Published in Science on January 14, 2005
Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans. J Biol Chem (2007) 1.86
Genetic and pharmacological factors that influence reproductive aging in nematodes. PLoS Genet (2006) 1.70
Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression. Mol Neurodegener (2015) 1.41
Hormesis and aging in Caenorhabditis elegans. Exp Gerontol (2006) 1.25
Comparative approaches to facilitate the discovery of prolongevity interventions: effects of tocopherols on lifespan of three invertebrate species. Mech Ageing Dev (2006) 1.06
Measuring Caenorhabditis elegans life span in 96 well microtiter plates. J Vis Exp (2011) 1.06
A pharmacological network for lifespan extension in Caenorhabditis elegans. Aging Cell (2013) 1.04
Antidepressants of the serotonin-antagonist type increase body fat and decrease lifespan of adult Caenorhabditis elegans. PLoS One (2008) 1.03
Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol (2008) 0.98
Lamotrigine extends lifespan but compromises health span in Drosophila melanogaster. Biogerontology (2009) 0.95
Mortality shifts in Caenorhabditis elegans: remembrance of conditions past. Aging Cell (2009) 0.95
Pharmacological lifespan extension of invertebrates. Ageing Res Rev (2012) 0.93
C. elegans in high-throughput drug discovery. Adv Drug Deliv Rev (2013) 0.93
Regulation of lifespan by chemosensory and thermosensory systems: findings in invertebrates and their implications in mammalian aging. Front Genet (2012) 0.92
Drug absorption efficiency in Caenorhbditis elegans delivered by different methods. PLoS One (2013) 0.90
The anticonvulsant ethosuximide disrupts sensory function to extend C. elegans lifespan. PLoS Genet (2008) 0.90
Pharmacological intervention in invertebrate aging. Age (Dordr) (2005) 0.88
Sirtuins in epigenetic regulation. Chem Rev (2015) 0.88
FDA-approved drugs that protect mammalian neurons from glucose toxicity slow aging dependent on cbp and protect against proteotoxicity. PLoS One (2011) 0.87
Allyl isothiocyanate that induces GST and UGT expression confers oxidative stress resistance on C. elegans, as demonstrated by nematode biosensor. PLoS One (2010) 0.87
Curcumin and neurodegenerative diseases. Biofactors (2013) 0.86
Beneficial effects of wheat gluten hydrolysate to extend lifespan and induce stress resistance in nematode Caenorhabditis elegans. PLoS One (2013) 0.86
Celecoxib extends C. elegans lifespan via inhibition of insulin-like signaling but not cyclooxygenase-2 activity. Aging Cell (2011) 0.85
Programming and Reprogramming Cellular Age in the Era of Induced Pluripotency. Cell Stem Cell (2015) 0.85
A predictable worm: application of Caenorhabditis elegans for mechanistic investigation of movement disorders. Neurotherapeutics (2012) 0.84
Neuroprotective effects of blockers for T-type calcium channels. Mol Neurodegener (2009) 0.83
Brivaracetam, but not ethosuximide, reverses memory impairments in an Alzheimer's disease mouse model. Alzheimers Res Ther (2015) 0.82
Anti-epileptic drugs delay age-related loss of spiral ganglion neurons via T-type calcium channel. Hear Res (2011) 0.82
Pharmacological classes that extend lifespan of Caenorhabditis elegans. Front Genet (2015) 0.81
Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans. Nat Chem Biol (2011) 0.81
Dietary intake of resveratrol enhances the adaptive immunity of aged rats. Rejuvenation Res (2012) 0.81
Mated progeny production is a biomarker of aging in Caenorhabditis elegans. G3 (Bethesda) (2013) 0.80
10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the Lifespan of Caenorhabditis elegans through Dietary Restriction and Target of Rapamycin Signaling. J Aging Res (2015) 0.79
Invertebrate models of dystonia. Curr Neuropharmacol (2013) 0.79
Pharmacological maintenance of protein homeostasis could postpone age-related disease. Aging Cell (2012) 0.79
Validated Liquid Culture Monitoring System for Lifespan Extension of Caenorhabditis elegans through Genetic and Dietary Manipulations. Aging Dis (2013) 0.79
Resveratrol affects the expression of glutamate cysteine ligase in the kidneys of aged rats. Exp Ther Med (2014) 0.78
Angiotensin Converting Enzyme (ACE) Inhibitor Extends Caenorhabditis elegans Life Span. PLoS Genet (2016) 0.78
Repurposing FDA-approved drugs for anti-aging therapies. Biogerontology (2016) 0.77
UV-photoconversion of ethosuximide from a longevity-promoting compound to a potent toxin. PLoS One (2013) 0.77
Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases. Chem Cent J (2015) 0.77
Anti-aging effect of polysaccharide from Bletilla striata on nematode Caenorhabditis elegans. Pharmacogn Mag (2015) 0.76
Geroscience approaches to increase healthspan and slow aging. F1000Res (2016) 0.76
Withania somnifera root extract extends lifespan of Caenorhabditis elegans. Ann Neurosci (2013) 0.75
Modulating Behavior in C. elegans Using Electroshock and Antiepileptic Drugs. PLoS One (2016) 0.75
Biomedicine. As the worm ages: epilepsy drugs lengthen nematode life span. Science (2005) 0.75
Association with pathogenic bacteria affects life-history traits and population growth in Caenorhabditis elegans. Ecol Evol (2015) 0.75
Finding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging Molecules. F1000Res (2016) 0.75
Anti-amyloid compounds protect from silica nanoparticle-induced neurotoxicity in the nematode C. elegans. Nanotoxicology (2015) 0.75
Healthspan Pharmacology. Rejuvenation Res (2015) 0.75
Gefitinib versus placebo as maintenance therapy in patients with locally advanced or metastatic non-small-cell lung cancer (INFORM; C-TONG 0804): a multicentre, double-blind randomised phase 3 trial. Lancet Oncol (2012) 2.98
Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans. Proc Natl Acad Sci U S A (2004) 2.84
Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene expression by promoting host mRNA degradation. Proc Natl Acad Sci U S A (2006) 2.31
The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response. Immunity (2012) 1.96
Neurosteroid access to the GABAA receptor. J Neurosci (2005) 1.95
An all-organic composite actuator material with a high dielectric constant. Nature (2002) 1.74
Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. J Biol Chem (2006) 1.72
Oxysterols are allosteric activators of the oncoprotein Smoothened. Nat Chem Biol (2012) 1.72
A viral RNA structural element alters host recognition of nonself RNA. Science (2014) 1.71
Genetic and pharmacological factors that influence reproductive aging in nematodes. PLoS Genet (2006) 1.70
Severe acute respiratory syndrome coronavirus nsp1 suppresses host gene expression, including that of type I interferon, in infected cells. J Virol (2008) 1.69
Severe acute respiratory syndrome coronavirus 3a protein is a viral structural protein. J Virol (2005) 1.64
Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease. Proc Natl Acad Sci U S A (2006) 1.62
Mechanisms of neurosteroid interactions with GABA(A) receptors. Pharmacol Ther (2007) 1.60
Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis. J Pharmacol Exp Ther (2007) 1.55
Cholesterol depletion results in site-specific increases in epidermal growth factor receptor phosphorylation due to membrane level effects. Studies with cholesterol enantiomers. J Biol Chem (2003) 1.52
Severe acute respiratory syndrome coronavirus infection of mice transgenic for the human Angiotensin-converting enzyme 2 virus receptor. J Virol (2006) 1.49
Neuroactive steroids have multiple actions to potentiate GABAA receptors. J Physiol (2004) 1.47
Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids. Mol Pharmacol (2008) 1.46
Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation? EMBO J (2007) 1.44
Study of the mechanisms of acupuncture and moxibustion treatment for ulcerative colitis rats in view of the gene expression of cytokines. World J Gastroenterol (1999) 1.42
A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein. Nat Struct Mol Biol (2009) 1.42
Retracted Reelin promotes peripheral synapse elimination and maturation. Science (2003) 1.41
The measurement and analysis of age-related changes in Caenorhabditis elegans. WormBook (2008) 1.40
MicroRNA-146a modulates TGF-beta1-induced hepatic stellate cell proliferation by targeting SMAD4. Cell Signal (2012) 1.37
miR-21 confers cisplatin resistance in gastric cancer cells by regulating PTEN. Toxicology (2013) 1.34
Oxidative stress in NPC1 deficient cells: protective effect of allopregnanolone. J Cell Mol Med (2008) 1.33
Natural and enantiomeric etiocholanolone interact with distinct sites on the rat alpha1beta2gamma2L GABAA receptor. Mol Pharmacol (2007) 1.33
Dual potentiating and inhibitory actions of a benz[e]indene neurosteroid analog on recombinant alpha1beta2gamma2 GABAA receptors. Mol Pharmacol (2006) 1.31
Neurosteroid analogues. 12. Potent enhancement of GABA-mediated chloride currents at GABAA receptors by ent-androgens. Eur J Med Chem (2007) 1.31
Estimation and uncertainty analysis of impacts of future heat waves on mortality in the eastern United States. Environ Health Perspect (2013) 1.27
Caenorhabditis elegans lin-45 raf is essential for larval viability, fertility and the induction of vulval cell fates. Genetics (2002) 1.26
Slow actions of neuroactive steroids at GABAA receptors. J Neurosci (2004) 1.24
Effects of natural and enantiomeric cholesterol on the thermotropic phase behavior and structure of egg sphingomyelin bilayer membranes. Biophys J (2003) 1.24
Selective antagonism of 5alpha-reduced neurosteroid effects at GABA(A) receptors. Mol Pharmacol (2004) 1.23
The potential of microRNAs in liver fibrosis. Cell Signal (2012) 1.22
Exogenous ACE2 expression allows refractory cell lines to support severe acute respiratory syndrome coronavirus replication. J Virol (2005) 1.22
The sticky issue of neurosteroids and GABA(A) receptors. Trends Neurosci (2010) 1.21
Disability among native-born and foreign-born blacks in the United States. Demography (2011) 1.20
Ultrathin broadband nearly perfect absorber with symmetrical coherent illumination. Opt Express (2012) 1.18
3beta -hydroxypregnane steroids are pregnenolone sulfate-like GABA(A) receptor antagonists. J Neurosci (2002) 1.18
Zinc ions and cation diffusion facilitator proteins regulate Ras-mediated signaling. Dev Cell (2002) 1.17
Side chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions. J Biol Chem (2008) 1.17
Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo. Brain Res (2005) 1.16
Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob mice. Diabetes (2009) 1.15
Sumoylation of LIN-1 promotes transcriptional repression and inhibition of vulval cell fates. Development (2005) 1.15
Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling. Elife (2013) 1.15
Improved Insulin Resistance and Lipid Metabolism by Cinnamon Extract through Activation of Peroxisome Proliferator-Activated Receptors. PPAR Res (2008) 1.15
The influence of neuroactive steroid lipophilicity on GABAA receptor modulation: evidence for a low-affinity interaction. J Neurophysiol (2009) 1.14
MicroRNA-29 family, a crucial therapeutic target for fibrosis diseases. Biochimie (2013) 1.12
Neurosteroids, stress and depression: potential therapeutic opportunities. Neurosci Biobehav Rev (2012) 1.12
Energetics by NMR: site-specific binding in a positively cooperative system. Proc Natl Acad Sci U S A (2002) 1.11
The pivotal role of microRNA-155 in the control of cancer. J Cell Physiol (2014) 1.11
Gastrointestinal absorption and plasma kinetics of soy Delta(5)-phytosterols and phytostanols in humans. Am J Physiol Endocrinol Metab (2002) 1.11
Virulence of water-induced coccoid Helicobacter pylori and its experimental infection in mice. World J Gastroenterol (2003) 1.10
Valproic acid extends Caenorhabditis elegans lifespan. Aging Cell (2008) 1.10
Estrogen-like compounds for ischemic neuroprotection. Stroke (2004) 1.10
First synthesis of ent-desmosterol and its conversion to ent-deuterocholesterol. Steroids (2003) 1.10
Lysosome-related organelles in intestinal cells are a zinc storage site in C. elegans. Cell Metab (2012) 1.09
The role of tanshinone IIA in the treatment of obesity through peroxisome proliferator-activated receptor gamma antagonism. Endocrinology (2008) 1.09
Junín virus pathogenesis and virus replication. Viruses (2012) 1.07
Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans. Exp Gerontol (2006) 1.07
Neurosteroid migration to intracellular compartments reduces steroid concentration in the membrane and diminishes GABA-A receptor potentiation. J Physiol (2007) 1.07
Neuroprotective effects of 17beta-estradiol and nonfeminizing estrogens against H2O2 toxicity in human neuroblastoma SK-N-SH cells. Mol Pharmacol (2006) 1.06
Multi-band circular polarizer using planar spiral metamaterial structure. Opt Express (2012) 1.06
Investigating the allosterism of acyl-CoA:cholesterol acyltransferase (ACAT) by using various sterols: in vitro and intact cell studies. Biochem J (2005) 1.06
Identification of cis-regulatory elements from the C. elegans Hox gene lin-39 required for embryonic expression and for regulation by the transcription factors LIN-1, LIN-31 and LIN-39. Dev Biol (2006) 1.05
Controversial correlation between Fcγ receptor IIB and Toll-like receptor 2 in rheumatoid arthritis: comment on the article by Abdollahi-Roodsaz et al. Arthritis Rheum (2013) 1.05
Neurosteroid analog photolabeling of a site in the third transmembrane domain of the β3 subunit of the GABA(A) receptor. Mol Pharmacol (2012) 1.05
DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats. Toxicol Appl Pharmacol (2012) 1.04
MiR-27a modulates the MDR1/P-glycoprotein expression by inhibiting FZD7/β-catenin pathway in hepatocellular carcinoma cells. Cell Signal (2013) 1.03
Neurosteroids enhance spontaneous glutamate release in hippocampal neurons. Possible role of metabotropic sigma1-like receptors. J Biol Chem (2002) 1.03
Anticonvulsant and anesthetic effects of a fluorescent neurosteroid analog activated by visible light. Nat Neurosci (2007) 1.03
Global protein-protein interaction network in the human pathogen Mycobacterium tuberculosis H37Rv. J Proteome Res (2010) 1.02
Design principles for infrared wide-angle perfect absorber based on plasmonic structure. Opt Express (2011) 1.02
Schimke immuno-osseous dysplasia: a cell autonomous disorder? Am J Med Genet A (2006) 1.02
GABAergic neurosteroids mediate the effects of ethanol on long-term potentiation in rat hippocampal slices. Eur J Neurosci (2007) 1.01
Characterization of enantiomeric bile acid-induced apoptosis in colon cancer cell lines. J Biol Chem (2008) 1.01
SARS coronavirus accessory proteins. Virus Res (2007) 1.01
Photoaffinity labeling with a neuroactive steroid analogue. 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain. J Biol Chem (2003) 1.01
Murine coronavirus nonstructural protein p28 arrests cell cycle in G0/G1 phase. J Virol (2004) 1.01
Neuroprotective effects of a novel non-receptor-binding estrogen analogue: in vitro and in vivo analysis. Stroke (2002) 1.01
Berberine inhibits PTP1B activity and mimics insulin action. Biochem Biophys Res Commun (2010) 1.00
Wnt signaling pathway in rheumatoid arthritis, with special emphasis on the different roles in synovial inflammation and bone remodeling. Cell Signal (2013) 1.00
Capn4 overexpression underlies tumor invasion and metastasis after liver transplantation for hepatocellular carcinoma. Hepatology (2009) 1.00
Entry of hepatitis B virus into immortalized human primary hepatocytes by clathrin-dependent endocytosis. J Virol (2012) 1.00
Neuroactive steroids and human recombinant rho1 GABAC receptors. J Pharmacol Exp Ther (2007) 1.00
Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids. J Med Chem (2007) 0.99
Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopenta[b]phenanthrenes and cyclopenta[b]anthracenes. J Med Chem (2008) 0.98
Novel nuclear export signal-interacting protein, NESI, critical for the assembly of hepatitis delta virus. J Virol (2005) 0.98
Suppression of host gene expression by nsp1 proteins of group 2 bat coronaviruses. J Virol (2009) 0.98
Relationship between phosphatidylinositol 4-phosphate synthesis, membrane organization, and lateral diffusion of PI4KIIalpha at the trans-Golgi network. J Lipid Res (2010) 0.98