Published in Curr Biol on December 09, 2008
The hippo signaling pathway in development and cancer. Dev Cell (2010) 10.54
Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell (2009) 7.39
Protein kinases of the Hippo pathway: regulation and substrates. Semin Cell Dev Biol (2012) 1.61
Mechanisms of Hippo pathway regulation. Genes Dev (2016) 1.45
Human NDR kinases control G(1)/S cell cycle transition by directly regulating p21 stability. Mol Cell Biol (2011) 1.23
Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development. Neuron (2012) 1.22
MOB control: reviewing a conserved family of kinase regulators. Cell Signal (2011) 1.21
Tumor suppressor ras association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis. J Biol Chem (2010) 1.20
ATM regulates a RASSF1A-dependent DNA damage response. Curr Biol (2009) 1.14
Regulation and functions of mammalian LATS/NDR kinases: looking beyond canonical Hippo signalling. Cell Biosci (2013) 1.09
The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2. J Biol Chem (2011) 1.09
Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases. Mol Cell Biol (2010) 1.04
MICALs in control of the cytoskeleton, exocytosis, and cell death. Cell Mol Life Sci (2011) 1.03
Hippo signalling in the G2/M cell cycle phase: lessons learned from the yeast MEN and SIN pathways. Semin Cell Dev Biol (2012) 1.00
MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis. Mol Cell Biol (2011) 0.99
Frequent epigenetic inactivation of KIBRA, an upstream member of the Salvador/Warts/Hippo (SWH) tumor suppressor network, is associated with specific genetic event in B-cell acute lymphocytic leukemia. Epigenetics (2011) 0.99
Mechanisms of epigenetic silencing of the Rassf1a gene during estrogen-induced breast carcinogenesis in ACI rats. Carcinogenesis (2009) 0.98
Mitotic exit control of the Saccharomyces cerevisiae Ndr/LATS kinase Cbk1 regulates daughter cell separation after cytokinesis. Mol Cell Biol (2010) 0.95
Mammalian Hippo signalling: a kinase network regulated by protein-protein interactions. Biochem Soc Trans (2012) 0.95
The mitosis-to-interphase transition is coordinated by cross talk between the SIN and MOR pathways in Schizosaccharomyces pombe. J Cell Biol (2010) 0.95
Cross-regulation between oncogenic BRAF(V600E) kinase and the MST1 pathway in papillary thyroid carcinoma. PLoS One (2011) 0.93
NDR functions as a physiological YAP1 kinase in the intestinal epithelium. Curr Biol (2015) 0.93
MICAL-family proteins: Complex regulators of the actin cytoskeleton. Antioxid Redox Signal (2013) 0.92
Regulation of proapoptotic mammalian ste20-like kinase MST2 by the IGF1-Akt pathway. PLoS One (2010) 0.91
Crosstalk between NDR kinase pathways coordinates cell cycle dependent actin rearrangements. Cell Div (2011) 0.90
Cullin-4A·DNA damage-binding protein 1 E3 ligase complex targets tumor suppressor RASSF1A for degradation during mitosis. J Biol Chem (2011) 0.89
STK38 is a critical upstream regulator of MYC's oncogenic activity in human B-cell lymphoma. Oncogene (2012) 0.89
Hydrophobic motif phosphorylation coordinates activity and polar localization of the Neurospora crassa nuclear Dbf2-related kinase COT1. Mol Cell Biol (2012) 0.89
Regulation of NDR1 activity by PLK1 ensures proper spindle orientation in mitosis. Sci Rep (2015) 0.88
Identification of a Novel Link between the Protein Kinase NDR1 and TGFβ Signaling in Epithelial Cells. PLoS One (2013) 0.86
Cyclin D1 promotes cell cycle progression through enhancing NDR1/2 kinase activity independent of cyclin-dependent kinase 4. J Biol Chem (2013) 0.86
Constitutively active NDR1-PIF kinase functions independent of MST1 and hMOB1 signalling. Cell Signal (2014) 0.86
Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling. EMBO J (2011) 0.85
Dynamic phosphorylation of HP1α regulates mitotic progression in human cells. Nat Commun (2014) 0.84
Regulation of DNA damage responses and cell cycle progression by hMOB2. Cell Signal (2014) 0.82
Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. PLoS One (2012) 0.82
Phosphorylation-dependent inhibition of Cdc42 GEF Gef1 by 14-3-3 protein Rad24 spatially regulates Cdc42 GTPase activity and oscillatory dynamics during cell morphogenesis. Mol Biol Cell (2015) 0.82
RASSF1A and the BH3-only mimetic ABT-737 promote apoptosis in pediatric medulloblastoma cell lines. Neuro Oncol (2011) 0.80
Proper actin ring formation and septum constriction requires coordinated regulation of SIN and MOR pathways through the germinal centre kinase MST-1. PLoS Genet (2014) 0.80
NDR Kinases Are Essential for Somitogenesis and Cardiac Looping during Mouse Embryonic Development. PLoS One (2015) 0.79
The cellular functions of RASSF1A and its inactivation in prostate cancer. J Carcinog (2012) 0.79
Interstitial 12p deletion involving more than 40 genes in a patient with postnatal microcephaly, psychomotor delay, optic nerve atrophy, and facial dysmorphism. Meta Gene (2014) 0.78
Generation of stable human cell lines with Tetracycline-inducible (Tet-on) shRNA or cDNA expression. J Vis Exp (2013) 0.78
Rassf5 and Ndr kinases regulate neuronal polarity through Par3 phosphorylation in a novel pathway. J Cell Sci (2014) 0.78
The Pro-apoptotic STK38 Kinase Is a New Beclin1 Partner Positively Regulating Autophagy. Curr Biol (2015) 0.77
The Roles of NDR Protein Kinases in Hippo Signalling. Genes (Basel) (2016) 0.77
hMOB3 modulates MST1 apoptotic signaling and supports tumor growth in glioblastoma multiforme. Cancer Res (2014) 0.77
NDR1 protein kinase promotes IL-17- and TNF-α-mediated inflammation by competitively binding TRAF3. EMBO Rep (2017) 0.75
The relationship between RASSF1A gene promoter methylation and the susceptibility and prognosis of melanoma: A meta-analysis and bioinformatics. PLoS One (2017) 0.75
Localization of Protein Kinase NDR2 to Peroxisomes and Its Role in Ciliogenesis. J Biol Chem (2017) 0.75
Structural basis for autoinhibition and its relief of MOB1 in the Hippo pathway. Sci Rep (2016) 0.75
Disease implication of hyper-Hippo signalling. Open Biol (2016) 0.75
The MST/Hippo Pathway and Cell Death: A Non-Canonical Affair. Genes (Basel) (2016) 0.75
Mitochondrial clearance by the STK38 kinase supports oncogenic Ras-induced cell transformation. Oncotarget (2016) 0.75
Stk38 Modulates Rbm24 Protein Stability to Regulate Sarcomere Assembly in Cardiomyocytes. Sci Rep (2017) 0.75
Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control. Nat Commun (2017) 0.75
Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem Sci (2004) 4.40
Structure, regulation and function of PKB/AKT--a major therapeutic target. Biochim Biophys Acta (2004) 4.11
Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase. J Biol Chem (2004) 4.01
Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP. Nat Struct Biol (2002) 3.77
Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation. Mol Cell (2002) 3.53
PKB binding proteins. Getting in on the Akt. Cell (2002) 3.34
PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival. Mol Cell (2008) 3.27
Protein kinase B alpha/Akt1 regulates placental development and fetal growth. J Biol Chem (2003) 3.27
Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis. Development (2005) 3.02
NDR kinases regulate essential cell processes from yeast to humans. Nat Rev Mol Cell Biol (2006) 2.88
PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury. J Clin Invest (2005) 2.36
Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo. PLoS Biol (2007) 2.28
Protein kinase B/Akt at a glance. J Cell Sci (2005) 2.18
Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB. Science (2002) 2.05
Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies. Mol Cell Biol (2006) 2.03
Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding. Mol Cell Biol (2006) 2.01
PIKKing on PKB: regulation of PKB activity by phosphorylation. Curr Opin Cell Biol (2009) 2.00
Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation. J Biol Chem (2004) 1.95
Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction. Am J Pathol (2008) 1.94
Protein kinase B (PKB/Akt), a key mediator of the PI3K signaling pathway. Curr Top Microbiol Immunol (2010) 1.85
Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice. Mol Cell Biol (2005) 1.75
PKB and the mitochondria: AKTing on apoptosis. Cell Signal (2007) 1.67
VHL loss causes spindle misorientation and chromosome instability. Nat Cell Biol (2009) 1.65
NDR family of AGC kinases--essential regulators of the cell cycle and morphogenesis. FEBS Lett (2003) 1.65
Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein. J Biol Chem (2004) 1.63
Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3. Mol Cell Biol (2005) 1.63
Inhibition of protein kinase B/Akt. implications for cancer therapy. Pharmacol Ther (2002) 1.61
The human tumour suppressor LATS1 is activated by human MOB1 at the membrane. Biochem Biophys Res Commun (2006) 1.58
Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1. Curr Biol (2002) 1.56
The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B. EMBO J (2004) 1.55
Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve development. Am J Pathol (2010) 1.51
AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer. Sci Signal (2011) 1.49
The MST1 and hMOB1 tumor suppressors control human centrosome duplication by regulating NDR kinase phosphorylation. Curr Biol (2009) 1.43
Human NDR kinases are rapidly activated by MOB proteins through recruitment to the plasma membrane and phosphorylation. Mol Cell Biol (2005) 1.43
PKB/Akt-dependent regulation of cell motility. J Natl Cancer Inst (2013) 1.41
Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2. Mol Cell (2006) 1.37
Centrosome-associated NDR kinase regulates centrosome duplication. Mol Cell (2007) 1.37
The endogenous inhibitor of Akt, CTMP, is critical to ischemia-induced neuronal death. Nat Neurosci (2009) 1.33
GSK3beta regulates differentiation and growth arrest in glioblastoma. PLoS One (2009) 1.32
Mechanism of Ca2+-mediated regulation of NDR protein kinase through autophosphorylation and phosphorylation by an upstream kinase. J Biol Chem (2002) 1.30
Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types. J Biol Chem (2005) 1.28
PKBalpha is required for adipose differentiation of mouse embryonic fibroblasts. J Cell Sci (2006) 1.24
Pyk2- and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions. Mol Cell Biol (2003) 1.23
Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling. Biofactors (2009) 1.23
Human NDR kinases control G(1)/S cell cycle transition by directly regulating p21 stability. Mol Cell Biol (2011) 1.23
Akt/PKB-mediated phosphorylation of Twist1 promotes tumor metastasis via mediating cross-talk between PI3K/Akt and TGF-β signaling axes. Cancer Discov (2012) 1.22
Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2. Nat Commun (2013) 1.21
Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase. J Biol Chem (2002) 1.20
Translation regulation as a therapeutic target in cancer. Cancer Res (2012) 1.14
Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein. J Biol Chem (2004) 1.13
MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas. J Clin Invest (2014) 1.13
Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle development. Mol Cell Biol (2005) 1.12
PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis. Expert Rev Mol Med (2012) 1.11
Mammalian NDR protein kinases: from regulation to a role in centrosome duplication. Biochim Biophys Acta (2007) 1.11
MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-β signaling pathway in human glioblastoma. Cancer Res (2011) 1.09
Downstream of human NDR kinases: impacting on c-myc and p21 protein stability to control cell cycle progression. Cell Cycle (2011) 1.09
Anchoring of FLT3 in the endoplasmic reticulum alters signaling quality. Blood (2009) 1.08
Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that sensitizes cells to apoptosis. Cell Signal (2009) 1.08
Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding. J Biol Chem (2007) 1.08
Association of LETM1 and MRPL36 contributes to the regulation of mitochondrial ATP production and necrotic cell death. Cancer Res (2009) 1.05
Bone vascularization and trabecular bone formation are mediated by PKB alpha/Akt1 in a gene-dosage-dependent manner: in vivo and ex vivo MRI. Magn Reson Med (2010) 1.05
Deletion of PKBalpha/Akt1 affects thymic development. PLoS One (2007) 1.04
Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases. Mol Cell Biol (2010) 1.04
cAMP synthesis and degradation by phagosomes regulate actin assembly and fusion events: consequences for mycobacteria. J Cell Sci (2006) 1.04
In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis. J Biol Chem (2008) 1.04
Acentrosomal spindle organization renders cancer cells dependent on the kinesin HSET. J Cell Sci (2012) 1.03
Constitutively active protein kinase B enhances Lck and Erk activities and influences thymocyte selection and activation. J Immunol (2003) 1.03
Regulation of renal epithelial tight junctions by the von Hippel-Lindau tumor suppressor gene involves occludin and claudin 1 and is independent of E-cadherin. Mol Biol Cell (2008) 1.03
Differential effects of protein kinase B/Akt isoforms on glucose homeostasis and islet mass. Mol Cell Biol (2009) 1.02
Promiscuous affairs of PKB/AKT isoforms in metabolism. Arch Physiol Biochem (2011) 1.00
Negative regulation of ERK and Elk by protein kinase B modulates c-Fos transcription. J Biol Chem (2002) 1.00
Hippo signalling in the G2/M cell cycle phase: lessons learned from the yeast MEN and SIN pathways. Semin Cell Dev Biol (2012) 1.00
MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis. Mol Cell Biol (2011) 0.99
PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage. Cell Signal (2012) 0.98
Regulation of OPA1-mediated mitochondrial fusion by leucine zipper/EF-hand-containing transmembrane protein-1 plays a role in apoptosis. Cell Signal (2009) 0.98
Acyl coenzyme A thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development. Mol Cell Biol (2012) 0.97
Ablation of the kinase NDR1 predisposes mice to the development of T cell lymphoma. Sci Signal (2010) 0.97
Deregulated signalling networks in human brain tumours. Biochim Biophys Acta (2009) 0.96
Diversity, developmental regulation and distribution of murine PR55/B subunits of protein phosphatase 2A. Eur J Neurosci (2002) 0.96
S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt. Biochem J (2012) 0.96
Pregnancy occurring during or following adjuvant trastuzumab in patients enrolled in the HERA trial (BIG 01-01). Breast Cancer Res Treat (2012) 0.95
Deletion of Akt1 causes heart defects and abnormal cardiomyocyte proliferation. Dev Biol (2010) 0.94
Identification of CLEC12B, an inhibitory receptor on myeloid cells. J Biol Chem (2007) 0.93
Expression profiling of insulin action in human myotubes: induction of inflammatory and pro-angiogenic pathways in relationship with glycogen synthesis and type 2 diabetes. Biochem Biophys Res Commun (2004) 0.93
The PI3K-PKB/Akt pathway. Cold Spring Harb Perspect Biol (2015) 0.92
Deltex-1 activates mitotic signaling and proliferation and increases the clonogenic and invasive potential of U373 and LN18 glioblastoma cells and correlates with patient survival. PLoS One (2013) 0.90