Published in Mol Cell on February 23, 2007
Protein kinases of the Hippo pathway: regulation and substrates. Semin Cell Dev Biol (2012) 1.61
When 2+2=5: the origins and fates of aneuploid and tetraploid cells. Biochim Biophys Acta (2008) 1.42
Breaking the ties that bind: new advances in centrosome biology. J Cell Biol (2012) 1.41
Human NDR kinases control G(1)/S cell cycle transition by directly regulating p21 stability. Mol Cell Biol (2011) 1.23
SADB phosphorylation of gamma-tubulin regulates centrosome duplication. Nat Cell Biol (2009) 1.18
PLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle. EMBO J (2010) 1.11
Regulation and functions of mammalian LATS/NDR kinases: looking beyond canonical Hippo signalling. Cell Biosci (2013) 1.09
Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases. Mol Cell Biol (2010) 1.04
Human papillomavirus type 16 E7 oncoprotein associates with the centrosomal component gamma-tubulin. J Virol (2007) 1.04
Regulation of cell shape, wing hair initiation and the actin cytoskeleton by Trc/Fry and Wts/Mats complexes. Dev Biol (2010) 1.00
Hippo signalling in the G2/M cell cycle phase: lessons learned from the yeast MEN and SIN pathways. Semin Cell Dev Biol (2012) 1.00
Cdc15 integrates Tem1 GTPase-mediated spatial signals with Polo kinase-mediated temporal cues to activate mitotic exit. Genes Dev (2011) 0.98
Nuclear DBF-2-related kinases are essential regulators of cytokinesis in bloodstream stage Trypanosoma brucei. J Biol Chem (2010) 0.94
NDR functions as a physiological YAP1 kinase in the intestinal epithelium. Curr Biol (2015) 0.93
A screen for round egg mutants in Drosophila identifies tricornered, furry, and misshapen as regulators of egg chamber elongation. G3 (Bethesda) (2012) 0.91
STK38 is a critical upstream regulator of MYC's oncogenic activity in human B-cell lymphoma. Oncogene (2012) 0.89
Constitutively active NDR1-PIF kinase functions independent of MST1 and hMOB1 signalling. Cell Signal (2014) 0.86
Cyclin D1 promotes cell cycle progression through enhancing NDR1/2 kinase activity independent of cyclin-dependent kinase 4. J Biol Chem (2013) 0.86
Dynamic phosphorylation of HP1α regulates mitotic progression in human cells. Nat Commun (2014) 0.84
Regulation of DNA damage responses and cell cycle progression by hMOB2. Cell Signal (2014) 0.82
The Drosophila Fry protein interacts with Trc and is highly mobile in vivo. BMC Dev Biol (2010) 0.82
Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. PLoS One (2012) 0.82
The Carboxy-Terminal Modulator Protein (CTMP) regulates mitochondrial dynamics. PLoS One (2009) 0.81
NDR Kinases Are Essential for Somitogenesis and Cardiac Looping during Mouse Embryonic Development. PLoS One (2015) 0.79
Regulation of a LATS-homolog by Ras GTPases is important for the control of cell division. BMC Cell Biol (2014) 0.79
Rassf5 and Ndr kinases regulate neuronal polarity through Par3 phosphorylation in a novel pathway. J Cell Sci (2014) 0.78
Generation of stable human cell lines with Tetracycline-inducible (Tet-on) shRNA or cDNA expression. J Vis Exp (2013) 0.78
The Pro-apoptotic STK38 Kinase Is a New Beclin1 Partner Positively Regulating Autophagy. Curr Biol (2015) 0.77
Phosphorylation-dephosphorylation cycle of HP1α governs accurate mitotic progression. Cell Cycle (2014) 0.77
The Roles of NDR Protein Kinases in Hippo Signalling. Genes (Basel) (2016) 0.77
The interplay between centrosomes and the Hippo tumor suppressor pathway. Chromosome Res (2016) 0.76
Binding of Kif23-iso1/CHO1 to 14-3-3 is regulated by sequential phosphorylations at two LATS kinase consensus sites. PLoS One (2015) 0.76
The Hippo Pathway Targets Rae1 to Regulate Mitosis and Organ Size and to Feed Back to Regulate Upstream Components Merlin, Hippo, and Warts. PLoS Genet (2016) 0.75
Stk38 Modulates Rbm24 Protein Stability to Regulate Sarcomere Assembly in Cardiomyocytes. Sci Rep (2017) 0.75
NDR1 protein kinase promotes IL-17- and TNF-α-mediated inflammation by competitively binding TRAF3. EMBO Rep (2017) 0.75
HEY1 functions are regulated by its phosphorylation at Ser-68. Biosci Rep (2016) 0.75
The ubiquitin ligase Cullin5(SOCS2) regulates NDR1/STK38 stability and NF-κB transactivation. Sci Rep (2017) 0.75
Localization of Protein Kinase NDR2 to Peroxisomes and Its Role in Ciliogenesis. J Biol Chem (2017) 0.75
Lats1 suppresses centrosome overduplication by modulating the stability of Cdc25B. Sci Rep (2015) 0.75
Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control. Nat Commun (2017) 0.75
Proteomic characterization of the human centrosome by protein correlation profiling. Nature (2003) 8.74
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal (2010) 8.61
Polo-like kinases and the orchestration of cell division. Nat Rev Mol Cell Biol (2004) 7.22
The Polo kinase Plk4 functions in centriole duplication. Nat Cell Biol (2005) 5.84
Plk4-induced centriole biogenesis in human cells. Dev Cell (2007) 5.68
The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4. Nat Genet (2006) 5.36
Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2. Science (2002) 4.94
Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells. EMBO J (2002) 4.54
Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem Sci (2004) 4.40
Active cyclin B1-Cdk1 first appears on centrosomes in prophase. Nat Cell Biol (2003) 4.31
Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis. Mol Biol Cell (2003) 4.28
Structure, regulation and function of PKB/AKT--a major therapeutic target. Biochim Biophys Acta (2004) 4.11
Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase. J Biol Chem (2004) 4.01
Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together. Cell (2007) 3.98
Cep164, a novel centriole appendage protein required for primary cilium formation. J Cell Biol (2007) 3.88
PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint. Cell (2007) 3.80
Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP. Nat Struct Biol (2002) 3.77
Human TPX2 is required for targeting Aurora-A kinase to the spindle. J Cell Biol (2002) 3.69
The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase. Mol Cell (2002) 3.65
The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. Oncogene (2005) 3.64
Phosphoproteome analysis of the human mitotic spindle. Proc Natl Acad Sci U S A (2006) 3.56
Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation. Mol Cell (2002) 3.53
Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. J Cell Biol (2004) 3.49
PKB binding proteins. Getting in on the Akt. Cell (2002) 3.34
PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival. Mol Cell (2008) 3.27
Protein kinase B alpha/Akt1 regulates placental development and fetal growth. J Biol Chem (2003) 3.27
Cell cycle regulation of central spindle assembly. Nature (2004) 3.27
HURP is a Ran-importin beta-regulated protein that stabilizes kinetochore microtubules in the vicinity of chromosomes. Curr Biol (2006) 3.21
Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis. J Cell Biol (2003) 3.12
Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis. Development (2005) 3.02
Aurora kinases link chromosome segregation and cell division to cancer susceptibility. Curr Opin Genet Dev (2004) 2.96
Tension-sensitive Plk1 phosphorylation on BubR1 regulates the stability of kinetochore microtubule interactions. Genes Dev (2007) 2.92
NDR kinases regulate essential cell processes from yeast to humans. Nat Rev Mol Cell Biol (2006) 2.88
Control of centriole length by CPAP and CP110. Curr Biol (2009) 2.67
Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase. Nat Cell Biol (2004) 2.63
Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1. Nat Cell Biol (2007) 2.54
Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2. J Cell Biol (2004) 2.44
Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication. EMBO J (2002) 2.41
Complex formation of Plk1 and INCENP required for metaphase-anaphase transition. Nat Cell Biol (2005) 2.41
Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. Dev Cell (2005) 2.40
Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway. EMBO Rep (2002) 2.40
Rootletin forms centriole-associated filaments and functions in centrosome cohesion. J Cell Biol (2005) 2.38
Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis. Mol Biol Cell (2007) 2.38
PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury. J Clin Invest (2005) 2.36
The crystal structure of the human polo-like kinase-1 polo box domain and its phospho-peptide complex. EMBO J (2003) 2.31
Proteome analysis of the human mitotic spindle. Mol Cell Proteomics (2004) 2.31
Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo. PLoS Biol (2007) 2.28
Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation. Genes Cells (2002) 2.28
Calcium triggers exit from meiosis II by targeting the APC/C inhibitor XErp1 for degradation. Nature (2005) 2.26
Molecular basis of tubulin transport within the cilium by IFT74 and IFT81. Science (2013) 2.25
3D-structured illumination microscopy provides novel insight into architecture of human centrosomes. Biol Open (2012) 2.23
Protein kinase B/Akt at a glance. J Cell Sci (2005) 2.18
Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation. Dev Cell (2003) 2.18
The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles. Mol Biol Cell (2004) 2.17
Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2. EMBO J (2006) 2.14
Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J (2011) 2.14
Different Plk1 functions show distinct dependencies on Polo-Box domain-mediated targeting. Mol Biol Cell (2005) 2.09
KIF14 and citron kinase act together to promote efficient cytokinesis. J Cell Biol (2006) 2.06
Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB. Science (2002) 2.05
Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies. Mol Cell Biol (2006) 2.03
Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding. Mol Cell Biol (2006) 2.01
PIKKing on PKB: regulation of PKB activity by phosphorylation. Curr Opin Cell Biol (2009) 2.00
Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation. J Biol Chem (2004) 1.95
Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction. Am J Pathol (2008) 1.94
Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP. Mol Biol Cell (2006) 1.94
The Plk1-dependent phosphoproteome of the early mitotic spindle. Mol Cell Proteomics (2010) 1.91
Protein kinase B (PKB/Akt), a key mediator of the PI3K signaling pathway. Curr Top Microbiol Immunol (2010) 1.85
Persistence of DNA threads in human anaphase cells suggests late completion of sister chromatid decatenation. Chromosoma (2007) 1.78
Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion. J Cell Sci (2007) 1.78
Stable kinetochore-microtubule interactions depend on the Ska complex and its new component Ska3/C13Orf3. EMBO J (2009) 1.76
NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis. Curr Biol (2008) 1.75
Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice. Mol Cell Biol (2005) 1.75
Plk4 trans-autophosphorylation regulates centriole number by controlling betaTrCP-mediated degradation. J Cell Sci (2010) 1.74
The mechanism regulating the dissociation of the centrosomal protein C-Nap1 from mitotic spindle poles. J Cell Sci (2002) 1.73
PKB and the mitochondria: AKTing on apoptosis. Cell Signal (2007) 1.67
Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint. EMBO J (2003) 1.67
NDR family of AGC kinases--essential regulators of the cell cycle and morphogenesis. FEBS Lett (2003) 1.65
Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly. J Cell Biol (2009) 1.64
Cell cycle-regulated phosphorylation of the Xenopus polo-like kinase Plx1. J Biol Chem (2002) 1.63
Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein. J Biol Chem (2004) 1.63
Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3. Mol Cell Biol (2005) 1.63
Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling. Sci Signal (2011) 1.62
Influence of human Ect2 depletion and overexpression on cleavage furrow formation and abscission. J Cell Sci (2006) 1.62
Inhibition of protein kinase B/Akt. implications for cancer therapy. Pharmacol Ther (2002) 1.61
Cell-cycle-regulated expression of STIL controls centriole number in human cells. J Cell Sci (2012) 1.60
The transforming parasite Theileria co-opts host cell mitotic and central spindles to persist in continuously dividing cells. PLoS Biol (2010) 1.60
Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora. Chromosoma (2008) 1.60
Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity. J Cell Biol (2007) 1.59
Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells. Cell Motil Cytoskeleton (2004) 1.59
The human tumour suppressor LATS1 is activated by human MOB1 at the membrane. Biochem Biophys Res Commun (2006) 1.58
Xenopus polo-like kinase Plx1 regulates XErp1, a novel inhibitor of APC/C activity. Genes Dev (2005) 1.57
Identification of a plasma membrane Raft-associated PKB Ser473 kinase activity that is distinct from ILK and PDK1. Curr Biol (2002) 1.56
Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication. J Cell Sci (2013) 1.55
The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B. EMBO J (2004) 1.55
Quantitative analysis of the human spindle phosphoproteome at distinct mitotic stages. J Proteome Res (2009) 1.53
Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve development. Am J Pathol (2010) 1.51