Published in Biochem J on January 01, 2009
Mitochondria: in sickness and in health. Cell (2012) 6.05
Physiological roles of mitochondrial reactive oxygen species. Mol Cell (2012) 5.05
TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature (2011) 4.16
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature (2014) 4.10
Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling. Immunity (2013) 4.08
Nox proteins in signal transduction. Free Radic Biol Med (2009) 3.47
Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem J (2012) 3.37
Chemistry and biology of reactive oxygen species in signaling or stress responses. Nat Chem Biol (2011) 3.36
Mitochondria in innate immune responses. Nat Rev Immunol (2011) 3.31
Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait. Nat Rev Genet (2010) 3.20
Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes. Trends Biochem Sci (2010) 3.17
Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo. Proc Natl Acad Sci U S A (2009) 2.95
The sites and topology of mitochondrial superoxide production. Exp Gerontol (2010) 2.91
DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell (2012) 2.81
Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity. Drug Metab Rev (2012) 2.76
Superoxide dismutases: role in redox signaling, vascular function, and diseases. Antioxid Redox Signal (2011) 2.66
The role of mitochondria in the pathogenesis of type 2 diabetes. Endocr Rev (2010) 2.59
Cellular metabolic stress: considering how cells respond to nutrient excess. Mol Cell (2010) 2.50
Unraveling the biological roles of reactive oxygen species. Cell Metab (2011) 2.45
Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences. EMBO J (2012) 2.36
Crystal structure of the entire respiratory complex I. Nature (2013) 2.34
Progressive multiple sclerosis: pathology and pathogenesis. Nat Rev Neurol (2012) 2.32
Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria. Biochem J (2014) 2.30
Taking a "good" look at free radicals in the aging process. Trends Cell Biol (2011) 2.21
The response to heat shock and oxidative stress in Saccharomyces cerevisiae. Genetics (2011) 2.16
Integration of cellular bioenergetics with mitochondrial quality control and autophagy. Biol Chem (2012) 2.08
GLP-1 Cleavage Product Reverses Persistent ROS Generation After Transient Hyperglycemia by Disrupting an ROS-Generating Feedback Loop. Diabetes (2015) 2.07
Upsides and downsides of reactive oxygen species for cancer: the roles of reactive oxygen species in tumorigenesis, prevention, and therapy. Antioxid Redox Signal (2012) 2.05
MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU. PLoS One (2010) 2.05
Oxidative stress and autophagy: the clash between damage and metabolic needs. Cell Death Differ (2014) 2.00
Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiol Rev (2014) 1.96
NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage. Ann Neurol (2014) 1.95
Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. Cell (2012) 1.91
Mitochondria-ros crosstalk in the control of cell death and aging. J Signal Transduct (2011) 1.89
Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix. Cell Metab (2011) 1.87
The role of oxidative stress in Parkinson's disease. J Parkinsons Dis (2013) 1.86
Regulation of reactive oxygen species generation in cell signaling. Mol Cells (2011) 1.85
NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury. Brain (2012) 1.82
A palette of fluorescent probes with varying emission colors for imaging hydrogen peroxide signaling in living cells. J Am Chem Soc (2010) 1.79
C. elegans epidermal wounding induces a mitochondrial ROS burst that promotes wound repair. Dev Cell (2014) 1.77
Mitochondrial complex II can generate reactive oxygen species at high rates in both the forward and reverse reactions. J Biol Chem (2012) 1.76
Cardiac metabolism in heart failure: implications beyond ATP production. Circ Res (2013) 1.72
Redox-optimized ROS balance: a unifying hypothesis. Biochim Biophys Acta (2010) 1.70
Mitochondrial DNA mutations in disease and aging. J Cell Biol (2011) 1.67
Signal transduction by mitochondrial oxidants. J Biol Chem (2011) 1.65
Boronate oxidation as a bioorthogonal reaction approach for studying the chemistry of hydrogen peroxide in living systems. Acc Chem Res (2011) 1.63
Mitochondrial proton and electron leaks. Essays Biochem (2010) 1.62
Redox signaling in cardiac myocytes. Free Radic Biol Med (2011) 1.62
Regulation of mitochondrial biogenesis. Essays Biochem (2010) 1.58
Elevated mitochondrial superoxide contributes to enhanced chemoreflex in heart failure rabbits. Am J Physiol Regul Integr Comp Physiol (2009) 1.58
Mitochondrial reactive oxygen species regulate hypoxic signaling. Curr Opin Cell Biol (2009) 1.58
Assessing the Mitochondrial Membrane Potential in Cells and In Vivo using Targeted Click Chemistry and Mass Spectrometry. Cell Metab (2015) 1.54
Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase. Nat Neurosci (2014) 1.53
Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver. J Lipid Res (2012) 1.53
Cytochrome c oxidase dysfunction in oxidative stress. Free Radic Biol Med (2012) 1.52
Electron transport chain-dependent and -independent mechanisms of mitochondrial H2O2 emission during long-chain fatty acid oxidation. J Biol Chem (2009) 1.52
Superoxide is produced by the reduced flavin in mitochondrial complex I: a single, unified mechanism that applies during both forward and reverse electron transfer. J Biol Chem (2011) 1.51
Ischemia/reperfusion injury and cardioprotective mechanisms: Role of mitochondria and reactive oxygen species. World J Cardiol (2011) 1.51
A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells. J Cell Sci (2011) 1.50
Reactive oxygen species and their role in plant defence and cell wall metabolism. Planta (2012) 1.47
Cellular metabolic and autophagic pathways: traffic control by redox signaling. Free Radic Biol Med (2013) 1.46
Current issues with acetaminophen hepatotoxicity--a clinically relevant model to test the efficacy of natural products. Life Sci (2011) 1.46
Pathway analysis reveals common pro-survival mechanisms of metyrapone and carbenoxolone after traumatic brain injury. PLoS One (2013) 1.44
Sites of reactive oxygen species generation by mitochondria oxidizing different substrates. Redox Biol (2013) 1.44
Iron and neurodegeneration in the multiple sclerosis brain. Ann Neurol (2013) 1.43
Neuroendocrine and metabolic components of dopamine agonist amelioration of metabolic syndrome in SHR rats. Diabetol Metab Syndr (2014) 1.43
The role of mitochondrial DNA mutations and free radicals in disease and ageing. J Intern Med (2013) 1.42
Mitochondrial respiratory chain dysfunction variably increases oxidant stress in Caenorhabditis elegans. Mitochondrion (2009) 1.41
Cause and prevention of demyelination in a model multiple sclerosis lesion. Ann Neurol (2016) 1.41
Mitochondrial gene polymorphisms alter hepatic cellular energy metabolism and aggravate diet-induced non-alcoholic steatohepatitis. Mol Metab (2016) 1.40
Mitochondria as signaling organelles. BMC Biol (2014) 1.40
Mitochondria in the regulation of innate and adaptive immunity. Immunity (2015) 1.40
Reactive oxygen species originating from mitochondria regulate the cardiac sodium channel. Circ Res (2010) 1.40
Current strategies to minimize hepatic ischemia-reperfusion injury by targeting reactive oxygen species. Transplant Rev (Orlando) (2012) 1.38
Blockade of cyclophilin D rescues dexamethasone-induced oxidative stress in gingival tissue. PLoS One (2017) 1.38
Mitochondrial Complex I Is a Global Regulator of Secondary Metabolism, Virulence and Azole Sensitivity in Fungi. PLoS One (2016) 1.38
ROS-dependent signal transduction. Curr Opin Cell Biol (2014) 1.37
Mitochondrial reactive oxygen species: a double edged sword in ischemia/reperfusion vs preconditioning. Redox Biol (2014) 1.37
An involvement of oxidative stress in endoplasmic reticulum stress and its associated diseases. Int J Mol Sci (2012) 1.37
Oxidative stress, redox signaling, and metal chelation in anthracycline cardiotoxicity and pharmacological cardioprotection. Antioxid Redox Signal (2012) 1.37
The muscle fiber type-fiber size paradox: hypertrophy or oxidative metabolism? Eur J Appl Physiol (2010) 1.36
The rate of oxygen utilization by cells. Free Radic Biol Med (2011) 1.36
The many roles of NOX2 NADPH oxidase-derived ROS in immunity. Semin Immunopathol (2010) 1.36
Oxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models? Free Radic Biol Med (2011) 1.35
Thioredoxin reductase-2 is essential for keeping low levels of H(2)O(2) emission from isolated heart mitochondria. J Biol Chem (2011) 1.35
Mouse mtDNA mutant model of Leber hereditary optic neuropathy. Proc Natl Acad Sci U S A (2012) 1.35
Redox regulation of mitochondrial function. Antioxid Redox Signal (2012) 1.34
OXPHOS mutations and neurodegeneration. EMBO J (2012) 1.33
Mitochondrial energy metabolism and redox signaling in brain aging and neurodegeneration. Antioxid Redox Signal (2012) 1.32
Respiration-dependent H2O2 removal in brain mitochondria via the thioredoxin/peroxiredoxin system. J Biol Chem (2010) 1.32
NADPH oxidase 2 mediates intermittent hypoxia-induced mitochondrial complex I inhibition: relevance to blood pressure changes in rats. Antioxid Redox Signal (2010) 1.30
Oxidative stress, tumor microenvironment, and metabolic reprogramming: a diabolic liaison. Int J Cell Biol (2012) 1.29
Mitochondrial c-Jun N-terminal kinase (JNK) signaling initiates physiological changes resulting in amplification of reactive oxygen species generation. J Biol Chem (2011) 1.29
The 2-oxoacid dehydrogenase complexes in mitochondria can produce superoxide/hydrogen peroxide at much higher rates than complex I. J Biol Chem (2014) 1.29
Redox regulation of mitochondrial function with emphasis on cysteine oxidation reactions. Redox Biol (2013) 1.28
Cysteine residues exposed on protein surfaces are the dominant intramitochondrial thiol and may protect against oxidative damage. FEBS J (2010) 1.28
Regulation of signal transduction by reactive oxygen species in the cardiovascular system. Circ Res (2015) 1.27
Mitochondria and endothelial function. Circ Res (2013) 1.27
A membrane-bound NAC transcription factor, ANAC017, mediates mitochondrial retrograde signaling in Arabidopsis. Plant Cell (2013) 1.26
Free radicals in the physiological control of cell function. Physiol Rev (2002) 19.62
Mitochondria, oxidants, and aging. Cell (2005) 16.11
Hydroperoxide metabolism in mammalian organs. Physiol Rev (1979) 14.13
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic Biol Med (2001) 11.92
Mitochondrial formation of reactive oxygen species. J Physiol (2003) 10.73
The free radical theory of aging matures. Physiol Rev (1998) 9.83
Thioredoxin. Annu Rev Biochem (1985) 9.82
Oxygen sensing by HIF hydroxylases. Nat Rev Mol Cell Biol (2004) 9.05
Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat Genet (1995) 7.17
The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem J (1973) 7.01
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci U S A (1998) 6.90
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab (2005) 6.85
Complete structure of the 11-subunit bovine mitochondrial cytochrome bc1 complex. Science (1998) 6.53
Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med (2000) 6.25
Peroxynitrite: biochemistry, pathophysiology and development of therapeutics. Nat Rev Drug Discov (2007) 5.65
Topology of superoxide production from different sites in the mitochondrial electron transport chain. J Biol Chem (2002) 5.31
The cellular production of hydrogen peroxide. Biochem J (1972) 5.25
High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria. FEBS Lett (1997) 5.21
Superoxide dismutase. Organelle specificity. J Biol Chem (1973) 4.67
Selective fluorescent imaging of superoxide in vivo using ethidium-based probes. Proc Natl Acad Sci U S A (2006) 4.64
Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria. Arch Biochem Biophys (1985) 4.59
Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus. Science (2006) 4.47
Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell (2005) 4.36
Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc Natl Acad Sci U S A (1996) 4.20
Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases. FEBS Lett (1994) 4.19
Targeting antioxidants to mitochondria by conjugation to lipophilic cations. Annu Rev Pharmacol Toxicol (2007) 4.16
Mitochondrial metabolism of reactive oxygen species. Biochemistry (Mosc) (2005) 3.92
Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha. Science (2003) 3.91
Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence. Proc Natl Acad Sci U S A (2005) 3.85
Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins. Free Radic Biol Med (2004) 3.85
Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins. Curr Opin Cell Biol (2005) 3.83
Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase. FEBS Lett (1994) 3.75
Activation of molecular oxygen by flavins and flavoproteins. J Biol Chem (1994) 3.73
Generation of reactive oxygen species by the mitochondrial electron transport chain. J Neurochem (2002) 3.61
Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia. Exp Physiol (2006) 3.61
Complex III releases superoxide to both sides of the inner mitochondrial membrane. J Biol Chem (2004) 3.59
Specific aquaporins facilitate the diffusion of hydrogen peroxide across membranes. J Biol Chem (2006) 3.54
The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production. J Cell Biol (2007) 3.47
Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria. Arch Biochem Biophys (1977) 3.40
Does nitric oxide modulate mitochondrial energy generation and apoptosis? Nat Rev Mol Cell Biol (2002) 3.38
Complex I is the major site of mitochondrial superoxide production by paraquat. J Biol Chem (2007) 3.31
Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state. Biochem J (2002) 3.13
Mitochondria, oxygen free radicals, disease and ageing. Trends Biochem Sci (2000) 3.04
Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol. J Biol Chem (2002) 2.94
Respiratory chain linked H(2)O(2) production in pigeon heart mitochondria. FEBS Lett (1971) 2.93
Peroxiredoxin, a novel family of peroxidases. IUBMB Life (2001) 2.91
Tissue oxygen tension and brain sensitivity to hypoxia. Respir Physiol (2001) 2.81
Membrane transport of hydrogen peroxide. Biochim Biophys Acta (2006) 2.81
The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria. Proc Natl Acad Sci U S A (2006) 2.78
Detection of 2-hydroxyethidium in cellular systems: a unique marker product of superoxide and hydroethidine. Nat Protoc (2008) 2.70
Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species. J Neurosci (2004) 2.57
Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells. Free Radic Biol Med (2003) 2.53
DeltaPsi(m)-Dependent and -independent production of reactive oxygen species by rat brain mitochondria. J Neurochem (2001) 2.53
Superoxide production by NADH:ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane. Biochem J (2004) 2.49
Regulation of brain mitochondrial H2O2 production by membrane potential and NAD(P)H redox state. J Neurochem (2003) 2.46
Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis. Mol Cell Biol (2007) 2.45
Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial NADH:ubiquinone oxidoreductase (complex I). J Biol Chem (2004) 2.42
Superoxide radicals as precursors of mitochondrial hydrogen peroxide. FEBS Lett (1974) 2.42
The effect of hyperoxia on superoxide production by lung submitochondrial particles. Arch Biochem Biophys (1982) 2.37
The nuclear encoded subunits of complex I from bovine heart mitochondria. Biochim Biophys Acta (2003) 2.37
Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants. Q Rev Biophys (1996) 2.29
Regulation of hypoxia-inducible factor-1alpha by nitric oxide through mitochondria-dependent and -independent pathways. Biochem J (2003) 2.27
Bioenergetics and the formation of mitochondrial reactive oxygen species. Trends Pharmacol Sci (2006) 2.22
Aconitase: sensitive target and measure of superoxide. Methods Enzymol (2002) 2.20
Characterization of superoxide-producing sites in isolated brain mitochondria. J Biol Chem (2003) 2.20
Dependence of H2O2 formation by rat heart mitochondria on substrate availability and donor age. J Bioenerg Biomembr (1997) 2.06
Determination of the production of superoxide radicals and hydrogen peroxide in mitochondria. Methods Enzymol (1984) 2.04
Respiratory complex I: mechanistic and structural insights provided by the crystal structure of the hydrophilic domain. Biochemistry (2007) 2.03
Nitric oxide and mitochondrial respiration. Biochim Biophys Acta (1999) 2.02
Mitochondrial NADPH, transhydrogenase and disease. Biochim Biophys Acta (2006) 2.01
Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase. FEBS Lett (1995) 2.01
Controlled elimination of intracellular H(2)O(2): regulation of peroxiredoxin, catalase, and glutathione peroxidase via post-translational modification. Antioxid Redox Signal (2005) 2.00
Generation of reactive oxygen species in the reaction catalyzed by alpha-ketoglutarate dehydrogenase. J Neurosci (2004) 1.97
Detection of catalase in rat heart mitochondria. J Biol Chem (1991) 1.90
Mitochondrial oxygen radical generation and leak: sites of production in states 4 and 3, organ specificity, and relation to aging and longevity. J Bioenerg Biomembr (1999) 1.87
The production of reactive oxygen species by complex I. Biochem Soc Trans (2008) 1.87
Superoxide and hydrogen peroxide production by Drosophila mitochondria. Free Radic Biol Med (2003) 1.87
Glutathionylation of mitochondrial proteins. Antioxid Redox Signal (2005) 1.79
NADH- and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NADH-ubiquinone reductase preparation. Biochem J (1979) 1.76
Control of mitochondrial beta-oxidation flux. Prog Lipid Res (2002) 1.74
O2-regulated gene expression: transcriptional control of cardiorespiratory physiology by HIF-1. J Appl Physiol (1985) (2004) 1.72
O2 solubility in aqueous media determined by a kinetic method. Anal Biochem (1985) 1.71
The interaction of energy and electron transfer reactions in mitochondria. I. General properties and nature of the products of succinate-linked reduction of pyridine nucleotide. J Biol Chem (1961) 1.69
Polarographic assay and intracellular distribution of superoxide dismutase in rat liver. Biochem J (1975) 1.67
The sites of superoxide anion generation in higher plant mitochondria. Arch Biochem Biophys (1978) 1.64
Generation of superoxide anion by succinate-cytochrome c reductase from bovine heart mitochondria. J Biol Chem (1998) 1.61
Generating, partitioning, targeting and functioning of superoxide in mitochondria. Biosci Rep (1997) 1.57
Nitric oxide partitioning into mitochondrial membranes and the control of respiration at cytochrome c oxidase. Proc Natl Acad Sci U S A (2001) 1.53
A metabolic enzyme that rapidly produces superoxide, fumarate reductase of Escherichia coli. J Biol Chem (1995) 1.53
Electron tunneling chains of mitochondria. Biochim Biophys Acta (2006) 1.49
How do enzymes activate oxygen without inactivating themselves? Acc Chem Res (2007) 1.45
Response of mitochondrial reactive oxygen species generation to steady-state oxygen tension: implications for hypoxic cell signaling. Am J Physiol Heart Circ Physiol (2006) 1.43
The three-dimensional structure of complex I from Yarrowia lipolytica: a highly dynamic enzyme. J Struct Biol (2006) 1.42
Partial resolution of the enzymes catalyzing oxidative phosphorylation. XV. Reverse electron transfer in the flavin-cytochrome beta region of the respiratory chain of beef heart submitochondrial particles. J Biol Chem (1967) 1.42
Antimycin-insensitive oxidation of succinate and reduced nicotinamide-adenine dinucleotide in electron-transport particles. I. pH dependency and hydrogen peroxide formation. Biochim Biophys Acta (1966) 1.41
Detection of reactive oxygen species-sensitive thiol proteins by redox difference gel electrophoresis: implications for mitochondrial redox signaling. J Biol Chem (2007) 1.38
A targeted antioxidant reveals the importance of mitochondrial reactive oxygen species in the hypoxic signaling of HIF-1alpha. FEBS Lett (2005) 1.36
Endogenous NO regulates superoxide production at low oxygen concentrations by modifying the redox state of cytochrome c oxidase. Proc Natl Acad Sci U S A (2004) 1.34
Cytochrome c-mediated oxidation of hydroethidine and mito-hydroethidine in mitochondria: identification of homo- and heterodimers. Free Radic Biol Med (2007) 1.34