|
1
|
Functional selectivity and classical concepts of quantitative pharmacology.
|
J Pharmacol Exp Ther
|
2006
|
7.03
|
|
2
|
Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with superpotent N-benzyl phenethylamine agonists.
|
Mol Pharmacol
|
2006
|
2.02
|
|
3
|
Effects of Schedule I drug laws on neuroscience research and treatment innovation.
|
Nat Rev Neurosci
|
2013
|
1.70
|
|
4
|
Functional selectivity of dopamine receptor agonists. II. Actions of dihydrexidine in D2L receptor-transfected MN9D cells and pituitary lactotrophs.
|
J Pharmacol Exp Ther
|
2002
|
1.25
|
|
5
|
Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase.
|
J Pharmacol Exp Ther
|
2002
|
1.25
|
|
6
|
trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist.
|
J Med Chem
|
2006
|
1.22
|
|
7
|
Functional selectivity of D2 receptor ligands in a Chinese hamster ovary hD2L cell line: evidence for induction of ligand-specific receptor states.
|
Mol Pharmacol
|
2004
|
1.19
|
|
8
|
Serotonin 5-hydroxytryptamine 2A receptor-coupled phospholipase C and phospholipase A2 signaling pathways have different receptor reserves.
|
J Pharmacol Exp Ther
|
2003
|
1.17
|
|
9
|
1-Aminomethylbenzocycloalkanes: conformationally restricted hallucinogenic phenethylamine analogues as functionally selective 5-HT2A receptor agonists.
|
J Med Chem
|
2006
|
1.13
|
|
10
|
Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists.
|
Mol Pharmacol
|
2005
|
1.12
|
|
11
|
WAY-100635 is a potent dopamine D4 receptor agonist.
|
Psychopharmacology (Berl)
|
2006
|
1.07
|
|
12
|
Ambient temperature effects on 3,4-methylenedioxymethamphetamine-induced thermodysregulation and pharmacokinetics in male monkeys.
|
Drug Metab Dispos
|
2007
|
1.06
|
|
13
|
WAY 100635 produces discriminative stimulus effects in rats mediated by dopamine D(4) receptor activation.
|
Behav Pharmacol
|
2009
|
1.01
|
|
14
|
Further evidence that the delayed temporal dopaminergic effects of LSD are mediated by a mechanism different than the first temporal phase of action.
|
Pharmacol Biochem Behav
|
2007
|
1.00
|
|
15
|
A complex signaling cascade links the serotonin2A receptor to phospholipase A2 activation: the involvement of MAP kinases.
|
J Neurochem
|
2003
|
0.99
|
|
16
|
Engineered zinc-binding sites confirm proximity and orientation of transmembrane helices I and III in the human serotonin transporter.
|
Protein Sci
|
2006
|
0.98
|
|
17
|
Assessment of the roles of serines 5.43(239) and 5.46(242) for binding and potency of agonist ligands at the human serotonin 5-HT2A receptor.
|
Mol Pharmacol
|
2007
|
0.97
|
|
18
|
Alpha1-adrenergic receptors mediate the locomotor response to systemic administration of (+/-)-3,4-methylenedioxymethamphetamine (MDMA) in rats.
|
Pharmacol Biochem Behav
|
2007
|
0.97
|
|
19
|
Differential phospholipase C activation by phenylalkylamine serotonin 5-HT 2A receptor agonists.
|
J Neurochem
|
2005
|
0.96
|
|
20
|
Extensive rigid analogue design maps the binding conformation of potent N-benzylphenethylamine 5-HT2A serotonin receptor agonist ligands.
|
ACS Chem Neurosci
|
2012
|
0.96
|
|
21
|
A single 20 mg dose of the full D1 dopamine agonist dihydrexidine (DAR-0100) increases prefrontal perfusion in schizophrenia.
|
Schizophr Res
|
2007
|
0.94
|
|
22
|
Dopamine D4 receptor involvement in the discriminative stimulus effects in rats of LSD, but not the phenethylamine hallucinogen DOI.
|
Psychopharmacology (Berl)
|
2008
|
0.93
|
|
23
|
Mapping the catechol binding site in dopamine D₁ receptors: synthesis and evaluation of two parallel series of bicyclic dopamine analogues.
|
ChemMedChem
|
2011
|
0.92
|
|
24
|
Comparative molecular field analysis using selectivity fields reveals residues in the third transmembrane helix of the serotonin transporter associated with substrate and antagonist recognition.
|
J Pharmacol Exp Ther
|
2008
|
0.92
|
|
25
|
New victims of current drug laws.
|
Nat Rev Neurosci
|
2013
|
0.92
|
|
26
|
Distinct temporal phases in the behavioral pharmacology of LSD: dopamine D2 receptor-mediated effects in the rat and implications for psychosis.
|
Psychopharmacology (Berl)
|
2005
|
0.91
|
|
27
|
A homology-based model of the human 5-HT2A receptor derived from an in silico activated G-protein coupled receptor.
|
J Comput Aided Mol Des
|
2002
|
0.91
|
|
28
|
Synthesis and pharmacological characterization of a series of geometrically constrained 5-HT(2A/2C) receptor ligands.
|
J Med Chem
|
2003
|
0.89
|
|
29
|
8,9-dihydroxy-1,2,3,11b-tetrahydrochromeno[4,3,2,-de]isoquinoline (dinoxyline), a high affinity and potent agonist at all dopamine receptor isoforms.
|
Bioorg Med Chem
|
2004
|
0.89
|
|
30
|
Serotonin 5-HT(2A) receptor activation induces 2-arachidonoylglycerol release through a phospholipase c-dependent mechanism.
|
J Neurochem
|
2006
|
0.87
|
|
31
|
A single 20 mg dose of dihydrexidine (DAR-0100), a full dopamine D1 agonist, is safe and tolerated in patients with schizophrenia.
|
Schizophr Res
|
2007
|
0.85
|
|
32
|
The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands.
|
Bioorg Med Chem
|
2008
|
0.84
|
|
33
|
Sulfur-substituted alpha-alkyl phenethylamines as selective and reversible MAO-A inhibitors: biological activities, CoMFA analysis, and active site modeling.
|
J Med Chem
|
2005
|
0.83
|
|
34
|
In vivo microdialysis and conditioned place preference studies in rats are consistent with abuse potential of tramadol.
|
Synapse
|
2002
|
0.83
|
|
35
|
Aripiprazole (OPC-14597) fully substitutes for the 5-HT1A receptor agonist LY293284 in the drug discrimination assay in rats.
|
Psychopharmacology (Berl)
|
2003
|
0.83
|
|
36
|
3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-mediated production of hydrogen peroxide in an in vitro model: the role of dopamine, the serotonin-reuptake transporter, and monoamine oxidase-B.
|
Neurosci Lett
|
2004
|
0.82
|
|
37
|
C-(4,5,6-trimethoxyindan-1-yl)methanamine: a mescaline analogue designed using a homology model of the 5-HT2A receptor.
|
J Med Chem
|
2006
|
0.81
|
|
38
|
Comparison of the enantiomers of (+/-)-doxanthrine, a high efficacy full dopamine D(1) receptor agonist, and a reversal of enantioselectivity at D(1) versus alpha(2C) adrenergic receptors.
|
Eur Neuropsychopharmacol
|
2008
|
0.81
|
|
39
|
Facile synthesis of octahydrobenzo[h]isoquinolines: novel and highly potent D1 dopamine agonists.
|
Bioorg Med Chem
|
2010
|
0.81
|
|
40
|
Substituted hexahydrobenzodipyrans as 5-HT2A/2C receptor probes.
|
Bioorg Med Chem
|
2002
|
0.81
|
|
41
|
Synthesis and SAR exploration of dinapsoline analogues.
|
Bioorg Med Chem
|
2004
|
0.81
|
|
42
|
Ligand-specific roles for transmembrane 5 serine residues in the binding and efficacy of dopamine D(1) receptor catechol agonists.
|
Mol Pharmacol
|
2012
|
0.80
|
|
43
|
An animal model of schizophrenia based on chronic LSD administration: old idea, new results.
|
Neuropharmacology
|
2011
|
0.80
|
|
44
|
A demand for clarity regarding a case report on the ingestion of 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT) in an Ayahuasca preparation.
|
J Anal Toxicol
|
2006
|
0.80
|
|
45
|
Translocation of the 5-alkoxy substituent of 2,5-dialkoxyarylalkylamines to the 6-position: effects on 5-HT(2A/2C) receptor affinity.
|
Bioorg Med Chem Lett
|
2002
|
0.79
|
|
46
|
trans-2-(2,5-Dimethoxy-4-iodophenyl)cyclopropylamine and trans-2-(2,5-dimethoxy-4-bromophenyl)cyclopropylamine as potent agonists for the 5-HT(2) receptor family.
|
Beilstein J Org Chem
|
2012
|
0.79
|
|
47
|
Assessment of dopamine D₁ receptor affinity and efficacy of three tetracyclic conformationally-restricted analogs of SKF38393.
|
Bioorg Med Chem
|
2011
|
0.79
|
|
48
|
Re-evaluation of lisuride pharmacology: 5-hydroxytryptamine1A receptor-mediated behavioral effects overlap its other properties in rats.
|
Psychopharmacology (Berl)
|
2002
|
0.79
|
|
49
|
Behavioral effects of α,α,β,β-tetradeutero-5-MeO-DMT in rats: comparison with 5-MeO-DMT administered in combination with a monoamine oxidase inhibitor.
|
Psychopharmacology (Berl)
|
2012
|
0.78
|
|
50
|
Structural analysis of the extracellular entrance to the serotonin transporter permeation pathway.
|
J Biol Chem
|
2010
|
0.78
|
|
51
|
Comparison of the D₁ dopamine full agonists, dihydrexidine and doxanthrine, in the 6-OHDA rat model of Parkinson's disease.
|
Psychopharmacology (Berl)
|
2012
|
0.78
|
|
52
|
Distinct molecular recognition of psychostimulants by human and Drosophila serotonin transporters.
|
J Pharmacol Exp Ther
|
2003
|
0.78
|
|
53
|
The Heffter Research Institute: past and hopeful future.
|
J Psychoactive Drugs
|
2014
|
0.78
|
|
54
|
Neurotoxicity of MDMA (ecstasy): beyond metabolism.
|
Trends Pharmacol Sci
|
2005
|
0.77
|
|
55
|
1-Methylpyridinium-4-(4-phenylmethanethiosulfonate) iodide, MTS-MPP+, a novel scanning cysteine accessibility method (SCAM) reagent for monoamine transporter studies.
|
Bioorg Med Chem
|
2006
|
0.77
|
|
56
|
Helix XI contributes to the entrance of the serotonin transporter permeation pathway.
|
Protein Sci
|
2008
|
0.77
|
|
57
|
Analogues of doxanthrine reveal differences between the dopamine D1 receptor binding properties of chromanoisoquinolines and hexahydrobenzo[a]phenanthridines.
|
Eur J Med Chem
|
2011
|
0.76
|
|
58
|
A reported "new synthesis of lysergic acid" yields only the derailment product: methyl 5-methoxy-4,5-dihydroindolo[4,3-f,g]quinoline-9-carboxylate.
|
Org Lett
|
2011
|
0.76
|
|
59
|
Potential serotonin 5-HT(1A) and dopamine D(4) receptor modulation of the discriminative stimulus effects of amphetamine in rats.
|
Behav Pharmacol
|
2011
|
0.76
|
|
60
|
Probing the steric space at the floor of the D1 dopamine receptor orthosteric binding domain: 7α-, 7β-, 8α-, and 8β-methyl substituted dihydrexidine analogues.
|
J Med Chem
|
2011
|
0.76
|
|
61
|
An antisense oligonucleotide targeted at MAO-B attenuates rat striatal serotonergic neurotoxicity induced by MDMA.
|
Pharmacol Biochem Behav
|
2002
|
0.76
|
|
62
|
A 5-HT(2C) receptor antagonist potentiates a low dose amphetamine-induced conditioned place preference.
|
Neurosci Lett
|
2011
|
0.76
|
|
63
|
'Hybrid' benzofuran-benzopyran congeners as rigid analogs of hallucinogenic phenethylamines.
|
Bioorg Med Chem
|
2008
|
0.75
|
|
64
|
Identification of a 2-phenyl-substituted octahydrobenzo[f]quinoline as a dopamine D₃ receptor-selective full agonist ligand.
|
Bioorg Med Chem
|
2012
|
0.75
|
|
65
|
Synthesis and pharmacological evaluation of substituted naphth[1,2,3-de]isoquinolines (dinapsoline analogues) as D1 and D2 dopamine receptor ligands.
|
Bioorg Med Chem
|
2003
|
0.75
|
|
66
|
4-aryl-substituted 2,5-dimethoxyphenethylamines: synthesis and serotonin 5-HT(2A) receptor affinities.
|
Chem Biodivers
|
2009
|
0.75
|