Extra-placental expression of vascular endothelial growth factor receptor-1, (Flt-1) and soluble Flt-1 (sFlt-1), by peripheral blood mononuclear cells (PBMCs) in normotensive and preeclamptic pregnant women.

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Published in Placenta on August 01, 2005

Authors

A Rajakumar1, H M Michael, P A Rajakumar, E Shibata, C A Hubel, S Ananth Karumanchi, R Thadhani, M Wolf, G Harger, N Markovic

Author Affiliations

1: Department of Obstetrics and Gynecology and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA. rsiar@mwri.magee.edu

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Role of intracellular calcium mobilization in the regulation of protein kinase C-mediated membrane processes. Nature (1985) 1.61

Interaction of protein kinase C with membranes is regulated by Ca2+, phorbol esters, and ATP. J Biol Chem (1985) 1.61

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Antibodies to macromolecular platelet factor 4-heparin complexes in heparin-induced thrombocytopenia: a study of 44 cases. Thromb Haemost (1995) 1.58

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Protein kinase C phosphorylates topoisomerase II: topoisomerase activation and its possible role in phorbol ester-induced differentiation of HL-60 cells. Proc Natl Acad Sci U S A (1986) 1.56

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Transient electronic structure and melting of a charge density wave in TbTe3. Science (2008) 1.56

Granulocyte colony-stimulating factor and neutrophil recovery after high-dose chemotherapy and autologous bone marrow transplantation. Lancet (1989) 1.54

VEGF and TGF-beta are required for the maintenance of the choroid plexus and ependyma. J Exp Med (2008) 1.54

Near-infrared study of fluctuations in cerebral hemodynamics during rest and motor stimulation: temporal analysis and spatial mapping. Med Phys (2000) 1.54

Endostatin causes G1 arrest of endothelial cells through inhibition of cyclin D1. J Biol Chem (2002) 1.51

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Familial factors in the association between preeclampsia and later ESRD. Clin J Am Soc Nephrol (2012) 1.47

Species-specific variation in SIV disease progression between Chinese and Indian subspecies of rhesus macaque. J Med Primatol (2002) 1.46

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Prevalence and severity of disordered mineral metabolism in Blacks with chronic kidney disease. Kidney Int (2008) 1.44

Further observations of true mosaic trisomy 17 ascertained in amniotic fluid cell cultures. Prenat Diagn (1998) 1.44

[Is there a correlation between C-reactive protein and calcification inhibitors with cardiovascular parameters and risk factors in hemodialysis patients?]. Dtsch Med Wochenschr (2007) 1.43

Prognostic impact of an activation of coagulation in lung cancer. Ann Oncol (1997) 1.42

Hypothesis: Uric acid, nephron number, and the pathogenesis of essential hypertension. Kidney Int (2004) 1.42

The expression profile of C19MC microRNAs in primary human trophoblast cells and exosomes. Mol Hum Reprod (2012) 1.41

Are esterases involved in multidrug resistance? J Natl Cancer Inst (1993) 1.41