Genetic and systems level analysis of Drosophila sticky/citron kinase and dFmr1 mutants reveals common regulation of genetic networks.

PubWeight™: 0.82‹?›

🔗 View Article (PMC 2610033)

Published in BMC Syst Biol on November 25, 2008

Authors

Christopher R Bauer1, Andrew M Epstein, Sarah J Sweeney, Daniela C Zarnescu, Giovanni Bosco

Author Affiliations

1: Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, USA. chrisb@email.arizona.edu

Articles cited by this

Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res (2003) 103.76

Statistical significance for genomewide studies. Proc Natl Acad Sci U S A (2003) 88.64

BiNGO: a Cytoscape plugin to assess overrepresentation of gene ontology categories in biological networks. Bioinformatics (2005) 24.04

Discovering regulatory and signalling circuits in molecular interaction networks. Bioinformatics (2002) 12.88

Using FlyAtlas to identify better Drosophila melanogaster models of human disease. Nat Genet (2007) 12.62

Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway. Nat Neurosci (2004) 4.69

Regulation of myosin II during cytokinesis in higher eukaryotes. Trends Cell Biol (2005) 3.28

Genetic suppression of polyglutamine toxicity in Drosophila. Science (2000) 3.23

CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X protein. Neuron (2003) 2.92

Drosophila rasiRNA pathway mutations disrupt embryonic axis specification through activation of an ATR/Chk2 DNA damage response. Dev Cell (2007) 2.86

The pathophysiology of fragile x syndrome. Annu Rev Genomics Hum Genet (2007) 2.85

The regulatory light chain of nonmuscle myosin is encoded by spaghetti-squash, a gene required for cytokinesis in Drosophila. Cell (1991) 2.76

BioNetBuilder: automatic integration of biological networks. Bioinformatics (2006) 2.76

PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation. Biochem J (2005) 2.19

Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis. Neuron (2000) 2.04

Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest. Neuron (2002) 2.03

Myosin light chain-activating phosphorylation sites are required for oogenesis in Drosophila. J Cell Biol (1997) 2.01

okra and spindle-B encode components of the RAD52 DNA repair pathway and affect meiosis and patterning in Drosophila oogenesis. Genes Dev (1998) 1.95

Mutations in sticky lead to defective organization of the contractile ring during cytokinesis and are enhanced by Rho and suppressed by Rac. J Cell Biol (2004) 1.94

Control of dendritic development by the Drosophila fragile X-related gene involves the small GTPase Rac1. Development (2003) 1.91

Toward a molecular understanding of pleiotropy. Genetics (2006) 1.88

EGF receptor signaling in Drosophila oogenesis. Curr Top Dev Biol (1999) 1.86

FMRP interferes with the Rac1 pathway and controls actin cytoskeleton dynamics in murine fibroblasts. Hum Mol Genet (2005) 1.60

Wrestling with pleiotropy: genomic and topological analysis of the yeast gene expression network. Bioessays (2002) 1.58

The Drosophila fragile X protein functions as a negative regulator in the orb autoregulatory pathway. Dev Cell (2005) 1.55

Regulation of cell cycles in Drosophila development: intrinsic and extrinsic cues. Annu Rev Genet (2003) 1.49

Drosophila nonmuscle myosin II is required for rapid cytoplasmic transport during oogenesis and for axial nuclear migration in early embryos. Development (1995) 1.49

Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus. J Neurosci (1999) 1.43

The Drosophila fragile X mental retardation protein controls actin dynamics by directly regulating profilin in the brain. Curr Biol (2005) 1.38

Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron. J Biol Chem (1998) 1.36

Patterning signals and proliferation in Drosophila imaginal discs. Curr Opin Genet Dev (2007) 1.30

Sprouty: how does the branch manager work? J Cell Sci (2003) 1.25

Drosophila citron kinase is required for the final steps of cytokinesis. Mol Biol Cell (2004) 1.21

Fragile X protein functions with lgl and the par complex in flies and mice. Dev Cell (2005) 1.14

Citron, a Rho target that affects contractility during cytokinesis. Microsc Res Tech (2000) 1.13

Citron, a Rho-target, interacts with PSD-95/SAP-90 at glutamatergic synapses in the thalamus. J Neurosci (1999) 1.08

Merlin, the Drosophila homologue of neurofibromatosis-2, is specifically required in posterior follicle cells for axis formation in the oocyte. Development (2001) 1.07

Fragile X mental retardation protein modulates the fate of germline stem cells in Drosophila. Hum Mol Genet (2007) 1.03

Transdetermination: Drosophila imaginal disc cells exhibit stem cell-like potency. Int J Biochem Cell Biol (2007) 1.02

Citron kinase is a regulator of mitosis and neurogenic cytokinesis in the neocortical ventricular zone. Cereb Cortex (2003) 1.02

The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase. J Cell Sci (2007) 0.98

Come FLY with us: toward understanding fragile X syndrome. Genes Brain Behav (2005) 0.90

Targeting and clustering citron to synapses. Mol Cell Neurosci (2005) 0.89

Citron kinase is required for postnatal neurogenesis in the hippocampus. Dev Neurosci (2007) 0.87

Differential effects of Cbl isoforms on Egfr signaling in Drosophila. Mech Dev (2006) 0.87

The drosophila fragile X protein dFMR1 is required during early embryogenesis for pole cell formation and rapid nuclear division cycles. Genetics (2006) 0.87

Role of citron kinase in dendritic morphogenesis of cortical neurons. Brain Res Bull (2003) 0.83

Signaling meets chromatin during tissue regeneration in Drosophila. Curr Opin Genet Dev (2006) 0.81

Drosophila sticky/citron kinase is a regulator of cell-cycle progression, genetically interacts with Argonaute 1 and modulates epigenetic gene silencing. Genetics (2008) 0.81

Articles by these authors

Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway. Nat Neurosci (2004) 4.69

RNA-mediated neurodegeneration caused by the fragile X premutation rCGG repeats in Drosophila. Neuron (2003) 2.81

Gene amplification as a developmental strategy: isolation of two developmental amplicons in Drosophila. Dev Cell (2004) 2.38

Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila. Nat Chem Biol (2008) 2.04

Chromosome alignment and transvection are antagonized by condensin II. Science (2008) 1.47

Condensin II resolves chromosomal associations to enable anaphase I segregation in Drosophila male meiosis. PLoS Genet (2008) 1.31

Condensin II promotes the formation of chromosome territories by inducing axial compaction of polyploid interphase chromosomes. PLoS Genet (2012) 1.24

Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS. Hum Mol Genet (2011) 1.18

Fragile X protein controls the efficacy of mRNA transport in Drosophila neurons. Mol Cell Neurosci (2008) 1.18

Developmentally regulated histone modifications in Drosophila follicle cells: initiation of gene amplification is associated with histone H3 and H4 hyperacetylation and H1 phosphorylation. Chromosoma (2007) 1.13

Fragile X protein controls neural stem cell proliferation in the Drosophila brain. Hum Mol Genet (2010) 1.02

Comparative genomic analysis of novel conserved peptide upstream open reading frames in Drosophila melanogaster and other dipteran species. BMC Genomics (2008) 1.01

Desmoplakin and talin2 are novel mRNA targets of fragile X-related protein-1 in cardiac muscle. Circ Res (2011) 1.00

SCFSlimb ubiquitin ligase suppresses condensin II-mediated nuclear reorganization by degrading Cap-H2. J Cell Biol (2013) 0.96

The N-terminal domain of the Drosophila retinoblastoma protein Rbf1 interacts with ORC and associates with chromatin in an E2F independent manner. PLoS One (2008) 0.96

The E2F cell cycle regulator is required for Drosophila nurse cell DNA replication and apoptosis. Mech Dev (2002) 0.96

Heads-up: new roles for the fragile X mental retardation protein in neural stem and progenitor cells. Genesis (2011) 0.96

Drosophila Fragile X protein controls cellular proliferation by regulating cbl levels in the ovary. Dev Biol (2009) 0.90

Pneumomediastinum and cervical emphysema associated with mandibular fracture. J Trauma (2007) 0.89

Fragile X Protein is required for inhibition of insulin signaling and regulates glial-dependent neuroblast reactivation in the developing brain. Brain Res (2012) 0.89

Maintenance of interphase chromosome compaction and homolog pairing in Drosophila is regulated by the condensin cap-h2 and its partner Mrg15. Genetics (2013) 0.89

Motor neurons and glia exhibit specific individualized responses to TDP-43 expression in a Drosophila model of amyotrophic lateral sclerosis. Dis Model Mech (2013) 0.88

Segmentation and detection of fluorescent 3D spots. Cytometry A (2012) 0.85

Vertebral artery dissection complicated by basilar artery occlusion successfully treated with intra-arterial thrombolysis: three case reports. Neurol Sci (2008) 0.82

TRIP/NOPO E3 ubiquitin ligase promotes ubiquitylation of DNA polymerase η. Development (2014) 0.82

Drosophila sticky/citron kinase is a regulator of cell-cycle progression, genetically interacts with Argonaute 1 and modulates epigenetic gene silencing. Genetics (2008) 0.81

Human 14-3-3 gamma protein results in abnormal cell proliferation in the developing eye of Drosophila melanogaster. Cell Div (2008) 0.80

Cell cycle: Retinoblastoma, a trip organizer. Nature (2010) 0.80

The cell adhesion molecule Roughest depends on beta(Heavy)-spectrin during eye morphogenesis in Drosophila. J Cell Sci (2010) 0.79

The RB/E2F pathway and regulation of RNA processing. Biochem Biophys Res Commun (2009) 0.79

Sqd interacts with the Drosophila retinoblastoma tumor suppressor Rbf. Biochem Biophys Res Commun (2009) 0.78

Serum levels of heat shock protein 27 in patients with acute ischemic stroke. Cell Stress Chaperones (2013) 0.77

Juvenile vertebrobasilar ischaemic stroke in a patient with Camurati-Engelmann disease. Cerebrovasc Dis (2005) 0.75

[Acute hepatitis C infection: epidemiological and clinical aspects, and efficacy of interferon therapy]. Infez Med (2007) 0.75

Gait and bilateral limb ataxia as isolated feature of a lower midbrain tegmental infarction. A clinical-MRI study. J Neurol (2008) 0.75