ T cell responses to self- and mutated p53 determinants during tumorigenesis in mice. J Immunol (2000) 0.85

Proprioceptive sensitivity and performance in anterior cruciate ligament-deficient knee joints. Scand J Med Sci Sports (2000) 0.84

A europium fluoroimmunoassay for measuring binding of antigen to class II MHC glycoproteins. J Immunol Methods (1993) 0.84

Cross-recognition of two middle T protein epitopes by immunodominant polyoma virus-specific CTL. J Immunol (1999) 0.84

Nucleotide sequence of cDNA encoding the BYMV coat protein gene. Nucleic Acids Res (1990) 0.83

Processing and reactivity of T cell epitopes containing two cysteine residues from hen egg-white lysozyme (HEL74-90). J Immunol (2000) 0.81

Class II-associated invariant chain peptide-independent binding of invariant chain to class II MHC molecules. J Immunol (1999) 0.81

Insulin-specific tolerance induction. I. Abrogation of helper T cell activity is controlled by H-2-linked Ir genes. J Immunol (1984) 0.81

Regulatory mechanisms of the immune response to heterologous insulins. I. Development and regulation of plaque-forming cell responses in vitro. Cell Immunol (1984) 0.81

Mechanisms of T cell epitope immunodominance analyzed in murine listeriosis. J Immunol (1995) 0.81

Sodium-calcium exchange in vascular smooth muscle. Ann N Y Acad Sci (1991) 0.81

Requirement for protein synthesis in antigen processing by B cells. Cell Immunol (1994) 0.80

Membrane interactions influence the peptide binding behavior of DR1. J Exp Med (1994) 0.80

The processing and presentation of the self-antigen hemoglobin. Self-reactivity can be limited by antigen availability and costimulator expression. J Immunol (1991) 0.80

The efficacy of Na-naproxen after diagnostic and therapeutic arthroscopy of the knee joint. Arthroscopy (1993) 0.80

Genetic polymorphisms of dsRNA ligating pattern recognition receptors TLR3, MDA5, and RIG-I. Association with systemic lupus erythematosus and clinical phenotypes. Rheumatol Int (2014) 0.79

Intact proteins can bind to class II histocompatibility molecules with high affinity. Mol Immunol (1997) 0.79

[Physical causes of accidental falls among the elderly in their own homes]. Ugeskr Laeger (1992) 0.79

CIITA promoter I CARD-deficient mice express functional MHC class II genes in myeloid and lymphoid compartments. Genes Immun (2012) 0.79

The effect of intracapsular pressure and extension of the hip on oxygenation of the juvenile femoral epiphysis. A study in the goat. J Bone Joint Surg Br (1989) 0.79

[Reduction of traumatic primary anterior shoulder dislocation under local analgesia]. Ugeskr Laeger (1995) 0.79

Lebetase, an alpha(beta)-fibrin(ogen)olytic metalloproteinase of Vipera lebetina snake venom, is inhibited by human alpha-macroglobulins. Biochim Biophys Acta (1999) 0.78

Reduction of traumatic, primary anterior shoulder dislocations with local anesthesia. J Shoulder Elbow Surg (2009) 0.78

The role of [Ca2+]i, membrane potential and pHi in the relaxation of rat mesenteric arteries to hyperosmolar acetate. Pflugers Arch (1998) 0.78

Microvascular free flaps in the treatment of defects of the lower legs. Scand J Plast Reconstr Surg Hand Surg (1996) 0.78

Helper T-cell clones that recognize autologous insulin are stimulated in nonresponder mice by pork insulin. Proc Natl Acad Sci U S A (1988) 0.78

Binding of soluble myelin basic protein to various conformational forms of alpha2-macroglobulin. Arch Biochem Biophys (1998) 0.77

The contact zones in human alpha2-macroglobulin--functional domains important for the regulation of the trapping mechanism. Eur J Biochem (1997) 0.77

Regulation of the costimulator B7, not class II major histocompatibility complex, restricts the ability of murine kidney tubule cells to stimulate CD4+ T cells. J Clin Invest (1994) 0.77

Peptide binding to mixed isotype Abeta(d)Ealpha(d) class II histocompatibility molecules. Mol Immunol (1997) 0.76

A role for microfilaments but not microtubules in processing soluble antigens. Cell Immunol (1995) 0.76

The regulation of pH in resistance arteries from spontaneously hypertensive and Wistar-Kyoto rats: the effect of bicarbonate. J Hypertens (1995) 0.76

Binding of lipoprotein lipase to alpha 2-macroglobulin. Biochem J (1994) 0.75

Assessment of the role of determinant selection in genetic control of the immune response to insulin in H-2b mice. J Immunol (1999) 0.75

Aberrant forms of alpha(2)-macroglobulin purified from patients with multiple sclerosis. Clin Chim Acta (2000) 0.75

Structural requirements of peptide and MHC for DR(alpha, beta 1*0401)-restricted T cell antigen recognition. J Immunol (1995) 0.75

[Knee joint dislocation with arterial rupture following trampoline jumping]. Ugeskr Laeger (1987) 0.75

Intersubunit cross-linking by cis-dichlorodiammineplatinum(II) stabilizes an alpha 2-macroglobulin "nascent" state: evidence that thiol ester bond cleavage correlates with receptor recognition site exposure. Biochemistry (1988) 0.75

Soluble MHC class I molecules induce cellular death in a CD8+ T-cell hybridoma tumor model. Int J Cancer (2001) 0.75

Protein transfer of the costimulatory molecule, B7-2 (CD86), into tumor membrane liposomes as a novel cell-free vaccine. J Immunol Methods (2000) 0.75

Prostatic crystalloids: association with adenocarcinoma. Prostate (1980) 0.75

Insulin-specific suppressor T cell factors. J Immunol (1986) 0.75

Decreased stability of alpha2-macroglobulin purified from patients with multiple sclerosis. Acta Neurol Scand (2000) 0.75

Cloning and expression of the 15-kDa C-terminal peptide from the human alpha 2-macroglobulin as a fusion-protein product in a prokaryotic cell line. Ann N Y Acad Sci (1994) 0.75

Insulin-specific tolerance induction. II. Tolerant helper T cells can be rescued by insulin complexed to Brucella abortus. J Immunol (1984) 0.75

Binding of lipoprotein lipase to alpha 2-macroglobulin. Ann N Y Acad Sci (1994) 0.75

Conformational variants of human alpha2-macroglobulin are reflected in a C-terminal 'switch region'. Eur J Biochem (2000) 0.75

[Late results following elective patellectomy]. Ugeskr Laeger (1987) 0.75

Induction of tumor-specific immunity in mice by immunization with reconstituted tumor membrane liposomes containing recombinant B7-2 (CD86). J Immunother (2000) 0.75

Probing different conformational states of pregnancy-zone protein. Fluorescence studies utilizing the binding of 4,4'-bis(8-anilino-1-naphthalenesulphonate). Eur J Biochem (1993) 0.75

The conformational state of human alpha 2-macroglobulin influences its dissociation into half-molecules by sodium thiocyanate. Arch Biochem Biophys (1996) 0.75

Spike generating smooth muscle cells in mesenteric artery of rats. Pflugers Arch (1993) 0.75