Published in J Biol Chem on December 02, 2008
Novel structural determinants of single channel conductance and ion selectivity in 5-hydroxytryptamine type 3 and nicotinic acetylcholine receptors. J Physiol (2009) 1.19
Gating mechanisms in Cys-loop receptors. Eur Biophys J (2009) 1.03
Engineering a prokaryotic Cys-loop receptor with a third functional domain. J Biol Chem (2011) 0.94
Chloride ions in the pore of glycine and GABA channels shape the time course and voltage dependence of agonist currents. J Neurosci (2011) 0.93
The pharmacological profile of ELIC, a prokaryotic GABA-gated receptor. Neuropharmacology (2012) 0.93
Rings of charge within the extracellular vestibule influence ion permeation of the 5-HT3A receptor. J Biol Chem (2011) 0.91
The activation mechanism of alpha1beta2gamma2S and alpha3beta3gamma2S GABAA receptors. J Gen Physiol (2010) 0.89
Protein interactions involving the gamma2 large cytoplasmic loop of GABA(A) receptors modulate conductance. FASEB J (2009) 0.89
5-HT3 receptor ion size selectivity is a property of the transmembrane channel, not the cytoplasmic vestibule portals. J Gen Physiol (2011) 0.88
Novel regulatory site within the TM3-4 loop of human recombinant alpha3 glycine receptors determines channel gating and domain structure. J Biol Chem (2009) 0.87
Molecular dissection of Cl--selective Cys-loop receptor points to components that are dispensable or essential for channel activity. J Biol Chem (2011) 0.87
Mutagenic analysis of the intracellular portals of the human 5-HT3A receptor. J Biol Chem (2013) 0.83
In glycine and GABA(A) channels, different subunits contribute asymmetrically to channel conductance via residues in the extracellular domain. J Biol Chem (2011) 0.83
Discrete M3-M4 intracellular loop subdomains control specific aspects of γ-aminobutyric acid type A receptor function. J Biol Chem (2011) 0.83
The basic property of Lys385 is important for potentiation of the human α1 glycine receptor by ethanol. J Pharmacol Exp Ther (2011) 0.82
Evidence for α-helices in the large intracellular domain mediating modulation of the α1-glycine receptor by ethanol and Gβγ. J Pharmacol Exp Ther (2014) 0.80
4-Chloropropofol enhances chloride currents in human hyperekplexic and artificial mutated glycine receptors. BMC Neurol (2012) 0.80
Identifying the elusive link between amino acid sequence and charge selectivity in pentameric ligand-gated ion channels. Proc Natl Acad Sci U S A (2016) 0.80
Functional Chimeras of GLIC Obtained by Adding the Intracellular Domain of Anion- and Cation-Conducting Cys-Loop Receptors. Biochemistry (2015) 0.80
External divalent cations increase anion-cation permeability ratio in glycine receptor channels. Pflugers Arch (2010) 0.80
Structural Studies of GABAA Receptor Binding Sites: Which Experimental Structure Tells us What? Front Mol Neurosci (2016) 0.77
Ethanol effects on glycinergic transmission: From molecular pharmacology to behavior responses. Pharmacol Res (2015) 0.76
The Intracellular Loop of the Glycine Receptor: It's not all about the Size. Front Mol Neurosci (2016) 0.75
Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain. J Clin Invest (2016) 0.75
Functional characterization of neurotransmitter activation and modulation in a nematode model ligand-gated ion channel. J Neurochem (2016) 0.75
Structure-Function Analysis of the GlyR α2 Subunit Autism Mutation p.R323L Reveals a Gain-of-Function. Front Mol Neurosci (2017) 0.75
Guide to Receptors and Channels (GRAC), 5th edition. Br J Pharmacol (2011) 10.40
The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands. Nucleic Acids Res (2013) 9.61
Transient receptor potential cation channels in disease. Physiol Rev (2007) 6.91
The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors. Br J Pharmacol (2013) 5.74
The Concise Guide to PHARMACOLOGY 2013/14: enzymes. Br J Pharmacol (2013) 5.57
Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals. J Neurosci (2009) 4.83
Neurosteroids: endogenous regulators of the GABA(A) receptor. Nat Rev Neurosci (2005) 4.07
Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors. Proc Natl Acad Sci U S A (2004) 3.21
The Concise Guide to PHARMACOLOGY 2013/14: ion channels. Br J Pharmacol (2013) 3.03
The Concise Guide to PHARMACOLOGY 2013/14: overview. Br J Pharmacol (2013) 2.48
A cytoplasmic region determines single-channel conductance in 5-HT3 receptors. Nature (2003) 2.47
How can drug discovery for psychiatric disorders be improved? Nat Rev Drug Discov (2007) 2.29
The Concise Guide to PHARMACOLOGY 2013/14: catalytic receptors. Br J Pharmacol (2013) 2.29
The Concise Guide to PHARMACOLOGY 2013/14: transporters. Br J Pharmacol (2013) 2.07
Extrasynaptic GABAA receptors of thalamocortical neurons: a molecular target for hypnotics. J Neurosci (2005) 2.03
Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms. J Neurosci (2003) 1.97
Ligand-gated ion channels: mechanisms underlying ion selectivity. Prog Biophys Mol Biol (2004) 1.96
The Concise Guide to PHARMACOLOGY 2013/14: ligand-gated ion channels. Br J Pharmacol (2013) 1.88
The influence of subunit composition on the interaction of neurosteroids with GABA(A) receptors. Neuropharmacology (2002) 1.85
The delta subunit of gamma-aminobutyric acid type A receptors does not confer sensitivity to low concentrations of ethanol. J Pharmacol Exp Ther (2005) 1.82
Neurosteroid modulation of GABAA receptors. Prog Neurobiol (2003) 1.80
Implications of microRNAs in the pathogenesis of diabetes. Arch Pharm Res (2013) 1.74
Early changes in KCC2 phosphorylation in response to neuronal stress result in functional downregulation. J Neurosci (2007) 1.72
The Concise Guide to PHARMACOLOGY 2013/14: nuclear hormone receptors. Br J Pharmacol (2013) 1.70
The 5-HT3 receptor--the relationship between structure and function. Neuropharmacology (2008) 1.70
IUPHAR-DB: updated database content and new features. Nucleic Acids Res (2012) 1.66
Neurosteroid modulation of synaptic and extrasynaptic GABA(A) receptors. Pharmacol Ther (2007) 1.56
Neurosteroids: endogenous allosteric modulators of GABA(A) receptors. Psychoneuroendocrinology (2009) 1.52
Microglia: actively surveying and shaping neuronal circuit structure and function. Trends Neurosci (2012) 1.49
Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo. Cancer Res (2004) 1.49
The expression of GABAA beta subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells. J Physiol (2007) 1.42
Common determinants of single channel conductance within the large cytoplasmic loop of 5-hydroxytryptamine type 3 and alpha4beta2 nicotinic acetylcholine receptors. J Biol Chem (2006) 1.39
Techniques: applications of the nerve-bouton preparation in neuropharmacology. Trends Pharmacol Sci (2003) 1.38
Cation-selective mutations in the M2 domain of the inhibitory glycine receptor channel reveal determinants of ion-charge selectivity. J Gen Physiol (2002) 1.30
Cocaine effects on mouse incentive-learning and human addiction are linked to alpha2 subunit-containing GABAA receptors. Proc Natl Acad Sci U S A (2010) 1.27
Distinct mechanisms regulate GABAA receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells. J Physiol (2011) 1.25
The in vitro and in vivo enantioselectivity of etomidate implicates the GABAA receptor in general anaesthesia. Neuropharmacology (2003) 1.22
Novel structural determinants of single channel conductance and ion selectivity in 5-hydroxytryptamine type 3 and nicotinic acetylcholine receptors. J Physiol (2009) 1.19
The contribution of proline 250 (P-2') to pore diameter and ion selectivity in the human glycine receptor channel. Neurosci Lett (2003) 1.18
Inhibition of thalamic excitability by 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-ol: a selective role for delta-GABA(A) receptors. Eur J Neurosci (2009) 1.18
Neurosteroid modulation of GABAA receptors: molecular determinants and significance in health and disease. Neurochem Int (2007) 1.16
Hyperekplexia associated with compound heterozygote mutations in the beta-subunit of the human inhibitory glycine receptor (GLRB). Hum Mol Genet (2002) 1.16
Molecular determinants of single-channel conductance and ion selectivity in the Cys-loop family: insights from the 5-HT3 receptor. Trends Pharmacol Sci (2005) 1.11
Developmental maturation of synaptic and extrasynaptic GABAA receptors in mouse thalamic ventrobasal neurones. J Physiol (2007) 1.10
Primary afferents with TRPM8 and TRPA1 profiles target distinct subpopulations of rat superficial dorsal horn neurones. Br J Pharmacol (2009) 1.09
Structural determinants of Ca2+ permeability and conduction in the human 5-hydroxytryptamine type 3A receptor. J Biol Chem (2008) 1.07
Assembly and cell surface expression of homomeric and heteromeric 5-HT3 receptors: the role of oligomerization and chaperone proteins. Mol Cell Neurosci (2002) 1.07
Role of charged residues in coupling ligand binding and channel activation in the extracellular domain of the glycine receptor. J Biol Chem (2003) 1.06
Dynamic modification of a mutant cytoplasmic cysteine residue modulates the conductance of the human 5-HT3A receptor. J Biol Chem (2007) 1.05
Microglia and synapse interactions: fine tuning neural circuits and candidate molecules. Front Cell Neurosci (2013) 1.04
Clustering of neuronal K+-Cl- cotransporters in lipid rafts by tyrosine phosphorylation. J Biol Chem (2009) 1.04
Neurosteroids and GABA(A) Receptor Interactions: A Focus on Stress. Front Neurosci (2011) 1.04
Gating mechanisms in Cys-loop receptors. Eur Biophys J (2009) 1.03
Mechanisms of channel gating of the ligand-gated ion channel superfamily inferred from protein structure. Exp Physiol (2004) 1.03
GABA-independent GABAA receptor openings maintain tonic currents. J Neurosci (2013) 1.00
Extrasynaptic GABA(A) receptors couple presynaptic activity to postsynaptic inhibition in the somatosensory thalamus. J Neurosci (2013) 1.00
Antidepressants and antipsychotic drugs colocalize with 5-HT3 receptors in raft-like domains. J Neurosci (2005) 1.00
Single channel analysis of conductance and rectification in cation-selective, mutant glycine receptor channels. J Gen Physiol (2002) 0.99
Phosphorylation influences neurosteroid modulation of synaptic GABAA receptors in rat CA1 and dentate gyrus neurones. Neuropharmacology (2003) 0.99
Dimensional reduction: a design tool for new radiation detection materials. Adv Mater (2011) 0.98
A model of the glycine receptor deduced from Brownian dynamics studies. Proc Natl Acad Sci U S A (2003) 0.97
Dysfunctional astrocytic and synaptic regulation of hypothalamic glutamatergic transmission in a mouse model of early-life adversity: relevance to neurosteroids and programming of the stress response. J Neurosci (2013) 0.96
GABA receptor-mediated effects in the peripheral nervous system: A cross-interaction with neuroactive steroids. J Mol Neurosci (2006) 0.95
Mutations in the Gabrb1 gene promote alcohol consumption through increased tonic inhibition. Nat Commun (2013) 0.94
Activation of presynaptic glycine receptors facilitates glycine release from presynaptic terminals synapsing onto rat spinal sacral dorsal commissural nucleus neurons. J Physiol (2003) 0.94
Functions of microglia in the central nervous system--beyond the immune response. Neuron Glia Biol (2012) 0.92
The Na(+)/H(+) exchanger is a major pH regulator in GABAergic presynaptic nerve terminals synapsing onto rat CA3 pyramidal neurons. J Neurochem (2006) 0.92
Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain. J Clin Invest (2016) 0.92
Rings of charge within the extracellular vestibule influence ion permeation of the 5-HT3A receptor. J Biol Chem (2011) 0.91
Charged residues at the 2' position of human GABAC rho 1 receptors invert ion selectivity and influence open state probability. J Biol Chem (2004) 0.91
Tonic inhibition of accumbal spiny neurons by extrasynaptic α4βδ GABAA receptors modulates the actions of psychostimulants. J Neurosci (2014) 0.91
Functional roles of presynaptic GABA(A) receptors on glycinergic nerve terminals in the rat spinal cord. J Physiol (2002) 0.91
The minimum M3-M4 loop length of neurotransmitter-activated pentameric receptors is critical for the structural integrity of cytoplasmic portals. J Biol Chem (2013) 0.88
Pore structure of the Cys-loop ligand-gated ion channels. Neurochem Res (2009) 0.88
GABAB receptor transduction mechanisms, and cross-talk between protein kinases A and C, in GABAergic terminals synapsing onto neurons of the rat nucleus basalis of Meynert. J Physiol (2003) 0.85
A transmembrane residue influences the interaction of propofol with the strychnine-sensitive glycine alpha1 and alpha1beta receptor. Anesth Analg (2008) 0.85
GABAB receptors in Schwann cells influence proliferation and myelin protein expression. Eur J Neurosci (2004) 0.84
Guide to receptors and channels, 1st edition (2005 revision). Br J Pharmacol (2005) 0.84
Alternative splicing of the TRPC3 ion channel calmodulin/IP3 receptor-binding domain in the hindbrain enhances cation flux. J Neurosci (2012) 0.84
A single P-loop glutamate point mutation to either lysine or arginine switches the cation-anion selectivity of the CNGA2 channel. J Gen Physiol (2006) 0.83