Improved Insulin Resistance and Lipid Metabolism by Cinnamon Extract through Activation of Peroxisome Proliferator-Activated Receptors.

PubWeight™: 1.15‹?› | Rank: Top 10%

🔗 View Article (PMC 2602825)

Published in PPAR Res on December 11, 2008

Authors

Xiaoyan Sheng1, Yuebo Zhang, Zhenwei Gong, Cheng Huang, Ying Qin Zang

Author Affiliations

1: Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of CAS, Chinese Academy of Sciences, 319 Yue Yang Road, Shanghai 200031, China.

Associated clinical trials:

Reducing Plasma Glucose Effect of Cinnamon in Type 2 Diabetic Patients in the Municipality of Comasagua (GCIG) | NCT03711682

Articles citing this

Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals. Annu Rev Nutr (2010) 1.44

A Dietary Supplement Containing Cinnamon, Chromium and Carnosine Decreases Fasting Plasma Glucose and Increases Lean Mass in Overweight or Obese Pre-Diabetic Subjects: A Randomized, Placebo-Controlled Trial. PLoS One (2015) 1.40

The use of complementary and alternative medicines (CAMs) in the treatment of diabetes mellitus: is continued use safe and effective? Nutr J (2014) 1.11

Glucose-lowering effect of DLBS3233 is mediated through phosphorylation of tyrosine and upregulation of PPARγ and GLUT4 expression. Int J Gen Med (2011) 1.05

Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis. Ann Fam Med (2013) 1.02

In vivo and in vitro antidiabetic effects of aqueous cinnamon extract and cinnamon polyphenol-enhanced food matrix. Food Chem (2012) 0.98

Flavonoids and age-related disease: risk, benefits and critical windows. Maturitas (2010) 0.96

Oxidative markers, nitric oxide and homocysteine alteration in hypercholesterolimic rats: role of atorvastatine and cinnamon. Int J Clin Exp Med (2009) 0.90

Female mice target deleted for the neuromedin B receptor have partial resistance to diet-induced obesity. J Physiol (2010) 0.88

The glycaemic outcomes of Cinnamon, a review of the experimental evidence and clinical trials. Nutr J (2015) 0.83

Extension of Drosophila lifespan by cinnamon through a sex-specific dependence on the insulin receptor substrate chico. Exp Gerontol (2014) 0.81

Peroxisome proliferator-activated receptor-(gamma) receptor ligand partially prevents the development of endometrial explants in baboons: a prospective, randomized, placebo-controlled study. Endocrinology (2010) 0.81

Therapeutic phytogenic compounds for obesity and diabetes. Int J Mol Sci (2014) 0.79

Swertiamarin: An Active Lead from Enicostemma littorale Regulates Hepatic and Adipose Tissue Gene Expression by Targeting PPAR- γ and Improves Insulin Sensitivity in Experimental NIDDM Rat Model. Evid Based Complement Alternat Med (2013) 0.78

Bark Extracts of Ceylon Cinnamon Possess Antilipidemic Activities and Bind Bile Acids In Vitro. Evid Based Complement Alternat Med (2017) 0.78

New Pathogenic Concepts and Therapeutic Approaches to Oxidative Stress in Chronic Kidney Disease. Oxid Med Cell Longev (2016) 0.76

Stimulatory Effects of Cinnamon Extract (Cinnamomum cassia) during the Initiation Stage of 3T3-L1 Adipocyte Differentiation. Foods (2016) 0.75

Anti-diabetic and antioxidant effect of cinnamon in poorly controlled type-2 diabetic Iraqi patients: A randomized, placebo-controlled clinical trial. J Intercult Ethnopharmacol (2016) 0.75

Cinnamon effects on metabolic syndrome: a review based on its mechanisms. Iran J Basic Med Sci (2016) 0.75

Cinnamon: Mystic powers of a minute ingredient. Pharmacognosy Res (2015) 0.75

Cinnamon Polyphenol Extract Inhibits Hyperlipidemia and Inflammation by Modulation of Transcription Factors in High-Fat Diet-Fed Rats. Oxid Med Cell Longev (2017) 0.75

Indian spices for healthy heart - an overview. Curr Cardiol Rev (2010) 0.75

Articles cited by this

Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA (2001) 118.65

MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet (2002) 44.28

Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study. JAMA (1998) 19.64

Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care (1991) 9.95

Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev (1999) 9.94

The high-fat diet-fed mouse: a model for studying mechanisms and treatment of impaired glucose tolerance and type 2 diabetes. Diabetes (2004) 4.09

The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes. Diabetes (2002) 3.63

Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care (2003) 3.14

Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists. J Clin Invest (2000) 2.80

A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes. Diabetes (2003) 2.63

Effect of fenofibrate on progression of coronary-artery disease in type 2 diabetes: the Diabetes Atherosclerosis Intervention Study, a randomised study. Lancet (2001) 2.62

Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity. J Agric Food Chem (2004) 1.79

Berberine inhibits 3T3-L1 adipocyte differentiation through the PPARgamma pathway. Biochem Biophys Res Commun (2006) 1.63

Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice. J Ethnopharmacol (2005) 1.60

Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2. Eur J Clin Invest (2006) 1.58

Improved glycemic control and enhanced insulin sensitivity in type 2 diabetic subjects treated with pioglitazone. Diabetes Care (2001) 1.56

Hepatotoxicity of commonly used drugs: nonsteroidal anti-inflammatory drugs, antihypertensives, antidiabetic agents, anticonvulsants, lipid-lowering agents, psychotropic drugs. Semin Liver Dis (2002) 1.32

Free fatty acids, insulin resistance, and type 2 diabetes mellitus. Proc Assoc Am Physicians (1999) 1.27

Troglitazone, an insulin action enhancer, improves metabolic control in NIDDM patients. Troglitazone Study Group. Diabetologia (1996) 1.17

Effect of cinnamon on glucose control and lipid parameters. Diabetes Care (2007) 1.17

Dissociated insulinotropic sensitivity to glucose and carbachol in high-fat diet-induced insulin resistance in C57BL/6J mice. Metabolism (1997) 1.14

Pharmacotherapy of type 2 diabetes mellitus. Ann Pharmacother (2001) 1.02

Effects of a novel formulation of essential oils on glucose-insulin metabolism in diabetic and hypertensive rats: a pilot study. Diabetes Obes Metab (2005) 0.86

Cinnamon water extracts increase glucose uptake but inhibit adiponectin secretion in 3T3-L1 adipose cells. Mol Nutr Food Res (2006) 0.83

Nonalcoholic fatty liver (NASH syndrome). Gastroenterologist (1997) 0.81

Benefits of lipid-lowering therapy in patients with type 2 diabetes mellitus. Am J Med (2005) 0.80

[Increased liver enzymes: what should be done?]. Ther Umsch (1992) 0.80

Articles by these authors

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet (2015) 7.99

Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990-2013: quantifying the epidemiological transition. Lancet (2015) 6.13

Gefitinib versus placebo as maintenance therapy in patients with locally advanced or metastatic non-small-cell lung cancer (INFORM; C-TONG 0804): a multicentre, double-blind randomised phase 3 trial. Lancet Oncol (2012) 2.98

Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene expression by promoting host mRNA degradation. Proc Natl Acad Sci U S A (2006) 2.31

Anticonvulsant medications extend worm life-span. Science (2005) 2.18

Final overall survival results from a phase III, randomized, placebo-controlled, parallel-group study of gefitinib versus placebo as maintenance therapy in patients with locally advanced or metastatic non-small-cell lung cancer (INFORM; C-TONG 0804). J Thorac Oncol (2015) 2.14

Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes. J Mol Cell Cardiol (2011) 1.77

An all-organic composite actuator material with a high dielectric constant. Nature (2002) 1.74

A viral RNA structural element alters host recognition of nonself RNA. Science (2014) 1.71

Severe acute respiratory syndrome coronavirus nsp1 suppresses host gene expression, including that of type I interferon, in infected cells. J Virol (2008) 1.69

Severe acute respiratory syndrome coronavirus 3a protein is a viral structural protein. J Virol (2005) 1.64

Berberine inhibits 3T3-L1 adipocyte differentiation through the PPARgamma pathway. Biochem Biophys Res Commun (2006) 1.63

Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation. J Clin Invest (2011) 1.54

Severe acute respiratory syndrome coronavirus infection of mice transgenic for the human Angiotensin-converting enzyme 2 virus receptor. J Virol (2006) 1.49

Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation? EMBO J (2007) 1.44

Study of the mechanisms of acupuncture and moxibustion treatment for ulcerative colitis rats in view of the gene expression of cytokines. World J Gastroenterol (1999) 1.42

A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein. Nat Struct Mol Biol (2009) 1.42

Retracted Reelin promotes peripheral synapse elimination and maturation. Science (2003) 1.41

The measurement and analysis of age-related changes in Caenorhabditis elegans. WormBook (2008) 1.40

MicroRNA-146a modulates TGF-beta1-induced hepatic stellate cell proliferation by targeting SMAD4. Cell Signal (2012) 1.37

miR-21 confers cisplatin resistance in gastric cancer cells by regulating PTEN. Toxicology (2013) 1.34

Berberine differentially modulates the activities of ERK, p38 MAPK, and JNK to suppress Th17 and Th1 T cell differentiation in type 1 diabetic mice. J Biol Chem (2009) 1.33

Estimation and uncertainty analysis of impacts of future heat waves on mortality in the eastern United States. Environ Health Perspect (2013) 1.27

The potential of microRNAs in liver fibrosis. Cell Signal (2012) 1.22

Exogenous ACE2 expression allows refractory cell lines to support severe acute respiratory syndrome coronavirus replication. J Virol (2005) 1.22

Disability among native-born and foreign-born blacks in the United States. Demography (2011) 1.20

Ultrathin broadband nearly perfect absorber with symmetrical coherent illumination. Opt Express (2012) 1.18

Imbalance between neutrophil elastase and its inhibitor α1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure. Cell Metab (2013) 1.16

MicroRNA-29 family, a crucial therapeutic target for fibrosis diseases. Biochimie (2013) 1.12

The pivotal role of microRNA-155 in the control of cancer. J Cell Physiol (2014) 1.11

Virulence of water-induced coccoid Helicobacter pylori and its experimental infection in mice. World J Gastroenterol (2003) 1.10

Valproic acid extends Caenorhabditis elegans lifespan. Aging Cell (2008) 1.10

The role of tanshinone IIA in the treatment of obesity through peroxisome proliferator-activated receptor gamma antagonism. Endocrinology (2008) 1.09

Junín virus pathogenesis and virus replication. Viruses (2012) 1.07

Multi-band circular polarizer using planar spiral metamaterial structure. Opt Express (2012) 1.06

Controversial correlation between Fcγ receptor IIB and Toll-like receptor 2 in rheumatoid arthritis: comment on the article by Abdollahi-Roodsaz et al. Arthritis Rheum (2013) 1.05

DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats. Toxicol Appl Pharmacol (2012) 1.04

C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane. Cell Metab (2011) 1.03

MiR-27a modulates the MDR1/P-glycoprotein expression by inhibiting FZD7/β-catenin pathway in hepatocellular carcinoma cells. Cell Signal (2013) 1.03

Global protein-protein interaction network in the human pathogen Mycobacterium tuberculosis H37Rv. J Proteome Res (2010) 1.02

Regulation of Th1 and Th17 cell differentiation and amelioration of experimental autoimmune encephalomyelitis by natural product compound berberine. J Immunol (2010) 1.02

Design principles for infrared wide-angle perfect absorber based on plasmonic structure. Opt Express (2011) 1.02

Schimke immuno-osseous dysplasia: a cell autonomous disorder? Am J Med Genet A (2006) 1.02

SARS coronavirus accessory proteins. Virus Res (2007) 1.01

Murine coronavirus nonstructural protein p28 arrests cell cycle in G0/G1 phase. J Virol (2004) 1.01

Capn4 overexpression underlies tumor invasion and metastasis after liver transplantation for hepatocellular carcinoma. Hepatology (2009) 1.00

Berberine inhibits PTP1B activity and mimics insulin action. Biochem Biophys Res Commun (2010) 1.00

Rhein ameliorates fatty liver disease through negative energy balance, hepatic lipogenic regulation, and immunomodulation in diet-induced obese mice. Am J Physiol Endocrinol Metab (2011) 1.00

Entry of hepatitis B virus into immortalized human primary hepatocytes by clathrin-dependent endocytosis. J Virol (2012) 1.00

Wnt signaling pathway in rheumatoid arthritis, with special emphasis on the different roles in synovial inflammation and bone remodeling. Cell Signal (2013) 1.00

TLR4 activation is required for IL-17-induced multiple tissue inflammation and wasting in mice. J Immunol (2010) 0.98

Novel nuclear export signal-interacting protein, NESI, critical for the assembly of hepatitis delta virus. J Virol (2005) 0.98

Innate immune response to arenaviral infection: a focus on the highly pathogenic New World hemorrhagic arenaviruses. J Mol Biol (2013) 0.98

Suppression of host gene expression by nsp1 proteins of group 2 bat coronaviruses. J Virol (2009) 0.98

Production of FaeG, the major subunit of K88 fimbriae, in transgenic tobacco plants and its immunogenicity in mice. Infect Immun (2003) 0.97

Participation of miR-200a in TGF-β1-mediated hepatic stellate cell activation. Mol Cell Biochem (2013) 0.97

Neurologic phenotype of Schimke immuno-osseous dysplasia and neurodevelopmental expression of SMARCAL1. J Neuropathol Exp Neurol (2008) 0.96

Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the β cell. FASEB J (2013) 0.96

Cycle arrest and apoptosis in MDA-MB-231/Her2 cells induced by curcumin. Eur J Pharmacol (2012) 0.96

Hepatoprotective effects of geniposide in a rat model of nonalcoholic steatohepatitis. J Pharm Pharmacol (2011) 0.96

New advances of microRNAs in the pathogenesis of rheumatoid arthritis, with a focus on the crosstalk between DNA methylation and the microRNA machinery. Cell Signal (2013) 0.96

On-road vehicle emission inventory and its uncertainty analysis for Shanghai, China. Sci Total Environ (2008) 0.96

Repression of Smad7 mediated by DNMT1 determines hepatic stellate cell activation and liver fibrosis in rats. Toxicol Lett (2013) 0.95

TRPM7 channel regulates PDGF-BB-induced proliferation of hepatic stellate cells via PI3K and ERK pathways. Toxicol Appl Pharmacol (2013) 0.95

Qualitative and quantitative PCR methods for event-specific detection of genetically modified cotton Mon1445 and Mon531. Transgenic Res (2005) 0.94

Association of migraine-like headaches with Schimke immuno-osseous dysplasia. Am J Med Genet A (2005) 0.93

Distinctive microRNA signature associated of neoplasms with the Wnt/β-catenin signaling pathway. Cell Signal (2013) 0.93

Targeting adipocyte apoptosis: a novel strategy for obesity therapy. Biochem Biophys Res Commun (2011) 0.92

A phase I pilot trial of MUC1-peptide-pulsed dendritic cells in the treatment of advanced pancreatic cancer. Clin Exp Med (2011) 0.92

Randomized, double-blind, crossover study of palonosetron compared with granisetron for the prevention of chemotherapy-induced nausea and vomiting in a Chinese population. Med Oncol (2010) 0.91

Zoledronic acid as an adjuvant therapy in patients with breast cancer: a systematic review and meta-analysis. PLoS One (2012) 0.91

7-Ketocholesterol induces P-glycoprotein through PI3K/mTOR signaling in hepatoma cells. Biochem Pharmacol (2013) 0.91

Preventive effects of total flavonoids of Litsea coreana leve on hepatic steatosis in rats fed with high fat diet. J Ethnopharmacol (2008) 0.91

Feedback regulation of telomerase reverse transcriptase: new insight into the evolving field of telomerase in cancer. Cell Signal (2013) 0.91

Identification of mutations that delay somatic or reproductive aging of Caenorhabditis elegans. Genetics (2011) 0.91

Truncated spherical voids for nearly omnidirectional optical absorption. Opt Express (2011) 0.91

Rhein Reduces Fat Weight in db/db Mouse and Prevents Diet-Induced Obesity in C57Bl/6 Mouse through the Inhibition of PPARγ Signaling. PPAR Res (2012) 0.90

Interruption of the MEK/ERK signaling cascade promotes dihydroartemisinin-induced apoptosis in vitro and in vivo. Apoptosis (2011) 0.90

Identification and quantification of three genetically modified insect resistant cotton lines using conventional and TaqMan real-time polymerase chain reaction methods. J Agric Food Chem (2005) 0.90

Wnt signaling in liver fibrosis: progress, challenges and potential directions. Biochimie (2013) 0.90

Aprepitant triple therapy for the prevention of chemotherapy-induced nausea and vomiting following high-dose cisplatin in Chinese patients: a randomized, double-blind, placebo-controlled phase III trial. Support Care Cancer (2013) 0.89

MeCP2 controls the expression of RASAL1 in the hepatic fibrosis in rats. Toxicology (2011) 0.89

Templated self-assembly of ZnO films on monolayer patterns with nanoscale resolution. Langmuir (2010) 0.89

Caffeine protects against alcoholic liver injury by attenuating inflammatory response and oxidative stress. Inflamm Res (2010) 0.89

Local expression of secondary lymphoid tissue chemokine delivered by adeno-associated virus within the tumor bed stimulates strong anti-liver tumor immunity. J Virol (2007) 0.89

Screening of anti-cancer agent using zebrafish: comparison with the MTT assay. Biochem Biophys Res Commun (2012) 0.89

Endoplasmic reticulum stress-induced hepatic stellate cell apoptosis through calcium-mediated JNK/P38 MAPK and Calpain/Caspase-12 pathways. Mol Cell Biochem (2014) 0.89

Emerging role of silent information regulator 1 (SIRT1) in hepatocellular carcinoma: a potential therapeutic target. Tumour Biol (2015) 0.89

Seasonal water relations of Lyginia barbata (Southern rush) in relation to root xylem development and summer dormancy of root apices. New Phytol (2010) 0.88

Rescue of a recombinant Machupo virus from cloned cDNAs and in vivo characterization in interferon (αβ/γ) receptor double knockout mice. J Virol (2013) 0.88

Mutational analysis of the Sendai virus V protein: importance of the conserved residues for Zn binding, virus pathogenesis, and efficient RNA editing. Virology (2002) 0.88

Investigation of Fano resonance in planar metamaterial with perturbed periodicity. Opt Express (2013) 0.88

Regulation of fasting fuel metabolism by toll-like receptor 4. Diabetes (2010) 0.88