PubRank

Dyann F Wirth

Author PubWeight™ 99.27‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A genome-wide map of diversity in Plasmodium falciparum. Nat Genet 2006 4.50
2 A systematic map of genetic variation in Plasmodium falciparum. PLoS Pathog 2006 2.92
3 High-throughput Plasmodium falciparum growth assay for malaria drug discovery. Antimicrob Agents Chemother 2006 2.70
4 A general SNP-based molecular barcode for Plasmodium falciparum identification and tracking. Malar J 2008 2.54
5 Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum. Genome Biol 2009 2.23
6 Population structure and transmission dynamics of Plasmodium vivax in rural Amazonia. J Infect Dis 2007 2.11
7 Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence. Genome Biol 2008 2.00
8 Extensive microsatellite diversity in the human malaria parasite Plasmodium vivax. Gene 2008 1.89
9 Geographic structure of Plasmodium vivax: microsatellite analysis of parasite populations from Sri Lanka, Myanmar, and Ethiopia. Am J Trop Med Hyg 2010 1.69
10 Widespread distribution of antisense transcripts in the Plasmodium falciparum genome. Mol Biochem Parasitol 2004 1.68
11 Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum. PLoS Genet 2011 1.68
12 In vitro chloroquine susceptibility and PCR analysis of pfcrt and pfmdr1 polymorphisms in Plasmodium falciparum isolates from Senegal. Am J Trop Med Hyg 2002 1.66
13 Hybrid selection for sequencing pathogen genomes from clinical samples. Genome Biol 2011 1.61
14 Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite. Proc Natl Acad Sci U S A 2012 1.58
15 Excess polymorphisms in genes for membrane proteins in Plasmodium falciparum. Science 2002 1.52
16 A high-throughput screen targeting malaria transmission stages opens new avenues for drug development. J Infect Dis 2011 1.49
17 In vivo transcriptome of Plasmodium falciparum reveals overexpression of transcripts that encode surface proteins. J Infect Dis 2005 1.46
18 Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model. J Biol Chem 2010 1.46
19 Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol 2012 1.46
20 Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum. J Med Chem 2009 1.42
21 Harnessing genomics and genome biology to understand malaria biology. Nat Rev Genet 2012 1.41
22 Genetic surveillance detects both clonal and epidemic transmission of malaria following enhanced intervention in Senegal. PLoS One 2013 1.40
23 Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem 2008 1.34
24 Rapid, field-deployable method for genotyping and discovery of single-nucleotide polymorphisms associated with drug resistance in Plasmodium falciparum. Antimicrob Agents Chemother 2012 1.30
25 On the road to eliminate malaria in Sri Lanka: lessons from history, challenges, gaps in knowledge and research needs. Malar J 2014 1.24
26 Single-nucleotide polymorphism, linkage disequilibrium and geographic structure in the malaria parasite Plasmodium vivax: prospects for genome-wide association studies. BMC Genet 2010 1.24
27 Low-complexity regions in Plasmodium falciparum: missing links in the evolution of an extreme genome. Mol Biol Evol 2010 1.23
28 Plasmodium falciparum: genome wide perturbations in transcript profiles among mixed stage cultures after chloroquine treatment. Exp Parasitol 2007 1.21
29 Gene conversion as a source of nucleotide diversity in Plasmodium falciparum. Mol Biol Evol 2003 1.19
30 A non-radioactive DAPI-based high-throughput in vitro assay to assess Plasmodium falciparum responsiveness to antimalarials--increased sensitivity of P. falciparum to chloroquine in Senegal. Am J Trop Med Hyg 2010 1.18
31 Identification of regulatory elements in the Plasmodium falciparum genome. Mol Biochem Parasitol 2004 1.18
32 RNA polymerase II synthesizes antisense RNA in Plasmodium falciparum. RNA 2005 1.15
33 Drug-induced alterations in gene expression of the asexual blood forms of Plasmodium falciparum. Mol Microbiol 2003 1.15
34 The paradoxical population genetics of Plasmodium falciparum. Trends Parasitol 2002 1.14
35 Mapping of the Plasmodium falciparum multidrug resistance gene 5'-upstream region, and evidence of induction of transcript levels by antimalarial drugs in chloroquine sensitive parasites. Mol Microbiol 2003 1.13
36 Genetic diversity and selection at the Plasmodium vivax apical membrane antigen-1 (PvAMA-1) locus in a Sri Lankan population. Mol Biol Evol 2007 1.12
37 Molecular analysis of erythrocyte invasion in Plasmodium falciparum isolates from Senegal. Infect Immun 2007 1.11
38 Duplication, gene conversion, and genetic diversity in the species-specific acyl-CoA synthetase gene family of Plasmodium falciparum. Mol Biochem Parasitol 2006 1.11
39 Colorimetric high-throughput screen for detection of heme crystallization inhibitors. Antimicrob Agents Chemother 2009 1.06
40 Regulatory motifs uncovered among gene expression clusters in Plasmodium falciparum. Mol Biochem Parasitol 2007 1.06
41 Patterns of gene-specific and total transcriptional activity during the Plasmodium falciparum intraerythrocytic developmental cycle. Eukaryot Cell 2009 1.05
42 Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins. Proc Natl Acad Sci U S A 2013 1.05
43 Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance. Proc Natl Acad Sci U S A 2013 1.05
44 Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors. Chem Biol 2011 1.04
45 Pre-amplification methods for tracking low-grade Plasmodium falciparum populations during scaled-up interventions in Southern Zambia. Malar J 2014 1.01
46 Confirmation of emergence of mutations associated with atovaquone-proguanil resistance in unexposed Plasmodium falciparum isolates from Africa. Malar J 2006 1.01
47 Genomic sequencing of Plasmodium falciparum malaria parasites from Senegal reveals the demographic history of the population. Mol Biol Evol 2012 1.00
48 In vivo and in vitro analysis of chloroquine resistance in Plasmodium falciparum isolates from Senegal. Parasitol Res 2005 1.00
49 Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors. Bioorg Med Chem Lett 2008 1.00
50 Malaria life cycle intensifies both natural selection and random genetic drift. Proc Natl Acad Sci U S A 2013 0.99
51 Relationship between chloroquine toxicity and iron acquisition in Saccharomyces cerevisiae. Antimicrob Agents Chemother 2002 0.98
52 Analysis of pfhrp2 genetic diversity in Senegal and implications for use of rapid diagnostic tests. Malar J 2014 0.97
53 Improving malaria control in West Africa: interruption of transmission as a paradigm shift. Acta Trop 2011 0.96
54 Application of genomics to field investigations of malaria by the international centers of excellence for malaria research. Acta Trop 2011 0.95
55 SNP genotyping identifies new signatures of selection in a deep sample of West African Plasmodium falciparum malaria parasites. Mol Biol Evol 2012 0.95
56 In vitro-reduced susceptibility to artemether in P. falciparum and its association with polymorphisms on transporter genes. J Infect Dis 2012 0.94
57 In vivo transcriptional profiling of Plasmodium falciparum. Malar J 2004 0.94
58 Evolution of the pfcrt T76 and pfmdr1 Y86 markers and chloroquine susceptibility 8 years after cessation of chloroquine use in Pikine, Senegal. Parasitol Res 2012 0.92
59 Sahel, savana, riverine and urban malaria in West Africa: Similar control policies with different outcomes. Acta Trop 2011 0.91
60 A new reporter gene for transient transfection of Plasmodium falciparum. Parasitol Res 2002 0.90
61 Nuclear repositioning precedes promoter accessibility and is linked to the switching frequency of a Plasmodium falciparum invasion gene. Cell Host Microbe 2012 0.89
62 Biological revelations. Nature 2002 0.89
63 Human cerebral malaria and Plasmodium falciparum genotypes in Malawi. Malar J 2012 0.88
64 Linker scanning mutagenesis of the Plasmodium gallinaceum sexual stage specific gene pgs28 reveals a novel downstream cis-control element. Mol Biochem Parasitol 2003 0.86
65 Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum. Antimicrob Agents Chemother 2011 0.86
66 Mutations in PFCRT K76T do not correlate with sulfadoxine-pyrimethamine-amodiaquine failure in Pikine, Senegal. Parasitol Res 2008 0.86
67 Development of a fluorescence polarization based assay for histone deacetylase ligand discovery. Bioorg Med Chem Lett 2008 0.85
68 Localization and activity of multidrug resistance protein 1 in the secretory pathway of Leishmania parasites. Mol Microbiol 2004 0.84
69 Genomic heterogeneity in the density of noncoding single-nucleotide and microsatellite polymorphisms in Plasmodium falciparum. Gene 2006 0.84
70 Analysis of the genetic diversity of the Plasmodium falciparum multidrug resistance gene 5' upstream region. Am J Trop Med Hyg 2005 0.84
71 Diversity-oriented synthesis-facilitated medicinal chemistry: toward the development of novel antimalarial agents. J Med Chem 2014 0.83
72 Aminoazabenzimidazoles, a novel class of orally active antimalarial agents. J Med Chem 2014 0.83
73 Modulation of PF10_0355 (MSPDBL2) alters Plasmodium falciparum response to antimalarial drugs. Antimicrob Agents Chemother 2013 0.82
74 Secreted antibody is required for immunity to Plasmodium berghei. Infect Immun 2008 0.81
75 Enrichment of reticulocytes from whole blood using aqueous multiphase systems of polymers. Am J Hematol 2014 0.81
76 A concise silylamine approach to 2-amino-3-hydroxy-indoles with potent in vivo antimalaria activity. Org Lett 2010 0.80
77 A genomic and evolutionary approach reveals non-genetic drug resistance in malaria. Genome Biol 2014 0.78
78 Distribution pattern of Plasmodium falciparum chloroquine transporter (pfcrt) gene haplotypes in Sri Lanka 1996-2006. Am J Trop Med Hyg 2011 0.78