Published in Ann N Y Acad Sci on November 01, 2008
PACAP: a master regulator of neuroendocrine stress circuits and the cellular stress response. Ann N Y Acad Sci (2011) 1.20
Pituitary adenylate cyclase-activating polypeptide controls stimulus-transcription coupling in the hypothalamic-pituitary-adrenal axis to mediate sustained hormone secretion during stress. J Neuroendocrinol (2011) 0.96
VIP, CRF, and PACAP act at distinct receptors to elicit different cAMP/PKA dynamics in the neocortex. Cereb Cortex (2010) 0.89
Neuropeptides, growth factors, and cytokines: a cohort of informational molecules whose expression is up-regulated by the stress-associated slow transmitter PACAP in chromaffin cells. Cell Mol Neurobiol (2010) 0.85
PAC1hop, null and hip receptors mediate differential signaling through cyclic AMP and calcium leading to splice variant-specific gene induction in neural cells. Peptides (2011) 0.82
RANTES release contributes to the protective action of PACAP38 against sodium nitroprusside in cortical neurons. Neuropeptides (2009) 0.81
Regulating the ubiquitin/proteasome pathway via cAMP-signaling: neuroprotective potential. Cell Biochem Biophys (2013) 0.81
The octadecaneuropeptide ODN protects astrocytes against hydrogen peroxide-induced apoptosis via a PKA/MAPK-dependent mechanism. PLoS One (2012) 0.80
Pituitary adenylate cyclase activating polypeptide modulates catecholamine storage and exocytosis in PC12 cells. PLoS One (2014) 0.77
PACAP Protects the Adolescent and Adult Mice Brain from Ethanol Toxicity and Modulates Distinct Sets of Genes Regulating Similar Networks. Mol Neurobiol (2016) 0.75
Systematic determination of genetic network architecture. Nat Genet (1999) 25.45
Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions. Cell (2004) 6.08
How does gene expression clustering work? Nat Biotechnol (2005) 3.61
The use and analysis of microarray data. Nat Rev Drug Discov (2002) 3.08
Selective deficits in the circadian light response in mice lacking PACAP. Am J Physiol Regul Integr Comp Physiol (2004) 2.01
Temperature-sensitive phenotype in mice lacking pituitary adenylate cyclase-activating polypeptide. Endocrinology (2002) 1.66
Pituitary adenylate cyclase-activating polypeptide is a sympathoadrenal neurotransmitter involved in catecholamine regulation and glucohomeostasis. Proc Natl Acad Sci U S A (2001) 1.63
A comprehensive evaluation of SAM, the SAM R-package and a simple modification to improve its performance. BMC Bioinformatics (2007) 1.55
Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP). Proc Natl Acad Sci U S A (2001) 1.48
Neuropeptides: opportunities for drug discovery. Lancet Neurol (2003) 1.41
Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6. Proc Natl Acad Sci U S A (2006) 1.39
Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia. Mol Psychiatry (2007) 1.38
Impairment of mossy fiber long-term potentiation and associative learning in pituitary adenylate cyclase activating polypeptide type I receptor-deficient mice. J Neurosci (2001) 1.33
Roles of the stress-induced gene IEX-1 in regulation of cell death and oncogenesis. Apoptosis (2003) 1.32
The 38-amino acid form of pituitary adenylate cyclase-activating polypeptide stimulates dual signaling cascades in PC12 cells and promotes neurite outgrowth. J Biol Chem (1992) 1.26
A cAMP-dependent, protein kinase A-independent signaling pathway mediating neuritogenesis through Egr1 in PC12 cells. Mol Pharmacol (2008) 1.24
Inhibition of B56-containing protein phosphatase 2As by the early response gene IEX-1 leads to control of Akt activity. J Biol Chem (2007) 1.22
The neurofibromatosis 1 gene product neurofibromin regulates pituitary adenylate cyclase-activating polypeptide-mediated signaling in astrocytes. J Neurosci (2003) 1.21
Stanniocalcin: A molecular guard of neurons during cerebral ischemia. Proc Natl Acad Sci U S A (2000) 1.18
Modulation of NMDA receptors by pituitary adenylate cyclase activating peptide in CA1 neurons requires G alpha q, protein kinase C, and activation of Src. J Neurosci (2005) 1.18
The neurotrophic effects of PACAP in PC12 cells: control by multiple transduction pathways. J Neurochem (2006) 1.14
Hypoxic preconditioning induces neuroprotective stanniocalcin-1 in brain via IL-6 signaling. Stroke (2007) 1.13
Neuroprotection by endogenous and exogenous PACAP following stroke. Regul Pept (2006) 1.12
Genomic profiling of the neuronal target genes of the plasticity-related transcription factor -- Zif268. J Neurochem (2005) 1.10
Analysis of the PC12 cell transcriptome after differentiation with pituitary adenylate cyclase-activating polypeptide (PACAP). J Neurochem (2002) 1.09
Glucocorticoid- and nerve growth factor-induced changes in chromogranin A expression define two different neuronal phenotypes in PC12 cells. Mol Endocrinol (1988) 1.08
Distinct domains for anti- and pro-apoptotic activities of IEX-1. J Biol Chem (2006) 1.08
A novel DISC1-interacting partner DISC1-Binding Zinc-finger protein: implication in the modulation of DISC1-dependent neurite outgrowth. Mol Psychiatry (2007) 1.06
Impaired nerve regeneration and enhanced neuroinflammatory response in mice lacking pituitary adenylyl cyclase activating peptide. Neuroscience (2007) 1.06
Delayed systemic administration of PACAP38 is neuroprotective in transient middle cerebral artery occlusion in the rat. Stroke (2000) 1.01
Selenoprotein T is a PACAP-regulated gene involved in intracellular Ca2+ mobilization and neuroendocrine secretion. FASEB J (2008) 1.01
Coincident elevation of cAMP and calcium influx by PACAP-27 synergistically regulates vasoactive intestinal polypeptide gene transcription through a novel PKA-independent signaling pathway. J Neurosci (2002) 1.01
PACAP and NGF regulate common and distinct traits of the sympathoadrenal lineage: effects on electrical properties, gene markers and transcription factors in differentiating PC12 cells. Eur J Neurosci (2003) 1.01
Disruption of the PACAP gene promotes medulloblastoma in ptc1 mutant mice. Dev Biol (2007) 1.00
Gene expression changes after focal stroke, traumatic brain and spinal cord injuries. Curr Opin Neurol (2003) 0.96
Pituitary adenylate cyclase-activating polypeptide protects rat cerebellar granule neurons against ethanol-induced apoptotic cell death. Proc Natl Acad Sci U S A (2002) 0.96
Peptidergic activation of transcription and secretion in chromaffin cells. Cis and trans signaling determinants of pituitary adenylyl cyclase-activating polypeptide (PACAP). J Clin Invest (1998) 0.96
The hop cassette of the PAC1 receptor confers coupling to Ca2+ elevation required for pituitary adenylate cyclase-activating polypeptide-evoked neurosecretion. J Biol Chem (2007) 0.95
Hypoxic preconditioning induces elevated expression of stanniocalcin-1 in the heart. Am J Physiol Heart Circ Physiol (2007) 0.94
PACAP activates calcium influx-dependent and -independent pathways to couple met-enkephalin secretion and biosynthesis in chromaffin cells. J Mol Neurosci (1998) 0.92
Cycloheximide treatment to identify components of the transitional transcriptome in PACAP-induced PC12 cell differentiation. J Neurochem (2006) 0.92
Microarray and suppression subtractive hybridization analyses of gene expression in pheochromocytoma cells reveal pleiotropic effects of pituitary adenylate cyclase-activating polypeptide on cell proliferation, survival, and adhesion. Endocrinology (2003) 0.92
Hedgehog signaling: new targets for GPCRs coupled to cAMP and protein kinase A. Ann N Y Acad Sci (2006) 0.91
Impaired long-term potentiation in vivo in the dentate gyrus of pituitary adenylate cyclase-activating polypeptide (PACAP) or PACAP type 1 receptor-mutant mice. Neuroreport (2003) 0.90
Transsynaptic regulation of galanin, neurotensin, and substance P in the adrenal medulla: combinatorial control by second-messenger signaling pathways. J Neurochem (1992) 0.90
Endogenous PACAP acts as a stress response peptide to protect cerebellar neurons from ethanol or oxidative insult. Peptides (2005) 0.88
PRG1: a novel early-response gene transcriptionally induced by pituitary adenylate cyclase activating polypeptide in a pancreatic carcinoma cell line. Cancer Res (1996) 0.87
The MAPK pathway is required for depolarization-induced "promiscuous" immediate-early gene expression but not for depolarization-restricted immediate-early gene expression in neurons. J Neurosci Res (2008) 0.86
Stanniocalcin 1 prevents cytosolic Ca2+ overload and cell hypercontracture in cardiomyocytes. Circ J (2007) 0.85
Pituitary adenylate-cyclase activating polypeptide (PACAP) evokes long-lasting secretion and de novo biosynthesis of bovine adrenal medullary neuropeptides. Neuropeptides (1996) 0.85
Vasoactive intestinal peptide and PACAP38 control N-methyl-D-aspartic acid-induced dendrite motility by modifying the activities of Rho GTPases and phosphatidylinositol 3-kinases. J Biol Chem (2006) 0.85
Pituitary adenylate cyclase-activating polypeptide regulation of vasoactive intestinal polypeptide transcription requires Ca2+ influx and activation of the serine/threonine phosphatase calcineurin. J Neurochem (1999) 0.85
Molecular mechanism of schizophrenia with reference to disrupted-in-schizophrenia 1 (DISC1). Neurochem Int (2007) 0.81
Meta-analysis of microarray-derived data from PACAP-deficient adrenal gland in vivo and PACAP-treated chromaffin cells identifies distinct classes of PACAP-regulated genes. Peptides (2007) 0.80
The effect of pituitary adenylate cyclase activating polypeptide on cultured rat cardiocytes as a cardioprotective factor. Regul Pept (2002) 0.80
Expression of depolarization-induced immediate early gene proteins in PC12 cells. J Neurosci Res (2003) 0.79
Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: IUPHAR review 1. Br J Pharmacol (2012) 1.64
Molecular pharmacology, regulation and function of mammalian melatonin receptors. Front Biosci (2003) 1.32
A cAMP-dependent, protein kinase A-independent signaling pathway mediating neuritogenesis through Egr1 in PC12 cells. Mol Pharmacol (2008) 1.24
High expression of transient receptor potential channels in human breast cancer epithelial cells and tissues: correlation with pathological parameters. Cell Physiol Biochem (2011) 1.17
The neurotrophic effects of PACAP in PC12 cells: control by multiple transduction pathways. J Neurochem (2006) 1.14
Neuroprotection by endogenous and exogenous PACAP following stroke. Regul Pept (2006) 1.12
Neurotrophic effects of PACAP in the cerebellar cortex. Peptides (2007) 1.07
Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP). J Neurochem (2003) 1.07
Over-expression of RCAN1 causes Down syndrome-like hippocampal deficits that alter learning and memory. Hum Mol Genet (2012) 1.03
PACAP-deficient mice show attenuated corticosterone secretion and fail to develop depressive behavior during chronic social defeat stress. Psychoneuroendocrinology (2012) 1.03
Role of complement anaphylatoxin receptors (C3aR, C5aR) in the development of the rat cerebellum. Mol Immunol (2008) 1.02
Inhibitory effect of PACAP on caspase activity in neuronal apoptosis: a better understanding towards therapeutic applications in neurodegenerative diseases. J Mol Neurosci (2008) 1.01
Molecular and conformational determinants of pituitary adenylate cyclase-activating polypeptide (PACAP) for activation of the PAC1 receptor. J Med Chem (2009) 0.99
Characterization of C3a and C5a receptors in rat cerebellar granule neurons during maturation. Neuroprotective effect of C5a against apoptotic cell death. J Biol Chem (2004) 0.98
Protective effects of pituitary adenylate cyclase-activating polypeptide (PACAP) against apoptosis. Curr Pharm Des (2011) 0.96
Cycloheximide treatment to identify components of the transitional transcriptome in PACAP-induced PC12 cell differentiation. J Neurochem (2006) 0.92
Novel stable PACAP analogs with potent activity towards the PAC1 receptor. Peptides (2008) 0.91
Opposite regulation of the mitochondrial apoptotic pathway by C2-ceramide and PACAP through a MAP-kinase-dependent mechanism in cerebellar granule cells. J Neurochem (2004) 0.91
Rapgef2 connects GPCR-mediated cAMP signals to ERK activation in neuronal and endocrine cells. Sci Signal (2013) 0.90
PACAP and a novel stable analog protect rat brain from ischemia: Insight into the mechanisms of action. Peptides (2011) 0.89
PACAP-cytokine interactions govern adrenal neuropeptide biosynthesis after systemic administration of LPS. Neuropharmacology (2009) 0.88
Receptor-independent cellular uptake of pituitary adenylate cyclase-activating polypeptide. Biochim Biophys Acta (2012) 0.87
Pituitary adenylate cyclase-activating polypeptide protects astroglial cells against oxidative stress-induced apoptosis. J Neurochem (2011) 0.87
Design and characterization of novel cell-penetrating peptides from pituitary adenylate cyclase-activating polypeptide. J Control Release (2012) 0.87
Design and in vitro characterization of PAC1/VPAC1-selective agonists with potent neuroprotective effects. Biochem Pharmacol (2010) 0.87
Systems immunology of human malaria. Trends Parasitol (2012) 0.86
Long-term alterations in vulnerability to addiction to drugs of abuse and in brain gene expression after early life ethanol exposure. Neuropharmacology (2008) 0.86
Pituitary adenylate cyclase-activating polypeptide prevents the effects of ceramides on migration, neurite outgrowth, and cytoskeleton remodeling. Proc Natl Acad Sci U S A (2005) 0.86
AT4 receptor is insulin-regulated membrane aminopeptidase: potential mechanisms of memory enhancement. Trends Endocrinol Metab (2003) 0.86
Structure-activity study of LVV-hemorphin-7: angiotensin AT4 receptor ligand and inhibitor of insulin-regulated aminopeptidase. J Pharmacol Exp Ther (2003) 0.85
Neuropeptides, growth factors, and cytokines: a cohort of informational molecules whose expression is up-regulated by the stress-associated slow transmitter PACAP in chromaffin cells. Cell Mol Neurobiol (2010) 0.85
A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90. Autophagy (2015) 0.85
Rescue of neuronal migration deficits in a mouse model of fetal Minamata disease by increasing neuronal Ca2+ spike frequency. Proc Natl Acad Sci U S A (2012) 0.84
PACAP and C2-ceramide generate different AP-1 complexes through a MAP-kinase-dependent pathway: involvement of c-Fos in PACAP-induced Bcl-2 expression. J Neurochem (2006) 0.84
Rational design of a low molecular weight, stable, potent, and long-lasting GPR103 aza-β3-pseudopeptide agonist. J Med Chem (2012) 0.84
PAC1hop, null and hip receptors mediate differential signaling through cyclic AMP and calcium leading to splice variant-specific gene induction in neural cells. Peptides (2011) 0.82
Localization and characterization of pituitary adenylate cyclase-activating polypeptide receptors in the human cerebellum during development. J Comp Neurol (2006) 0.82
Y2Y4 receptor double knockout protects against obesity due to a high-fat diet or Y1 receptor deficiency in mice. Diabetes (2006) 0.82
Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates endozepine release from cultured rat astrocytes via a PKA-dependent mechanism. FASEB J (2003) 0.82
Functional GPR37 trafficking protects against toxicity induced by 6-OHDA, MPP+ or rotenone in a catecholaminergic cell line. J Neurochem (2012) 0.81
Regulation of neurosteroid biosynthesis by neurotransmitters and neuropeptides. Front Endocrinol (Lausanne) (2012) 0.81
Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates the expression and the release of tissue plasminogen activator (tPA) in neuronal cells: involvement of tPA in the neuroprotective effect of PACAP. J Neurochem (2011) 0.81
Identification of cysteines involved in ligand binding to the human melatonin MT(2) receptor. Eur J Pharmacol (2002) 0.81
Biofilm-induced modifications in the proteome of Pseudomonas aeruginosa planktonic cells. Biochim Biophys Acta (2010) 0.81
Paradoxical effect of ethanol on potassium channel currents and cell survival in cerebellar granule neurons. J Neurochem (2009) 0.80
Meta-analysis of microarray-derived data from PACAP-deficient adrenal gland in vivo and PACAP-treated chromaffin cells identifies distinct classes of PACAP-regulated genes. Peptides (2007) 0.80
Neuropeptidomics of mouse hypothalamus after imipramine treatment reveal somatostatin as a potential mediator of antidepressant effects. Neuropharmacology (2011) 0.80
The octadecaneuropeptide ODN protects astrocytes against hydrogen peroxide-induced apoptosis via a PKA/MAPK-dependent mechanism. PLoS One (2012) 0.80
The octadecaneuropeptide ODN prevents 6-hydroxydopamine-induced apoptosis of cerebellar granule neurons through a PKC-MAPK-dependent pathway. J Neurochem (2013) 0.80
Spatio-temporal characterization of the pleiotrophinergic system in mouse cerebellum: evidence for its key role during ontogenesis. Exp Neurol (2013) 0.80
Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo. J Med Chem (2012) 0.80
Protective effect of the octadecaneuropeptide on hydrogen peroxide-induced oxidative stress and cell death in cultured rat astrocytes. J Neurochem (2011) 0.80
GPR37 protein trafficking to the plasma membrane regulated by prosaposin and GM1 gangliosides promotes cell viability. J Biol Chem (2013) 0.80
PACAP stimulates biosynthesis and release of endozepines from rat astrocytes. Ann N Y Acad Sci (2006) 0.79
Identification by photoaffinity labeling of the extracellular N-terminal domain of PAC1 receptor as the major binding site for PACAP. Biochimie (2010) 0.79
N-methyl-D-aspartate blocks activation of JNK and mitochondrial apoptotic pathway induced by potassium deprivation in cerebellar granule cells. J Biol Chem (2005) 0.79
Evaluation of ubiquitinated proteins by proteomics reveals the role of the ubiquitin proteasome system in the regulation of Grp75 and Grp78 chaperone proteins during intestinal inflammation. Proteomics (2013) 0.78
PACAP prevents toxicity induced by cisplatin in rat and primate neurons but not in proliferating ovary cells: involvement of the mitochondrial apoptotic pathway. Neurobiol Dis (2008) 0.78
Peroxiredoxin 2 is involved in the neuroprotective effects of PACAP in cultured cerebellar granule neurons. J Mol Neurosci (2008) 0.78
Angiotensin II receptor (type 1 and 2) expression peaks when placental growth is maximal in sheep. Am J Physiol Regul Integr Comp Physiol (2002) 0.78
Enteral glutamine infusion modulates ubiquitination of heat shock proteins, Grp-75 and Apg-2, in the human duodenal mucosa. Amino Acids (2014) 0.78
Regulation of basal rhythmicity in protein kinase C activity by melatonin in immortalized rat suprachiasmatic nucleus cells. Neurosci Lett (2003) 0.78
Biological and structural analysis of truncated analogs of PACAP27. J Mol Neurosci (2008) 0.78
ATP derived from astrocytes modulates memory in the chick. Neuron Glia Biol (2012) 0.78
Biochemical characterization of a Caspase-3 far-red fluorescent probe for non-invasive optical imaging of neuronal apoptosis. J Mol Neurosci (2014) 0.77
Neuroprotective effects of PACAP against ethanol-induced toxicity in the developing rat cerebellum. Neurotox Res (2010) 0.77
PACAP and VIP promote initiation of electrophysiological activity in differentiating embryonic stem cells. Ann N Y Acad Sci (2006) 0.77
Spatiotemporal expression and functional implication of CXCL14 in the developing mice cerebellum. Mol Cells (2012) 0.77
Comparison of the deleterious effects of binge drinking-like alcohol exposure in adolescent and adult mice. J Neurochem (2015) 0.77
The role of calcium and cyclic nucleotide signaling in cerebellar granule cell migration under normal and pathological conditions. Dev Neurobiol (2014) 0.77
Role of PACAP in controlling granule cell migration. Cerebellum (2009) 0.77
Activation of PAC1 Receptors in Rat Cerebellar Granule Cells Stimulates Both Calcium Mobilization from Intracellular Stores and Calcium Influx through N-Type Calcium Channels. Front Endocrinol (Lausanne) (2013) 0.76
Neurosteroid biosynthesis in the brain of amphibians. Front Endocrinol (Lausanne) (2011) 0.76
Gastric inhibitory polypeptide and its receptor are expressed in the central nervous system and support neuronal survival. Cent Nerv Syst Agents Med Chem (2011) 0.76
Involvement of stathmin 1 in the neurotrophic effects of PACAP in PC12 cells. J Neurochem (2010) 0.76
Ontogeny of PACAP receptors in the human cerebellum: perspectives of therapeutic applications. Regul Pept (2006) 0.76
Identification of proteins regulated by PACAP in PC12 cells by 2D gel electrophoresis coupled to mass spectrometry. Ann N Y Acad Sci (2006) 0.76
Cortical-layer-specific effects of PACAP and tPA on interneuron migration during post-natal development of the cerebellum. J Neurochem (2014) 0.76
Human duodenal proteome modulations by glutamine and antioxidants. Proteomics Clin Appl (2010) 0.76
Cardiotoxin-I: an unexpectedly potent insulinotropic agent. Chembiochem (2012) 0.76
The stimulatory effect of the octadecaneuropeptide ODN on astroglial antioxidant enzyme systems is mediated through a GPCR. Front Endocrinol (Lausanne) (2012) 0.76
Light stimuli control neuronal migration by altering of insulin-like growth factor 1 (IGF-1) signaling. Proc Natl Acad Sci U S A (2012) 0.76
Impact of toxicant exposure on the proteomic response to intertidal condition in Mytilus edulis. Comp Biochem Physiol Part D Genomics Proteomics (2011) 0.75
Latent fluorophores based on a self-immolative linker strategy and suitable for protease sensing. Bioconjug Chem (2008) 0.75
Induction of serpinb1a by PACAP or NGF is required for PC12 cells survival after serum withdrawal. J Neurochem (2014) 0.75
Correction: Structure-Activity Relationship Studies of N- and C-Terminally Modified Secretin Analogs for the Human Secretin Receptor. PLoS One (2016) 0.75
The delayed rectifier channel current IK plays a key role in the control of programmed cell death by PACAP and ethanol in cerebellar granule neurons. Ann N Y Acad Sci (2006) 0.75
PACAP and ceramides exert opposite effects on migration, neurite outgrowth, and cytoskeleton remodeling. Ann N Y Acad Sci (2006) 0.75
Comparison of protein-extraction methods for gills of the shore crab, Carcinus maenas (L.), and application to 2DE. J Biomol Tech (2013) 0.75
Lycium europaeum fruit extract: antiproliferative activity on A549 human lung carcinoma cells and PC12 rat adrenal medulla cancer cells and assessment of its cytotoxicity on cerebellum granule cells. Nutr Cancer (2015) 0.75
[Effects of PACAP and C2-ceramide on motility of cerebellar granule neurons: the fastest is not the farthest]. Med Sci (Paris) (2005) 0.75
Effects of an enteral glucose supply on protein synthesis, proteolytic pathways, and proteome in human duodenal mucosa. Am J Clin Nutr (2011) 0.75
Molecular, cellular, and functional characterizations of pituitary adenylate cyclase-activating polypeptide and its receptors in the cerebellum of New and Old World monkeys. J Comp Neurol (2007) 0.75
An enteral leucine supply modulates human duodenal mucosal proteome and decreases the expression of enzymes involved in fatty acid beta-oxidation. J Proteomics (2012) 0.75
Foreword to special issue: molecular and cellular mechanisms of VIP, PACAP and secretin signaling applied to systems biology. Regul Pept (2006) 0.75