Published in Placenta on November 17, 2008
Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth. Nat Med (2009) 2.39
Transcriptionally active syncytial aggregates in the maternal circulation may contribute to circulating soluble fms-like tyrosine kinase 1 in preeclampsia. Hypertension (2012) 1.86
Angiogenic factors and preeclampsia. Semin Nephrol (2011) 1.58
Beyond oxygen: complex regulation and activity of hypoxia inducible factors in pregnancy. Hum Reprod Update (2009) 1.29
Control of soluble fms-like tyrosine-1 (sFlt-1) production response to placental ischemia/hypoxia: role of tumor necrosis factor-α. Am J Physiol Regul Integr Comp Physiol (2012) 0.95
Preeclampsia and soluble fms-like tyrosine kinase 1. J Clin Endocrinol Metab (2009) 0.92
The adaptation of the blood-brain barrier to vascular endothelial growth factor and placental growth factor during pregnancy. FASEB J (2011) 0.90
Differential placental methylation and expression of VEGF, FLT-1 and KDR genes in human term and preterm preeclampsia. Clin Epigenetics (2013) 0.84
Bevacizumab-mediated interference with VEGF signaling is sufficient to induce a preeclampsia-like syndrome in nonpregnant women. Rev Obstet Gynecol (2012) 0.84
Glyceryl trinitrate inhibits hypoxia-induced release of soluble fms-like tyrosine kinase-1 and endoglin from placental tissues. Am J Pathol (2011) 0.82
Full-length human placental sFlt-1-e15a isoform induces distinct maternal phenotypes of preeclampsia in mice. PLoS One (2015) 0.78
Aspirin inhibits expression of sFLT1 from human cytotrophoblasts induced by hypoxia, via cyclo-oxygenase 1. Placenta (2015) 0.78
Vascular pool of releasable soluble VEGF receptor-1 (sFLT1) in women with previous preeclampsia and uncomplicated pregnancy. J Clin Endocrinol Metab (2013) 0.78
Ouabain inhibits placental sFlt1 production by repressing HSP27-dependent HIF-1α pathway. FASEB J (2014) 0.76
Hypoxia-Mediated Soluble Fms-Like Tyrosine Kinase 1 Increase Is Not Attenuated in Interleukin 6-Deficient Mice. Reprod Sci (2014) 0.75
Regulation of soluble fms-like tyrosine kinase-1 production in response to placental ischemia/hypoxia: role of angiotensin II. Physiol Rep (2015) 0.75
Maternal and fetoplacental hypoxia do not alter circulating angiogenic growth effectors during human pregnancy. Biol Reprod (2014) 0.75
Circulating Levels of sFlt1 Splice Variants as Predictive Markers for the Development of Preeclampsia. Int J Mol Sci (2015) 0.75
The prediction of late-onset preeclampsia: Results from a longitudinal proteomics study. PLoS One (2017) 0.75
Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med (2004) 14.00
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest (2003) 13.72
Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. Proc Natl Acad Sci U S A (1993) 5.02
Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy. Hypertension (2003) 4.28
The vascular endothelial growth factor receptor Flt-1 mediates biological activities. Implications for a functional role of placenta growth factor in monocyte activation and chemotaxis. J Biol Chem (1996) 3.53
Identification of a natural soluble form of the vascular endothelial growth factor receptor, FLT-1, and its heterodimerization with KDR. Biochem Biophys Res Commun (1996) 3.33
Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia. J Biol Chem (1997) 2.95
Uteroplacental ischemia results in proteinuric hypertension and elevated sFLT-1. Kidney Int (2007) 2.87
Cytotrophoblasts up-regulate soluble fms-like tyrosine kinase-1 expression under reduced oxygen: an implication for the placental vascular development and the pathophysiology of preeclampsia. Endocrinology (2004) 2.83
Uric acid is as important as proteinuria in identifying fetal risk in women with gestational hypertension. Hypertension (2005) 2.58
Hypertension produced by reduced uterine perfusion in pregnant rats is associated with increased soluble fms-like tyrosine kinase-1 expression. Hypertension (2007) 2.53
Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia. Circ Res (2004) 2.52
Structure and function of VEGF/VEGF-receptor system involved in angiogenesis. Cell Struct Funct (2001) 2.48
Expression of vascular endothelial growth factor and its receptors flt and KDR in ovarian carcinoma. J Natl Cancer Inst (1995) 2.44
Autoantibody from women with preeclampsia induces soluble Fms-like tyrosine kinase-1 production via angiotensin type 1 receptor and calcineurin/nuclear factor of activated T-cells signaling. Hypertension (2008) 2.42
A vascular endothelial growth factor antagonist is produced by the human placenta and released into the maternal circulation. Biol Reprod (1998) 2.12
Molecular evidence of placental hypoxia in preeclampsia. J Clin Endocrinol Metab (2005) 1.98
Increased expression of sFlt-1 in in vivo and in vitro models of human placental hypoxia is mediated by HIF-1. Am J Physiol Regul Integr Comp Physiol (2006) 1.81
Comparative analysis of structurally defined heparin binding sequences reveals a distinct spatial distribution of basic residues. J Biol Chem (1993) 1.57
Regulation of placental vascular endothelial growth factor (VEGF) and placenta growth factor (PIGF) and soluble Flt-1 by oxygen--a review. Placenta (2000) 1.50
Placental productions and expressions of soluble endoglin, soluble fms-like tyrosine kinase receptor-1, and placental growth factor in normal and preeclamptic pregnancies. J Clin Endocrinol Metab (2007) 1.49
Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy. Circ Res (2006) 1.48
Evidence for the functional activity of hypoxia-inducible transcription factors overexpressed in preeclamptic placentae. Placenta (2004) 1.46
Preeclampsia--a pressing problem: an executive summary of a National Institute of Child Health and Human Development workshop. Reprod Sci (2007) 1.42
Hypoxia-induced increase in soluble Flt-1 production correlates with enhanced oxidative stress in trophoblast cells from the human placenta. Placenta (2005) 1.42
Soluble VEGFR-1 secreted by endothelial cells and monocytes is present in human serum and plasma from healthy donors. Angiogenesis (2001) 1.25
Intronic polyadenylation signal sequences and alternate splicing generate human soluble Flt1 variants and regulate the abundance of soluble Flt1 in the placenta. FASEB J (2007) 1.22
Impaired oxygen-dependent reduction of HIF-1alpha and -2alpha proteins in pre-eclamptic placentae. Placenta (2003) 1.21
Hypoxia reduces expression and function of system A amino acid transporters in cultured term human trophoblasts. Am J Physiol Cell Physiol (2002) 1.20
Post-transcriptional control of expression of sFlt-1, an endogenous inhibitor of vascular endothelial growth factor. J Cell Biochem (2004) 1.03
The fourth immunoglobulin-like loop in the extracellular domain of FLT-1, a VEGF receptor, includes a major heparin-binding site. Biochem Biophys Res Commun (1999) 0.99
Increased chymotrypsin-like protease (chymase) expression and activity in placentas from women with preeclampsia. Placenta (2006) 0.93
Thrombin regulates soluble fms-like tyrosine kinase-1 (sFlt-1) expression in first trimester decidua: implications for preeclampsia. Am J Pathol (2007) 0.86
Expression and localization of membrane type matrix metalloproteinase-1 (MT1-MMP) in trophoblast cells of cultured mouse blastocysts and ectoplacental cones. Placenta (1998) 0.84
Preeclampsia: an endothelial cell disorder. Am J Obstet Gynecol (1989) 5.73
The two stage model of preeclampsia: variations on the theme. Placenta (2008) 2.78
Elevated levels of S-nitrosoalbumin in preeclampsia plasma. Circ Res (2001) 2.21
The C3(1)/SV40 T-antigen transgenic mouse model of mammary cancer: ductal epithelial cell targeting with multistage progression to carcinoma. Oncogene (2000) 2.15
Is oxidative stress the link in the two-stage model of pre-eclampsia? Lancet (1999) 1.80
Altered global gene expression in first trimester placentas of women destined to develop preeclampsia. Placenta (2008) 1.76
Invasive cytotrophoblasts manifest evidence of oxidative stress in preeclampsia. Am J Pathol (2000) 1.48
The expression profile of C19MC microRNAs in primary human trophoblast cells and exosomes. Mol Hum Reprod (2012) 1.41
The levels of hypoxia-regulated microRNAs in plasma of pregnant women with fetal growth restriction. Placenta (2010) 1.32
Hyperuricemia and xanthine oxidase in preeclampsia, revisited. Am J Obstet Gynecol (1996) 1.27
Sera antioxidant activity in uncomplicated and preeclamptic pregnancies. Obstet Gynecol (1992) 1.16
Vitamin D improves the angiogenic properties of endothelial progenitor cells. Am J Physiol Cell Physiol (2012) 1.11
Relationships between maternal plasma leptin, placental leptin mRNA and protein in normal pregnancy, pre-eclampsia and intrauterine growth restriction without pre-eclampsia. Mol Hum Reprod (2006) 1.09
Proteins of the inter-alpha-trypsin inhibitor family stabilize the cumulus extracellular matrix through their direct binding with hyaluronic acid. J Biol Chem (1994) 1.07
Uric acid inhibits placental system A amino acid uptake. Placenta (2008) 1.06
Maternal and fetal amino acid concentrations and fetal outcomes during pre-eclampsia. Reproduction (2003) 1.03
Combination therapy with short interfering RNA vectors against VEGF-C and VEGF-A suppresses lymph node and lung metastasis in a mouse immunocompetent mammary cancer model. Cancer Gene Ther (2008) 1.01
Occlusion of the innominate, common carotid, and subclavian arteries: long-term results of surgical treatment. Surgery (1983) 1.00
Placental system A amino acid transport is reduced in pregnancies with small for gestational age (SGA) infants but not in preeclampsia with SGA infants. Placenta (2008) 0.98
2-difluoromethylornithine and dehydroepiandrosterone inhibit mammary tumor progression but not mammary or prostate tumor initiation in C3(1)/SV40 T/t-antigen transgenic mice. Cancer Res (2001) 0.97
Circulating and placental endoglin concentrations in pregnancies complicated by intrauterine growth restriction and preeclampsia. Placenta (2008) 0.96
Leptin affects system A amino acid transport activity in the human placenta: evidence for STAT3 dependent mechanisms. Placenta (2009) 0.94
A cohort mortality study of construction workers. Am J Ind Med (1997) 0.94
Autonomic transmitter actions on cardiac pacemaker tissue: a brief review. Fed Proc (1981) 0.91
Binding of fatty acids facilitates oxidation of cysteine-34 and converts copper-albumin complexes from antioxidants to prooxidants. Arch Biochem Biophys (2003) 0.88
Asbestos fibers in human pulmonary and extrapulmonary tissues. Am J Ind Med (1988) 0.88
Maternal gene expression profiling during pregnancy and preeclampsia in human peripheral blood mononuclear cells. Placenta (2010) 0.88
Comparative antiplatelet efficacy of a novel, nonpeptide GPIIb/IIIa antagonist (XV454) and abciximab (c7E3) in flow models of thrombosis. Arterioscler Thromb Vasc Biol (2001) 0.88
2-Bromopropane causes ovarian dysfunction by damaging primordial follicles and their oocytes in female rats. Toxicol Appl Pharmacol (1999) 0.88
Human placental adenosine receptor expression is elevated in preeclampsia and hypoxia increases expression of the A2A receptor. Placenta (2009) 0.88
Association between musculoskeletal pain in Japanese construction workers and job, age, alcohol consumption, and smoking. Ind Health (1999) 0.87
1-Bromopropane, an alternative to ozone layer depleting solvents, is dose-dependently neurotoxic to rats in long-term inhalation exposure. Toxicol Sci (2000) 0.87
Proteasomal activity in placentas from women with preeclampsia and intrauterine growth restriction: implications for expression of HIF-alpha proteins. Placenta (2008) 0.87
Asbestos and nonasbestos fiber content in lung tissue of Japanese patients with malignant mesothelioma. Cancer (1994) 0.87
An efficient SAS program for extract stratification of person-years. Comput Biol Med (1997) 0.87
Suppression of mammary carcinoma growth in vitro and in vivo by inducible expression of the Cdk inhibitor p21. Cancer Gene Ther (2001) 0.87
Endothelial progenitor cells: their potential in the placental vasculature and related complications. Placenta (2009) 0.86
Covalent linkage between proteins of the inter-alpha-inhibitor family and hyaluronic acid is mediated by a factor produced by granulosa cells. J Biol Chem (1996) 0.84
Effect of inhalation exposure to 2-bromopropane on the nervous system in rats. Toxicology (1999) 0.84
Determination of urinary 2,5-hexanedione concentration by an improved analytical method as an index of exposure to n-hexane. Br J Ind Med (1991) 0.83
Toluene induces behavioral activation without affecting striatal dopamine metabolism in the rat: behavioral and microdialysis studies. Pharmacol Biochem Behav (1995) 0.83
Neurotoxicity of 2-bromopropane and 1-bromopropane, alternative solvents for chlorofluorocarbons. Environ Res (2001) 0.83
Reproductive toxicity of 1-bromopropane, a newly introduced alternative to ozone layer depleting solvents, in male rats. Toxicol Sci (2000) 0.83
Cyclooxygenase-dependent vasoconstrictor alters vascular function in the vitamin E-deprived rat. Circ Res (1993) 0.82
Polychlorinated biphenyls (PCBs) decrease the placental syncytiotrophoblast volume and increase Placental Growth Factor (PlGF) in the placenta of normal pregnancy. Placenta (2013) 0.82
Decreased antipyrine clearance following endotoxin administration: in vivo evidence of the role of nitric oxide. Antimicrob Agents Chemother (1999) 0.82
[Concentration and fiber size of asbestos in lungs of residents living close to the serpentinite area]. Nihon Koshu Eisei Zasshi (1996) 0.82
[Asbestos concentration and fiber size in lungs of the urban residents]. Nihon Koshu Eisei Zasshi (1991) 0.81
Pulmonary metal distribution in urban dwellers. Int Arch Occup Environ Health (1997) 0.81
Effects of asymmetric dynamic and isometric liftings on strength/force and rating of perceived exertion. Ergonomics (1996) 0.81
Occupational musculoskeletal disorders in lunch centre workers. Ergonomics (1988) 0.81
[Inhaled nonasbestos fibers; pulmonary concentrations and fiber size in autopsied urban residents]. Nihon Koshu Eisei Zasshi (1993) 0.81
Urinary 8-oxo-7, 8-dihydro-2'-deoxyguanosine and biopyrrins levels among construction workers with asbestos exposure history. Ind Health (2001) 0.80
Urinary cotinine concentration confirms the reduced risk of preeclampsia with tobacco exposure. Am J Obstet Gynecol (1999) 0.80
Expression of mitochondrial thioredoxin-dependent antioxidant protein, SP-22, in normal human and inflammatory mouse placentae. Placenta (2000) 0.80
Mortality among Japanese construction workers in Mie Prefecture. Occup Environ Med (2002) 0.79
Endothelial dysfunction yes, cytotoxicity no! Am J Obstet Gynecol (1995) 0.79
Absence of blue-yellow color vision loss among workers exposed to toluene or tetrachloroethylene, mostly at levels below occupational exposure limits. Int Arch Occup Environ Health (1992) 0.79
Impairment of vascular function is associated with an age-related increase of lipid peroxidation in rats. Am J Physiol (1996) 0.78
Effects of subacute toluene exposure on neuronal and glial marker proteins in rat brain. Toxicology (1990) 0.78
[Positive skin test and age] J Pediatr (Rio J) (2003) 0.77
Regional differences in residential environments and the association of dwellings and residential factors with the sick house syndrome: a nationwide cross-sectional questionnaire study in Japan. Indoor Air (2009) 0.77
Endothelial function and myogenic reactivity in small mesenteric arteries of hyperlipidemic pregnant rats. Am J Physiol Regul Integr Comp Physiol (2001) 0.77
Distinct factors in plasma of preeclamptic women increase endothelial nitric oxide or prostacyclin. Hypertension (1996) 0.77
Modification of metabolism and neurotoxicity of hexane by co-exposure of toluene. Int Arch Occup Environ Health (1993) 0.77
Dose dependent effects of chronic exposure to toluene on neuronal and glial cell marker proteins in the central nervous system of rats. Br J Ind Med (1992) 0.77
Urinary 2,5-hexanedione increases with potentiation of neurotoxicity in chronic coexposure to n-hexane and methyl ethyl ketone. Int Arch Occup Environ Health (1998) 0.77
Health status of the workers using mechanized hand tools in an electric parts' maker. Cent Eur J Public Health (1995) 0.76
Elevated urinary cadmium concentrations in a patient with acute cadmium pneumonitis. Scand J Work Environ Health (1996) 0.76
The effects of kinesthetic illusory sensation induced by a visual stimulus on the corticomotor excitability of the leg muscles. Neurosci Lett (2012) 0.76
Mechanisms of renal vasodilation and hyperfiltration during pregnancy: current perspectives and potential implications for preeclampsia. Endothelium (2005) 0.76
Role of tachykinin and bradykinin receptors and mast cells in gaseous formaldehyde-induced airway microvascular leakage in rats. Eur J Pharmacol (1996) 0.76
Relationships between mite allergen levels, mold concentrations, and sick building syndrome symptoms in newly built dwellings in Japan. Indoor Air (2010) 0.76
Nerve-specific marker proteins as indicators of organic solvent neurotoxicity. Environ Res (1993) 0.76
Differential effect of phosphodiesterase inhibitors on IL-13 release from peripheral blood mononuclear cells. Clin Exp Immunol (2001) 0.76
Adrenomedullin and proadrenomedullin N-terminal 20 peptide induce histamine release from rat peritoneal mast cell. Regul Pept (2001) 0.76
Phosphorus flame retardants in indoor dust and their relation to asthma and allergies of inhabitants. Indoor Air (2013) 0.76
[Pre-eclampsia: a disorders of the endothelial cells?]. Gynakologe (1992) 0.75
Comprehensive health evaluation of workers in the ceramics industry. Br J Ind Med (1993) 0.75
Plasma vitamin E in preeclampsia. Am J Obstet Gynecol (1997) 0.75
Lobular carcinoma in situ. J Surg Oncol (1980) 0.75
Induction of histamine release from rat peritoneal mast cells by histatins. Biol Pharm Bull (2001) 0.75
Toxic effects of hexane derivatives on cultured rat Schwann cells. Toxicology (1996) 0.75
[P-glycoprotein inhibition by macrolide antibiotics: The effects on resistance of cancer cells to antineoplastic agents and pharmacokinetics of the agents as P-glycoprotein substrate]. Jpn J Antibiot (2001) 0.75
Metabolic acidosis and renal tubular injury due to pure toluene inhalation. Arch Environ Health (1994) 0.75
Serum levels of volatile organic compounds in patients with sick building syndrome. Bull Environ Contam Toxicol (2006) 0.75
Ganglioneuroma of left adrenal gland in a patient with Turner syndrome during growth hormone therapy. Acta Paediatr Jpn (1997) 0.75
Effects of box weight, vertical location and symmetry on lifting capacities and ratings on category scale in Japanese female workers. Ergonomics (2000) 0.75
A node or not a node; that is the question? QJM (2012) 0.75
Airborne fiber concentration and size distribution of mineral fibers in area with serpentinite outcrops in Aichi prefecture, Japan. Ind Health (2001) 0.75
Properties of the strongly immobilized signal observed in spin-labeled erythrocytes. Biochim Biophys Acta (1983) 0.75
2,5-Hexanedione concentrations and morphological changes within the eye of albino rat. Arch Toxicol (1998) 0.75
[Types and dimensions of mineral fibers in the atmosphere and from lungs of residents in the urban area]. Nihon Koshu Eisei Zasshi (1998) 0.75