Published in Neuropeptides on June 03, 2009
Macrophage Resistance to HIV-1 Infection Is Enhanced by the Neuropeptides VIP and PACAP. PLoS One (2013) 0.79
PACAP27 is protective against tat-induced neurotoxicity. J Mol Neurosci (2014) 0.78
The chemokine, macrophage inflammatory protein-2γ, reduces the expression of glutamate transporter-1 on astrocytes and increases neuronal sensitivity to glutamate excitotoxicity. J Neuroinflammation (2012) 0.78
CCR5(+) and CXCR3(+) T cells are increased in multiple sclerosis and their ligands MIP-1alpha and IP-10 are expressed in demyelinating brain lesions. Proc Natl Acad Sci U S A (1999) 3.07
Inflammatory processes in Alzheimer's disease. J Neuroimmunol (2007) 2.91
Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases. Brain Res Brain Res Rev (2005) 2.78
MCP-1 (CCL2) protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosis. J Neurochem (2003) 2.21
Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms. Int J Dev Neurosci (2006) 1.68
Perspectives on pituitary adenylate cyclase activating polypeptide (PACAP) in the neuroendocrine, endocrine, and nervous systems. Jpn J Physiol (1998) 1.67
Chemokines and chemokine receptors in inflammation of the nervous system: manifold roles and exquisite regulation. Immunol Rev (2000) 1.61
Inflammation, anti-inflammatory agents and Alzheimer disease: the last 12 years. J Alzheimers Dis (2006) 1.58
Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro. Glia (2001) 1.53
Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6. Proc Natl Acad Sci U S A (2006) 1.39
Mechanisms of cell death in primary cortical neurons and PC12 cells. J Neurosci Res (2001) 1.17
PACAP protects cerebellar granule neurons against oxidative stress-induced apoptosis. Eur J Neurosci (2002) 1.16
Multiple actions of pituitary adenylyl cyclase activating peptide in nervous system development and regeneration. Dev Neurosci (2002) 1.12
Neuroprotection by endogenous and exogenous PACAP following stroke. Regul Pept (2006) 1.12
Pituitary adenylate cyclase activating polypeptide: a potential neuroprotective peptide. Curr Pharm Des (2004) 1.09
Neuroprotective potential of three neuropeptides PACAP, VIP and PHI. Pharmacol Rep (2005) 1.09
Impaired nerve regeneration and enhanced neuroinflammatory response in mice lacking pituitary adenylyl cyclase activating peptide. Neuroscience (2007) 1.06
Microvessels from Alzheimer's disease brains kill neurons in vitro. Am J Pathol (1999) 1.06
The many roles of chemokine receptors in neurodegenerative disorders: emerging new therapeutical strategies. Curr Med Chem (2007) 1.03
VIP-PACAP system in immunity: new insights for multitarget therapy. Ann N Y Acad Sci (2006) 1.03
Free radical production in CA1 neurons induces MIP-1alpha expression, microglia recruitment, and delayed neuronal death after transient forebrain ischemia. J Neurosci (2008) 1.02
Pleiotropic functions of PACAP in the CNS: neuroprotection and neurodevelopment. Ann N Y Acad Sci (2006) 1.02
Inhibitory effect of PACAP on caspase activity in neuronal apoptosis: a better understanding towards therapeutic applications in neurodegenerative diseases. J Mol Neurosci (2008) 1.01
Role of PACAP in ischemic neural death. J Mol Neurosci (2008) 1.00
G-protein-coupled receptor screen reveals a role for chemokine receptor CCR5 in suppressing microglial neurotoxicity. J Neurosci (2008) 1.00
Acetaminophen inhibits neuronal inflammation and protects neurons from oxidative stress. J Neuroinflammation (2009) 0.99
PACAP and its receptors exert pleiotropic effects in the nervous system by activating multiple signaling pathways. Curr Protein Pept Sci (2002) 0.98
RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75. Br J Pharmacol (2006) 0.98
Neuroprotection of interleukin-6 against NMDA attack and its signal transduction by JAK and MAPK. Neurosci Lett (2008) 0.95
The neuropeptide PACAP attenuates beta-amyloid (1-42)-induced toxicity in PC12 cells. Peptides (2002) 0.94
Interleukin-6 produces neuronal loss in developing cerebellar granule neuron cultures. J Neuroimmunol (2004) 0.93
Interleukin-6 protects cultured cerebellar granule neurons against glutamate-induced neurotoxicity. Neurosci Lett (2004) 0.92
Neuropeptide mimetics and antagonists in the treatment of inflammatory disease: focus on VIP and PACAP. Curr Top Med Chem (2006) 0.92
PACAP protects neuronal differentiated PC12 cells against the neurotoxicity induced by a mitochondrial complex I inhibitor, rotenone. FEBS Lett (2005) 0.92
Neuroprotective action of endogenous PACAP in cultured rat cortical neurons. Regul Pept (2005) 0.89
Response of cell cycle proteins to neurotrophic factor and chemokine stimulation in human neuroglia. Exp Neurol (2001) 0.89
Gene expression profile activated by the chemokine CCL5/RANTES in human neuronal cells. J Neurosci Res (2004) 0.89
Discovery of pituitary adenylate cyclase-activating polypeptide-regulated genes through microarray analyses in cell culture and in vivo. Ann N Y Acad Sci (2008) 0.88
Mechanisms of interleukin-6 synthesis and release induced by interleukin-1 and cell depolarisation in neurones. Mol Cell Neurosci (2007) 0.87
Temporal mRNA profiles of inflammatory mediators in the murine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine model of Parkinson's disease. Neuroscience (2007) 0.87
Chemokine release is associated with the protective action of PACAP-38 against HIV envelope protein neurotoxicity. Neuropeptides (2002) 0.86
Are multiple sclerosis and amyotrophic lateral sclerosis autoimmune disorders of endogenous vasoactive neuropeptides? Med Hypotheses (2007) 0.83
PACAP--a multifacetted neuropeptide. Chronobiol Int (2006) 0.83
Chemokines as modulators of neuroendocrine functions. J Mol Endocrinol (2007) 0.83
Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit LPS-stimulated MIP-1alpha production and mRNA expression. Cytokine (2002) 0.82
Transduction of PACAP38 protects primary cortical neurons from neurotoxic injury. Neurosci Lett (2008) 0.82
Chemokines and pro-inflammatory cytokines in Down's syndrome: an early marker for Alzheimer-type dementia? Psychother Psychosom (2002) 0.80
Neuropeptide PACAP inhibits hypoxic activation of brain microglia: a protective mechanism against microglial neurotoxicity in ischemia. Brain Res (2004) 0.80
PACAP38 protects rat cortical neurons against the neurotoxicity evoked by sodium nitroprusside and thrombin. Regul Pept (2008) 0.80
Is Parkinson's disease an autoimmune disorder of endogenous vasoactive neuropeptides? Med Hypotheses (2007) 0.79
Tissue-specific and developmental expression of pituitary adenylate cyclase-activating polypeptide (PACAP) receptors in rat brain. Eur J Neurosci (1996) 0.78
Tails of the unexpected - an atypical receptor for the chemokine RANTES/CCL5 expressed in brain. Br J Pharmacol (2006) 0.78
Properties and distribution of receptors for pituitary adenylate cyclase activating peptide (PACAP) in rat brain and spinal cord. Regul Pept (1991) 0.78
Can PACAP-38 modulate immune and endocrine responses during lipopolysaccharide (LPS)-induced acute inflammation? Ann N Y Acad Sci (2006) 0.76
Strategies to advance translational research into brain barriers. Lancet Neurol (2008) 2.16
New perspectives on vitamin E: gamma-tocopherol and carboxyelthylhydroxychroman metabolites in biology and medicine. Free Radic Biol Med (2004) 1.78
Message and protein-level elevation of tumor necrosis factor alpha (TNF alpha) and TNF alpha-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosis. Neurobiol Dis (2003) 1.51
HIV-1 gp120 proteins alter tight junction protein expression and brain endothelial cell permeability: implications for the pathogenesis of HIV-associated dementia. J Neuropathol Exp Neurol (2005) 1.45
Transcriptional and posttranscriptional regulation of angiopoietin-2 expression mediated by IGF and PDGF in vascular smooth muscle cells. Am J Physiol Cell Physiol (2005) 1.20
Induction of apoptosis and endothelin-1 secretion in primary human lung endothelial cells by HIV-1 gp120 proteins. Biochem Biophys Res Commun (2005) 1.17
The arachidonic acid 5-lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor alpha activation of microglia and extends survival of G93A-SOD1 transgenic mice. J Neurochem (2004) 1.15
Thrombin, a mediator of neurotoxicity and memory impairment. Neurobiol Aging (2004) 1.15
IL-8 induces expression of matrix metalloproteinases, cell cycle and pro-apoptotic proteins, and cell death in cultured neurons. J Alzheimers Dis (2007) 1.10
HIV-1 gp120 proteins and gp160 peptides are toxic to brain endothelial cells and neurons: possible pathway for HIV entry into the brain and HIV-associated dementia. J Neuropathol Exp Neurol (2002) 1.03
RANTES upregulation in the Alzheimer's disease brain: a possible neuroprotective role. Neurobiol Aging (2008) 1.02
CAP37, a neutrophil-derived inflammatory mediator, augments leukocyte adhesion to endothelial monolayers. Microvasc Res (2003) 1.01
Angiogenic proteins are expressed by brain blood vessels in Alzheimer's disease. J Alzheimers Dis (2006) 1.00
Acetaminophen inhibits neuronal inflammation and protects neurons from oxidative stress. J Neuroinflammation (2009) 0.99
Brain endothelial cells synthesize neurotoxic thrombin in Alzheimer's disease. Am J Pathol (2010) 0.98
Cyclin D1, cdk4, and Bim are involved in thrombin-induced apoptosis in cultured cortical neurons. J Neurochem (2007) 0.94
Acetaminophen protects brain endothelial cells against oxidative stress. Microvasc Res (2009) 0.92
The nitration product 5-nitro-gamma-tocopherol is increased in the Alzheimer brain. Nitric Oxide (2002) 0.91
Brain microvasculature and hypoxia-related proteins in Alzheimer's disease. Int J Clin Exp Pathol (2011) 0.90
The involvement of epoxygenase metabolites of arachidonic acid in cAMP-stimulated steroidogenesis and steroidogenic acute regulatory protein gene expression. J Endocrinol (2006) 0.89
CAP37, a novel inflammatory mediator: its expression in endothelial cells and localization to atherosclerotic lesions. Am J Pathol (2002) 0.89
Expression of macrophage inflammatory protein 1-alpha is elevated in Alzheimer's vessels and is regulated by oxidative stress. J Alzheimers Dis (2007) 0.89
Thrombin, a mediator of cerebrovascular inflammation in AD and hypoxia. Front Aging Neurosci (2013) 0.88
Functional modulation of smooth muscle cells by the inflammatory mediator CAP37. Microvasc Res (2004) 0.86
Molecular neuropsychology: creation of test-specific blood biomarker algorithms. Dement Geriatr Cogn Disord (2013) 0.86
Vascular signaling abnormalities in Alzheimer disease. Cleve Clin J Med (2011) 0.85
Multiple neurotrophic effects of VEGF on cultured neurons. Neuropeptides (2010) 0.85
Neurovascular unit and the effects of dosage in VEGF toxicity: role for oxidative stress and thrombin. J Alzheimers Dis (2013) 0.84
Cerebrovascular expression of proteins related to inflammation, oxidative stress and neurotoxicity is altered with aging. J Neuroinflammation (2010) 0.84
p38 MAPK: a mediator of hypoxia-induced cerebrovascular inflammation. J Alzheimers Dis (2012) 0.84
Endothelin-1 is elevated in Alzheimer's disease brain microvessels and is neuroprotective. J Alzheimers Dis (2010) 0.83
Structural changes in Alzheimer's disease brain microvessels. Curr Alzheimer Res (2008) 0.82
Transduction of PACAP38 protects primary cortical neurons from neurotoxic injury. Neurosci Lett (2008) 0.82
Blocking L-type calcium channels reduced the threshold of cAMP-induced steroidogenic acute regulatory gene expression in MA-10 mouse Leydig cells. J Endocrinol (2009) 0.82
Sunitinib enhances neuronal survival in vitro via NF-κB-mediated signaling and expression of cyclooxygenase-2 and inducible nitric oxide synthase. J Neuroinflammation (2013) 0.81
Chrysin, a natural flavonoid enhances steroidogenesis and steroidogenic acute regulatory protein gene expression in mouse Leydig cells. J Endocrinol (2008) 0.81
Involvement of PGE2 and PGDH but not COX-2 in thrombin-induced cortical neuron apoptosis. Neurosci Lett (2009) 0.81
Inhibition of thromboxane a synthase activity enhances steroidogenesis and steroidogenic acute regulatory gene expression in MA-10 mouse Leydig cells. Endocrinology (2007) 0.81
Is HIV involved in the pathogenesis of non-infectious pulmonary complications in infected patients? Curr HIV Res (2003) 0.81
Cyclin C and cyclin dependent kinases 1, 2 and 3 in thrombin-induced neuronal cell cycle progression and apoptosis. Neurosci Lett (2008) 0.80
Aortic cholesterol accumulation correlates with systemic inflammation but not hepatic and gonadal adipose tissue inflammation in low-density lipoprotein receptor null mice. Nutr Res (2013) 0.80
VEGF and VEGF receptor levels in retinal and brain-derived endothelial cells. Biochem Biophys Res Commun (2002) 0.80
Oxidized LDLs affect nitric oxide and radical generation in brain endothelial cells. Biochem Biophys Res Commun (2003) 0.80
PACAP38 protects rat cortical neurons against the neurotoxicity evoked by sodium nitroprusside and thrombin. Regul Pept (2008) 0.80
Oxidative stress impairs learning and memory in apoE knockout mice. Pharmacol Biochem Behav (2010) 0.79
Chronic thrombin exposure results in an increase in apolipoprotein-E levels. J Neurosci Res (2006) 0.78
Age-related decrease in cerebrovascular-derived neuroprotective proteins: effect of acetaminophen. Microvasc Res (2012) 0.77
Vascular inflammatory, oxidative and protease-based processes: implications for neuronal cell death in Alzheimer's disease. Neurol Res (2004) 0.77
Infection of baboon microglia with SIV-HIV recombinant viruses: role of CD4 and chemokine receptors. AIDS Res Hum Retroviruses (2002) 0.77
Effects of apigenin on steroidogenesis and steroidogenic acute regulatory gene expression in mouse Leydig cells. J Nutr Biochem (2011) 0.77
Gene expression profiling in Alzheimer's disease brain microvessels. J Alzheimers Dis (2012) 0.77
Involvement of the thromboxane A2 receptor in the regulation of steroidogenic acute regulatory gene expression in murine Leydig cells. Endocrinology (2009) 0.76
Purification of endothelial cells from rat brain. Methods Mol Biol (2014) 0.75