Stromal gene signatures in large-B-cell lymphomas.

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🔗 View Article (PMID 19038878)

Published in N Engl J Med on November 27, 2008

Authors

G Lenz1, G Wright, S S Dave, W Xiao, J Powell, H Zhao, W Xu, B Tan, N Goldschmidt, J Iqbal, J Vose, M Bast, K Fu, D D Weisenburger, T C Greiner, J O Armitage, A Kyle, L May, R D Gascoyne, J M Connors, G Troen, H Holte, S Kvaloy, D Dierickx, G Verhoef, J Delabie, E B Smeland, P Jares, A Martinez, A Lopez-Guillermo, E Montserrat, E Campo, R M Braziel, T P Miller, L M Rimsza, J R Cook, B Pohlman, J Sweetenham, R R Tubbs, R I Fisher, E Hartmann, A Rosenwald, G Ott, H-K Muller-Hermelink, D Wrench, T A Lister, E S Jaffe, W H Wilson, W C Chan, L M Staudt, Lymphoma/Leukemia Molecular Profiling Project

Author Affiliations

1: Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Associated clinical trials:

Phase II Trial of Alemtuzumab (Campath) and Dose-Adjusted EPOCH-Rituximab (DA-EPOCH-R) in Relapsed or Refractory Diffuse Large B-Cell and Hodgkin Lymphomas | NCT01030900

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The transcriptional program in the response of human fibroblasts to serum. Science (1999) 19.19

Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol (1986) 18.40

Report of an international workshop to standardize response criteria for non-Hodgkin's lymphomas. NCI Sponsored International Working Group. J Clin Oncol (1999) 17.43

World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting-Airlie House, Virginia, November 1997. J Clin Oncol (1999) 12.42

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osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev (1998) 7.81

Effect of nesiritide in patients with acute decompensated heart failure. N Engl J Med (2011) 7.62

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The vagus influences giving rise to the phenomena accompanying expansion and collapse of the lungs. J Physiol (1932) 5.96

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Human leukocyte interferon produced by E. coli is biologically active. Nature (1980) 5.86

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Thrombotic thrombocytopenic purpura associated with clopidogrel. N Engl J Med (2000) 5.43

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A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature (1990) 4.69

Random genetic drift in the female germline explains the rapid segregation of mammalian mitochondrial DNA. Nat Genet (1996) 4.68

Chronic lymphocytic leukemia. N Engl J Med (1995) 4.52

Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope. Curr Biol (1995) 4.46

Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy. J Clin Oncol (1995) 4.42

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Distinct functions for the two importin subunits in nuclear protein import. Nature (1995) 4.16

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Mantle cell lymphoma. A proposal for unification of morphologic, immunologic, and molecular data. Am J Surg Pathol (1992) 4.04

Identification of a tRNA-specific nuclear export receptor. Mol Cell (1998) 3.94

Increased incidence of lymphoproliferative disorder after immunosuppression with the monoclonal antibody OKT3 in cardiac-transplant recipients. N Engl J Med (1990) 3.88

Contemporary classification of histiocytic disorders. The WHO Committee On Histiocytic/Reticulum Cell Proliferations. Reclassification Working Group of the Histiocyte Society. Med Pediatr Oncol (1997) 3.83

SURF1, encoding a factor involved in the biogenesis of cytochrome c oxidase, is mutated in Leigh syndrome. Nat Genet (1998) 3.79

A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation. Cell (1992) 3.78

The synaptic SNARE complex is a parallel four-stranded helical bundle. Nat Struct Biol (1998) 3.74

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Signatures of the immune response. Immunity (2001) 3.66

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Light control of Arabidopsis development entails coordinated regulation of genome expression and cellular pathways. Plant Cell (2001) 3.60

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Pursuit and practice of complementary therapies by cancer patients receiving conventional treatment. BMJ (1994) 3.52

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Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome. Nature (1997) 3.47

Posttranslational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2p. Cell (1995) 3.46

Undergraduate research. Genomics Education Partnership. Science (2008) 3.45

beta-catenin destruction complex: insights and questions from a structural perspective. Oncogene (2006) 3.43

A piston model for transmembrane signaling of the aspartate receptor. Science (1999) 3.42

Mapping of contralateral space in retinotopic coordinates by a parietal cortical area in humans. Science (2001) 3.41

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Spiral Tube Assembly for High-Speed Countercurrent Chromatography: Choice of Elution Modes for Four Typical Two-Phase Solvent Systems. J Liq Chromatogr Relat Technol (2008) 3.33

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Epidemiology of the non-Hodgkin's lymphomas: distributions of the major subtypes differ by geographic locations. Non-Hodgkin's Lymphoma Classification Project. Ann Oncol (1998) 3.21

A protein of the endoplasmic reticulum involved early in polypeptide translocation. Nature (1992) 3.20

Complete molecular remissions induced by patient-specific vaccination plus granulocyte-monocyte colony-stimulating factor against lymphoma. Nat Med (1999) 3.18

Improved sex-specific criteria of left ventricular hypertrophy for clinical and computer interpretation of electrocardiograms: validation with autopsy findings. Circulation (1987) 3.16

Unfavorable histologies of non-Hodgkin's lymphoma treated with ProMACE-CytaBOM: a groupwide Southwest Oncology Group study. J Clin Oncol (1990) 3.14

Diffuse large B-cell lymphoma subgroups have distinct genetic profiles that influence tumor biology and improve gene-expression-based survival prediction. Blood (2005) 3.12

Antisera to acute lymphoblastic leukemia cells. Clin Immunol Immunopathol (1975) 3.12

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Immunoglobulin-gene rearrangements as unique clonal markers in human lymphoid neoplasms. N Engl J Med (1983) 2.96

International standardized approach for flow cytometric residual disease monitoring in chronic lymphocytic leukaemia. Leukemia (2007) 2.96

Transport route for synaptobrevin via a novel pathway of insertion into the endoplasmic reticulum membrane. EMBO J (1995) 2.96

Prognostic significance of anaplastic lymphoma kinase (ALK) protein expression in adults with anaplastic large cell lymphoma. Blood (1999) 2.95