Published in Bioorg Med Chem Lett on November 24, 2008
Arrested oocyst maturation in Plasmodium parasites lacking type II NADH:ubiquinone dehydrogenase. J Biol Chem (2011) 1.09
Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors. Chem Biol (2011) 1.04
Variation among Plasmodium falciparum strains in their reliance on mitochondrial electron transport chain function. Eukaryot Cell (2011) 1.03
The structure of the yeast NADH dehydrogenase (Ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates. Proc Natl Acad Sci U S A (2012) 1.02
Type II NADH dehydrogenase inhibitor 1-hydroxy-2-dodecyl-4(1H)quinolone leads to collapse of mitochondrial inner-membrane potential and ATP depletion in Toxoplasma gondii. Eukaryot Cell (2009) 0.91
A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity. J Antibiot (Tokyo) (2013) 0.90
Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2). J Med Chem (2012) 0.90
HDQ, a potent inhibitor of Plasmodium falciparum proliferation, binds to the quinone reduction site of the cytochrome bc1 complex. Antimicrob Agents Chemother (2012) 0.88
In vitro and in vivo activities of 1-hydroxy-2-alkyl-4(1H)quinolone derivatives against Toxoplasma gondii. Antimicrob Agents Chemother (2009) 0.85
How mitochondrial dysfunction affects zebrafish development and cardiovascular function: an in vivo model for testing mitochondria-targeted drugs. Br J Pharmacol (2013) 0.83
A Dedicated Type II NADPH Dehydrogenase Performs the Penultimate Step in the Biosynthesis of Vitamin K1 in Synechocystis and Arabidopsis. Plant Cell (2015) 0.81
Expression, purification, crystallization and preliminary X-ray diffraction analysis of a type II NADH:quinone oxidoreductase from the human pathogen Staphylococcus aureus. Acta Crystallogr F Struct Biol Commun (2015) 0.75
Mitochondrial type II NAD(P)H dehydrogenases in fungal cell death. Microb Cell (2015) 0.75
The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils. Specific labelling of a component polypeptide of the oxidase. Biochem J (1986) 4.35
Chloroquine resistance in Plasmodium falciparum. Am J Trop Med Hyg (1961) 3.49
Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum. Nature (2007) 3.08
Resistance mutations reveal the atovaquone-binding domain of cytochrome b in malaria parasites. Mol Microbiol (1999) 2.69
Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs. FASEB J (1991) 2.57
The malaria parasite type II NADH:quinone oxidoreductase: an alternative enzyme for an alternative lifestyle. Trends Parasitol (2007) 2.54
DRUG RESISTANCE IN PLASMODIUM FALCIPARUM FROM THAILAND. Am J Trop Med Hyg (1963) 2.42
World malaria situation in 1994. Part I. Population at risk. Wkly Epidemiol Rec (1997) 2.41
Identification and localization of enzymes of the fumarate reductase and nitrate respiration systems of escherichia coli by crossed immunoelectrophoresis. J Bacteriol (1983) 1.76
Yeast model uncovers dual roles of mitochondria in action of artemisinin. PLoS Genet (2005) 1.72
New insights into type II NAD(P)H:quinone oxidoreductases. Microbiol Mol Biol Rev (2004) 1.68
The validity of mitochondrial dehydrogenases as antimalarial drug targets. Trends Parasitol (2007) 1.68
Resistance of East African varieties of Plasmodium falciparum to pyrimethamine. Trans R Soc Trop Med Hyg (1954) 1.42
Diphenyleneiodonium inhibits reduction of iron-sulfur clusters in the mitochondrial NADH-ubiquinone oxidoreductase (Complex I). J Biol Chem (1994) 1.38
Characterization of the isoprenoid chain of coenzyme Q in Plasmodium falciparum. FEMS Microbiol Lett (2002) 1.30
Delayed mitochondrial dysfunction in excitotoxic neuron death: cytochrome c release and a secondary increase in superoxide production. J Neurosci (2000) 1.29
Purification and characterization of a rotenone-insensitive NADH:Q6 oxidoreductase from mitochondria of Saccharomyces cerevisiae. Eur J Biochem (1988) 1.27
Homologues of yeast and bacterial rotenone-insensitive NADH dehydrogenases in higher eukaryotes: two enzymes are present in potato mitochondria. Plant J (1999) 1.21
Functional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondria. Antimicrob Agents Chemother (2006) 1.21
Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase. Biochemistry (2008) 1.13
Fansidar-resistant Plasmodium falciparum infection from Tanzania. Trop Geogr Med (1982) 1.11
HDQ (1-hydroxy-2-dodecyl-4(1H)quinolone), a high affinity inhibitor for mitochondrial alternative NADH dehydrogenase: evidence for a ping-pong mechanism. J Biol Chem (2004) 1.10
Evidence for a gram-positive, eubacterial root of the tree of life. Mol Biol Evol (2007) 1.10
Pyrimidine biosynthesis in Saccharomyces cerevisiae: the ura2 cluster gene, its multifunctional enzyme product, and other structural or regulatory genes involved in de novo UMP synthesis. Biochem Cell Biol (1989) 1.07
Inhibition of cytochrome P450 reductase by the diphenyliodonium cation. Kinetic analysis and covalent modifications. Biochemistry (1993) 1.07
Novel FMN-containing rotenone-insensitive NADH dehydrogenase from Trypanosoma brucei mitochondria: isolation and characterization. Biochemistry (2002) 1.04
Purification of the 45 kDa, membrane bound NADH dehydrogenase of Escherichia coli (NDH-2) and analysis of its interaction with ubiquinone analogues. FEBS Lett (2000) 1.03
Combined chloroquine/Fansidar-resistant falciparum malaria appears in East Africa. Am J Trop Med Hyg (1983) 1.01
NADH oxidase activity of human xanthine oxidoreductase--generation of superoxide anion. Eur J Biochem (1997) 1.01
An enzymatic assay for poly(ADP-ribose) polymerase-1 (PARP-1) via the chemical quantitation of NAD(+): application to the high-throughput screening of small molecules as potential inhibitors. Anal Biochem (2004) 1.00
A single external enzyme confers alternative NADH:ubiquinone oxidoreductase activity in Yarrowia lipolytica. J Cell Sci (1999) 0.99
Growth inhibition of Toxoplasma gondii and Plasmodium falciparum by nanomolar concentrations of 1-hydroxy-2-dodecyl-4(1H)quinolone, a high-affinity inhibitor of alternative (type II) NADH dehydrogenases. Antimicrob Agents Chemother (2007) 0.95
Biosynthetic dihydroorotate dehydrogenase from Lactobacillus bulgaricus. J Bacteriol (1971) 0.95
The external calcium-dependent NADPH dehydrogenase from Neurospora crassa mitochondria. J Biol Chem (2000) 0.93
NADH dehydrogenase of Corynebacterium glutamicum. Purification of an NADH dehydrogenase II homolog able to oxidize NADPH. FEMS Microbiol Lett (2001) 0.92
A new type-II NADH dehydrogenase from the archaeon Acidianus ambivalens: characterization and in vitro reconstitution of the respiratory chain. J Bioenerg Biomembr (2001) 0.90
Mitochondrial NADH dehydrogenase from Plasmodium falciparum and Plasmodium berghei. Exp Parasitol (2002) 0.87
The respiratory chain of the thermophilic archaeon Sulfolobus metallicus: studies on the type-II NADH dehydrogenase. Biochim Biophys Acta (2003) 0.85
Fansidar resistant falciparum malaria in Indonesia. Lancet (1979) 0.84
Acidianus ambivalens type-II NADH dehydrogenase: genetic characterisation and identification of the flavin moiety as FMN. FEBS Lett (2002) 0.84
Surveys on chloroquine resistant P. falciparum in Thailand. Trans R Soc Trop Med Hyg (1968) 0.83
Catalytic properties of dihydroorotate dehydrogenase from Saccharomyces cerevisiae: studies on pH, alternate substrates, and inhibitors. Arch Biochem Biophys (2000) 0.83
Drug-resistant malaria. Lancet (1969) 0.83
The appearance of pyrimethamine resistance in Plasmodium falciparum following self-medication by a rural community in Ghana. Bull World Health Organ (1962) 0.80
Chloroquine-resistant falciparum malaria. Lancet (1968) 0.78
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38
Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. Cancer Cell (2006) 4.52
A genome-wide map of diversity in Plasmodium falciparum. Nat Genet (2006) 4.50
Small-molecule pheromones that control dauer development in Caenorhabditis elegans. Nat Chem Biol (2007) 4.26
A hub-and-spoke circuit drives pheromone attraction and social behaviour in C. elegans. Nature (2009) 4.05
Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum. Nature (2011) 3.83
Bacterial protection of beetle-fungus mutualism. Science (2008) 3.69
D-amino acids trigger biofilm disassembly. Science (2010) 3.60
D-amino acids govern stationary phase cell wall remodeling in bacteria. Science (2009) 3.55
Primary cilia regulate mTORC1 activity and cell size through Lkb1. Nat Cell Biol (2010) 3.55
A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells. Cancer Cell (2003) 3.29
Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations. Nat Med (2002) 3.29
A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes. Science (2010) 3.27
A systematic map of genetic variation in Plasmodium falciparum. PLoS Pathog (2006) 2.92
Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes. Science (2005) 2.81
The evolution of gene collectives: How natural selection drives chemical innovation. Proc Natl Acad Sci U S A (2008) 2.71
High-throughput Plasmodium falciparum growth assay for malaria drug discovery. Antimicrob Agents Chemother (2006) 2.70
Dentigerumycin: a bacterial mediator of an ant-fungus symbiosis. Nat Chem Biol (2009) 2.57
Two chemoreceptors mediate developmental effects of dauer pheromone in C. elegans. Science (2009) 2.55
A general SNP-based molecular barcode for Plasmodium falciparum identification and tracking. Malar J (2008) 2.54
Target identification using drug affinity responsive target stability (DARTS). Proc Natl Acad Sci U S A (2009) 2.40
Tyrosol is a quorum-sensing molecule in Candida albicans. Proc Natl Acad Sci U S A (2004) 2.39
A potent dauer pheromone component in Caenorhabditis elegans that acts synergistically with other components. Proc Natl Acad Sci U S A (2008) 2.35
Kidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys. J Natl Cancer Inst (2008) 2.25
Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum. Genome Biol (2009) 2.23
Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin. Proc Natl Acad Sci U S A (2009) 2.22
The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis. Proc Natl Acad Sci U S A (2007) 2.22
Loss of oriented cell division does not initiate cyst formation. J Am Soc Nephrol (2009) 2.20
Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity. Proc Natl Acad Sci U S A (2002) 2.15
The Jekyll-and-Hyde chemistry of Phaeobacter gallaeciensis. Nat Chem (2011) 2.12
Population structure and transmission dynamics of Plasmodium vivax in rural Amazonia. J Infect Dis (2007) 2.11
A novel erythrocyte binding antigen-175 paralogue from Plasmodium falciparum defines a new trypsin-resistant receptor on human erythrocytes. J Biol Chem (2003) 2.08
Siderophores from neighboring organisms promote the growth of uncultured bacteria. Chem Biol (2010) 2.04
Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence. Genome Biol (2008) 2.00
Reticulocyte-binding protein homologue 1 is required for sialic acid-dependent invasion into human erythrocytes by Plasmodium falciparum. Mol Microbiol (2005) 1.98
Regulating alternative lifestyles in entomopathogenic bacteria. Curr Biol (2010) 1.97
Biosynthesis of the Caenorhabditis elegans dauer pheromone. Proc Natl Acad Sci U S A (2009) 1.96
Extensive microsatellite diversity in the human malaria parasite Plasmodium vivax. Gene (2008) 1.89
Isolation of antibiotics turbomycin a and B from a metagenomic library of soil microbial DNA. Appl Environ Microbiol (2002) 1.89
A single promoter inversion switches Photorhabdus between pathogenic and mutualistic states. Science (2012) 1.82
High-throughput screens for small-molecule inhibitors of Pseudomonas aeruginosa biofilm development. Antimicrob Agents Chemother (2007) 1.74
A bacterial sulfonolipid triggers multicellular development in the closest living relatives of animals. Elife (2012) 1.72
Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum. PLoS Biol (2009) 1.72
Geographic structure of Plasmodium vivax: microsatellite analysis of parasite populations from Sri Lanka, Myanmar, and Ethiopia. Am J Trop Med Hyg (2010) 1.69
Widespread distribution of antisense transcripts in the Plasmodium falciparum genome. Mol Biochem Parasitol (2004) 1.68
Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum. PLoS Genet (2011) 1.68
In vitro chloroquine susceptibility and PCR analysis of pfcrt and pfmdr1 polymorphisms in Plasmodium falciparum isolates from Senegal. Am J Trop Med Hyg (2002) 1.66
One pathway, many products. Nat Chem Biol (2007) 1.63
Evidence-based annotation of the malaria parasite's genome using comparative expression profiling. PLoS One (2008) 1.61
Hybrid selection for sequencing pathogen genomes from clinical samples. Genome Biol (2011) 1.61
Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria. Proc Natl Acad Sci U S A (2010) 1.59
Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes. Proc Natl Acad Sci U S A (2003) 1.58
Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite. Proc Natl Acad Sci U S A (2012) 1.58
A flow cytometry-based assay for measuring invasion of red blood cells by Plasmodium falciparum. Am J Hematol (2010) 1.57
Frequency and outcomes of aortocoronary dissection during percutaneous coronary intervention of chronic total occlusions: a case series and systematic review of the literature. Catheter Cardiovasc Interv (2013) 1.53
FeeM, an N-acyl amino acid synthase from an uncultured soil microbe: structure, mechanism, and acyl carrier protein binding. Structure (2006) 1.53
Excess polymorphisms in genes for membrane proteins in Plasmodium falciparum. Science (2002) 1.52
A high-throughput screen targeting malaria transmission stages opens new avenues for drug development. J Infect Dis (2011) 1.49
New natural product families from an environmental DNA (eDNA) gene cluster. J Am Chem Soc (2002) 1.49
In vivo transcriptome of Plasmodium falciparum reveals overexpression of transcripts that encode surface proteins. J Infect Dis (2005) 1.46
Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model. J Biol Chem (2010) 1.46
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol (2012) 1.46
A Bacillus subtilis sensor kinase involved in triggering biofilm formation on the roots of tomato plants. Mol Microbiol (2012) 1.45
Mycangimycin, a polyene peroxide from a mutualist Streptomyces sp. Org Lett (2009) 1.45
Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum. J Med Chem (2009) 1.42
Production of α-galactosylceramide by a prominent member of the human gut microbiota. PLoS Biol (2013) 1.42
An indole-containing dauer pheromone component with unusual dauer inhibitory activity at higher concentrations. Org Lett (2009) 1.41
Harnessing genomics and genome biology to understand malaria biology. Nat Rev Genet (2012) 1.41
Retracted A self-produced trigger for biofilm disassembly that targets exopolysaccharide. Cell (2012) 1.41
Genetic surveillance detects both clonal and epidemic transmission of malaria following enhanced intervention in Senegal. PLoS One (2013) 1.40
Differential analysis of 2D NMR spectra: new natural products from a pilot-scale fungal extract library. Angew Chem Int Ed Engl (2007) 1.40
A biosynthetic gene cluster for the acetyl-CoA carboxylase inhibitor andrimid. J Am Chem Soc (2006) 1.39
Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans. Science (2010) 1.36
Fluid flow induces mechanosensitive ATP release, calcium signalling and Cl- transport in biliary epithelial cells through a PKCzeta-dependent pathway. J Physiol (2008) 1.36
Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem (2008) 1.34
Using the heat-shock response to discover anticancer compounds that target protein homeostasis. ACS Chem Biol (2011) 1.31
Liver-stage malaria parasites vulnerable to diverse chemical scaffolds. Proc Natl Acad Sci U S A (2012) 1.31
Rapid, field-deployable method for genotyping and discovery of single-nucleotide polymorphisms associated with drug resistance in Plasmodium falciparum. Antimicrob Agents Chemother (2012) 1.30
Crystal and solution structures of an odorant-binding protein from the southern house mosquito complexed with an oviposition pheromone. Proc Natl Acad Sci U S A (2010) 1.28
Roseobacticides: small molecule modulators of an algal-bacterial symbiosis. J Am Chem Soc (2011) 1.24
A DOC2 protein identified by mutational profiling is essential for apicomplexan parasite exocytosis. Science (2012) 1.24
On the road to eliminate malaria in Sri Lanka: lessons from history, challenges, gaps in knowledge and research needs. Malar J (2014) 1.24
Single-nucleotide polymorphism, linkage disequilibrium and geographic structure in the malaria parasite Plasmodium vivax: prospects for genome-wide association studies. BMC Genet (2010) 1.24
Low-complexity regions in Plasmodium falciparum: missing links in the evolution of an extreme genome. Mol Biol Evol (2010) 1.23
Palmitoylputrescine, an antibiotic isolated from the heterologous expression of DNA extracted from bromeliad tank water. J Nat Prod (2004) 1.23
Synthesis and in vitro biocompatibility of injectable polyurethane foam scaffolds. Tissue Eng (2006) 1.22
Plasmodium falciparum Sir2: an unusual sirtuin with dual histone deacetylase and ADP-ribosyltransferase activity. Eukaryot Cell (2007) 1.21
Plasmodium falciparum: genome wide perturbations in transcript profiles among mixed stage cultures after chloroquine treatment. Exp Parasitol (2007) 1.21
Variant merozoite protein expression is associated with erythrocyte invasion phenotypes in Plasmodium falciparum isolates from Tanzania. Mol Biochem Parasitol (2007) 1.20
Mutations of HNF-1beta inhibit epithelial morphogenesis through dysregulation of SOCS-3. Proc Natl Acad Sci U S A (2007) 1.20
Suggestive evidence for Darwinian Selection against asparagine-linked glycans of Plasmodium falciparum and Toxoplasma gondii. Eukaryot Cell (2009) 1.20