Allosteric inhibitors of Akt1 and Akt2: discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity.

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Published in Bioorg Med Chem Lett on December 07, 2008

Authors

Yiwei Li1, Jun Liang, Tony Siu, Essa Hu, Michael A Rossi, Stanley F Barnett, Deborah Defeo-Jones, Raymond E Jones, Ronald G Robinson, Karen Leander, Hans E Huber, Sachin Mittal, Nicholas Cosford, Peppi Prasit

Author Affiliations

1: Department of Medicinal Chemistry, Merck Research Laboratories, Merck & Co., 770 Sumneytown Pike, WP14-2, West Point, PA 19486, USA. yiwei_li@merck.com

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